Abstract:
:Colorectal cancer (CRC) remains the most cancer type related to chronic inflammation; however, the mechanisms that link inflammation to CRC development and progression are still poorly understood. Our study aimed to investigate one of the prominent inflammatory response in cancers, iNOS/NO system. In this regard, we evaluated the link between the iNOS/NO system and CRC progression, its relation with the host immune responses and its response to cetuximab combined with chemotherapy. We found that the nitrite levels were nearly twice as high in metastatic CRC plasma and culture supernatants from PBMCs and tumor explants compared with those without metastases and healthy controls. Interestingly, we showed that the highest iNOS expression and NO levels are present in the damaged CRC tissues that have highest leukocyte infiltration. Our findings highlight the implication of iNOS/NO system in tissue alteration and leukocyte invasion. Thus, we observed imbalance between effector/memory T cell markers and Treg transcription factor (Foxp3). Accordingly, we detected higher IFNγ and T-bet expression levels in colorectal tumor tissues at early stage. In contrast, consistent with iNOS and Foxp3 expression, TGFβ, CTLA-4 and IL-10 were significantly related to the tumor stage progression. Furthermore, our study revealed that Cetuximab combined with chemotherapy treatment markedly down-regulates iNOS/NO system as well as IL-10 and TGFβ levels. Altogether, we conclude that cetuximab can potentiate the efficacy of chemotherapy, particularly by iNOS/NO system and immunosuppressive cytokines modulation. Thus, we suggest that iNOS/NO system may represent an attractive candidate biomarker for monitoring CRC progression, malignity and response to therapy.
journal_name
Inflammopharmacologyjournal_title
Inflammopharmacologyauthors
Benkhelifa S,Rafa H,Belhadef S,Ait-Kaci H,Medjeber O,Belkhelfa M,Hetit S,Ait-Younes S,De Launoit Y,Moralès O,Mahfouf H,Delhem N,Touil-Boukoffa Cdoi
10.1007/s10787-019-00566-9subject
Has Abstractpub_date
2019-08-01 00:00:00pages
685-700issue
4eissn
0925-4692issn
1568-5608pii
10.1007/s10787-019-00566-9journal_volume
27pub_type
杂志文章abstract::Nicotine mediates some of the injurious effects caused by consuming tobacco products. The aim of this work is to investigate the protective effects of Mentha spicata extract (ME) supplementation on the testis and brain of nicotine-induced oxidative damage rats. ME extract showed interesting hydrogen peroxide-scavengin...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-019-00650-0
更新日期:2020-08-01 00:00:00
abstract::We clarified the roles of histamine H(1)-, H(2)-, H(3)-receptors and oxyradicals in the exacerbation of acid-induced gastric haemorrhage and stomach ulcer in endotoxaemic rats by measuring changes in gastric mucosal glutathione concentrations, lipid peroxide generation and histamine levels as well as in luminal electr...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-998-0017-1
更新日期:1998-01-01 00:00:00
abstract::In the process of the oxygen reduction, NADPH oxidase is the enzyme that produces superoxide anion, which subsequently produces reactive oxygen species (ROS) and causes damage in various tissues and microorganisms. NADPH oxidase is demonstrated to exist in several types of cells such as endothelial cells and vascular ...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-007-1587-z
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND:There is considerable interest in the possible importance of the gut microflora in the pathophysiology of the inflammatory bowel diseases (IBD) ulcerative colitis (UC) and Crohn's disease (CD). Probiotics offer a potential adjuvant treatment in these patients by modifying the intestinal milieu, but reports o...
journal_title:Inflammopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10787-019-00595-4
更新日期:2019-06-01 00:00:00
abstract::The up-regulation of angiotensin II AT1 receptors has been implicated as a major mediator in the development of hypertension and progressive nephropathy in experimental diabetes. In spite of the documented potential of garlic treatments in ameliorating diabetic complications, the possible involvement of the angiotensi...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-012-0139-3
更新日期:2013-04-01 00:00:00
abstract::There is a growing body of evidence that plant polyphenols such as resveratrol, anthocyanins, catechins, and terpenes like taxol are effectively used in the treatment of chronic conditions including cancer, Alzheimer, Parkinsonism, diabetes, aging, etc. The link between oxidative stress and inflammation is well accept...
