Abstract：
:Based on a unifying theory presented here, it is predicted that the immune defects resulting in chronic inflammation rather than effective immune responses could be rectified by the therapeutic use of agents prepared from micro-organisms. With appropriate molecular patterns, these should be able to induce protective immunoregulatory networks or to reprogramme defective ones. In contrast to acute inflammation, chronic inflammation appears to have no beneficial role, but is a state of sustained immune reactivity in the presence or progression of a disease process. This results in an escalating cycle of tissue damage followed by unproductive tissue repair, breaks in self-tolerance, malignant transformation or deleterious changes in tissue morphology and function. Such inappropriate immune reactivity is an underlying characteristic, either in initiation or maintenance, of a diverse range of disease states including chronic infection, autoimmunity, allergy, cancer, vascular disease and metabolic alterations. Evidence is presented that the inappropriate immune reactivity is due, at least to some extent, to failures in the establishment of immunoregulatory networks as a result of hygiene-related factors. Such networks are the result of activation of antigen-presenting cells, principally dendritic cells, by molecular patterns of micro-organisms encountered sequentially during life and establishing the 'biography' of the immune system.
journal_name
Inflammopharmacologyjournal_title
Inflammopharmacologyauthors
Bottasso O,Docena G,Stanford JL,Grange JMdoi
10.1007/s10787-009-0008-xsubject
Has Abstractpub_date
2009-08-01 00:00:00pages
193-203issue
4eissn
0925-4692issn
1568-5608journal_volume
17pub_type
杂志文章,评审abstract：:P38 mitogen-activated protein kinase (p38 MAPK), a tissue inflammatory factor can be activated under oxidative stress and in conditions associated with hyperglycemia. Gingerol containing various natural herbs has been extensively studied for its pharmacological actions both in reducing the inflammation and as immunity...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00569-6
更新日期：2019-12-01 00:00:00
abstract：:Mitochondria can interchange morphology due to their dynamic nature. It can exist in either fragmented disconnected arrangement or elongated interconnected mitochondrial networks due to fission and fusion, respectively. The recent studies have revealed the remarkable and unexpected insights into the physiological impa...
journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s10787-017-0347-y
更新日期：2017-08-01 00:00:00
abstract：:The intestinal mucosa is subject to a variety of physical forces in a complex manner during normal gut function and in disease. Intestinal mucosal atrophy during some disease states is a troubling phenomenon that is only partially explained by nutritional parameters. Increasing evidence suggests the possibility that r...
journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s10787-007-1562-8
更新日期：2007-06-01 00:00:00
abstract：AIM:Experimental autoimmune encephalomyelitis (EAE) is a CD4(+)-mediated autoimmune pathology of the central nervous system (CNS) that is used as a model for the study of the human neuroinflammatory disease, multiple sclerosis. During the development of EAE, auto-reactive Th1 and Th17 CD4(+) T cells infiltrate the CNS ...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-015-0252-1
更新日期：2015-12-01 00:00:00
abstract：:A new compound derivative of glycoside 19-α-hydroxy-ursolic acid glucoside (19-α-hydroxyurs-12(13)-ene-28-oic acid-3-O-β-D-glucopyranoside (HEG) was isolated from whole plant of Wedelia calendulacea (Compositae). The structure was elucidated and established by standard spectroscopy approaches. Diethylnitrosamine (DEN)...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-017-0310-y
更新日期：2017-02-01 00:00:00
abstract：:Propolis is a resinous substance collected by honeybees from leaf buds and cracks in the bark of various plants. Propolis has been reported to have immunomodulatory activity. We hypothesized that propolis would be able to reduce the disease severity of rheumatoid arthritis. We evaluated the effect of Brazilian propoli...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-011-0088-2
更新日期：2012-02-01 00:00:00
abstract：BACKGROUND:The role of angiotensin converting enzyme inhibitors on the inflammation process has been demonstrated previously. In the present study, the effects of captopril on lung injury induced by lipopolysaccharide (LPS) were investigated. METHODS:Control, LPS, 12.5, 25 and 50 mg/kg captopril-treated before LPS adm...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-018-0535-4
更新日期：2019-06-01 00:00:00
abstract：:Euphorbia hirta L. (Euphorbiaceae) (E. hirta) is a tree locally used as a traditional medicine in Africa and Australia to treat numerous diseases such as hypertension, respiratory ailments, tumors, antipyretic, anti-inflammatory activities. In the present study, we investigated the anti-arthritic activity of fresh lea...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-012-0161-5
更新日期：2013-10-01 00:00:00
abstract：:The central nervous system, one of the most delicate microenvironments of the body, is protected by the blood-brain barrier regulating its homeostasis. Blood-brain barrier is a highly complex structure that tightly regulates the movement of ions of a limited number of small molecules and of an even more restricted num...
journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s10787-018-0468-y
更新日期：2018-06-01 00:00:00
abstract：:Excess eicosanoid formation during inflammation has been attributed to the expression of the gene coding for the inducible isoform of prostaglandin G/H synthase (PGHS-2). Human and murine PGHS-2 proteins differ in 73 out of the 604 amino acids. When comparing the inhibitory effects of a panel of PGHS-inhibitors in a w...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-997-0020-y
更新日期：1997-01-01 00:00:00
abstract：:We clarified the roles of histamine H(1)-, H(2)-, H(3)-receptors and oxyradicals in the exacerbation of acid-induced gastric haemorrhage and stomach ulcer in endotoxaemic rats by measuring changes in gastric mucosal glutathione concentrations, lipid peroxide generation and histamine levels as well as in luminal electr...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-998-0017-1
更新日期：1998-01-01 00:00:00
abstract：:This review considers the problem of the serious concomitant side effects of powerful anti-inflammatory drugs modelled upon the principal human glucocorticoid hormone, cortisol. The very nature of the original bio-assays to validate their cortisol-like hormonal and anti-inflammatory activities ensured that pleiotropic...
journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s10787-010-0056-2
更新日期：2011-02-01 00:00:00
abstract：:The aim of this study was to investigate the effect of the nitric oxide donor isosorbide-5-mononitrate (5-ISMN) alone or in combination with the natural hepatoprotectant with anti-oxidant activity silymarin on the carbon tetrachloride (CCl(4))-induced hepatic injury in rats. 5-ISMN (1.8, 3.6 or 7.2 mg/kg), silymarin (...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-009-0027-7
更新日期：2010-04-01 00:00:00
abstract：:A small GTPase, Rac1, is recognized as an important modulator of the inflammatory responses to bacterial lipopolysaccharide (LPS) by affecting the processes of phospholipase C activation. The activation of Rac1 involves the exchange of GDP for GTP and is catalyzed by the guanine nucleotide exchange factors (GEFs). Her...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-015-0235-2
更新日期：2015-06-01 00:00:00
abstract：:Since their development and licensing no class of drug has received as much attention both in the scientific and lay press as the cyclo-oxygenase 2 (COX-2) inhibitors. These compounds, also known as coxibs, were developed as a safer alternative to traditional non-steroidal anti-inflammatory drugs (NSAIDs) due to their...
journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1163/156856005774415619
更新日期：2005-01-01 00:00:00
abstract：AIM:The aim of the present study was to evaluate the anti-inflammatory effect of thymol in acetic acid-induced rat colitis through inhibiting the NF-κB signaling pathway. METHODS:Colitis was induced by intra-rectal administration of 2 mL of diluted acetic acid (4%) solution using a flexible plastic rubber catheter in ...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00583-8
更新日期：2019-12-01 00:00:00
abstract：:Paracetamol-induced toxicity is mainly due to the accumulation of its CYP450-mediated N-hydroxylation product - N-acetylimidoquinone. We examined cell viability, proliferation rates and intracellular calcium in PC12 cells and in a PC12 cell line transfected with cytochrome P4502E1 exposed to paracetamol. This drug had...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-998-0030-4
更新日期：1998-01-01 00:00:00
abstract：:The side effects of NSAIDs are equally evident in the stomach and the small bowel. The latter is increasingly seen as being clinically significant, contributing substantially to the iron-deficiency anaemia that is so common in patients with rheumatoid arthritis. Furthermore, NSAID-enteropathy may be associated with li...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1163/156856003322699546
更新日期：2003-01-01 00:00:00
abstract：:TRP channels have been discovered as a specialized group of somatosensory neurons involved in the detection of noxious stimuli. Desensitization of TRPV1 located on dorsal root and trigeminal ganglia exhibits analgesic effect and makes it potential therapeutic target for treatment of neuropathic pain. With this backgro...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-016-0285-0
更新日期：2016-12-01 00:00:00
