Rheumatoid arthritis and the era of biologic therapy.

abstract：:Kerabala (CB) is a novel ayurvedic formulation used for treating various inflammatory diseases. This formulation was made from virgin coconut oil and it comprises extracts of Sida cordifolia, coconut milk and sesame oil. The current study was performed to evaluate the anti-inflammatory action of CB on carrageenan-indu...

journal_title：Inflammopharmacology

authors： Ratheesh M,Sandya S,Pramod C,Asha S,Svenia JP,Premlal S,GrishKumar B

更新日期：2017-02-01 00:00:00

abstract：:2-(4-phenylquinoline-2-yl)phenol derivatives (4a-l) with COX-2 enzyme inhibition, analgesic, anti-inflammatory and antipyretic potentials were executed and reported. From the in vitro COX-2 enzyme inhibition assay, compounds 4 h (IC50 0.026 µM) and 4j (IC50 0.102 µM) were found as most potent COX-2 inhibitors. Consequ...

journal_title：Inflammopharmacology

authors： Manikandan A,Ravichandran S,Sathiyanarayanan KI,Sivakumar A

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVE:To evaluate the potential of Azadirachta indica leaf extracts against Salmonella typhimurium-induced inflammation in BALB/c mice. DESIGN:Qualitative tests of A. indica leaf extracts were conducted for screening of various phytochemicals. The antiinflammatory potential of A. indica leaf extracts on S. typhimu...

journal_title：Inflammopharmacology

authors： Koul A,Bharrhan S,Singh B,Rishi P

更新日期：2009-02-01 00:00:00

abstract：:TRP channels have been discovered as a specialized group of somatosensory neurons involved in the detection of noxious stimuli. Desensitization of TRPV1 located on dorsal root and trigeminal ganglia exhibits analgesic effect and makes it potential therapeutic target for treatment of neuropathic pain. With this backgro...

journal_title：Inflammopharmacology

authors： Marwaha L,Bansal Y,Singh R,Saroj P,Sodhi RK,Kuhad A

更新日期：2016-12-01 00:00:00

abstract：:Centella asiatica is claimed to have a neuroprotective effect; however, its ability to protect the cerebrum against damage in diabetes has never been identified. The aims were to identify the possibility that C. asiatica ameliorates inflammation, oxidative stress, and apoptosis in the cerebrum in diabetes. C. asiatica...

journal_title：Inflammopharmacology

authors： Giribabu N,Karim K,Kilari EK,Nelli SR,Salleh N

更新日期：2020-12-01 00:00:00

abstract：:Bioactivity-guided investigation of the methanol extract of Crepis sancta aerial parts, collected off Al-Tafilah, South Jordan, was applied, and in this study, the extract was explored for its phytochemical components and in vivo antiulcer activity. In addition, a docking study involving the purified compounds with th...

journal_title：Inflammopharmacology

authors： Ebada SS,Al-Jawabri NA,Youssef FS,Albohy A,Aldalaien SM,Disi AM,Proksch P

更新日期：2020-02-01 00:00:00

abstract：:Excess eicosanoid formation during inflammation has been attributed to the expression of the gene coding for the inducible isoform of prostaglandin G/H synthase (PGHS-2). Human and murine PGHS-2 proteins differ in 73 out of the 604 amino acids. When comparing the inhibitory effects of a panel of PGHS-inhibitors in a w...

journal_title：Inflammopharmacology

authors： Berg J,Fellier H,Bodenteich A,Christoph T,Towart R

更新日期：1997-01-01 00:00:00

abstract：:Central nervous system (CNS) has a completely separate immune system that communicates with the neurons by small molecules called cytokines. Cytokines are involved in many crucial processes in neuron including cell metabolism and neurotransmitter synthesis. It has been reported that cytokine imbalance is involved in t...

journal_title：Inflammopharmacology

authors： Al-Amin MM,Uddin MM,Rahman MM,Reza HM,Rana MS

更新日期：2013-12-01 00:00:00

abstract：AIM:Activation of sphingosine kinase (SK) is a key response to many inflammatory processes. The present studies test the hypothesis that an orally available SK inhibitor, ABC294640, would be effective in rodent models of Crohn's disease. METHODS:Trinitrobenzene sulfonic acid (TNBS) was administered rectally to mice an...

journal_title：Inflammopharmacology

authors： Maines LW,Fitzpatrick LR,Green CL,Zhuang Y,Smith CD

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:There is considerable interest in the possible importance of the gut microflora in the pathophysiology of the inflammatory bowel diseases (IBD) ulcerative colitis (UC) and Crohn's disease (CD). Probiotics offer a potential adjuvant treatment in these patients by modifying the intestinal milieu, but reports o...