journal_title:Inflammopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s10787-015-0236-1
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Osthole is a bioactive component reported in medicinal plants such as Angelica pubescens and Cnidium monnieri, known for analgesic activity. However, the toxicity, median effective dose (ED50), and dual modulation of nitric oxide and cyclooxygenase pathways along with inflammatory cytokines of osthole are ye...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-018-0486-9
更新日期:2019-10-01 00:00:00
abstract::To clarify roles of H2S in regulation of gastric circulation, we investigated effects of NaHS, a H2S donor, on tension of isolated rat gastric artery and gastric mucosal blood flow in rats. In the precontracted ring preparations, NaHS caused contraction and relaxation at low and high concentrations, respectively. The ...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-007-1590-4
更新日期:2007-12-01 00:00:00
abstract::- The use of the non-steroidal anti-inflammatory drug, diclofenac, is associated with occasional serious side effects in the gastrointestinal (GI) tract. We examined the effect of altering the site of release of diclofenac sodium on GI tract side effects. Dissolution and pharmacokinetic studies were carried out to sub...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1163/156856004773121383
更新日期:2004-01-01 00:00:00
abstract::The safety of the cyclo-oxygenase-2 (COX-2) selective NSAID, nimesulide, has been evaluated from information (a) in clinical trials in osteoarthritis that have been performed in Europe as well as in earlier pilot studies that were performed in patients with rheumatoid arthritis in the USA, and (b) in post-marketing st...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-998-0020-6
更新日期:1998-01-01 00:00:00
abstract::Pain is recognized as a multifactorial sensory experience that is wholly unpleasant. It can vary in intensity from mild to severe and its duration can be anything from transient to persistent. Today we know so much more about the peripheral nociceptor as the primary detection apparatus for painful stimuli. We also und...
journal_title:Inflammopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s10787-009-0006-z
更新日期:2009-06-01 00:00:00
abstract::Chronic inflammation is a world health problem. There is a need to develop new anti-inflammatory and analgesic drugs with improved activity and reduced side effects. In this context, the aim of this study was to evaluate the antinociceptive and anti-inflammatory effects of the pyrazole compound LQFM-021 after acute an...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-016-0282-3
更新日期:2016-10-01 00:00:00
abstract::The ozonised sunflower oil, Bioperoxoil, was tested for its antimicrobial activity against some pathological strains in vitro together with its healing potential against Staphylococcus aureus in vivo. Bioperoxoil was tested against S. aureus, Pseudomonas aeroginosa, Candida albicans, S. typhimurium and Escherichia col...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1163/1568560042342275
更新日期:2004-01-01 00:00:00
abstract::Most of the gastroprotective drugs which had been marketed in Japan were considered to have insufficient rationale for use as ulcer treatments. Such drugs may have a crucial role in maintaining mucosal integrity by the mechanisms other than inhibition of acid secretion. We re-evaluated the effect of gastroprotective d...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-006-0300-y
更新日期:2007-02-01 00:00:00
abstract::Regular moderate wine consumption is often associated with reduced morbidity and mortality from to a variety of chronic diseases in which inflammation is a root cause. Wine comes in a wide variety of styles that contain quite different ethanol and polyphenol contents. Controversy remains as to whether the alcohol or p...