abstract：:- The use of the non-steroidal anti-inflammatory drug, diclofenac, is associated with occasional serious side effects in the gastrointestinal (GI) tract. We examined the effect of altering the site of release of diclofenac sodium on GI tract side effects. Dissolution and pharmacokinetic studies were carried out to sub...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1163/156856004773121383
更新日期：2004-01-01 00:00:00
abstract：:The anti-inflammatory activity of the aqueous extract of Chromolaena odorata was investigated in rats using the carrageenan-induced oedema, cotton pellet granuloma and formalin-induced oedema methods. The extract was administered orally at doses of 25, 50, 100 and 200 mg/kg. In the carrageenan method the paw oedema wa...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1163/156856005774649386
更新日期：2005-01-01 00:00:00
abstract：:Central nervous system (CNS) has a completely separate immune system that communicates with the neurons by small molecules called cytokines. Cytokines are involved in many crucial processes in neuron including cell metabolism and neurotransmitter synthesis. It has been reported that cytokine imbalance is involved in t...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-013-0181-9
更新日期：2013-12-01 00:00:00
abstract：:There is a growing body of evidence that plant polyphenols such as resveratrol, anthocyanins, catechins, and terpenes like taxol are effectively used in the treatment of chronic conditions including cancer, Alzheimer, Parkinsonism, diabetes, aging, etc. The link between oxidative stress and inflammation is well accept...
journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s10787-015-0236-1
更新日期：2015-08-01 00:00:00
abstract：:The present investigation assessed the potential of Prunus cerasoides fruit extract (PCFE) in alleviation of inflammatory stress in response to lipopolysaccharide (LPS) and interferon-γ (IFN-γ)-stimulated murine peritoneal macrophages as well as in concanavalin A (Con A)-activated splenic lymphocytes. We observed a st...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-018-0448-2
更新日期：2018-12-01 00:00:00
abstract：:Kynurenate, a metabolite of tryptophan formed serially from kynurenine, inhibits N-methyl-D-aspartate (NMDA) receptor responses. Non-steroidal anti-inflammatory drugs (NSAIDs) may produce anti-hyperalgesic effects by altering tryptophan metabolism to increase kynurenate concentrations. We examined whether the NSAID di...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1163/156856003322315622
更新日期：2003-01-01 00:00:00
abstract：:Some B vitamins exhibit activities in models of nociceptive pain, inflammatory pain, and neuropathic pain induced by nerve lesions and also in certain painful conditions in humans. In the present study, we investigated the effects of thiamine, riboflavin, and nicotinamide in a neuropathic pain model induced by the che...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00625-1
更新日期：2020-02-01 00:00:00
abstract：:The effect of lupeol, a natural pentacyclic triterpene on ethanol-induced gastric damage in mice was evaluated. The gastroprotection was assessed by determination of changes in mean gastric lesion area, quantification of mucosal non-protein sulfhydryls (NP-SH), and characterized using drugs that influence the endogeno...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-009-0009-9
更新日期：2009-08-01 00:00:00
abstract：AIM:The capture, analysis and utilisation of health status information are attended by logistic considerations and interpretation challenges. We report a preliminary evaluation of cellular technology in capturing WOMAC NRS 3.1 Index data. METHODS:A Java midlet for delivering the WOMAC NRS3.1 Index on Nokia-6300, Motor...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-008-8045-4
更新日期：2009-04-01 00:00:00
abstract：:Centella asiatica is claimed to have a neuroprotective effect; however, its ability to protect the cerebrum against damage in diabetes has never been identified. The aims were to identify the possibility that C. asiatica ameliorates inflammation, oxidative stress, and apoptosis in the cerebrum in diabetes. C. asiatica...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-020-00733-3
更新日期：2020-12-01 00:00:00
abstract：:The aim of this study was to determine whether ethanol extracts of Etlingera pavieana rhizomes (EPE) can inhibit the expression of ICAM-1 and VCAM-1 in TNF-α-stimulated human vascular endothelial cells. EPE significantly reduced ICAM-1 and VCAM-1 expression in a concentration-dependent manner. EPE also suppressed phos...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00676-4
更新日期：2020-12-01 00:00:00
