Oral administration of NSP-116, a free radical scavenger, suppresses the symptoms of retinal vein occlusion in the murine model.

abstract：:Previously, we demonstrated that the inwardly rectifying K(+) (Kir) channel subunit Kir7.1 is highly expressed in bovine and human retinal pigment epithelium (RPE). The purpose of this study was to determine whether any of the 14 other members of the Kir gene family are expressed in native human RPE. Conventional reve...

journal_title：Experimental eye research

authors： Yang D,Zhang X,Hughes BA

更新日期：2008-09-01 00:00:00

abstract：:The gene for microphthalmia in the homozygous cinnamon mouse produces colobomatous microphthalmia due to failure of closure of the optic fissure. Optic fissure formation and closure were examined in control cinnamon and homozygous microphthalmic foetuses from the 10th to the 13th gestational day using light and electr...

journal_title：Experimental eye research

authors： Hero I

更新日期：1989-08-01 00:00:00

abstract：:Corneal mycotic ulceration is predominantly due to Aspergillus and Fusarium solani infection in tropical countries. In this study, we examined the proteome profile of tear samples from A. flavus keratitis patients at various stages of infection. The proteome was profiled using 2D PAGE and the protein levels were quant...

journal_title：Experimental eye research

authors： Parthiban N,Sampath NL,JeyaMaheshwari J,Prajna NV,Lalitha P,Dharmalingam K

更新日期：2019-09-01 00:00:00

abstract：:Much controversy has arisen on the nature and sources of stem cells in the adult human retina. Whilst ciliary epithelium has been thought to constitute a source of neural stem cells, a population of Müller glia in the neural retina has also been shown to exhibit neurogenic characteristics. This study aimed to compare ...

journal_title：Experimental eye research

authors： Bhatia B,Jayaram H,Singhal S,Jones MF,Limb GA

更新日期：2011-12-01 00:00:00

abstract：:The aim of this study was to examine the murine subbasal nerve fibre plexus (SNP) regeneration altered by surgical dissection. Investigations in the mouse model addressed the regeneration capabilities of the SNP, and the influence of local ciliary neurotrophic factor (CNTF) application on the regeneration process. In ...

journal_title：Experimental eye research

authors： Reichard M,Hovakimyan M,Guthoff RF,Stachs O

更新日期：2014-03-01 00:00:00

abstract：:Calf lenses which are incubated in solutions of 1-150 mM H2O2 for 24 hr remain clear at 20 degrees C. While insoluble lens protein increases by at most 2-3%, we find extensive oxidation of exposed protein thiols, major shifts in the size distribution of crystallins, and progressive generation of more acidic polypeptid...

journal_title：Experimental eye research

authors： Siezen RJ,Coppin CM,Kaplan ED,Dwyer D,Thomson JA

更新日期：1989-02-01 00:00:00

abstract：:This is a brief overview of multifaceted anatomical, experimental and clinical studies conducted by the author since 1955 on the optic nerve head circulation in health and disease. Conclusions, based on the accumulated information provided by these studies, are summarized. The studies on the pattern of blood supply of...

journal_title：Experimental eye research

authors： Hayreh SS

更新日期：1995-09-01 00:00:00

abstract：:Understanding how tissues and organs acquire and maintain an appropriate size and shape remains one of the most challenging areas in developmental biology. The eye lens represents an excellent system to provide insights into regulatory mechanisms because in addition to its relative simplicity in cellular composition (...

journal_title：Experimental eye research

authors： McAvoy JW,Dawes LJ,Sugiyama Y,Lovicu FJ

更新日期：2017-03-01 00:00:00

abstract：:Changes in the distribution of keratan sulfate in the anterior segment of developing ocular tissue were investigated histochemically and immunohistochemically using human eyes from 5 weeks gestation to 2 years after birth. Enzyme digestion methods with streptomyces hyaluronidase, chondroitinase and keratanase showed t...

journal_title：Experimental eye research

authors： Azuma N,Hirakata A,Hida T,Kohsaka S

更新日期：1994-03-01 00:00:00

abstract：:Electron-microscope immunocytochemistry and antibody staining of nitrocellulose replicas of SDS gels (Western blots) were used in a developmental study to detect the presence and localization of opsin in the developing photoreceptors of rds (020/A) mutant mice and their BALB/c normal controls. Western blot analysis of...

journal_title：Experimental eye research

authors： Usukura J,Bok D

更新日期：1987-10-01 00:00:00

abstract：:Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) were isolated from frog retinal rod outer segment (ROS) membranes and their major molecular species determined. Saturated fatty acids are predominantly located on position-1 and polyunsaturates on position-2, although this assignment is not absolute. One-fifth...