journal_title:Inflammopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s10787-008-8027-6
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE:To study the effect of hyaluronan on cell adhesion and recruitment both in vitro and in vivo, since hyaluronan both inhibits restenosis and is anti-inflammatory. When administered to animals undergoing angioplasty the recruitment of cells into the restenotic plaque is inhibited, as well as into inflammatory l...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1163/156856005774382733
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVE:This pilot study aimed to determine the efficacy of acamprosate (N-acetyl homotaurine) in reducing the pathological features of experimental autoimmune encephalomyelitis (EAE) which is an animal model for multiple sclerosis (MS). BACKGROUND:The amino acid taurine has multiple biological activities including ...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-011-0097-1
更新日期:2012-02-01 00:00:00
abstract::Pioglitazone, a specific ligand for peroxisome proliferator-activated receptor gamma (PPAR-gamma), was recently implicated in the control of inflammatory processes and in the modulation of the expression of various cytokines such as tumor necrosis factor alpha (TNF-alpha), but its role in the mechanism of gastric muco...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1163/156856005774423908
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Resveratrol exerts an anti-inflammatory effect on collagen-induced arthritis and osteoarthritis in rats via activation of sirtuin 1 (SIRT1). Autophagy can be induced by resveratrol and leads to amelioration of interleukin-1 beta (IL-1β) release in vitro. We aimed to determine the anti-inflammatory mechanisms...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-018-00555-4
更新日期:2019-02-01 00:00:00
abstract::Kerabala (CB) is a novel ayurvedic formulation used for treating various inflammatory diseases. This formulation was made from virgin coconut oil and it comprises extracts of Sida cordifolia, coconut milk and sesame oil. The current study was performed to evaluate the anti-inflammatory action of CB on carrageenan-indu...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-016-0298-8
更新日期:2017-02-01 00:00:00
abstract::Allanblackia gabonensis (Guttiferae) is a plant used in the African traditional medicine as remedies against pain, rheumatism, inflammations. In the present work, the analgesic effect of aqueous extract has been evaluated using acetic acid, formalin, hot-plate test, tail immersion and paw-pressure test. The anti-infla...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-011-0096-2
更新日期:2013-02-01 00:00:00
abstract::The Maytenus genus is a member of the Celastraceae family. Numerous medicinal uses were assigned to species of this genus, with the use of roots, bark, and leaves for the treatment of gastric ulcers, as anti-inflammatory, analgesic, antiallergic, antitumor, among others. Several studies have demonstrated that natural ...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-018-0496-7
更新日期:2019-06-01 00:00:00
abstract::Euphorbia hirta L. (Euphorbiaceae) (E. hirta) is a tree locally used as a traditional medicine in Africa and Australia to treat numerous diseases such as hypertension, respiratory ailments, tumors, antipyretic, anti-inflammatory activities. In the present study, we investigated the anti-arthritic activity of fresh lea...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-012-0161-5
更新日期:2013-10-01 00:00:00
abstract::Rheumatoid arthritis (RA) is a systemic autoimmune disease, which is characterized by a chronic fluctuating course and immune dysfunction, resulting in affecting the health and life quality of RA patients. Methotrexate (MTX), as the standard gold treatment of RA, has received more and more clinical applications and ba...
journal_title:Inflammopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s10787-020-00741-3
更新日期:2020-10-01 00:00:00
abstract::Euphorbia hirta L. (Euphorbiaceae) (E. hirta) is a tree locally used as a traditional medicine in Africa and Australia to treat numerous diseases such as hypertension, respiratory ailments, tumors, wounds, antipyretic, anti-inflammatory activities, etc. Therefore, we undertook to investigate their immunomodulatory eff...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-012-0144-6
更新日期:2013-04-01 00:00:00
abstract::Biologic disease modifying anti-rheumatic drugs have transformed the management of rheumatoid arthritis (RA) since their introduction into clinical practice over a decade ago. Following large-scale clinical trials, a number of biologics, with different mechanisms of action, have been licensed for the condition. In thi...
journal_title:Inflammopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s10787-012-0123-y
更新日期:2012-04-01 00:00:00
abstract::P38 mitogen-activated protein kinase (p38 MAPK), a tissue inflammatory factor can be activated under oxidative stress and in conditions associated with hyperglycemia. Gingerol containing various natural herbs has been extensively studied for its pharmacological actions both in reducing the inflammation and as immunity...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-019-00569-6
更新日期:2019-12-01 00:00:00
abstract::Caffeic acid phenethyl ester (CAPE) is the active component of honey bee propolis extracts. The results of the current study demonstrate that CAPE attenuated immunoglobulin (Ig)E-mediated allergic response in mast cells. Oral administration of CAPE inhibited IgE-mediated passive cutaneous anaphylaxis. CAPE effectively...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-012-0138-4
更新日期:2013-04-01 00:00:00
abstract::The central nervous system, one of the most delicate microenvironments of the body, is protected by the blood-brain barrier regulating its homeostasis. Blood-brain barrier is a highly complex structure that tightly regulates the movement of ions of a limited number of small molecules and of an even more restricted num...
journal_title:Inflammopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s10787-018-0468-y
更新日期:2018-06-01 00:00:00
abstract::The aim of this study was to determine whether ethanol extracts of Etlingera pavieana rhizomes (EPE) can inhibit the expression of ICAM-1 and VCAM-1 in TNF-α-stimulated human vascular endothelial cells. EPE significantly reduced ICAM-1 and VCAM-1 expression in a concentration-dependent manner. EPE also suppressed phos...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-019-00676-4
更新日期:2020-12-01 00:00:00