Potential of Azadirachta indica against Salmonella typhimurium-induced inflammation in BALB/c mice.

abstract：AIM:The aim of the present study was to evaluate the anti-inflammatory effect of thymol in acetic acid-induced rat colitis through inhibiting the NF-κB signaling pathway. METHODS:Colitis was induced by intra-rectal administration of 2 mL of diluted acetic acid (4%) solution using a flexible plastic rubber catheter in ...

journal_title：Inflammopharmacology

authors： Chamanara M,Abdollahi A,Rezayat SM,Ghazi-Khansari M,Dehpour A,Nassireslami E,Rashidian A

更新日期：2019-12-01 00:00:00

abstract：:The Maytenus genus is a member of the Celastraceae family. Numerous medicinal uses were assigned to species of this genus, with the use of roots, bark, and leaves for the treatment of gastric ulcers, as anti-inflammatory, analgesic, antiallergic, antitumor, among others. Several studies have demonstrated that natural ...

journal_title：Inflammopharmacology

authors： Veloso CC,Oliveira MC,Rodrigues VG,Oliveira CC,Duarte LP,Teixeira MM,Ferreira AVM,Perez AC

更新日期：2019-06-01 00:00:00

abstract：:The therapeutic efficacy of the contemporary anti-inflammatory drugs are well established; however, prolonged use of such can often lead to serious and life-threatening side effects. Natural product-based anti-inflammatory compounds with superior efficacy and minimum toxicity can serve as possible therapeutic alternat...

journal_title：Inflammopharmacology

authors： Jalil J,Attiq A,Hui CC,Yao LJ,Zakaria NA

更新日期：2020-10-01 00:00:00

abstract：:In the process of the oxygen reduction, NADPH oxidase is the enzyme that produces superoxide anion, which subsequently produces reactive oxygen species (ROS) and causes damage in various tissues and microorganisms. NADPH oxidase is demonstrated to exist in several types of cells such as endothelial cells and vascular ...

journal_title：Inflammopharmacology

authors： Nakagiri A,Sunamoto M,Murakami M

更新日期：2007-12-01 00:00:00

abstract：:Alzheimer's disease (AD) is prevalent in old age people and is one of the most common brain diseases. Brain insulin resistance, neuroinflammation, oxidative stress, and mitochondrial and cholinergic dysfunction are key features of the disease. In our study, streptozotocin (STZ) in a dose of 3 mg/kg was injected in mal...

journal_title：Inflammopharmacology

authors： Akhtar A,Dhaliwal J,Saroj P,Uniyal A,Bishnoi M,Sah SP

更新日期：2020-04-01 00:00:00

abstract：:A small GTPase, Rac1, is recognized as an important modulator of the inflammatory responses to bacterial lipopolysaccharide (LPS) by affecting the processes of phospholipase C activation. The activation of Rac1 involves the exchange of GDP for GTP and is catalyzed by the guanine nucleotide exchange factors (GEFs). Her...

journal_title：Inflammopharmacology

authors： Slomiany BL,Slomiany A

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVE:To study the effect of hyaluronan on cell adhesion and recruitment both in vitro and in vivo, since hyaluronan both inhibits restenosis and is anti-inflammatory. When administered to animals undergoing angioplasty the recruitment of cells into the restenotic plaque is inhibited, as well as into inflammatory l...

journal_title：Inflammopharmacology

authors： Alam CA,Seed MP,Freemantle C,Brown J,Perretti M,Carrier M,Divwedi A,West DC,Gustafson S,Colville-Nash PR,Willoughby DA

更新日期：2005-01-01 00:00:00

abstract：:Caffeic acid phenethyl ester (CAPE) is the active component of honey bee propolis extracts. The results of the current study demonstrate that CAPE attenuated immunoglobulin (Ig)E-mediated allergic response in mast cells. Oral administration of CAPE inhibited IgE-mediated passive cutaneous anaphylaxis. CAPE effectively...

journal_title：Inflammopharmacology

authors： Nader MA

更新日期：2013-04-01 00:00:00

abstract：:Helicobacter pylori infection, as well as NSAIDs induce oxidative stress on gastric mucosa, thereby causing mucosal damage and retarding mucosal repair. Cells can survive against chronic oxidative stress by enhancing activities of anti-oxidant enzymes, thereby protecting cells from DNA damage. Recent studies have clea...

journal_title：Inflammopharmacology

authors： Yanaka A,Zhang S,Tauchi M,Suzuki H,Shibahara T,Matsui H,Nakahara A,Tanaka N,Yamamoto M

更新日期：2005-01-01 00:00:00

abstract：:We clarified the roles of histamine H(1)-, H(2)-, H(3)-receptors and oxyradicals in the exacerbation of acid-induced gastric haemorrhage and stomach ulcer in endotoxaemic rats by measuring changes in gastric mucosal glutathione concentrations, lipid peroxide generation and histamine levels as well as in luminal electr...

