Abstract：
:Silver and silver oxides are gaining interest in medical applications for their prominent antibacterial and antimicrobial potentials. Recent studies suggest that nanosilver oxide has remarkable anti-inflammatory effects and enhances wound healing. Nevertheless, its effect on gastric ulcer has not yet been illustrated. Thus the current study aimed to explore the prospect protective effect of nanosilver oxide against indomethacin-induced gastric ulcer. A new approach has been followed to synthesize nanosilver oxide. X-ray diffraction, UV-Vis spectroscopy and transition electron microscope techniques have been successfully used to characterize the synthesized nanoparticles. Treatment of ulcerated rats with different doses of nanosilver oxide especially (175 and 350 ppm/p.o.) alleviated adverse effects of indomethacin-induced gastric injury as demonstrated by decreasing ulcer index and elevating % of ulcer inhibition. These positive effects excelled those exerted by the reference antiulcer drug omeprazole. Nanosilver oxide suppressed gastric inflammation by reducing myeloperoxidase, tumor necrosis alpha, interleukin 1beta and interferon gamma. Moreover, nanosilver oxide halted gastric oxidative stress via inhibiting lipid peroxidation and enhancing glutathione and paraoxonase-1. Regarding gastric apoptosis, nanosilver oxide down regulated the expression of caspase 9, tumor protein 53, and nuclear factor kappa B and allograft inflammatory factor-1 genes. These findings emphasize the antiulcerogenic potential of nanosilver oxide against indomethacin-induced gastric ulcers which are multi-factorial including anti-inflammatory, antioxidant and antiapoptotic effects.
journal_name
Inflammopharmacologyjournal_title
Inflammopharmacologyauthors
Salem NA,Wahba MA,Eisa WH,El-Shamarka M,Khalil Wdoi
10.1007/s10787-017-0424-2subject
Has Abstractpub_date
2018-08-01 00:00:00pages
1025-1035issue
4eissn
0925-4692issn
1568-5608pii
10.1007/s10787-017-0424-2journal_volume
26pub_type
杂志文章abstract：:Euphorbia hirta L. (Euphorbiaceae) (E. hirta) is a tree locally used as a traditional medicine in Africa and Australia to treat numerous diseases such as hypertension, respiratory ailments, tumors, antipyretic, anti-inflammatory activities. In the present study, we investigated the anti-arthritic activity of fresh lea...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-012-0161-5
更新日期：2013-10-01 00:00:00
abstract：:Most of the gastroprotective drugs which had been marketed in Japan were considered to have insufficient rationale for use as ulcer treatments. Such drugs may have a crucial role in maintaining mucosal integrity by the mechanisms other than inhibition of acid secretion. We re-evaluated the effect of gastroprotective d...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-006-0300-y
更新日期：2007-02-01 00:00:00
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journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1163/156856005774423755
更新日期：2005-01-01 00:00:00
abstract：:Allanblackia gabonensis (Guttiferae) is a plant used in the African traditional medicine as remedies against pain, rheumatism, inflammations. In the present work, the analgesic effect of aqueous extract has been evaluated using acetic acid, formalin, hot-plate test, tail immersion and paw-pressure test. The anti-infla...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-011-0096-2
更新日期：2013-02-01 00:00:00
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journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-018-0512-y
更新日期：2018-10-01 00:00:00
abstract：:Pulmonary fibrosis is a result of an abnormal wound healing in lung tissue triggered by an excessive accumulation of extracellular matrix proteins, loss of tissue elasticity, and debit of ventilatory function. NKT cells are a major source of Th1 and Th2 cytokines and may be crucial in the polarization of M1/M2 macroph...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-017-0383-7
更新日期：2018-04-01 00:00:00
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journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00643-z
更新日期：2020-04-01 00:00:00
abstract：:Euphorbia hirta L. (Euphorbiaceae) (E. hirta) is a tree locally used as a traditional medicine in Africa and Australia to treat numerous diseases such as hypertension, respiratory ailments, tumors, wounds, antipyretic, anti-inflammatory activities, etc. Therefore, we undertook to investigate their immunomodulatory eff...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-012-0144-6
更新日期：2013-04-01 00:00:00
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journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00579-4
更新日期：2019-12-01 00:00:00
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journal_title：Inflammopharmacology
pub_type： 杂志文章
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更新日期：2019-12-01 00:00:00
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journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
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更新日期：2015-08-01 00:00:00
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journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s10787-008-8027-6
更新日期：2008-12-01 00:00:00
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journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-016-0285-0
更新日期：2016-12-01 00:00:00
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journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-012-0139-3
更新日期：2013-04-01 00:00:00
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journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s10787-020-00741-3
更新日期：2020-10-01 00:00:00
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journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00637-x
更新日期：2020-02-01 00:00:00
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journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s10787-020-00734-2
更新日期：2020-10-01 00:00:00
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journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-006-1507-7
更新日期：2006-03-01 00:00:00
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journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-012-0138-4
更新日期：2013-04-01 00:00:00
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journal_title：Inflammopharmacology
pub_type： 杂志文章,随机对照试验
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更新日期：2019-06-01 00:00:00
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更新日期：2020-12-01 00:00:00
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journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-015-0235-2
更新日期：2015-06-01 00:00:00
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journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1163/156856003322315622
更新日期：2003-01-01 00:00:00
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journal_title：Inflammopharmacology
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更新日期：2020-02-01 00:00:00
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journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-998-0009-1
更新日期：1998-01-01 00:00:00
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journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-009-0027-7
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journal_title：Inflammopharmacology
pub_type： 杂志文章
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更新日期：2019-06-01 00:00:00
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journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-007-1587-z
更新日期：2007-12-01 00:00:00
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journal_title：Inflammopharmacology
pub_type： 杂志文章
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更新日期：2020-12-01 00:00:00
abstract：:Pioglitazone, a specific ligand for peroxisome proliferator-activated receptor gamma (PPAR-gamma), was recently implicated in the control of inflammatory processes and in the modulation of the expression of various cytokines such as tumor necrosis factor alpha (TNF-alpha), but its role in the mechanism of gastric muco...
journal_title：Inflammopharmacology
pub_type： 杂志文章
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更新日期：2005-01-01 00:00:00
