Abstract:
:Rheumatoid arthritis (RA) is a systemic autoimmune disease, which is characterized by a chronic fluctuating course and immune dysfunction, resulting in affecting the health and life quality of RA patients. Methotrexate (MTX), as the standard gold treatment of RA, has received more and more clinical applications and basic pharmacological research. In several observational studies, MTXR, and treatment responses in RA patients show that the ratio of MTXR and non- response is about 30%-50%, namely MTX resistance (MTXR). Extensive efforts have been made into the investigation of the mechanism and effective biomarkers in MTXR of RA. In this paper, we discuss the recent findings regarding the critical signaling pathways of MTXR in RA. Provide research targets and directions for a drug therapy that develop preventive strategies and effective treatments of MTXR.
journal_name
Inflammopharmacologyjournal_title
Inflammopharmacologyauthors
Yu J,Zhou Pdoi
10.1007/s10787-020-00741-3subject
Has Abstractpub_date
2020-10-01 00:00:00pages
1183-1193issue
5eissn
0925-4692issn
1568-5608pii
10.1007/s10787-020-00741-3journal_volume
28pub_type
杂志文章,评审abstract:INTRODUCTION:Retinoic Acid Related Orphan Nuclear Receptor gamma T (RORγT) is a lineage specifying transcription factor for IL-17 expressing cells, which may contribute to the pathogenesis of Inflammatory Bowel Disease (IBD). VPR-254 is a selective in vitro inhibitor of RORγT. AIMS:The main goals of our study were two...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-019-00643-z
更新日期:2020-04-01 00:00:00
abstract::The side effects of NSAIDs are equally evident in the stomach and the small bowel. The latter is increasingly seen as being clinically significant, contributing substantially to the iron-deficiency anaemia that is so common in patients with rheumatoid arthritis. Furthermore, NSAID-enteropathy may be associated with li...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1163/156856003322699546
更新日期:2003-01-01 00:00:00
abstract::R-phenylpiracetam (R-PhP, (4R)-2-(4-phenyl-2-oxopyrrolidin-1-yl)acetamide) is an optical isomer of phenotropil, a clinically-used nootropic drug that improves physical condition and cognition. Recently, R-PhP was shown to bind to the dopamine transporter (DAT). Since growing evidence suggests that dysfunction of the d...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-020-00705-7
更新日期:2020-10-01 00:00:00
abstract::Silver and silver oxides are gaining interest in medical applications for their prominent antibacterial and antimicrobial potentials. Recent studies suggest that nanosilver oxide has remarkable anti-inflammatory effects and enhances wound healing. Nevertheless, its effect on gastric ulcer has not yet been illustrated....
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-017-0424-2
更新日期:2018-08-01 00:00:00
abstract::A small GTPase, Rac1, is recognized as an important modulator of the inflammatory responses to bacterial lipopolysaccharide (LPS) by affecting the processes of phospholipase C activation. The activation of Rac1 involves the exchange of GDP for GTP and is catalyzed by the guanine nucleotide exchange factors (GEFs). Her...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-015-0235-2
更新日期:2015-06-01 00:00:00
abstract::Regular moderate wine consumption is often associated with reduced morbidity and mortality from to a variety of chronic diseases in which inflammation is a root cause. Wine comes in a wide variety of styles that contain quite different ethanol and polyphenol contents. Controversy remains as to whether the alcohol or p...