journal_title：Inflammopharmacology

authors： Hung CR,Hsu DZ

更新日期：1998-01-01 00:00:00

abstract：:The initial precipitating injury such as SE progresses to chronic epilepsy through multiple epileptogenic processes. Early epileptogenic events are generally characterized by neuroinflammation, neurodegeneration and abnormal neurogenesis in the hippocampus. Metformin has exhibited anti-inflammatory and neuroprotective...

journal_title：Inflammopharmacology

authors： Bojja SL,Medhi B,Anand S,Bhatia A,Joshi R,Minz RW

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:There is considerable interest in the possible importance of the gut microflora in the pathophysiology of the inflammatory bowel diseases (IBD) ulcerative colitis (UC) and Crohn's disease (CD). Probiotics offer a potential adjuvant treatment in these patients by modifying the intestinal milieu, but reports o...

journal_title：Inflammopharmacology

authors： Bjarnason I,Sission G,Hayee B

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Resveratrol exerts an anti-inflammatory effect on collagen-induced arthritis and osteoarthritis in rats via activation of sirtuin 1 (SIRT1). Autophagy can be induced by resveratrol and leads to amelioration of interleukin-1 beta (IL-1β) release in vitro. We aimed to determine the anti-inflammatory mechanisms...

journal_title：Inflammopharmacology

authors： Yang QB,He YL,Zhong XW,Xie WG,Zhou JG

更新日期：2019-02-01 00:00:00

abstract：:The authors would like to inform you that Jie Yu and Haimei Lu contributed equally to this study and should be considered as co-first authors. ...

journal_title：Inflammopharmacology

authors： Yu J,Lu H,Zhou J,Xie Z,Wen C,Xu Z

更新日期：2019-02-01 00:00:00

abstract：:Gout, the most prevalent inflammatory arthritis worldwide, released interleukin-1β (IL-1β) and Cathepsin B inflammatory mediators that constitute the hallmark of the disease. Herein we aimed to investigate whether procyanidin B2 (PCB2), a natural dietary compound, can suppress MSU crystals-stimulated gouty inflammatio...

journal_title：Inflammopharmacology

authors： Qiao CY,Li Y,Shang Y,Jiang M,Liu J,Zhan ZY,Ye H,Lin YC,Jiao JY,Sun RH,Zhang ZH,Piao MH,Wu YL,Nan JX,Lian LH

更新日期：2020-12-01 00:00:00

abstract：AIM:The capture, analysis and utilisation of health status information are attended by logistic considerations and interpretation challenges. We report a preliminary evaluation of cellular technology in capturing WOMAC NRS 3.1 Index data. METHODS:A Java midlet for delivering the WOMAC NRS3.1 Index on Nokia-6300, Motor...

journal_title：Inflammopharmacology

authors： Bellamy N,Wilson C,Hendrikz J,Patel B,Dennison S

更新日期：2009-04-01 00:00:00

abstract：:Tumour necrosis factor (TNF) and kinins have been associated with neuropathic pain-like behaviour in numerous animal models. However, the way that they interact to cause neuron sensitisation remains unclear. This study assessed the interaction of kinin receptors and TNF receptor TNFR1/p55 in mechanical hypersensitivit...

journal_title：Inflammopharmacology

authors： Quintão NLM,Rocha LW,da Silva GF,Paszcuk AF,Manjavachi MN,Bento AF,da Silva KABS,Campos MM,Calixto JB

更新日期：2019-06-01 00:00:00

abstract：:Prolonged stimulation of newborn mice by intraperitoneal injections with inactivated staphylococci induces a chronic neonatal inflammatory reaction and an associated oxidative-stress response. The chronically stimulated animals exhibit anorexy. show a reduction in their body weight and undergo a depression in both ant...

journal_title：Inflammopharmacology

authors： García-Tamayo F,Malpica López N,Aguirre M,Terrazas-Valdés LI

更新日期：1999-01-01 00:00:00

abstract：:The anti-inflammatory activity of the aqueous extract of Chromolaena odorata was investigated in rats using the carrageenan-induced oedema, cotton pellet granuloma and formalin-induced oedema methods. The extract was administered orally at doses of 25, 50, 100 and 200 mg/kg. In the carrageenan method the paw oedema wa...

journal_title：Inflammopharmacology

authors： Owoyele VB,Adediji JO,Soladoye AO

更新日期：2005-01-01 00:00:00

abstract：:The side effects of NSAIDs are equally evident in the stomach and the small bowel. The latter is increasingly seen as being clinically significant, contributing substantially to the iron-deficiency anaemia that is so common in patients with rheumatoid arthritis. Furthermore, NSAID-enteropathy may be associated with li...

