Dynamin-related protein-1 as potential therapeutic target in various diseases.

abstract：BACKGROUND:Resveratrol exerts an anti-inflammatory effect on collagen-induced arthritis and osteoarthritis in rats via activation of sirtuin 1 (SIRT1). Autophagy can be induced by resveratrol and leads to amelioration of interleukin-1 beta (IL-1β) release in vitro. We aimed to determine the anti-inflammatory mechanisms...

journal_title：Inflammopharmacology

authors： Yang QB,He YL,Zhong XW,Xie WG,Zhou JG

更新日期：2019-02-01 00:00:00

abstract：:The central nervous system, one of the most delicate microenvironments of the body, is protected by the blood-brain barrier regulating its homeostasis. Blood-brain barrier is a highly complex structure that tightly regulates the movement of ions of a limited number of small molecules and of an even more restricted num...

journal_title：Inflammopharmacology

authors： Nair KGS,Ramaiyan V,Sukumaran SK

更新日期：2018-06-01 00:00:00

abstract：:Centella asiatica is claimed to have a neuroprotective effect; however, its ability to protect the cerebrum against damage in diabetes has never been identified. The aims were to identify the possibility that C. asiatica ameliorates inflammation, oxidative stress, and apoptosis in the cerebrum in diabetes. C. asiatica...

journal_title：Inflammopharmacology

authors： Giribabu N,Karim K,Kilari EK,Nelli SR,Salleh N

更新日期：2020-12-01 00:00:00

abstract：:A new compound derivative of glycoside 19-α-hydroxy-ursolic acid glucoside (19-α-hydroxyurs-12(13)-ene-28-oic acid-3-O-β-D-glucopyranoside (HEG) was isolated from whole plant of Wedelia calendulacea (Compositae). The structure was elucidated and established by standard spectroscopy approaches. Diethylnitrosamine (DEN)...

journal_title：Inflammopharmacology

authors： Verma A,Ahmed B,Anwar F,Rahman M,Patel DK,Kaithwas G,Rani R,Bhatt PC,Kumar V

更新日期：2017-02-01 00:00:00

abstract：:The ozonised sunflower oil, Bioperoxoil, was tested for its antimicrobial activity against some pathological strains in vitro together with its healing potential against Staphylococcus aureus in vivo. Bioperoxoil was tested against S. aureus, Pseudomonas aeroginosa, Candida albicans, S. typhimurium and Escherichia col...

journal_title：Inflammopharmacology

authors： Rodrigues KL,Cardoso CC,Caputo LR,Carvalho JC,Fiorini JE,Schneedorf JM

更新日期：2004-01-01 00:00:00

abstract：:Some B vitamins exhibit activities in models of nociceptive pain, inflammatory pain, and neuropathic pain induced by nerve lesions and also in certain painful conditions in humans. In the present study, we investigated the effects of thiamine, riboflavin, and nicotinamide in a neuropathic pain model induced by the che...

journal_title：Inflammopharmacology

authors： Braga AV,Costa SOAM,Rodrigues FF,Melo ISF,Morais MI,Coelho MM,Machado RR

更新日期：2020-02-01 00:00:00

abstract：AIM:The aim of the present study was to evaluate the anti-inflammatory effect of thymol in acetic acid-induced rat colitis through inhibiting the NF-κB signaling pathway. METHODS:Colitis was induced by intra-rectal administration of 2 mL of diluted acetic acid (4%) solution using a flexible plastic rubber catheter in ...

journal_title：Inflammopharmacology

authors： Chamanara M,Abdollahi A,Rezayat SM,Ghazi-Khansari M,Dehpour A,Nassireslami E,Rashidian A

更新日期：2019-12-01 00:00:00

abstract：:Inflammatory bowel diseases are associated with reduced colonic contractility and induction of cyclooxygenase-2. In this study a possible role of cyclooxygenase-2 in and the underlying mechanism of the reduced contractility were investigated in experimental colitis. The effects of meloxicam, a cyclooxygenase-2 selecti...

journal_title：Inflammopharmacology

authors： Khan I,Oriowo MA

更新日期：2006-03-01 00:00:00

abstract：:Caffeic acid phenethyl ester (CAPE) is the active component of honey bee propolis extracts. The results of the current study demonstrate that CAPE attenuated immunoglobulin (Ig)E-mediated allergic response in mast cells. Oral administration of CAPE inhibited IgE-mediated passive cutaneous anaphylaxis. CAPE effectively...

journal_title：Inflammopharmacology

authors： Nader MA

更新日期：2013-04-01 00:00:00

abstract：:Silver and silver oxides are gaining interest in medical applications for their prominent antibacterial and antimicrobial potentials. Recent studies suggest that nanosilver oxide has remarkable anti-inflammatory effects and enhances wound healing. Nevertheless, its effect on gastric ulcer has not yet been illustrated....