journal_title:Inflammopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s10787-008-8027-6
更新日期:2008-12-01 00:00:00
abstract::Bioactivity-guided investigation of the methanol extract of Crepis sancta aerial parts, collected off Al-Tafilah, South Jordan, was applied, and in this study, the extract was explored for its phytochemical components and in vivo antiulcer activity. In addition, a docking study involving the purified compounds with th...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-019-00637-x
更新日期:2020-02-01 00:00:00
abstract::In 1952 I re-joined the Pharmacological Division of the Research Department of the Boots Co. in Nottingham UK to work on rheumatoid arthritis (RA) but with the distinct disadvantage that the Division was housed in a group of rambling buildings attached to a Victorian house. The Division had moved there at the beginnin...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-999-0002-3
更新日期:1999-01-01 00:00:00
abstract::Pulmonary fibrosis is a result of an abnormal wound healing in lung tissue triggered by an excessive accumulation of extracellular matrix proteins, loss of tissue elasticity, and debit of ventilatory function. NKT cells are a major source of Th1 and Th2 cytokines and may be crucial in the polarization of M1/M2 macroph...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-017-0383-7
更新日期:2018-04-01 00:00:00
abstract::Propolis has been extensively used to improve health and prevent inflammatory diseases. Different types of Cuban propolis (red, brown and yellow) have been documented. The purpose of this research was to investigate the cytotoxic effects of Cuban red propolis (CP) on MDA MB-231 cell line, since breast cancer is consid...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-018-0492-y
更新日期:2019-10-01 00:00:00
abstract:AIM AND OBJECTIVE:6-hydroxy dopamine (6-OHDA) is a neurotoxin which on intranigral administration produces severe nigrostriatal damage with motor and cognitive deficit in animals. Curcumin (CMN) in combination with bioenhancer piperine (PP) in 6-hydroxydopamine-induced Parkinsonian rats was used to investigate the anti...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-016-0297-9
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:Osthole is a bioactive component reported in medicinal plants such as Angelica pubescens and Cnidium monnieri, known for analgesic activity. However, the toxicity, median effective dose (ED50), and dual modulation of nitric oxide and cyclooxygenase pathways along with inflammatory cytokines of osthole are ye...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-018-0486-9
更新日期:2019-10-01 00:00:00
abstract::Euphorbia hirta L. (Euphorbiaceae) (E. hirta) is a tree locally used as a traditional medicine in Africa and Australia to treat numerous diseases such as hypertension, respiratory ailments, tumors, wounds, antipyretic, anti-inflammatory activities, etc. Therefore, we undertook to investigate their immunomodulatory eff...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-012-0144-6
更新日期:2013-04-01 00:00:00
abstract::Paracetamol-induced toxicity is mainly due to the accumulation of its CYP450-mediated N-hydroxylation product - N-acetylimidoquinone. We examined cell viability, proliferation rates and intracellular calcium in PC12 cells and in a PC12 cell line transfected with cytochrome P4502E1 exposed to paracetamol. This drug had...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-998-0030-4
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:To study the effect of hyaluronan on cell adhesion and recruitment both in vitro and in vivo, since hyaluronan both inhibits restenosis and is anti-inflammatory. When administered to animals undergoing angioplasty the recruitment of cells into the restenotic plaque is inhibited, as well as into inflammatory l...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1163/156856005774382733
更新日期:2005-01-01 00:00:00
abstract::The Maytenus genus is a member of the Celastraceae family. Numerous medicinal uses were assigned to species of this genus, with the use of roots, bark, and leaves for the treatment of gastric ulcers, as anti-inflammatory, analgesic, antiallergic, antitumor, among others. Several studies have demonstrated that natural ...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-018-0496-7
更新日期:2019-06-01 00:00:00
abstract::The aim of the study was to evaluate the effect of Pterocarpus marsupium (PM) on acetic acid (AA)-induced ulcerative colitis (UC) in rats. The rats were divided into five groups, each having six rats. PM extract 100 mg and 200 mg/kg was given orally to groups four and five, respectively, and standard drug sulfasalazin...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-015-0234-3
更新日期:2015-08-01 00:00:00
abstract::Mitochondria can interchange morphology due to their dynamic nature. It can exist in either fragmented disconnected arrangement or elongated interconnected mitochondrial networks due to fission and fusion, respectively. The recent studies have revealed the remarkable and unexpected insights into the physiological impa...
