Abstract：
:Stress is a reflex response, both psychological and physiological, of the body to a difficult situation that requires adaptation. Stress is at the intersection of the objective event and the subjective event. The physiological mechanisms involved in chronic stress are numerous and can contribute to a wide variety of disorders, in all systems including the immune system. Stress modifies the Th1/Th2 balance via the HPA axis and a set of immune mediators. This will make the body more vulnerable to external infections in a scientific way while others claim the opposite, stress could be considered immune stimulatory. The development of synthetic LXR ligands such as T0901317 and GW3965 as well as an understanding of the direct involvement of these receptors in the regulation of proopiomelanocortin (POMC) gene expression and indirectly by producing a variety of cytokines in a stressor response, will open in the near future new therapeutic methods against the undesirable effects of stress on the behavior of the immune system.
journal_name
Inflammopharmacologyjournal_title
Inflammopharmacologyauthors
Nessaibia I,Fouache A,Lobaccaro JA,Tahraoui A,Trousson A,Souidi Mdoi
10.1007/s10787-018-0546-1subject
Has Abstractpub_date
2019-02-01 00:00:00pages
15-25issue
1eissn
0925-4692issn
1568-5608pii
10.1007/s10787-018-0546-1journal_volume
27pub_type
杂志文章,评审abstract：:Biologic disease modifying anti-rheumatic drugs have transformed the management of rheumatoid arthritis (RA) since their introduction into clinical practice over a decade ago. Following large-scale clinical trials, a number of biologics, with different mechanisms of action, have been licensed for the condition. In thi...
journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s10787-012-0123-y
更新日期：2012-04-01 00:00:00
abstract：:Pioglitazone, a specific ligand for peroxisome proliferator-activated receptor gamma (PPAR-gamma), was recently implicated in the control of inflammatory processes and in the modulation of the expression of various cytokines such as tumor necrosis factor alpha (TNF-alpha), but its role in the mechanism of gastric muco...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1163/156856005774423908
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND:Osthole is a bioactive component reported in medicinal plants such as Angelica pubescens and Cnidium monnieri, known for analgesic activity. However, the toxicity, median effective dose (ED50), and dual modulation of nitric oxide and cyclooxygenase pathways along with inflammatory cytokines of osthole are ye...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-018-0486-9
更新日期：2019-10-01 00:00:00
abstract：:This review considers the problem of the serious concomitant side effects of powerful anti-inflammatory drugs modelled upon the principal human glucocorticoid hormone, cortisol. The very nature of the original bio-assays to validate their cortisol-like hormonal and anti-inflammatory activities ensured that pleiotropic...
journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s10787-010-0056-2
更新日期：2011-02-01 00:00:00
abstract：:The central nervous system, one of the most delicate microenvironments of the body, is protected by the blood-brain barrier regulating its homeostasis. Blood-brain barrier is a highly complex structure that tightly regulates the movement of ions of a limited number of small molecules and of an even more restricted num...
journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s10787-018-0468-y
更新日期：2018-06-01 00:00:00
abstract：:Gout, the most prevalent inflammatory arthritis worldwide, released interleukin-1β (IL-1β) and Cathepsin B inflammatory mediators that constitute the hallmark of the disease. Herein we aimed to investigate whether procyanidin B2 (PCB2), a natural dietary compound, can suppress MSU crystals-stimulated gouty inflammatio...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-020-00758-8
更新日期：2020-12-01 00:00:00
abstract：:The ozonised sunflower oil, Bioperoxoil, was tested for its antimicrobial activity against some pathological strains in vitro together with its healing potential against Staphylococcus aureus in vivo. Bioperoxoil was tested against S. aureus, Pseudomonas aeroginosa, Candida albicans, S. typhimurium and Escherichia col...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1163/1568560042342275
更新日期：2004-01-01 00:00:00
abstract：:Bioactivity-guided investigation of the methanol extract of Crepis sancta aerial parts, collected off Al-Tafilah, South Jordan, was applied, and in this study, the extract was explored for its phytochemical components and in vivo antiulcer activity. In addition, a docking study involving the purified compounds with th...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00637-x
更新日期：2020-02-01 00:00:00
abstract：:The aim of the study was to evaluate the effect of Pterocarpus marsupium (PM) on acetic acid (AA)-induced ulcerative colitis (UC) in rats. The rats were divided into five groups, each having six rats. PM extract 100 mg and 200 mg/kg was given orally to groups four and five, respectively, and standard drug sulfasalazin...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-015-0234-3
更新日期：2015-08-01 00:00:00
abstract：:Colorectal cancer (CRC) remains the most cancer type related to chronic inflammation; however, the mechanisms that link inflammation to CRC development and progression are still poorly understood. Our study aimed to investigate one of the prominent inflammatory response in cancers, iNOS/NO system. In this regard, we e...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00566-9
更新日期：2019-08-01 00:00:00
abstract：:Excess eicosanoid formation during inflammation has been attributed to the expression of the gene coding for the inducible isoform of prostaglandin G/H synthase (PGHS-2). Human and murine PGHS-2 proteins differ in 73 out of the 604 amino acids. When comparing the inhibitory effects of a panel of PGHS-inhibitors in a w...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-997-0020-y
更新日期：1997-01-01 00:00:00
abstract：AIM:The capture, analysis and utilisation of health status information are attended by logistic considerations and interpretation challenges. We report a preliminary evaluation of cellular technology in capturing WOMAC NRS 3.1 Index data. METHODS:A Java midlet for delivering the WOMAC NRS3.1 Index on Nokia-6300, Motor...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-008-8045-4
更新日期：2009-04-01 00:00:00
abstract：OBJECTIVE:The present study aimed to evaluate the anti-inflammatory and analgesic activities of the ginsenoside metabolite compound K (CK) and its mechanisms. METHODS:Mice model of xylene-induced ear swelling and rat model of carrageenan-induced paw swelling were used to evaluate the effect of CK on acute inflammation...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-018-0504-y
更新日期：2019-02-01 00:00:00
abstract：:The idea that microbes induce disease has steered medical research toward the discovery of antibacterial products for the prevention and treatment of microbial infections. The twentieth century saw increasing dependency on antimicrobials as mainline therapy accentuating the notion that bacterial interactions with huma...
journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s10787-012-0126-8
更新日期：2012-10-01 00:00:00
abstract：:R-phenylpiracetam (R-PhP, (4R)-2-(4-phenyl-2-oxopyrrolidin-1-yl)acetamide) is an optical isomer of phenotropil, a clinically-used nootropic drug that improves physical condition and cognition. Recently, R-PhP was shown to bind to the dopamine transporter (DAT). Since growing evidence suggests that dysfunction of the d...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-020-00705-7
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:There is considerable interest in the possible importance of the gut microflora in the pathophysiology of the inflammatory bowel diseases (IBD) ulcerative colitis (UC) and Crohn's disease (CD). Probiotics offer a potential adjuvant treatment in these patients by modifying the intestinal milieu, but reports o...
journal_title：Inflammopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10787-019-00595-4
更新日期：2019-06-01 00:00:00
abstract：AIM:The aim of the present study was to evaluate the anti-inflammatory effect of thymol in acetic acid-induced rat colitis through inhibiting the NF-κB signaling pathway. METHODS:Colitis was induced by intra-rectal administration of 2 mL of diluted acetic acid (4%) solution using a flexible plastic rubber catheter in ...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00583-8
更新日期：2019-12-01 00:00:00