journal_title：Experimental eye research

authors： Wiegand RD,Anderson RE

更新日期：1983-08-01 00:00:00

abstract：:The elimination of spermine, the end product of cellular polyamine, from the retina to the blood across the blood-retinal barrier (BRB) was investigated. The in vivo microdialysis study revealed that the elimination of [(3)H]spermine from vitreous humor after vitreous bolus injection was in a biexponential manner. The...

journal_title：Experimental eye research

authors： Kubo Y,Tomise A,Tsuchiyama A,Akanuma S,Hosoya K

更新日期：2014-07-01 00:00:00

abstract：:Sodium hyaluronates with molecular weights of 18000, 500000 and 4 x 10(6), labelled with either 3H or 14C, were injected into the anterior chamber or into the centre of the vitreous body of rabbits and their rates of disappearance were followed. The out-flow from the anterior chamber in anaesthetized animals was virtu...

journal_title：Experimental eye research

authors： Laurent UB,Fraser JR

更新日期：1983-04-01 00:00:00

abstract：:Peroxisomes were localized in the head of wild-type and mutant strains of Drosophila melanogaster by use of a cytochemical method for the demonstration of D-amino acid oxidase activity. With similar techniques we had found previously that vertebrate photoreceptors have few, if any, bodies with cytochemically demonstra...

journal_title：Experimental eye research

authors： St Jules R,Setlik W,Kennard J,Holtzman E

更新日期：1990-11-01 00:00:00

abstract：:Müller cells can completely repair retinal injury by acting as endogenous stem/progenitor cells in lower-order vertebrates. However, a safe and effective approach to activate progenitor potential of retinal Müller cells in higher-order vertebrates, which rarely re-enter the cell cycle, is a bottleneck problem. In the ...

journal_title：Experimental eye research

authors： Jian Q,Li Y,Yin ZQ

更新日期：2015-03-01 00:00:00

abstract：:The transmembrane glycoprotein CD44 is a cell adhesion molecule which has recently been localized in a variety of cell types. It mediates cell attachment to extracellular matrix components and also binds to the actin cytoskeleton within the cell. In this study, the presence and distribution of CD44 in the mouse retina...

journal_title：Experimental eye research

authors： Chaitin MH,Wortham HS,Brun-Zinkernagel AM

更新日期：1994-03-01 00:00:00

abstract：:Electrophysiological responses of the retina to a series of grating stimuli (6-768 min of arc/phase) were recorded in seven sessions using normal Beagles and in 21 sessions using Beagles afflicted with inherited glaucoma. A 15 degrees and a 30 degrees field, centered around the animal's area centralis, were used to st...

journal_title：Experimental eye research

authors： Ofri R,Dawson WW,Foli K,Gelatt KN

更新日期：1993-04-01 00:00:00

abstract：:Lens epithelium-derived growth factor (LEDGF) has been shown to enhance survival of lens epithelial cells (LECs) against stress. The objectives of these studies are to determine how LEDGF controls PKC gamma activity in normal LECs: how this control of PKC gamma regulates the phosphorylation of Connexin 43, the inhibit...

journal_title：Experimental eye research

authors： Nguyen TA,Boyle DL,Wagner LM,Shinohara T,Takemoto DJ

更新日期：2003-05-01 00:00:00

abstract：:In a variety of tissues including gastrointestinal mucosa, rebamipide (REB) provides cytoprotection, prevents inflammation, and promotes wound healing. Clinically, REB ophthalmic dispersions are used to treat diabetic keratopathy. In this study, we investigated the optimal particle size of REB to promote corneal wound...

journal_title：Experimental eye research

authors： Nagai N,Ito Y,Okamoto N,Shimomura Y

更新日期：2016-10-01 00:00:00

abstract：:In the ophthalmological clinic, intravitreally applied antibodies or Fc-containing fusion proteins are frequently used, but the biology and pharmacokinetics of these therapeutics in the retina are not well understood. We have previously shown intracellular uptake of Fc-containing molecules in RPE cells. In this study,...

journal_title：Experimental eye research

authors： Dithmer M,Hattermann K,Pomarius P,Aboul Naga SH,Meyer T,Mentlein R,Roider J,Klettner A

更新日期：2016-04-01 00:00:00

abstract：:The identification of genes that modify pathological ocular phenotypes in mouse models may improve our understanding of disease mechanisms and lead to new treatment strategies. Here, we identify modifier loci affecting photoreceptor cell loss in homozygous Mfrp(rd6) mice, which exhibit a slowly progressive photorecept...