journal_title:Inflammopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s10787-017-0347-y
更新日期:2017-08-01 00:00:00
abstract:AIM:The aim of the present study was to evaluate the anti-inflammatory effect of thymol in acetic acid-induced rat colitis through inhibiting the NF-κB signaling pathway. METHODS:Colitis was induced by intra-rectal administration of 2 mL of diluted acetic acid (4%) solution using a flexible plastic rubber catheter in ...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-019-00583-8
更新日期:2019-12-01 00:00:00
abstract::Prolonged stimulation of newborn mice by intraperitoneal injections with inactivated staphylococci induces a chronic neonatal inflammatory reaction and an associated oxidative-stress response. The chronically stimulated animals exhibit anorexy. show a reduction in their body weight and undergo a depression in both ant...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/BF02918381
更新日期:1999-01-01 00:00:00
abstract::Tovophyllin A (TA) is a xanthone isolated from Garcinia mangostana L. (GM, Guttiferae) pericarps that possesses various beneficial bioactivities. However, its protective effects on acute lung injury (ALI) and lung carcinoma have not yet been explored. The current work was designed to investigate the protective potenti...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-019-00609-1
更新日期:2020-02-01 00:00:00
abstract::Ischemia/reperfusion (I/R) damages gastric mucosa via reactive oxygen species (ROS) activity. ROS was reportedly produced through angiotensin II stimulation in tissues such as kidney, heart and brain. To determine whether AT1 receptor plays a role in gastric mucosal damage, we examined the effect of AT1 receptor block...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-006-1551-3
更新日期:2007-08-01 00:00:00
abstract::Centella asiatica is claimed to have a neuroprotective effect; however, its ability to protect the cerebrum against damage in diabetes has never been identified. The aims were to identify the possibility that C. asiatica ameliorates inflammation, oxidative stress, and apoptosis in the cerebrum in diabetes. C. asiatica...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-020-00733-3
更新日期:2020-12-01 00:00:00
abstract::The aim of this study was to investigate the effect of the nitric oxide donor isosorbide-5-mononitrate (5-ISMN) alone or in combination with the natural hepatoprotectant with anti-oxidant activity silymarin on the carbon tetrachloride (CCl(4))-induced hepatic injury in rats. 5-ISMN (1.8, 3.6 or 7.2 mg/kg), silymarin (...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-009-0027-7
更新日期:2010-04-01 00:00:00
abstract::Alzheimer's disease (AD) is prevalent in old age people and is one of the most common brain diseases. Brain insulin resistance, neuroinflammation, oxidative stress, and mitochondrial and cholinergic dysfunction are key features of the disease. In our study, streptozotocin (STZ) in a dose of 3 mg/kg was injected in mal...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-019-00681-7
更新日期:2020-04-01 00:00:00
abstract:AIMS:To compare methodological aspects of the impact of different classification procedures used in three phases of a twin study examining genetic factors in the aetiopathogenesis of rheumatoid arthritis (RA). METHODS:We have previously reported the results of a study of the aetiopathogenesis of RA based on the Austra...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-998-0009-1
更新日期:1998-01-01 00:00:00
abstract::Inflammatory bowel diseases are associated with reduced colonic contractility and induction of cyclooxygenase-2. In this study a possible role of cyclooxygenase-2 in and the underlying mechanism of the reduced contractility were investigated in experimental colitis. The effects of meloxicam, a cyclooxygenase-2 selecti...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-006-1507-7
更新日期:2006-03-01 00:00:00
abstract::Since their development and licensing no class of drug has received as much attention both in the scientific and lay press as the cyclo-oxygenase 2 (COX-2) inhibitors. These compounds, also known as coxibs, were developed as a safer alternative to traditional non-steroidal anti-inflammatory drugs (NSAIDs) due to their...
journal_title:Inflammopharmacology
pub_type: 杂志文章,评审
doi:10.1163/156856005774415619
更新日期:2005-01-01 00:00:00
abstract::The therapeutic efficacy of the contemporary anti-inflammatory drugs are well established; however, prolonged use of such can often lead to serious and life-threatening side effects. Natural product-based anti-inflammatory compounds with superior efficacy and minimum toxicity can serve as possible therapeutic alternat...
journal_title:Inflammopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s10787-020-00734-2
更新日期:2020-10-01 00:00:00
abstract::Chronic inflammation is a world health problem. There is a need to develop new anti-inflammatory and analgesic drugs with improved activity and reduced side effects. In this context, the aim of this study was to evaluate the antinociceptive and anti-inflammatory effects of the pyrazole compound LQFM-021 after acute an...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-016-0282-3
更新日期:2016-10-01 00:00:00