abstract：:The aim of this study was to determine whether ethanol extracts of Etlingera pavieana rhizomes (EPE) can inhibit the expression of ICAM-1 and VCAM-1 in TNF-α-stimulated human vascular endothelial cells. EPE significantly reduced ICAM-1 and VCAM-1 expression in a concentration-dependent manner. EPE also suppressed phos...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00676-4
更新日期：2020-12-01 00:00:00
abstract：OBJECTIVE:To study the effect of hyaluronan on cell adhesion and recruitment both in vitro and in vivo, since hyaluronan both inhibits restenosis and is anti-inflammatory. When administered to animals undergoing angioplasty the recruitment of cells into the restenotic plaque is inhibited, as well as into inflammatory l...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1163/156856005774382733
更新日期：2005-01-01 00:00:00
abstract：:Kynurenate, a metabolite of tryptophan formed serially from kynurenine, inhibits N-methyl-D-aspartate (NMDA) receptor responses. Non-steroidal anti-inflammatory drugs (NSAIDs) may produce anti-hyperalgesic effects by altering tryptophan metabolism to increase kynurenate concentrations. We examined whether the NSAID di...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1163/156856003322315622
更新日期：2003-01-01 00:00:00
abstract：:- The use of the non-steroidal anti-inflammatory drug, diclofenac, is associated with occasional serious side effects in the gastrointestinal (GI) tract. We examined the effect of altering the site of release of diclofenac sodium on GI tract side effects. Dissolution and pharmacokinetic studies were carried out to sub...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1163/156856004773121383
更新日期：2004-01-01 00:00:00
abstract：:Kerabala (CB) is a novel ayurvedic formulation used for treating various inflammatory diseases. This formulation was made from virgin coconut oil and it comprises extracts of Sida cordifolia, coconut milk and sesame oil. The current study was performed to evaluate the anti-inflammatory action of CB on carrageenan-indu...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-016-0298-8
更新日期：2017-02-01 00:00:00
abstract：:The up-regulation of angiotensin II AT1 receptors has been implicated as a major mediator in the development of hypertension and progressive nephropathy in experimental diabetes. In spite of the documented potential of garlic treatments in ameliorating diabetic complications, the possible involvement of the angiotensi...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-012-0139-3
更新日期：2013-04-01 00:00:00
abstract：:The ulcerogenic effect of rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, on the gastrointestinal mucosa was investigated in the presence of a low dose of indomethacin. Indomethacin at 3 mg/kg did not cause any damage in both the stomach and small intestine, despite inhibiting prostaglandin (PG) production....
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1163/156856005774423755
更新日期：2005-01-01 00:00:00
abstract：:The anti-inflammatory activity of the aqueous extract of Chromolaena odorata was investigated in rats using the carrageenan-induced oedema, cotton pellet granuloma and formalin-induced oedema methods. The extract was administered orally at doses of 25, 50, 100 and 200 mg/kg. In the carrageenan method the paw oedema wa...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1163/156856005774649386
更新日期：2005-01-01 00:00:00
abstract：:The present investigation assessed the potential of Prunus cerasoides fruit extract (PCFE) in alleviation of inflammatory stress in response to lipopolysaccharide (LPS) and interferon-γ (IFN-γ)-stimulated murine peritoneal macrophages as well as in concanavalin A (Con A)-activated splenic lymphocytes. We observed a st...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-018-0448-2
更新日期：2018-12-01 00:00:00
abstract：:Previous reports suggest flavonoids as potent analgesic compounds. Based on these observations, the present study investigated the antinociceptive action of flavonol, 3', 4'-dimethoxy flavonol, 6, 3'-dimethoxy flavonol, 7, 2'-dimethoxy flavonol, and 7, 3'-dimethoxy flavonol and the possible mechanisms involved in thes...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00579-4
更新日期：2019-12-01 00:00:00
abstract：:In 1952 I re-joined the Pharmacological Division of the Research Department of the Boots Co. in Nottingham UK to work on rheumatoid arthritis (RA) but with the distinct disadvantage that the Division was housed in a group of rambling buildings attached to a Victorian house. The Division had moved there at the beginnin...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-999-0002-3
更新日期：1999-01-01 00:00:00
abstract：:Since their development and licensing no class of drug has received as much attention both in the scientific and lay press as the cyclo-oxygenase 2 (COX-2) inhibitors. These compounds, also known as coxibs, were developed as a safer alternative to traditional non-steroidal anti-inflammatory drugs (NSAIDs) due to their...
journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1163/156856005774415619
更新日期：2005-01-01 00:00:00
abstract：:The Maytenus genus is a member of the Celastraceae family. Numerous medicinal uses were assigned to species of this genus, with the use of roots, bark, and leaves for the treatment of gastric ulcers, as anti-inflammatory, analgesic, antiallergic, antitumor, among others. Several studies have demonstrated that natural ...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-018-0496-7
更新日期：2019-06-01 00:00:00
