Abstract：
:Gout, the most prevalent inflammatory arthritis worldwide, released interleukin-1β (IL-1β) and Cathepsin B inflammatory mediators that constitute the hallmark of the disease. Herein we aimed to investigate whether procyanidin B2 (PCB2), a natural dietary compound, can suppress MSU crystals-stimulated gouty inflammation. Treated with lipopolysaccharide (LPS) plus MSU, both mouse peritoneal macrophages (MPM) and mouse bone marrow-derived macrophages (BMDM) released a large amount of mature IL-1β compared to those treated with MSU or LPS alone, while IL-1β release was blocked by TLR4 and its downstream effector inhibitors. In two mouse models of gout, oral administration of PCB2 suppressed MSU crystals-induced increasing expression of IL-1β, Cathepsin B and NLRP3 in the air pouch skin and paws, accompanied with the downregulation prostaglandin E2 (PGE2) in pouch exudates. Inflammatory immune cell infiltration including macrophages and neutrophils were significantly blocked by PCB2 in air pouch skin and paws of mice gout groups. PCB2 also suppressed the release of IL-1β and Cathepsin B induced by MSU plus LPS in MPM. Our results suggest that the inhibitory effects of PCB2 on NLRP3 inflammasome may alleviate inflammatory response in gout, and this might be a promising anti-inflammatory mechanism of PCB2 against the inflammation in gout.
journal_name
Inflammopharmacologyjournal_title
Inflammopharmacologyauthors
Qiao CY,Li Y,Shang Y,Jiang M,Liu J,Zhan ZY,Ye H,Lin YC,Jiao JY,Sun RH,Zhang ZH,Piao MH,Wu YL,Nan JX,Lian LHdoi
10.1007/s10787-020-00758-8subject
Has Abstractpub_date
2020-12-01 00:00:00pages
1481-1493issue
6eissn
0925-4692issn
1568-5608pii
10.1007/s10787-020-00758-8journal_volume
28pub_type
杂志文章abstract：:Rheumatoid arthritis (RA) is a systemic autoimmune disease, which is characterized by a chronic fluctuating course and immune dysfunction, resulting in affecting the health and life quality of RA patients. Methotrexate (MTX), as the standard gold treatment of RA, has received more and more clinical applications and ba...
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journal_title：Inflammopharmacology
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doi：10.1007/BF02918381
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