journal_title：Experimental eye research

authors： Won J,Charette JR,Philip VM,Stearns TM,Zhang W,Naggert JK,Krebs MP,Nishina PM

更新日期：2014-01-01 00:00:00

abstract：:The C-terminal region of peripherin/rds contains three predicted alpha-helical domains. One of these domains, corresponding to amino acids 311-322, form an amphiphilic alpha-helix previously shown to promote membrane fusion. The present studies were conducted to determine how the additional alpha-helical regions of th...

journal_title：Experimental eye research

authors： Muller-Weeks S,Boesze-Battaglia K,Fitzgerald C

更新日期：2002-08-01 00:00:00

abstract：:Lack of an optimal in vitro model of human corneal epithelial (HCE) cells is a major limitation in studying normal functions and gene regulations in HCE. Moreover, availability of a multi-layered HCE culture can reduce the usage of animals in the toxicity testing of consumer products. We have developed tetracycline-re...

journal_title：Experimental eye research

authors： Mohan RR,Possin DE,Mohan RR,Sinha S,Wilson SE

更新日期：2003-10-01 00:00:00

abstract：:Myo/Nog cells are essential for eye development in the chick embryo and respond to injury in adult tissues. These cells express mRNA for the skeletal muscle specific transcription factor MyoD, the bone morphogenetic protein (BMP) inhibitor Noggin and the cell surface protein recognized by the G8 monoclonal antibody (m...

journal_title：Experimental eye research

authors： Bravo-Nuevo A,Brandli AA,Gerhart J,Nichols J,Pitts M,Sutera CK,Assali S,Scheinfeld V,Prendergast GC,Stone J,George-Weinstein M

更新日期：2016-05-01 00:00:00

abstract：:The purpose of this investigation is to characterize parvalbumin-immunoreactive (IR) neurons in the inner nuclear layer (INL) of zebrafish retina through immunocytochemistry, quantitative analysis, and confocal microscopy. In the INL, parvalbumin-IR neurons were located in the inner marginal portion of the INL. On the...

journal_title：Experimental eye research

authors： Yeo JY,Lee ES,Jeon CJ

更新日期：2009-03-01 00:00:00

abstract：:Movement of water in the lens, specifically water diffusion, was examined with diffusion imaging and H217O-enhanced proton imaging. Diffusion imaging showed restricted water self-diffusion in the cortex which was not concurrent with the change in proton density; nevertheless it was dependent on the gradient direction ...

journal_title：Experimental eye research

authors： Cheng HM,Kuan WP,Garrido L,Xiong J,Chang C

更新日期：1992-01-01 00:00:00

abstract：:The lacrimal functional unit (LFU) is defined by the 2007 International Dry Eye WorkShop as 'an integrated system comprising the lacrimal glands, ocular surface (cornea, conjunctiva and meibomian glands) and lids, and the sensory and motor nerves that connect them'. The LFU maintains a healthy ocular surface primarily...

journal_title：Experimental eye research

authors： McKown RL,Wang N,Raab RW,Karnati R,Zhang Y,Williams PB,Laurie GW

更新日期：2009-05-01 00:00:00

abstract：:Experiments were performed using [1-14C]PGH2 endoperoxide as substrate to assess which, if any, of the PGH2 utilizing enzymes were present in rat lens microsomes. After a 15 min incubation, prostaglandins (PGs) were extracted, separated by thin-layer chromatography and labeled PGs located by autoradiography. The bands...

journal_title：Experimental eye research

authors： Keeting PE,Dong DS,Fu SC,Lysz TW

更新日期：1987-02-01 00:00:00

abstract：:Erythropoietin (EPO) plays a critical role in the vascular system and exhibits angiogenic activity in endothelial cells (ECs) such as stimulation of cell proliferation, migration and tube formation in vitro. EPO is the major regulator of cell proliferation and differentiation of erythroid precursors and there by preve...

journal_title：Experimental eye research

authors： Haribalaganesh R,Sheikpranbabu S,Banumathi E,Gurunathan S

更新日期：2010-06-01 00:00:00

abstract：:Whole mounts of lens epithelia from rats fed on a galactose-rich diet for one, two, three or seven days were examined for morphological alterations. The meridional rows of epithelia from lenses of animals fed on galactose for seven days were found to be grossly disorganized or abnormally elongated. There was some indi...

journal_title：Experimental eye research

authors： Gona O

更新日期：1984-06-01 00:00:00