journal_title：Inflammopharmacology

authors： Hotz-Behofsits CM,Walley MJ,Simpson R,Bjarnason IT

更新日期：2003-01-01 00:00:00

abstract：:Prompted by the findings that smokers have lowered brain and blood platelet monoamine oxidase-A and -B activities compared to non-smokers and that smokers have a lowered incidence of Parkinson's disease, we have examined the neuroprotective properties of an MAO inhibitor, 2,3,6-trimethyl-1,4-naphthoquinone (TMN), whic...

journal_title：Inflammopharmacology

authors： Castagnoli K,Petzer JB,Steyn SJ,van der Schyf CJ,Castagnoli N Jr

更新日期：2003-01-01 00:00:00

abstract：:The ulcerogenic effect of rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, on the gastrointestinal mucosa was investigated in the presence of a low dose of indomethacin. Indomethacin at 3 mg/kg did not cause any damage in both the stomach and small intestine, despite inhibiting prostaglandin (PG) production....

journal_title：Inflammopharmacology

authors： Yokota A,Taniguchi M,Tanaka A,Takeuchi K

更新日期：2005-01-01 00:00:00

abstract：:Neuropathic pain triggers a cascade of events in the sensory neurons. It is the main complication of diabetes after cardiovascular disease. Nitric oxide (NO) produced from nitric oxide synthases (NOS) is an important signaling molecule which is crucial for many physiological processes such as synaptic plasticity, neur...

journal_title：Inflammopharmacology

authors： Ahlawat A,Rana A,Goyal N,Sharma S

更新日期：2014-10-01 00:00:00

abstract：:The effect of lupeol, a natural pentacyclic triterpene on ethanol-induced gastric damage in mice was evaluated. The gastroprotection was assessed by determination of changes in mean gastric lesion area, quantification of mucosal non-protein sulfhydryls (NP-SH), and characterized using drugs that influence the endogeno...

journal_title：Inflammopharmacology

authors： Lira SR,Rao VS,Carvalho AC,Guedes MM,de Morais TC,de Souza AL,Trevisan MT,Lima AF,Chaves MH,Santos FA

更新日期：2009-08-01 00:00:00

abstract：:Bioactivity-guided investigation of the methanol extract of Crepis sancta aerial parts, collected off Al-Tafilah, South Jordan, was applied, and in this study, the extract was explored for its phytochemical components and in vivo antiulcer activity. In addition, a docking study involving the purified compounds with th...

journal_title：Inflammopharmacology

authors： Ebada SS,Al-Jawabri NA,Youssef FS,Albohy A,Aldalaien SM,Disi AM,Proksch P

更新日期：2020-02-01 00:00:00

abstract：:Acute lung injury (ALI) and acute kidney injury (AKI) are major causes of sepsis-induced mortality. The objective of the study is to evaluate the effect of tocilizumab (TCZ), an IL-6 receptor inhibitor, in sepsis-induced ALI and AKI using the cecal ligation and puncture (CLP) rat model of sepsis. Clinical and experime...

journal_title：Inflammopharmacology

authors： Ibrahim YF,Moussa RA,Bayoumi AMA,Ahmed AF

更新日期：2020-02-01 00:00:00

abstract：:Regular moderate wine consumption is often associated with reduced morbidity and mortality from to a variety of chronic diseases in which inflammation is a root cause. Wine comes in a wide variety of styles that contain quite different ethanol and polyphenol contents. Controversy remains as to whether the alcohol or p...

journal_title：Inflammopharmacology

authors： Walzem RL

更新日期：2008-12-01 00:00:00

abstract：:Propolis is a resinous substance collected by honeybees from leaf buds and cracks in the bark of various plants. Propolis has been reported to have immunomodulatory activity. We hypothesized that propolis would be able to reduce the disease severity of rheumatoid arthritis. We evaluated the effect of Brazilian propoli...

journal_title：Inflammopharmacology

authors： Tanaka M,Okamoto Y,Fukui T,Masuzawa T

更新日期：2012-02-01 00:00:00

abstract：:P38 mitogen-activated protein kinase (p38 MAPK), a tissue inflammatory factor can be activated under oxidative stress and in conditions associated with hyperglycemia. Gingerol containing various natural herbs has been extensively studied for its pharmacological actions both in reducing the inflammation and as immunity...

journal_title：Inflammopharmacology

authors： Song S,Dang M,Kumar M

更新日期：2019-12-01 00:00:00

abstract：:This review considers the problem of the serious concomitant side effects of powerful anti-inflammatory drugs modelled upon the principal human glucocorticoid hormone, cortisol. The very nature of the original bio-assays to validate their cortisol-like hormonal and anti-inflammatory activities ensured that pleiotropic...

journal_title：Inflammopharmacology

authors： Whitehouse MW

更新日期：2011-02-01 00:00:00