Abstract：
:The present investigation assessed the potential of Prunus cerasoides fruit extract (PCFE) in alleviation of inflammatory stress in response to lipopolysaccharide (LPS) and interferon-γ (IFN-γ)-stimulated murine peritoneal macrophages as well as in concanavalin A (Con A)-activated splenic lymphocytes. We observed a strong inhibition in production of nitric oxide (NO), reactive oxygen species (ROS), inflammatory cytokines (TNF-α/IL-6/IL-1β), inducible nitric oxide synthase (iNOS), and NF-kB in macrophages treated with PCFE. Splenic lymphocytes treated with PCFE also showed a reduction in Con-A-induced cell proliferation and numbers of CD3+CD4+ T cells. Furthermore, PCFE treatment to Con A-stimulated lymphocytes decreased the production of inflammatory cytokines (TNF-α/IL-6/IL-1β) with a concomitant increase in IL-10 suggesting its possible role in alleviation of inflammation-driven Th1/Th2 immune imbalance. PCFE appeared to influence innate immune response even at lower concentrations (25 and 50 µg/ml), while such effects were more pronounced in lymphocytes only at higher concentrations (100 and 200 µg/ml). UPLC-ESI-MS of PCFE revealed the presence of major bioactive phenolics including catechin, naringin as well as ascorbic acid which could have contributed in above findings. Overall, it is indicative that P. cerasoides fruit could be a valuable source for the development of anti-inflammatory functional foods and nutraceuticals.
journal_name
Inflammopharmacologyjournal_title
Inflammopharmacologyauthors
Sharma A,Joshi R,Kumar S,Sharma R,Rajneesh,Padwad Y,Gupta Mdoi
10.1007/s10787-018-0448-2subject
Has Abstractpub_date
2018-12-01 00:00:00pages
1483-1495issue
6eissn
0925-4692issn
1568-5608pii
10.1007/s10787-018-0448-2journal_volume
26pub_type
杂志文章abstract：:In the process of the oxygen reduction, NADPH oxidase is the enzyme that produces superoxide anion, which subsequently produces reactive oxygen species (ROS) and causes damage in various tissues and microorganisms. NADPH oxidase is demonstrated to exist in several types of cells such as endothelial cells and vascular ...
journal_title：Inflammopharmacology
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journal_title：Inflammopharmacology
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journal_title：Inflammopharmacology
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journal_title：Inflammopharmacology
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journal_title：Inflammopharmacology
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journal_title：Inflammopharmacology
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更新日期：2004-01-01 00:00:00
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journal_title：Inflammopharmacology
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journal_title：Inflammopharmacology
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journal_title：Inflammopharmacology
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journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
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journal_title：Inflammopharmacology
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更新日期：2020-10-01 00:00:00
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journal_title：Inflammopharmacology
pub_type： 杂志文章
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更新日期：2005-01-01 00:00:00
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journal_title：Inflammopharmacology
pub_type： 杂志文章
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更新日期：2003-01-01 00:00:00
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journal_title：Inflammopharmacology
pub_type： 杂志文章
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更新日期：2009-02-01 00:00:00
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journal_title：Inflammopharmacology
pub_type： 杂志文章
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更新日期：2017-02-01 00:00:00
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journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
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更新日期：2015-08-01 00:00:00
