Reduced plasma levels of soluble interleukin-7 receptor during graft-versus-host disease (GVHD) in children and adults.

abstract：BACKGROUND:Expressed in embryonic development, matrix metalloprotein-9 (MMP-9) is absent in most of developed adult tissues, but recurs in inflammation during tissue injury, wound healing, tumor formation and metastasis. Expression of MMP-9 is tightly controlled by extracellular cues including pro-inflammatory cytokine...

journal_title：BMC immunology

authors： Zhou L,Yan C,Gieling RG,Kida Y,Garner W,Li W,Han YP

更新日期：2009-03-19 00:00:00

abstract：BACKGROUND:CD33 is a membrane receptor containing a lectin domain and a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM) that is able to inhibit cytokine production. CD33 is expressed by monocytes, and reduced expression of CD33 correlates with augmented production of inflammatory cytokines, such as IL...

journal_title：BMC immunology

authors： Gonzalez Y,Herrera MT,Soldevila G,Garcia-Garcia L,Fabián G,Pérez-Armendariz EM,Bobadilla K,Guzmán-Beltrán S,Sada E,Torres M

更新日期：2012-04-14 00:00:00

abstract：BACKGROUND:Active cancer immunotherapies are beginning to yield clinical benefit, especially those using peptide-pulsed dendritic cells (DCs). Different adjuvants, including Toll-like receptor (TLR) agonists, commonly co-administered to cancer patients as part of a DC-based vaccine, are being widely tested in the clini...

journal_title：BMC immunology

authors： Ioannou K,Derhovanessian E,Tsakiri E,Samara P,Kalbacher H,Voelter W,Trougakos IP,Pawelec G,Tsitsilonis OE

更新日期：2013-09-22 00:00:00

abstract：BACKGROUND:In celiac disease gluten, the disease-inducing toxic component in wheat, induces the secretion of autoantibodies which are targeted against transglutaminase 2 (TG2). These autoantibodies are produced in the small-intestinal mucosa, where they can be found deposited extracellularly below the epithelial baseme...

journal_title：BMC immunology

authors： Stenman SM,Lindfors K,Korponay-Szabo IR,Lohi O,Saavalainen P,Partanen J,Haimila K,Wieser H,Mäki M,Kaukinen K

更新日期：2008-02-29 00:00:00

abstract：BACKGROUND:The adaptive immune system maintains a diversity of T cells capable of recognizing a broad array of antigens. Each T cell's specificity for antigens is determined by its T cell receptors (TCRs), which together across all T cells form a repertoire of millions of unique receptors in each individual. Although m...

journal_title：BMC immunology

authors： Chu ND,Bi HS,Emerson RO,Sherwood AM,Birnbaum ME,Robins HS,Alm EJ

更新日期：2019-06-21 00:00:00

abstract：BACKGROUND:Macrophages have heterogeneous phenotypes and complex functions within both innate and adaptive immune responses. To date, most experimental studies have been performed on macrophages derived from bone marrow, spleen and peritoneum. However, differences among macrophages from these particular sources remain ...

journal_title：BMC immunology

authors： Wang C,Yu X,Cao Q,Wang Y,Zheng G,Tan TK,Zhao H,Zhao Y,Wang Y,Harris DCh

更新日期：2013-02-05 00:00:00

abstract：BACKGROUND:Dendritic cells (DC) play the key role in directing antigen-specific immune responses and manipulating their function may be a useful tool for immunotherapy. The balance between immune stimulation and tolerance is particularly important at mucosal interfaces, where discrimination between dangerous pathogens ...

journal_title：BMC immunology

authors： Polak ME,Borthwick NJ,Gabriel FG,Jager MJ,Cree IA

更新日期：2008-03-18 00:00:00

abstract：BACKGROUND:Egg white must provide nutrients and protection to the developing avian embryo. One way in which this is achieved is an arsenal of antimicrobial proteins and peptides which are essentially extensions of the innate immune system. Gallin is a recently identified member of a family of peptides that are found in...

journal_title：BMC immunology

authors： Gong D,Wilson PW,Bain MM,McDade K,Kalina J,Hervé-Grépinet V,Nys Y,Dunn IC

更新日期：2010-03-12 00:00:00

abstract：BACKGROUND:Early detection of capecitabine-resistance could largely increase overall survival of colorectal cancer (CRC) patients. Previous studies suggested examination of immune cells in peripheral blood would help to predict efficacy of chemotherapy. METHODS:We examined the immunological characteristics of peripher...

journal_title：BMC immunology

authors： Lu Y,Huang Y,Huang L,Xu Y,Wang Z,Li H,Zhang T,Zhong M,Gao WQ,Zhang Y

更新日期：2020-08-08 00:00:00

abstract：BACKGROUND:Immunophenotyping of blood lymphocytes is an essential tool to evaluate the immune function of patients with immunodeficiency or autoimmunity. Predominately identified CD4+T cell subsets, Th1, Th2, Th17, as well as regulatory T (Treg) cells, play crucial roles in several immunological and pathological condit...

