Selective prostaglandin G/H synthase (PGHS)-2 inhibitors show greater inhibitory activities on human PGHS-2 than on murine PGHS-2 in intact cells.

abstract：:TRP channels have been discovered as a specialized group of somatosensory neurons involved in the detection of noxious stimuli. Desensitization of TRPV1 located on dorsal root and trigeminal ganglia exhibits analgesic effect and makes it potential therapeutic target for treatment of neuropathic pain. With this backgro...

journal_title：Inflammopharmacology

authors： Marwaha L,Bansal Y,Singh R,Saroj P,Sodhi RK,Kuhad A

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVE AND DESIGN:The objective of this study was to investigate the leucocyte-related antiinflammatory properties of rose hip. MATERIALS AND METHODS:The effect of rose hip on a number of inflammatory parameters was evaluated using the following models: (1) The effect of rose hip extract on chemotaxis and chemilumi...

journal_title：Inflammopharmacology

authors： Kharazmi A,Winther K

更新日期：1999-01-01 00:00:00

abstract：:Bioactivity-guided investigation of the methanol extract of Crepis sancta aerial parts, collected off Al-Tafilah, South Jordan, was applied, and in this study, the extract was explored for its phytochemical components and in vivo antiulcer activity. In addition, a docking study involving the purified compounds with th...

journal_title：Inflammopharmacology

authors： Ebada SS,Al-Jawabri NA,Youssef FS,Albohy A,Aldalaien SM,Disi AM,Proksch P

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Resveratrol exerts an anti-inflammatory effect on collagen-induced arthritis and osteoarthritis in rats via activation of sirtuin 1 (SIRT1). Autophagy can be induced by resveratrol and leads to amelioration of interleukin-1 beta (IL-1β) release in vitro. We aimed to determine the anti-inflammatory mechanisms...

journal_title：Inflammopharmacology

authors： Yang QB,He YL,Zhong XW,Xie WG,Zhou JG

更新日期：2019-02-01 00:00:00

abstract：:Stress is a reflex response, both psychological and physiological, of the body to a difficult situation that requires adaptation. Stress is at the intersection of the objective event and the subjective event. The physiological mechanisms involved in chronic stress are numerous and can contribute to a wide variety of d...

journal_title：Inflammopharmacology

authors： Nessaibia I,Fouache A,Lobaccaro JA,Tahraoui A,Trousson A,Souidi M

更新日期：2019-02-01 00:00:00

abstract：:Colorectal cancer (CRC) remains the most cancer type related to chronic inflammation; however, the mechanisms that link inflammation to CRC development and progression are still poorly understood. Our study aimed to investigate one of the prominent inflammatory response in cancers, iNOS/NO system. In this regard, we e...

journal_title：Inflammopharmacology

authors： Benkhelifa S,Rafa H,Belhadef S,Ait-Kaci H,Medjeber O,Belkhelfa M,Hetit S,Ait-Younes S,De Launoit Y,Moralès O,Mahfouf H,Delhem N,Touil-Boukoffa C

更新日期：2019-08-01 00:00:00

abstract：:The idea that microbes induce disease has steered medical research toward the discovery of antibacterial products for the prevention and treatment of microbial infections. The twentieth century saw increasing dependency on antimicrobials as mainline therapy accentuating the notion that bacterial interactions with huma...

journal_title：Inflammopharmacology

authors： Vitetta L,Briskey D,Hayes E,Shing C,Peake J

更新日期：2012-10-01 00:00:00

abstract：:Allanblackia gabonensis (Guttiferae) is a plant used in the African traditional medicine as remedies against pain, rheumatism, inflammations. In the present work, the analgesic effect of aqueous extract has been evaluated using acetic acid, formalin, hot-plate test, tail immersion and paw-pressure test. The anti-infla...

journal_title：Inflammopharmacology

authors： Ymele EV,Dongmo AB,Dimo T

更新日期：2013-02-01 00:00:00

abstract：:The ozonised sunflower oil, Bioperoxoil, was tested for its antimicrobial activity against some pathological strains in vitro together with its healing potential against Staphylococcus aureus in vivo. Bioperoxoil was tested against S. aureus, Pseudomonas aeroginosa, Candida albicans, S. typhimurium and Escherichia col...

journal_title：Inflammopharmacology

authors： Rodrigues KL,Cardoso CC,Caputo LR,Carvalho JC,Fiorini JE,Schneedorf JM

更新日期：2004-01-01 00:00:00

abstract：:Prompted by the findings that smokers have lowered brain and blood platelet monoamine oxidase-A and -B activities compared to non-smokers and that smokers have a lowered incidence of Parkinson's disease, we have examined the neuroprotective properties of an MAO inhibitor, 2,3,6-trimethyl-1,4-naphthoquinone (TMN), whic...

