Abstract:
:Propolis has been extensively used to improve health and prevent inflammatory diseases. Different types of Cuban propolis (red, brown and yellow) have been documented. The purpose of this research was to investigate the cytotoxic effects of Cuban red propolis (CP) on MDA MB-231 cell line, since breast cancer is considered one of the most common causes of mortality among women. Antiproliferative and cytotoxic activity of CP against MDA MB-231 cells were determined by the 3-[4,5-dimethylth-iazol-2-yl]-2,5-diphenyl tetrazoliumbromide (MTT) and lactate dehydrogenase (LDH) assays. Apoptosis/necrosis, involvement of PI3K/Akt and ERK1/2 pathways, mitochondrial membrane potential and expression of genes were investigated. CP extract exhibited antiproliferative and cytotoxic effects on MDA MB-231 cells, what may be probably related to PI3K/Akt and ERK1/2 pathways. A decreased expression of apoptosis-related genes (TP53, CASP3, BAX and P21) was seen, whereas the expressions of BCL-2, BCL-XL, NOXA and PUMA were unaffected. CP extract induced mitochondrial dysfunction and LDH release, what indicated cell necrosis associated with reactive oxygen species production and decreased cell migration. Our findings provide a basis for future investigation of chemopreventive and/or therapeutic studies against apoptosis-resistant breast cancer, in animals and humans.
journal_name
Inflammopharmacologyjournal_title
Inflammopharmacologyauthors
Frión-Herrera Y,Díaz-García A,Ruiz-Fuentes J,Rodríguez-Sánchez H,Sforcin JMdoi
10.1007/s10787-018-0492-ysubject
Has Abstractpub_date
2019-10-01 00:00:00pages
1081-1089issue
5eissn
0925-4692issn
1568-5608pii
10.1007/s10787-018-0492-yjournal_volume
27pub_type
杂志文章abstract::2-(4-phenylquinoline-2-yl)phenol derivatives (4a-l) with COX-2 enzyme inhibition, analgesic, anti-inflammatory and antipyretic potentials were executed and reported. From the in vitro COX-2 enzyme inhibition assay, compounds 4 h (IC50 0.026 µM) and 4j (IC50 0.102 µM) were found as most potent COX-2 inhibitors. Consequ...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-017-0342-3
更新日期:2017-12-01 00:00:00
abstract::- The use of the non-steroidal anti-inflammatory drug, diclofenac, is associated with occasional serious side effects in the gastrointestinal (GI) tract. We examined the effect of altering the site of release of diclofenac sodium on GI tract side effects. Dissolution and pharmacokinetic studies were carried out to sub...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1163/156856004773121383
更新日期:2004-01-01 00:00:00
abstract::The aim of this study was to investigate the effect of the nitric oxide donor isosorbide-5-mononitrate (5-ISMN) alone or in combination with the natural hepatoprotectant with anti-oxidant activity silymarin on the carbon tetrachloride (CCl(4))-induced hepatic injury in rats. 5-ISMN (1.8, 3.6 or 7.2 mg/kg), silymarin (...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-009-0027-7
更新日期:2010-04-01 00:00:00
abstract::Rheumatoid arthritis (RA) is a systemic autoimmune disease, which is characterized by a chronic fluctuating course and immune dysfunction, resulting in affecting the health and life quality of RA patients. Methotrexate (MTX), as the standard gold treatment of RA, has received more and more clinical applications and ba...
