Abstract：
:A methanol extract of the seeds of Adenanthera pavonina was evaluated for pharmacological effects in animal models. The extract (50-200 mg/kg) produced statistically significant (P < 0.05) inhibition of the carrageenan-induced paw oedema in the rat, as well as the acetic-acid-induced vascular permeability in mice. At doses of 100 and 200 mg/kg, pleurisy induced with carrageenan was also inhibited. The extract (50-200 mg/kg) exhibited a dose-dependent and significant (P < 0.05) analgesic activity in the acetic-induced writhing in mice. In addition, both early and late phases of the formalin-induced paw licking in mice was inhibited by the extract. Acute toxicity studies revealed that the extract produced reduced motor activity. The LD50 value of the extract was found to be 1.36 g/kg. This study demonstrated the anti-inflammatory and analgesic effects of A. pavonina extract.
journal_name
Inflammopharmacologyjournal_title
Inflammopharmacologyauthors
Olajide OA,Echianu CA,Adedapo AD,Makinde JMdoi
10.1163/1568560041352310subject
Has Abstractpub_date
2004-01-01 00:00:00pages
196-202issue
2eissn
0925-4692issn
1568-5608journal_volume
12pub_type
杂志文章abstract：:Tumour necrosis factor (TNF) and kinins have been associated with neuropathic pain-like behaviour in numerous animal models. However, the way that they interact to cause neuron sensitisation remains unclear. This study assessed the interaction of kinin receptors and TNF receptor TNFR1/p55 in mechanical hypersensitivit...
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journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
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journal_title：Inflammopharmacology
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更新日期：1999-01-01 00:00:00
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更新日期：2003-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2013-04-01 00:00:00
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journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
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更新日期：2008-10-01 00:00:00
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更新日期：2016-10-01 00:00:00
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更新日期：2020-02-01 00:00:00
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journal_title：Inflammopharmacology
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doi：10.1163/156856005774423908
更新日期：2005-01-01 00:00:00
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journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-013-0181-9
更新日期：2013-12-01 00:00:00
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更新日期：2016-12-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2003-01-01 00:00:00
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更新日期：2018-08-01 00:00:00
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journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
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更新日期：2009-08-01 00:00:00
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更新日期：2007-06-01 00:00:00
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journal_title：Inflammopharmacology
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doi：10.1163/156856005774382733
更新日期：2005-01-01 00:00:00
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更新日期：2018-06-01 00:00:00
abstract：:The authors would like to inform you that Jie Yu and Haimei Lu contributed equally to this study and should be considered as co-first authors. ...
journal_title：Inflammopharmacology
pub_type： 杂志文章,已发布勘误
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更新日期：2019-02-01 00:00:00
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journal_title：Inflammopharmacology
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更新日期：2019-12-01 00:00:00
abstract：:Euphorbia hirta L. (Euphorbiaceae) (E. hirta) is a tree locally used as a traditional medicine in Africa and Australia to treat numerous diseases such as hypertension, respiratory ailments, tumors, antipyretic, anti-inflammatory activities. In the present study, we investigated the anti-arthritic activity of fresh lea...
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更新日期：2013-10-01 00:00:00