journal_title：BMC immunology

authors： Niu HQ,Zhao XC,Li W,Xie JF,Liu XQ,Luo J,Zhao WP,Li XF

更新日期：2020-08-03 00:00:00

abstract：BACKGROUND:Class I major histocompatibility complex (MHC) molecules bind, and present to T cells, short peptides derived from intracellular processing of proteins. The peptide repertoire of a specific molecule is to a large extent determined by the molecular structure accommodating so-called main anchor positions of th...

journal_title：BMC immunology

authors： Sidney J,Peters B,Frahm N,Brander C,Sette A

更新日期：2008-01-22 00:00:00

abstract：BACKGROUND:Anthrax lethal toxin (LT), produced by the Gram-positive bacterium Bacillus anthracis, is a highly effective zinc dependent metalloprotease that cleaves the N-terminus of mitogen-activated protein kinase kinases (MAPKK or MEKs) and is known to play a role in impairing the host immune system during an inhalat...

journal_title：BMC immunology

authors： Chauncey KM,Lopez MC,Sidhu G,Szarowicz SE,Baker HV,Quinn C,Southwick FS

更新日期：2012-07-02 00:00:00

abstract：BACKGROUND:Burkholderia pseudomallei is the causative agent for melioidosis. For many bacterial infections, cytokine dysregulation is one of the contributing factors to the severe clinical outcomes in the susceptible hosts. The C57BL/6 and BALB/c mice have been established as a differential model of susceptibility in m...

journal_title：BMC immunology

authors： Koo GC,Gan YH

更新日期：2006-08-18 00:00:00

abstract：BACKGROUND:Myeloid derived suppressor cells (MDSCs) present a significant obstacle to cancer immunotherapy because they dampen anti-tumor cytotoxic T cell responses. Previous groups, including our own, have reported on the myelo-depletive effects of certain chemotherapy agents. We have shown previously that decitabine ...

journal_title：BMC immunology

authors： Luker AJ,Graham LJ,Smith TM Jr,Camarena C,Zellner MP,Gilmer JS,Damle SR,Conrad DH,Bear HD,Martin RK

更新日期：2020-02-27 00:00:00

abstract：BACKGROUND:Interleukin-9 (IL-9) was reported as an active participant in the pathogenesis of allergic asthma. This study aimed to investigate the major source ofIL-9 and its effect on interferon γ (IFN-γ) and immunoglobulin (Ig) secretion by B cells. METHODS:We isolated peripheral blood mononuclear cells from children...

journal_title：BMC immunology

authors： Jia L,Wang Y,Li J,Li S,Zhang Y,Shen J,Tan W,Wu C

更新日期：2017-07-19 00:00:00

abstract：BACKGROUND:Shiga toxin 2 (Stx2), one of two Stx liberated by Stx-producing Escherichia coli, is composed of an A subunit monomer and a B subunit pentamer, and is directly linked with hemolytic uremic syndrome in children. The pentameric B subunit binds to its cell surface receptor Gb3 for toxin internalization, and the...

journal_title：BMC immunology

authors： Jeong KI,Chapman-Bonofiglio S,Singh P,Lee J,Tzipori S,Sheoran AS

更新日期：2010-03-24 00:00:00

abstract：:The immunological roles of B-cells are being revealed as increasingly complex by functions that are largely beyond their commitment to differentiate into plasma cells and produce antibodies, the key molecular protagonists of innate immunity, and also by their compartmentalisation, a more recently acknowledged property...

journal_title：BMC immunology

authors： Garraud O,Borhis G,Badr G,Degrelle S,Pozzetto B,Cognasse F,Richard Y

更新日期：2012-11-29 00:00:00

abstract：BACKGROUND:Pattern recognition receptors (PRRs) for double-stranded RNA (dsRNA) are components of innate immunity that recognize the presence of viral infection and initiate efficient defense mechanisms. In addition to previously well-characterized signaling pathways that are mediated by PKR and TLR3, new intracellular...

journal_title：BMC immunology

authors： Yun JJ,Tsao MS,Der SD

更新日期：2011-02-10 00:00:00

abstract：BACKGROUND:The CXCR3 receptor and its three interferon-inducible ligands (CXCL9, CXCL10 and CXCL11) have been implicated as playing a central role in directing a Th1 inflammatory response. Recent studies strongly support that the CXCR3 receptor is a very attractive therapeutic target for treating autoimmune diseases, s...

journal_title：BMC immunology

authors： Jenh CH,Cox MA,Cui L,Reich EP,Sullivan L,Chen SC,Kinsley D,Qian S,Kim SH,Rosenblum S,Kozlowski J,Fine JS,Zavodny PJ,Lundell D

更新日期：2012-01-10 00:00:00

abstract：BACKGROUND:Bv8, prokineticin-1, or endocrine gland-vascular endothelial growth factor, and prokineticin-2 are recently isolated peptide agonists of two G protein-coupled receptors, prokineticin receptor-1 (PROKR 1) and PROKR 2, and have been described as affecting a number of myeloid cell functions. We evaluated the im...

