Abstract:
:Ultraviolet A (UVA) light-based photoactivation of riboflavin (Rf) to induce corneal crosslinking (CXL) and mechanical stiffening is now a well-known treatment for corneal ectasia and Keratoconus that is being used in a topographically guided photorefractive intrastromal CXL (PiXL) procedure to treat low degrees of refractive errors. Alternative approaches for non-invasive treatment of refractive errors have also been proposed that use femtosecond lasers (FS) that provide much faster, more precise, and safer results than UVA CXL. One such treatment, nonlinear optical crosslinking (NLO CXL), has been able to replicate the effects of UVA CXL, while producing a smaller area of cellular damage and requiring a shorter procedure time. Unlike UVA CXL, the treatment volume of NLO CXL only occurs within the focal volume of the laser, which can be placed at any depth and scanned into any pattern for true topographically guided refractive correction. This review presents our experience with using FS lasers to photoactivate Rf and perform highly controlled corneal CXL that leads to mechanical stiffening and changes in corneal shape.
journal_name
Exp Eye Resjournal_title
Experimental eye researchauthors
Bradford S,Mikula E,Juhasz T,Brown DJ,Jester JVdoi
10.1016/j.exer.2020.108199subject
Has Abstractpub_date
2020-10-01 00:00:00pages
108199eissn
0014-4835issn
1096-0007pii
S0014-4835(20)30457-7journal_volume
199pub_type
杂志文章,评审abstract::Simultaneous non-invasive visualization of blood vessels and nerves in patients can be obtained in the eye. The retinal vasculature is a target of many retinopathies. Inflammation, readily manifest by leukocyte adhesion to the endothelial lining, is a key pathophysiological mechanism of many retinopathies, making it a...
journal_title:Experimental eye research
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journal_title:Experimental eye research
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journal_title:Experimental eye research
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abstract::Changes in the distribution of keratan sulfate in the anterior segment of developing ocular tissue were investigated histochemically and immunohistochemically using human eyes from 5 weeks gestation to 2 years after birth. Enzyme digestion methods with streptomyces hyaluronidase, chondroitinase and keratanase showed t...
journal_title:Experimental eye research
pub_type: 杂志文章
doi:10.1006/exer.1994.1018
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journal_title:Experimental eye research
pub_type: 杂志文章
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journal_title:Experimental eye research
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journal_title:Experimental eye research
pub_type: 杂志文章
doi:10.1006/exer.1996.0133
更新日期:1996-10-01 00:00:00
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journal_title:Experimental eye research
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journal_title:Experimental eye research
pub_type: 杂志文章
doi:10.1016/0014-4835(86)90022-9
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journal_title:Experimental eye research
pub_type: 杂志文章
doi:10.1006/exer.1994.1107
更新日期:1994-09-01 00:00:00
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journal_title:Experimental eye research
pub_type: 杂志文章
doi:10.1006/exer.1996.0194
更新日期:1997-02-01 00:00:00
abstract::With the combined purpose of facilitating useful vision over a lifetime, a number of ocular cells have evolved specialized features not found elsewhere in the body. The trabecular meshwork (TM) cell at the irido-corneal angle, which is a key regulator of intraocular pressure, is no exception. Examination of cells in c...
journal_title:Experimental eye research
pub_type: 杂志文章,评审
doi:10.1016/j.exer.2016.07.009
更新日期:2017-05-01 00:00:00
abstract::Movement of water in the lens, specifically water diffusion, was examined with diffusion imaging and H217O-enhanced proton imaging. Diffusion imaging showed restricted water self-diffusion in the cortex which was not concurrent with the change in proton density; nevertheless it was dependent on the gradient direction ...
journal_title:Experimental eye research
pub_type: 杂志文章
doi:10.1016/0014-4835(92)90076-5
更新日期:1992-01-01 00:00:00
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doi:10.1016/j.exer.2020.108331
更新日期:2021-01-01 00:00:00
abstract::Primary cultures of chick lens annular pad (CLAP) cells were exposed to beta-adrenergic drugs and lipid soluble cAMP analogues. In dose-dependent manners, these agents inhibited re-entry into the cell cycle when these normally post-mitotic cells were cultured in the presence of serum. The inhibition of cell division w...
journal_title:Experimental eye research
pub_type: 杂志文章
doi:10.1006/exer.1993.1131
更新日期:1993-09-01 00:00:00
abstract::Retinal degenerations, regardless of the initiating event or gene defect, often result in a loss of photoreceptors. This formal deafferentation of the neural retina eliminates the intrinsic glutamatergic drive of the sensory retina and, perhaps more importantly, removes coordinated Ca++-coupled signaling to the neural...
journal_title:Experimental eye research
pub_type: 杂志文章,评审
doi:10.1016/j.exer.2005.03.006
更新日期:2005-08-01 00:00:00
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journal_title:Experimental eye research
pub_type: 杂志文章
doi:10.1006/exer.1997.0356
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journal_title:Experimental eye research
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pub_type: 杂志文章
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journal_title:Experimental eye research
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pub_type: 杂志文章
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