journal_title:Inflammopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s10787-020-00741-3
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:This pilot study aimed to determine the efficacy of acamprosate (N-acetyl homotaurine) in reducing the pathological features of experimental autoimmune encephalomyelitis (EAE) which is an animal model for multiple sclerosis (MS). BACKGROUND:The amino acid taurine has multiple biological activities including ...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-011-0097-1
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:Osthole is a bioactive component reported in medicinal plants such as Angelica pubescens and Cnidium monnieri, known for analgesic activity. However, the toxicity, median effective dose (ED50), and dual modulation of nitric oxide and cyclooxygenase pathways along with inflammatory cytokines of osthole are ye...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-018-0486-9
更新日期:2019-10-01 00:00:00
abstract::Methyl gallate is a gallotannin widely distributed in nature. Previous studies have demonstrated its antioxidant, anti-inflammatory, antimicrobial and anti-tumor activities. In the present study, the activity of methyl gallate on experimental models of inflammatory bowel disease has been investigated. Experimental col...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-017-0412-6
更新日期:2018-06-01 00:00:00
abstract::In the process of the oxygen reduction, NADPH oxidase is the enzyme that produces superoxide anion, which subsequently produces reactive oxygen species (ROS) and causes damage in various tissues and microorganisms. NADPH oxidase is demonstrated to exist in several types of cells such as endothelial cells and vascular ...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-007-1587-z
更新日期:2007-12-01 00:00:00
abstract:OBJECTIVE:To study the effect of hyaluronan on cell adhesion and recruitment both in vitro and in vivo, since hyaluronan both inhibits restenosis and is anti-inflammatory. When administered to animals undergoing angioplasty the recruitment of cells into the restenotic plaque is inhibited, as well as into inflammatory l...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1163/156856005774382733
更新日期:2005-01-01 00:00:00
abstract:AIM:The capture, analysis and utilisation of health status information are attended by logistic considerations and interpretation challenges. We report a preliminary evaluation of cellular technology in capturing WOMAC NRS 3.1 Index data. METHODS:A Java midlet for delivering the WOMAC NRS3.1 Index on Nokia-6300, Motor...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-008-8045-4
更新日期:2009-04-01 00:00:00
abstract::The aim of this study was to determine whether ethanol extracts of Etlingera pavieana rhizomes (EPE) can inhibit the expression of ICAM-1 and VCAM-1 in TNF-α-stimulated human vascular endothelial cells. EPE significantly reduced ICAM-1 and VCAM-1 expression in a concentration-dependent manner. EPE also suppressed phos...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-019-00676-4
更新日期:2020-12-01 00:00:00
abstract::Propolis is a resinous substance collected by honeybees from leaf buds and cracks in the bark of various plants. Propolis has been reported to have immunomodulatory activity. We hypothesized that propolis would be able to reduce the disease severity of rheumatoid arthritis. We evaluated the effect of Brazilian propoli...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-011-0088-2
更新日期:2012-02-01 00:00:00
abstract::The aim of the study was to evaluate the effect of Pterocarpus marsupium (PM) on acetic acid (AA)-induced ulcerative colitis (UC) in rats. The rats were divided into five groups, each having six rats. PM extract 100 mg and 200 mg/kg was given orally to groups four and five, respectively, and standard drug sulfasalazin...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-015-0234-3
更新日期:2015-08-01 00:00:00
abstract::Biologic disease modifying anti-rheumatic drugs have transformed the management of rheumatoid arthritis (RA) since their introduction into clinical practice over a decade ago. Following large-scale clinical trials, a number of biologics, with different mechanisms of action, have been licensed for the condition. In thi...
journal_title:Inflammopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s10787-012-0123-y
更新日期:2012-04-01 00:00:00
abstract::Kynurenate, a metabolite of tryptophan formed serially from kynurenine, inhibits N-methyl-D-aspartate (NMDA) receptor responses. Non-steroidal anti-inflammatory drugs (NSAIDs) may produce anti-hyperalgesic effects by altering tryptophan metabolism to increase kynurenate concentrations. We examined whether the NSAID di...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1163/156856003322315622
更新日期:2003-01-01 00:00:00
abstract::We clarified the roles of histamine H(1)-, H(2)-, H(3)-receptors and oxyradicals in the exacerbation of acid-induced gastric haemorrhage and stomach ulcer in endotoxaemic rats by measuring changes in gastric mucosal glutathione concentrations, lipid peroxide generation and histamine levels as well as in luminal electr...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-998-0017-1
更新日期:1998-01-01 00:00:00
abstract::The safety of the cyclo-oxygenase-2 (COX-2) selective NSAID, nimesulide, has been evaluated from information (a) in clinical trials in osteoarthritis that have been performed in Europe as well as in earlier pilot studies that were performed in patients with rheumatoid arthritis in the USA, and (b) in post-marketing st...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-998-0020-6