journal_title：Inflammopharmacology

authors： Salem NA,Wahba MA,Eisa WH,El-Shamarka M,Khalil W

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:The role of angiotensin converting enzyme inhibitors on the inflammation process has been demonstrated previously. In the present study, the effects of captopril on lung injury induced by lipopolysaccharide (LPS) were investigated. METHODS:Control, LPS, 12.5, 25 and 50 mg/kg captopril-treated before LPS adm...

journal_title：Inflammopharmacology

authors： Boskabadi J,Askari VR,Hosseini M,Boskabady MH

更新日期：2019-06-01 00:00:00

abstract：:The effect of lupeol, a natural pentacyclic triterpene on ethanol-induced gastric damage in mice was evaluated. The gastroprotection was assessed by determination of changes in mean gastric lesion area, quantification of mucosal non-protein sulfhydryls (NP-SH), and characterized using drugs that influence the endogeno...

journal_title：Inflammopharmacology

authors： Lira SR,Rao VS,Carvalho AC,Guedes MM,de Morais TC,de Souza AL,Trevisan MT,Lima AF,Chaves MH,Santos FA

更新日期：2009-08-01 00:00:00

abstract：:In the process of the oxygen reduction, NADPH oxidase is the enzyme that produces superoxide anion, which subsequently produces reactive oxygen species (ROS) and causes damage in various tissues and microorganisms. NADPH oxidase is demonstrated to exist in several types of cells such as endothelial cells and vascular ...

journal_title：Inflammopharmacology

authors： Nakagiri A,Sunamoto M,Murakami M

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Osthole is a bioactive component reported in medicinal plants such as Angelica pubescens and Cnidium monnieri, known for analgesic activity. However, the toxicity, median effective dose (ED50), and dual modulation of nitric oxide and cyclooxygenase pathways along with inflammatory cytokines of osthole are ye...

journal_title：Inflammopharmacology

authors： Singh G,Bhatti R,Mannan R,Singh D,Kesavan A,Singh P

更新日期：2019-10-01 00:00:00

abstract：:A methanol extract of the seeds of Adenanthera pavonina was evaluated for pharmacological effects in animal models. The extract (50-200 mg/kg) produced statistically significant (P < 0.05) inhibition of the carrageenan-induced paw oedema in the rat, as well as the acetic-acid-induced vascular permeability in mice. At ...

journal_title：Inflammopharmacology

authors： Olajide OA,Echianu CA,Adedapo AD,Makinde JM

更新日期：2004-01-01 00:00:00

abstract：:The inflamed mucosa in ulcerative colitis produces high amount of prostaglandin (PG) and nitric oxide (NO) through inducible enzymes: cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), respectively, implicating them as potential anti-inflammatory drug targets. COX-2 or iNOS-related treatments in diff...

journal_title：Inflammopharmacology

authors： Dudhgaonkar SP,Tandan SK,Kumar D,Raviprakash V,Kataria M

更新日期：2007-10-01 00:00:00

abstract：:Colorectal cancer (CRC) remains the most cancer type related to chronic inflammation; however, the mechanisms that link inflammation to CRC development and progression are still poorly understood. Our study aimed to investigate one of the prominent inflammatory response in cancers, iNOS/NO system. In this regard, we e...

journal_title：Inflammopharmacology

authors： Benkhelifa S,Rafa H,Belhadef S,Ait-Kaci H,Medjeber O,Belkhelfa M,Hetit S,Ait-Younes S,De Launoit Y,Moralès O,Mahfouf H,Delhem N,Touil-Boukoffa C

更新日期：2019-08-01 00:00:00

abstract：:Alzheimer's disease (AD) is prevalent in old age people and is one of the most common brain diseases. Brain insulin resistance, neuroinflammation, oxidative stress, and mitochondrial and cholinergic dysfunction are key features of the disease. In our study, streptozotocin (STZ) in a dose of 3 mg/kg was injected in mal...

journal_title：Inflammopharmacology

authors： Akhtar A,Dhaliwal J,Saroj P,Uniyal A,Bishnoi M,Sah SP

更新日期：2020-04-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a systemic autoimmune disease, which is characterized by a chronic fluctuating course and immune dysfunction, resulting in affecting the health and life quality of RA patients. Methotrexate (MTX), as the standard gold treatment of RA, has received more and more clinical applications and ba...

journal_title：Inflammopharmacology

authors： Yu J,Zhou P

更新日期：2020-10-01 00:00:00

abstract：:Propolis is a resinous substance collected by honeybees from leaf buds and cracks in the bark of various plants. Propolis has been reported to have immunomodulatory activity. We hypothesized that propolis would be able to reduce the disease severity of rheumatoid arthritis. We evaluated the effect of Brazilian propoli...