journal_title：Inflammopharmacology

authors： Castagnoli K,Petzer JB,Steyn SJ,van der Schyf CJ,Castagnoli N Jr

更新日期：2003-01-01 00:00:00

abstract：:Tumour necrosis factor (TNF) and kinins have been associated with neuropathic pain-like behaviour in numerous animal models. However, the way that they interact to cause neuron sensitisation remains unclear. This study assessed the interaction of kinin receptors and TNF receptor TNFR1/p55 in mechanical hypersensitivit...

journal_title：Inflammopharmacology

authors： Quintão NLM,Rocha LW,da Silva GF,Paszcuk AF,Manjavachi MN,Bento AF,da Silva KABS,Campos MM,Calixto JB

更新日期：2019-06-01 00:00:00

abstract：:The central nervous system, one of the most delicate microenvironments of the body, is protected by the blood-brain barrier regulating its homeostasis. Blood-brain barrier is a highly complex structure that tightly regulates the movement of ions of a limited number of small molecules and of an even more restricted num...

journal_title：Inflammopharmacology

authors： Nair KGS,Ramaiyan V,Sukumaran SK

更新日期：2018-06-01 00:00:00

abstract：:Some B vitamins exhibit activities in models of nociceptive pain, inflammatory pain, and neuropathic pain induced by nerve lesions and also in certain painful conditions in humans. In the present study, we investigated the effects of thiamine, riboflavin, and nicotinamide in a neuropathic pain model induced by the che...

journal_title：Inflammopharmacology

authors： Braga AV,Costa SOAM,Rodrigues FF,Melo ISF,Morais MI,Coelho MM,Machado RR

更新日期：2020-02-01 00:00:00

abstract：AIM:Experimental autoimmune encephalomyelitis (EAE) is a CD4(+)-mediated autoimmune pathology of the central nervous system (CNS) that is used as a model for the study of the human neuroinflammatory disease, multiple sclerosis. During the development of EAE, auto-reactive Th1 and Th17 CD4(+) T cells infiltrate the CNS ...

journal_title：Inflammopharmacology

authors： de Oliveira DM,de Oliveira EM,Ferrari Mde F,Semedo P,Hiyane MI,Cenedeze MA,Pacheco-Silva A,Câmara NO,Peron JP

更新日期：2015-12-01 00:00:00

abstract：:Propolis has been extensively used to improve health and prevent inflammatory diseases. Different types of Cuban propolis (red, brown and yellow) have been documented. The purpose of this research was to investigate the cytotoxic effects of Cuban red propolis (CP) on MDA MB-231 cell line, since breast cancer is consid...

journal_title：Inflammopharmacology

authors： Frión-Herrera Y,Díaz-García A,Ruiz-Fuentes J,Rodríguez-Sánchez H,Sforcin JM

更新日期：2019-10-01 00:00:00

abstract：:Pulmonary fibrosis is a result of an abnormal wound healing in lung tissue triggered by an excessive accumulation of extracellular matrix proteins, loss of tissue elasticity, and debit of ventilatory function. NKT cells are a major source of Th1 and Th2 cytokines and may be crucial in the polarization of M1/M2 macroph...

journal_title：Inflammopharmacology

authors： Grabarz F,Aguiar CF,Correa-Costa M,Braga TT,Hyane MI,Andrade-Oliveira V,Landgraf MA,Câmara NOS

更新日期：2018-04-01 00:00:00

abstract：:The side effects of NSAIDs are equally evident in the stomach and the small bowel. The latter is increasingly seen as being clinically significant, contributing substantially to the iron-deficiency anaemia that is so common in patients with rheumatoid arthritis. Furthermore, NSAID-enteropathy may be associated with li...

journal_title：Inflammopharmacology

authors： Hotz-Behofsits CM,Walley MJ,Simpson R,Bjarnason IT

更新日期：2003-01-01 00:00:00

abstract：:Ischemia/reperfusion (I/R) damages gastric mucosa via reactive oxygen species (ROS) activity. ROS was reportedly produced through angiotensin II stimulation in tissues such as kidney, heart and brain. To determine whether AT1 receptor plays a role in gastric mucosal damage, we examined the effect of AT1 receptor block...

journal_title：Inflammopharmacology

authors： Nakagiri A,Sunamoto M,Murakami M

更新日期：2007-08-01 00:00:00

abstract：:The present investigation assessed the potential of Prunus cerasoides fruit extract (PCFE) in alleviation of inflammatory stress in response to lipopolysaccharide (LPS) and interferon-γ (IFN-γ)-stimulated murine peritoneal macrophages as well as in concanavalin A (Con A)-activated splenic lymphocytes. We observed a st...

journal_title：Inflammopharmacology

authors： Sharma A,Joshi R,Kumar S,Sharma R,Rajneesh,Padwad Y,Gupta M

更新日期：2018-12-01 00:00:00

abstract：:Pain is recognized as a multifactorial sensory experience that is wholly unpleasant. It can vary in intensity from mild to severe and its duration can be anything from transient to persistent. Today we know so much more about the peripheral nociceptor as the primary detection apparatus for painful stimuli. We also und...