journal_title：BMC immunology

authors： Franchi S,Giannini E,Lattuada D,Lattanzi R,Tian H,Melchiorri P,Negri L,Panerai AE,Sacerdote P

更新日期：2008-10-28 00:00:00

abstract：BACKGROUND:The USDA, Wildlife Services cooperative oral rabies vaccination (ORV) program uses a live vaccinia virus-vectored (genus Orthopoxvirus) vaccine, Raboral V-RG (V-RG), to vaccinate specific wildlife species against rabies virus in several regions of the U.S. Several naturally occurring orthopoxviruses have bee...

journal_title：BMC immunology

authors： Root JJ,McLean RG,Slate D,MacCarthy KA,Osorio JE

更新日期：2008-10-03 00:00:00

abstract：BACKGROUND:Streptococcus sanguinis (S.sanguinis), a predominant bacterium in the human oral cavity, has been widely associated with the development of infective endocarditis. Platelets play both a haemostatic function and can influence both innate and adaptive immune responses. Previous studies have shown that S.sangui...

journal_title：BMC immunology

authors： Cognasse F,Hamzeh-Cognasse H,Chabert A,Jackson E,Arthaud CA,Garraud O,McNicol A

更新日期：2014-04-22 00:00:00

abstract：BACKGROUND:Allergen immunotherapy (SIT) is the only treatment for allergic disease capable of modifying disease long term. To reduce the risk of anaphylaxis from SIT, allergen-extracts have been modified by polymerisation with glutaraldehyde to reduce IgE binding. It is suggested that these allergoid extracts also have...

journal_title：BMC immunology

authors： Urry ZL,Richards DF,Black C,Morales M,Carnés J,Hawrylowicz CM,Robinson DS

更新日期：2014-05-29 00:00:00

abstract：BACKGROUND:Tuberculous pleural effusion (TPE) is one of the most common forms of extrapulmonary tuberculosis. Because most studies of TPE focused on the pleural space, little information regarding lung parenchyma is available. We therefore aimed to investigate immune responses in the lung parenchyma of TPE patients wit...

journal_title：BMC immunology

authors： Qama D,Choi WI,Kwon KY

更新日期：2012-08-13 00:00:00

abstract：BACKGROUND:Down syndrome (DS) is the most common syndromic immunodeficiency with an increased risk of infection, mortality from sepsis, and autoinflammation. Innate immune function is altered in DS and therefore we examined responses in CD11b and Toll like receptor 4 (TLR-4), which are important immune cell surface mar...

journal_title：BMC immunology

authors： Huggard D,McGrane F,Lagan N,Roche E,Balfe J,Leahy TR,Franklin O,Moreno A,Melo AM,Doherty DG,Molloy EJ

更新日期：2018-11-03 00:00:00

abstract：BACKGROUND:We have recently demonstrated that all-trans-retinoic acid (ATRA) and 9-cis-retinoic acid (9-cis RA) promote IL-4, IL-5 and IL-13 synthesis, while decreasing IFN-gamma and TNF-alpha expression by activated human T cells and reduces the synthesis of IL-12p70 from accessory cells. Here, we have demonstrated th...

journal_title：BMC immunology

authors： Dawson HD,Collins G,Pyle R,Key M,Taub DD

更新日期：2008-04-16 00:00:00

abstract：BACKGROUND:Activation signals can be negatively regulated by cell surface receptors bearing immunoreceptor tyrosine-based inhibitory motifs (ITIMs). CD300a, an ITIM bearing type I transmembrane protein, is expressed on many hematopoietic cells, including subsets of lymphocytes. RESULTS:We have taken two approaches to ...

journal_title：BMC immunology

authors： DeBell KE,Simhadri VR,Mariano JL,Borrego F

更新日期：2012-04-26 00:00:00

abstract：BACKGROUND:Marginal zone (MZ) B cells play important roles in the early phases of humoral immune responses. In addition to possessing an inherent capacity to rapidly differentiate into antibody secreting cells, MZ B cells also help to regulate the fate of both T-independent and T-dependent blood-borne antigens in the s...

journal_title：BMC immunology

authors： Ferguson AR,Corley RB

更新日期：2005-04-18 00:00:00

abstract：BACKGROUND:Extracellular vesicles (EVs) are nano-sized particles secreted by most cells. EVs carry nucleic acids that hold promise as potential biomarkers in various diseases. Human immunodeficiency virus type 1 (HIV) infects CD4+ T cells and induces immune dysfunction, inflammation, and EV secretion, but little is kno...

journal_title：BMC immunology

authors： Chettimada S,Lorenz DR,Misra V,Wolinsky SM,Gabuzda D

更新日期：2020-11-11 00:00:00

abstract：BACKGROUND:Gene transfer studies in primary T cells have suffered from the limitations of conventional viral transduction or transfection techniques. Replication-defective adenoviral vectors are an attractive alternative for gene delivery. However, naive lymphocytes are not readily susceptible to infection with adenovi...

journal_title：BMC immunology

authors： Hurez V,Dzialo-Hatton R,Oliver J,Matthews RJ,Weaver CT

更新日期：2002-05-02 00:00:00