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Streptococcus sanguinis-induced cytokine and matrix metalloproteinase-1 release from platelets.

Abstract：

BACKGROUND:Streptococcus sanguinis (S.sanguinis), a predominant bacterium in the human oral cavity, has been widely associated with the development of infective endocarditis. Platelets play both a haemostatic function and can influence both innate and adaptive immune responses. Previous studies have shown that S.sanguinis can interact with, and activate, platelets. RESULTS:The aim of this study was to determine whether S.sanguinis stimulates the release of matrix metalloproteinases (MMPs) 1, 2 and 9 and the pro-inflammatory mediators SDF-1, VEGF and sCD40L, from platelets and to subsequently pharmacologically address the release mechanism (s). S.sanguinis stimulated the release of MMP-1, SDF-1, VEGF and sCD40L from platelets and inhibitors of cyclooxygenase and phosphatidylinositol 3-kinase, and antagonists of the αIIbβ3 integrin and glycoprotein Ib, each inhibited the secretion of all factors. CONCLUSIONS:Therefore the release of MMP-1, SDF-1, VEGF and sCD40L occurs late in the platelet response to S.sanguinis and highlights the complex intracellular signalling pathways stimulated in response to S.sanguinis which lead to haemostasis, MMP and pro-inflammatory mediator secretion.

journal_name

BMC Immunol

journal_title

BMC immunology

authors

Cognasse F,Hamzeh-Cognasse H,Chabert A,Jackson E,Arthaud CA,Garraud O,McNicol A

doi

10.1186/1471-2172-15-15

subject

Has Abstract

pub_date

2014-04-22 00:00:00

pages

15

issn

1471-2172

pii

1471-2172-15-15

journal_volume

15

pub_type

杂志文章

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