journal_title：Inflammopharmacology

authors： Rodger IW

更新日期：2009-06-01 00:00:00

abstract：AIMS:To compare methodological aspects of the impact of different classification procedures used in three phases of a twin study examining genetic factors in the aetiopathogenesis of rheumatoid arthritis (RA). METHODS:We have previously reported the results of a study of the aetiopathogenesis of RA based on the Austra...

journal_title：Inflammopharmacology

authors： Bellamy N,Duffy DL,Sambrook P,Buchanan RR,Brooks PM,Dunckley H,Healey SC,Mason S,Martin NG

更新日期：1998-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is prevalent in old age people and is one of the most common brain diseases. Brain insulin resistance, neuroinflammation, oxidative stress, and mitochondrial and cholinergic dysfunction are key features of the disease. In our study, streptozotocin (STZ) in a dose of 3 mg/kg was injected in mal...

journal_title：Inflammopharmacology

authors： Akhtar A,Dhaliwal J,Saroj P,Uniyal A,Bishnoi M,Sah SP

更新日期：2020-04-01 00:00:00

abstract：:Tovophyllin A (TA) is a xanthone isolated from Garcinia mangostana L. (GM, Guttiferae) pericarps that possesses various beneficial bioactivities. However, its protective effects on acute lung injury (ALI) and lung carcinoma have not yet been explored. The current work was designed to investigate the protective potenti...

journal_title：Inflammopharmacology

authors： El-Agamy DS,Mohamed GA,Ahmed N,Elkablawy MA,Elfaky MA,Elsaed WM,Mohamed SGA,Ibrahim SRM

更新日期：2020-02-01 00:00:00

abstract：:The therapeutic efficacy of the contemporary anti-inflammatory drugs are well established; however, prolonged use of such can often lead to serious and life-threatening side effects. Natural product-based anti-inflammatory compounds with superior efficacy and minimum toxicity can serve as possible therapeutic alternat...

journal_title：Inflammopharmacology

authors： Jalil J,Attiq A,Hui CC,Yao LJ,Zakaria NA

更新日期：2020-10-01 00:00:00

abstract：:We clarified the roles of histamine H(1)-, H(2)-, H(3)-receptors and oxyradicals in the exacerbation of acid-induced gastric haemorrhage and stomach ulcer in endotoxaemic rats by measuring changes in gastric mucosal glutathione concentrations, lipid peroxide generation and histamine levels as well as in luminal electr...

journal_title：Inflammopharmacology

authors： Hung CR,Hsu DZ

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVE:This pilot study aimed to determine the efficacy of acamprosate (N-acetyl homotaurine) in reducing the pathological features of experimental autoimmune encephalomyelitis (EAE) which is an animal model for multiple sclerosis (MS). BACKGROUND:The amino acid taurine has multiple biological activities including ...

journal_title：Inflammopharmacology

authors： Sternberg Z,Cesario A,Rittenhouse-Olson K,Sobel RA,Leung YK,Pankewycz O,Zhu B,Whitcomb T,Sternberg DS,Munschauer FE

更新日期：2012-02-01 00:00:00

abstract：:The ulcerogenic effect of rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, on the gastrointestinal mucosa was investigated in the presence of a low dose of indomethacin. Indomethacin at 3 mg/kg did not cause any damage in both the stomach and small intestine, despite inhibiting prostaglandin (PG) production....

journal_title：Inflammopharmacology

authors： Yokota A,Taniguchi M,Tanaka A,Takeuchi K

更新日期：2005-01-01 00:00:00

abstract：:The initial precipitating injury such as SE progresses to chronic epilepsy through multiple epileptogenic processes. Early epileptogenic events are generally characterized by neuroinflammation, neurodegeneration and abnormal neurogenesis in the hippocampus. Metformin has exhibited anti-inflammatory and neuroprotective...

journal_title：Inflammopharmacology

authors： Bojja SL,Medhi B,Anand S,Bhatia A,Joshi R,Minz RW

更新日期：2021-01-01 00:00:00

abstract：:Silver and silver oxides are gaining interest in medical applications for their prominent antibacterial and antimicrobial potentials. Recent studies suggest that nanosilver oxide has remarkable anti-inflammatory effects and enhances wound healing. Nevertheless, its effect on gastric ulcer has not yet been illustrated....

journal_title：Inflammopharmacology

authors： Salem NA,Wahba MA,Eisa WH,El-Shamarka M,Khalil W

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:There is considerable interest in the possible importance of the gut microflora in the pathophysiology of the inflammatory bowel diseases (IBD) ulcerative colitis (UC) and Crohn's disease (CD). Probiotics offer a potential adjuvant treatment in these patients by modifying the intestinal milieu, but reports o...

journal_title：Inflammopharmacology

authors： Bjarnason I,Sission G,Hayee B

更新日期：2019-06-01 00:00:00