journal_title：Inflammopharmacology

authors： Bjarnason I,Sission G,Hayee B

更新日期：2019-06-01 00:00:00

abstract：:The inflamed mucosa in ulcerative colitis produces high amount of prostaglandin (PG) and nitric oxide (NO) through inducible enzymes: cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), respectively, implicating them as potential anti-inflammatory drug targets. COX-2 or iNOS-related treatments in diff...

journal_title：Inflammopharmacology

authors： Dudhgaonkar SP,Tandan SK,Kumar D,Raviprakash V,Kataria M

更新日期：2007-10-01 00:00:00

abstract：:Silver and silver oxides are gaining interest in medical applications for their prominent antibacterial and antimicrobial potentials. Recent studies suggest that nanosilver oxide has remarkable anti-inflammatory effects and enhances wound healing. Nevertheless, its effect on gastric ulcer has not yet been illustrated....

journal_title：Inflammopharmacology

authors： Salem NA,Wahba MA,Eisa WH,El-Shamarka M,Khalil W

更新日期：2018-08-01 00:00:00

abstract：AIM:The aim of the present study was to evaluate the anti-inflammatory effect of thymol in acetic acid-induced rat colitis through inhibiting the NF-κB signaling pathway. METHODS:Colitis was induced by intra-rectal administration of 2 mL of diluted acetic acid (4%) solution using a flexible plastic rubber catheter in ...

journal_title：Inflammopharmacology

authors： Chamanara M,Abdollahi A,Rezayat SM,Ghazi-Khansari M,Dehpour A,Nassireslami E,Rashidian A

更新日期：2019-12-01 00:00:00

abstract：:This review considers the problem of the serious concomitant side effects of powerful anti-inflammatory drugs modelled upon the principal human glucocorticoid hormone, cortisol. The very nature of the original bio-assays to validate their cortisol-like hormonal and anti-inflammatory activities ensured that pleiotropic...

journal_title：Inflammopharmacology

authors： Whitehouse MW

更新日期：2011-02-01 00:00:00

abstract：:- The use of the non-steroidal anti-inflammatory drug, diclofenac, is associated with occasional serious side effects in the gastrointestinal (GI) tract. We examined the effect of altering the site of release of diclofenac sodium on GI tract side effects. Dissolution and pharmacokinetic studies were carried out to sub...

journal_title：Inflammopharmacology

authors： Khazaeinia T,Jamali F

更新日期：2004-01-01 00:00:00

abstract：:To clarify roles of H2S in regulation of gastric circulation, we investigated effects of NaHS, a H2S donor, on tension of isolated rat gastric artery and gastric mucosal blood flow in rats. In the precontracted ring preparations, NaHS caused contraction and relaxation at low and high concentrations, respectively. The ...

journal_title：Inflammopharmacology

authors： Kubo S,Kajiwara M,Kawabata A

更新日期：2007-12-01 00:00:00

abstract：:Tovophyllin A (TA) is a xanthone isolated from Garcinia mangostana L. (GM, Guttiferae) pericarps that possesses various beneficial bioactivities. However, its protective effects on acute lung injury (ALI) and lung carcinoma have not yet been explored. The current work was designed to investigate the protective potenti...

journal_title：Inflammopharmacology

authors： El-Agamy DS,Mohamed GA,Ahmed N,Elkablawy MA,Elfaky MA,Elsaed WM,Mohamed SGA,Ibrahim SRM

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:To study the effect of hyaluronan on cell adhesion and recruitment both in vitro and in vivo, since hyaluronan both inhibits restenosis and is anti-inflammatory. When administered to animals undergoing angioplasty the recruitment of cells into the restenotic plaque is inhibited, as well as into inflammatory l...

journal_title：Inflammopharmacology

authors： Alam CA,Seed MP,Freemantle C,Brown J,Perretti M,Carrier M,Divwedi A,West DC,Gustafson S,Colville-Nash PR,Willoughby DA

更新日期：2005-01-01 00:00:00

abstract：:Euphorbia hirta L. (Euphorbiaceae) (E. hirta) is a tree locally used as a traditional medicine in Africa and Australia to treat numerous diseases such as hypertension, respiratory ailments, tumors, antipyretic, anti-inflammatory activities. In the present study, we investigated the anti-arthritic activity of fresh lea...

journal_title：Inflammopharmacology

authors： Fayaz Ahmad S,Sultan P,Ashour AE,Khan TH,Attia SM,Bakheet SA,Abd-Allah AR

更新日期：2013-10-01 00:00:00

abstract：:We clarified the roles of histamine H(1)-, H(2)-, H(3)-receptors and oxyradicals in the exacerbation of acid-induced gastric haemorrhage and stomach ulcer in endotoxaemic rats by measuring changes in gastric mucosal glutathione concentrations, lipid peroxide generation and histamine levels as well as in luminal electr...