更新日期:1998-01-01 00:00:00
abstract::Paracetamol-induced toxicity is mainly due to the accumulation of its CYP450-mediated N-hydroxylation product - N-acetylimidoquinone. We examined cell viability, proliferation rates and intracellular calcium in PC12 cells and in a PC12 cell line transfected with cytochrome P4502E1 exposed to paracetamol. This drug had...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-998-0030-4
更新日期:1998-01-01 00:00:00
abstract::R-phenylpiracetam (R-PhP, (4R)-2-(4-phenyl-2-oxopyrrolidin-1-yl)acetamide) is an optical isomer of phenotropil, a clinically-used nootropic drug that improves physical condition and cognition. Recently, R-PhP was shown to bind to the dopamine transporter (DAT). Since growing evidence suggests that dysfunction of the d...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-020-00705-7
更新日期:2020-10-01 00:00:00
abstract::Colorectal cancer (CRC) remains the most cancer type related to chronic inflammation; however, the mechanisms that link inflammation to CRC development and progression are still poorly understood. Our study aimed to investigate one of the prominent inflammatory response in cancers, iNOS/NO system. In this regard, we e...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-019-00566-9
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Resveratrol exerts an anti-inflammatory effect on collagen-induced arthritis and osteoarthritis in rats via activation of sirtuin 1 (SIRT1). Autophagy can be induced by resveratrol and leads to amelioration of interleukin-1 beta (IL-1β) release in vitro. We aimed to determine the anti-inflammatory mechanisms...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-018-00555-4
更新日期:2019-02-01 00:00:00
abstract::Inflammatory bowel diseases are associated with reduced colonic contractility and induction of cyclooxygenase-2. In this study a possible role of cyclooxygenase-2 in and the underlying mechanism of the reduced contractility were investigated in experimental colitis. The effects of meloxicam, a cyclooxygenase-2 selecti...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-006-1507-7
更新日期:2006-03-01 00:00:00
abstract::Central nervous system (CNS) has a completely separate immune system that communicates with the neurons by small molecules called cytokines. Cytokines are involved in many crucial processes in neuron including cell metabolism and neurotransmitter synthesis. It has been reported that cytokine imbalance is involved in t...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-013-0181-9
更新日期:2013-12-01 00:00:00
abstract::The inflamed mucosa in ulcerative colitis produces high amount of prostaglandin (PG) and nitric oxide (NO) through inducible enzymes: cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), respectively, implicating them as potential anti-inflammatory drug targets. COX-2 or iNOS-related treatments in diff...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-007-1603-3
更新日期:2007-10-01 00:00:00
abstract::The effect of lupeol, a natural pentacyclic triterpene on ethanol-induced gastric damage in mice was evaluated. The gastroprotection was assessed by determination of changes in mean gastric lesion area, quantification of mucosal non-protein sulfhydryls (NP-SH), and characterized using drugs that influence the endogeno...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-009-0009-9
更新日期:2009-08-01 00:00:00
abstract::TRP channels have been discovered as a specialized group of somatosensory neurons involved in the detection of noxious stimuli. Desensitization of TRPV1 located on dorsal root and trigeminal ganglia exhibits analgesic effect and makes it potential therapeutic target for treatment of neuropathic pain. With this backgro...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-016-0285-0
更新日期:2016-12-01 00:00:00
abstract::Most of the gastroprotective drugs which had been marketed in Japan were considered to have insufficient rationale for use as ulcer treatments. Such drugs may have a crucial role in maintaining mucosal integrity by the mechanisms other than inhibition of acid secretion. We re-evaluated the effect of gastroprotective d...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-006-0300-y
更新日期:2007-02-01 00:00:00
abstract:AIM AND OBJECTIVE:6-hydroxy dopamine (6-OHDA) is a neurotoxin which on intranigral administration produces severe nigrostriatal damage with motor and cognitive deficit in animals. Curcumin (CMN) in combination with bioenhancer piperine (PP) in 6-hydroxydopamine-induced Parkinsonian rats was used to investigate the anti...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-016-0297-9
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:The role of angiotensin converting enzyme inhibitors on the inflammation process has been demonstrated previously. In the present study, the effects of captopril on lung injury induced by lipopolysaccharide (LPS) were investigated. METHODS:Control, LPS, 12.5, 25 and 50 mg/kg captopril-treated before LPS adm...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-018-0535-4
更新日期:2019-06-01 00:00:00
abstract::Excess eicosanoid formation during inflammation has been attributed to the expression of the gene coding for the inducible isoform of prostaglandin G/H synthase (PGHS-2). Human and murine PGHS-2 proteins differ in 73 out of the 604 amino acids. When comparing the inhibitory effects of a panel of PGHS-inhibitors in a w...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-997-0020-y
更新日期:1997-01-01 00:00:00