Abstract：
:Allanblackia gabonensis (Guttiferae) is a plant used in the African traditional medicine as remedies against pain, rheumatism, inflammations. In the present work, the analgesic effect of aqueous extract has been evaluated using acetic acid, formalin, hot-plate test, tail immersion and paw-pressure test. The anti-inflammatory effect of this extract was also investigated on carrageenan, histamine or serotonin induced by paw oedema. Aqueous extract of stem bark of A. gabonensis administrated p.o. showed significant activity against paw oedema induced by carrageenan, with a maximum percentage of inhibition reaching the 74.01% at the preventive test at a dose of 200 mg/kg. A. gabonensis exhibited a significant reduction of paw oedema induced by both histamine and serotonin with a maximal inhibition of 56.94% (200 mg/kg) and 40.83% (100 mg/kg), respectively. It showed significant protective effects against chemical stimuli (acetic acid and formalin) in the mouse. Administered orally at the doses of 100-400 mg/kg, exhibited protective effect of at least 69.78% on the pain induced by acetic acid and also reduced first (67.18% at 200 mg/kg) and second (83.87% at 400 mg/kg) phase of pain-induced par formalin. It also produced a significant increase of the threshold of sensitivity to pressure and hot plate-induced pain in the rats. These results suggest a peripheral and central analgesic activities as well as an anti-inflammatory effect of the stem bark of A. gabonensis.
journal_name
Inflammopharmacologyjournal_title
Inflammopharmacologyauthors
Ymele EV,Dongmo AB,Dimo Tdoi
10.1007/s10787-011-0096-2subject
Has Abstractpub_date
2013-02-01 00:00:00pages
21-30issue
1eissn
0925-4692issn
1568-5608journal_volume
21pub_type
杂志文章abstract：OBJECTIVE AND DESIGN:The objective of this study was to investigate the leucocyte-related antiinflammatory properties of rose hip. MATERIALS AND METHODS:The effect of rose hip on a number of inflammatory parameters was evaluated using the following models: (1) The effect of rose hip extract on chemotaxis and chemilumi...
journal_title：Inflammopharmacology
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更新日期：1999-01-01 00:00:00
abstract：:Methyl gallate is a gallotannin widely distributed in nature. Previous studies have demonstrated its antioxidant, anti-inflammatory, antimicrobial and anti-tumor activities. In the present study, the activity of methyl gallate on experimental models of inflammatory bowel disease has been investigated. Experimental col...
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更新日期：2018-06-01 00:00:00
abstract：:Acute lung injury (ALI) and acute kidney injury (AKI) are major causes of sepsis-induced mortality. The objective of the study is to evaluate the effect of tocilizumab (TCZ), an IL-6 receptor inhibitor, in sepsis-induced ALI and AKI using the cecal ligation and puncture (CLP) rat model of sepsis. Clinical and experime...
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更新日期：2020-04-01 00:00:00
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更新日期：2010-04-01 00:00:00
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更新日期：2020-12-01 00:00:00
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更新日期：2003-01-01 00:00:00
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更新日期：2013-04-01 00:00:00
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更新日期：2020-12-01 00:00:00
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更新日期：2010-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2009-02-01 00:00:00
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更新日期：1998-01-01 00:00:00
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更新日期：2015-06-01 00:00:00
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