journal_title：Inflammopharmacology

authors： Tanaka M,Okamoto Y,Fukui T,Masuzawa T

更新日期：2012-02-01 00:00:00

abstract：:P38 mitogen-activated protein kinase (p38 MAPK), a tissue inflammatory factor can be activated under oxidative stress and in conditions associated with hyperglycemia. Gingerol containing various natural herbs has been extensively studied for its pharmacological actions both in reducing the inflammation and as immunity...

journal_title：Inflammopharmacology

authors： Song S,Dang M,Kumar M

更新日期：2019-12-01 00:00:00

abstract：:Regular moderate wine consumption is often associated with reduced morbidity and mortality from to a variety of chronic diseases in which inflammation is a root cause. Wine comes in a wide variety of styles that contain quite different ethanol and polyphenol contents. Controversy remains as to whether the alcohol or p...

journal_title：Inflammopharmacology

authors： Walzem RL

更新日期：2008-12-01 00:00:00

abstract：:The therapeutic efficacy of the contemporary anti-inflammatory drugs are well established; however, prolonged use of such can often lead to serious and life-threatening side effects. Natural product-based anti-inflammatory compounds with superior efficacy and minimum toxicity can serve as possible therapeutic alternat...

journal_title：Inflammopharmacology

authors： Jalil J,Attiq A,Hui CC,Yao LJ,Zakaria NA

更新日期：2020-10-01 00:00:00

abstract：:The ulcerogenic effect of rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, on the gastrointestinal mucosa was investigated in the presence of a low dose of indomethacin. Indomethacin at 3 mg/kg did not cause any damage in both the stomach and small intestine, despite inhibiting prostaglandin (PG) production....

journal_title：Inflammopharmacology

authors： Yokota A,Taniguchi M,Tanaka A,Takeuchi K

更新日期：2005-01-01 00:00:00

abstract：:The Maytenus genus is a member of the Celastraceae family. Numerous medicinal uses were assigned to species of this genus, with the use of roots, bark, and leaves for the treatment of gastric ulcers, as anti-inflammatory, analgesic, antiallergic, antitumor, among others. Several studies have demonstrated that natural ...

journal_title：Inflammopharmacology

authors： Veloso CC,Oliveira MC,Rodrigues VG,Oliveira CC,Duarte LP,Teixeira MM,Ferreira AVM,Perez AC

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVE:This pilot study aimed to determine the efficacy of acamprosate (N-acetyl homotaurine) in reducing the pathological features of experimental autoimmune encephalomyelitis (EAE) which is an animal model for multiple sclerosis (MS). BACKGROUND:The amino acid taurine has multiple biological activities including ...

journal_title：Inflammopharmacology

authors： Sternberg Z,Cesario A,Rittenhouse-Olson K,Sobel RA,Leung YK,Pankewycz O,Zhu B,Whitcomb T,Sternberg DS,Munschauer FE

更新日期：2012-02-01 00:00:00

abstract：:Biologic disease modifying anti-rheumatic drugs have transformed the management of rheumatoid arthritis (RA) since their introduction into clinical practice over a decade ago. Following large-scale clinical trials, a number of biologics, with different mechanisms of action, have been licensed for the condition. In thi...

journal_title：Inflammopharmacology

authors： Malaviya AP,Ostör AJ

更新日期：2012-04-01 00:00:00

abstract：:Gout, the most prevalent inflammatory arthritis worldwide, released interleukin-1β (IL-1β) and Cathepsin B inflammatory mediators that constitute the hallmark of the disease. Herein we aimed to investigate whether procyanidin B2 (PCB2), a natural dietary compound, can suppress MSU crystals-stimulated gouty inflammatio...

journal_title：Inflammopharmacology

authors： Qiao CY,Li Y,Shang Y,Jiang M,Liu J,Zhan ZY,Ye H,Lin YC,Jiao JY,Sun RH,Zhang ZH,Piao MH,Wu YL,Nan JX,Lian LH

更新日期：2020-12-01 00:00:00

abstract：:Excess eicosanoid formation during inflammation has been attributed to the expression of the gene coding for the inducible isoform of prostaglandin G/H synthase (PGHS-2). Human and murine PGHS-2 proteins differ in 73 out of the 604 amino acids. When comparing the inhibitory effects of a panel of PGHS-inhibitors in a w...

journal_title：Inflammopharmacology

authors： Berg J,Fellier H,Bodenteich A,Christoph T,Towart R

更新日期：1997-01-01 00:00:00

abstract：:Rhynchosia minima root, a folk herbal medicine in southern China, is used to relieve itch and swelling. In this study, we examined the anti-inflammatory property of an ethanol fraction (EEF6) from R. minima root on lipopolysaccharide (LPS)-induced RAW 264.7 cells, as well as its underlying mechanism. The compound comp...

journal_title：Inflammopharmacology

authors： Jia X,Zhang C,Bao J,Wang K,Tu Y,Wan JB,He C

更新日期：2020-02-01 00:00:00