journal_title：Inflammopharmacology

authors： Hung CR,Hsu DZ

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Indomethacin (IND) is a widely used non-steroidal anti-inflammatory agent in the treatment of various inflammatory disorders, which causes gastrointestinal injury in humans and animal experiments. Vitamin A and beta-carotene prevent the IND-induced gastric mucosal injury. These compounds modify the membrane-...

journal_title：Inflammopharmacology

authors： Mózsik G,Rumi G,Bódis B,Figler M,Király A,Sütõ G,Vincze A

更新日期：1999-01-01 00:00:00

abstract：:Triptolide has been widely reported to exhibit potential therapeutic value in multiple inflammatory diseases, such as rheumatoid arthritis, systemic lupus erythematosus, and psoriasis. Although its safety and efficacy as an anti-inflammatory agent have been verified by many studies, the effect of triptolide on osteoar...

journal_title：Inflammopharmacology

authors： Qian K,Zhang L,Shi K

更新日期：2019-02-01 00:00:00

abstract：:Prolonged stimulation of newborn mice by intraperitoneal injections with inactivated staphylococci induces a chronic neonatal inflammatory reaction and an associated oxidative-stress response. The chronically stimulated animals exhibit anorexy. show a reduction in their body weight and undergo a depression in both ant...

journal_title：Inflammopharmacology

authors： García-Tamayo F,Malpica López N,Aguirre M,Terrazas-Valdés LI

更新日期：1999-01-01 00:00:00

abstract：AIMS:To compare methodological aspects of the impact of different classification procedures used in three phases of a twin study examining genetic factors in the aetiopathogenesis of rheumatoid arthritis (RA). METHODS:We have previously reported the results of a study of the aetiopathogenesis of RA based on the Austra...

journal_title：Inflammopharmacology

authors： Bellamy N,Duffy DL,Sambrook P,Buchanan RR,Brooks PM,Dunckley H,Healey SC,Mason S,Martin NG

更新日期：1998-01-01 00:00:00

abstract：:A new compound derivative of glycoside 19-α-hydroxy-ursolic acid glucoside (19-α-hydroxyurs-12(13)-ene-28-oic acid-3-O-β-D-glucopyranoside (HEG) was isolated from whole plant of Wedelia calendulacea (Compositae). The structure was elucidated and established by standard spectroscopy approaches. Diethylnitrosamine (DEN)...

journal_title：Inflammopharmacology

authors： Verma A,Ahmed B,Anwar F,Rahman M,Patel DK,Kaithwas G,Rani R,Bhatt PC,Kumar V

更新日期：2017-02-01 00:00:00

abstract：:The intestinal mucosa is subject to a variety of physical forces in a complex manner during normal gut function and in disease. Intestinal mucosal atrophy during some disease states is a troubling phenomenon that is only partially explained by nutritional parameters. Increasing evidence suggests the possibility that r...

journal_title：Inflammopharmacology

authors： Basson MD

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:Hydroxychloroquine (HCQ) is a widely prescribed medication to patients with systemic lupus erythematosus (SLE), with potential anti-inflammatory effects. This study was performed to investigate the efficacy of HCQ therapy by serial assessment of disease activity and serum levels of proinflammatory cytokines ...

journal_title：Inflammopharmacology

authors： Monzavi SM,Alirezaei A,Shariati-Sarabi Z,Tavakol Afshari J,Mahmoudi M,Dormanesh B,Jahandoost F,Khoshdel AR,Etemad Rezaie A

更新日期：2018-10-01 00:00:00

abstract：:In 1952 I re-joined the Pharmacological Division of the Research Department of the Boots Co. in Nottingham UK to work on rheumatoid arthritis (RA) but with the distinct disadvantage that the Division was housed in a group of rambling buildings attached to a Victorian house. The Division had moved there at the beginnin...

journal_title：Inflammopharmacology

authors： Adams SS

更新日期：1999-01-01 00:00:00

abstract：:The idea that microbes induce disease has steered medical research toward the discovery of antibacterial products for the prevention and treatment of microbial infections. The twentieth century saw increasing dependency on antimicrobials as mainline therapy accentuating the notion that bacterial interactions with huma...

journal_title：Inflammopharmacology

authors： Vitetta L,Briskey D,Hayes E,Shing C,Peake J

更新日期：2012-10-01 00:00:00

abstract：:The up-regulation of angiotensin II AT1 receptors has been implicated as a major mediator in the development of hypertension and progressive nephropathy in experimental diabetes. In spite of the documented potential of garlic treatments in ameliorating diabetic complications, the possible involvement of the angiotensi...

journal_title：Inflammopharmacology

authors： Mansour MH,Al-Qattan K,Thomson M,Ali M

更新日期：2013-04-01 00:00:00