Modulation of inflammatory pathways, medicinal uses and toxicities of Uvaria species: potential role in the prevention and treatment of inflammation.

abstract：:- The use of the non-steroidal anti-inflammatory drug, diclofenac, is associated with occasional serious side effects in the gastrointestinal (GI) tract. We examined the effect of altering the site of release of diclofenac sodium on GI tract side effects. Dissolution and pharmacokinetic studies were carried out to sub...

journal_title：Inflammopharmacology

authors： Khazaeinia T,Jamali F

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Resveratrol exerts an anti-inflammatory effect on collagen-induced arthritis and osteoarthritis in rats via activation of sirtuin 1 (SIRT1). Autophagy can be induced by resveratrol and leads to amelioration of interleukin-1 beta (IL-1β) release in vitro. We aimed to determine the anti-inflammatory mechanisms...

journal_title：Inflammopharmacology

authors： Yang QB,He YL,Zhong XW,Xie WG,Zhou JG

更新日期：2019-02-01 00:00:00

abstract：:Propolis is a resinous substance collected by honeybees from leaf buds and cracks in the bark of various plants. Propolis has been reported to have immunomodulatory activity. We hypothesized that propolis would be able to reduce the disease severity of rheumatoid arthritis. We evaluated the effect of Brazilian propoli...

journal_title：Inflammopharmacology

authors： Tanaka M,Okamoto Y,Fukui T,Masuzawa T

更新日期：2012-02-01 00:00:00

abstract：:The inflamed mucosa in ulcerative colitis produces high amount of prostaglandin (PG) and nitric oxide (NO) through inducible enzymes: cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), respectively, implicating them as potential anti-inflammatory drug targets. COX-2 or iNOS-related treatments in diff...

journal_title：Inflammopharmacology

authors： Dudhgaonkar SP,Tandan SK,Kumar D,Raviprakash V,Kataria M

更新日期：2007-10-01 00:00:00

abstract：:The effect of lupeol, a natural pentacyclic triterpene on ethanol-induced gastric damage in mice was evaluated. The gastroprotection was assessed by determination of changes in mean gastric lesion area, quantification of mucosal non-protein sulfhydryls (NP-SH), and characterized using drugs that influence the endogeno...

journal_title：Inflammopharmacology

authors： Lira SR,Rao VS,Carvalho AC,Guedes MM,de Morais TC,de Souza AL,Trevisan MT,Lima AF,Chaves MH,Santos FA

更新日期：2009-08-01 00:00:00

abstract：:Centella asiatica is claimed to have a neuroprotective effect; however, its ability to protect the cerebrum against damage in diabetes has never been identified. The aims were to identify the possibility that C. asiatica ameliorates inflammation, oxidative stress, and apoptosis in the cerebrum in diabetes. C. asiatica...

journal_title：Inflammopharmacology

authors： Giribabu N,Karim K,Kilari EK,Nelli SR,Salleh N

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:The role of angiotensin converting enzyme inhibitors on the inflammation process has been demonstrated previously. In the present study, the effects of captopril on lung injury induced by lipopolysaccharide (LPS) were investigated. METHODS:Control, LPS, 12.5, 25 and 50 mg/kg captopril-treated before LPS adm...

journal_title：Inflammopharmacology

authors： Boskabadi J,Askari VR,Hosseini M,Boskabady MH

更新日期：2019-06-01 00:00:00

abstract：:Alzheimer's disease (AD) is prevalent in old age people and is one of the most common brain diseases. Brain insulin resistance, neuroinflammation, oxidative stress, and mitochondrial and cholinergic dysfunction are key features of the disease. In our study, streptozotocin (STZ) in a dose of 3 mg/kg was injected in mal...

journal_title：Inflammopharmacology

authors： Akhtar A,Dhaliwal J,Saroj P,Uniyal A,Bishnoi M,Sah SP

更新日期：2020-04-01 00:00:00

abstract：:Inflammatory bowel diseases are associated with reduced colonic contractility and induction of cyclooxygenase-2. In this study a possible role of cyclooxygenase-2 in and the underlying mechanism of the reduced contractility were investigated in experimental colitis. The effects of meloxicam, a cyclooxygenase-2 selecti...

journal_title：Inflammopharmacology

authors： Khan I,Oriowo MA

更新日期：2006-03-01 00:00:00

abstract：:Previous reports suggest flavonoids as potent analgesic compounds. Based on these observations, the present study investigated the antinociceptive action of flavonol, 3', 4'-dimethoxy flavonol, 6, 3'-dimethoxy flavonol, 7, 2'-dimethoxy flavonol, and 7, 3'-dimethoxy flavonol and the possible mechanisms involved in thes...

journal_title：Inflammopharmacology

authors： Sayeli V,Nadipelly J,Kadhirvelu P,Cheriyan BV,Shanmugasundaram J,Subramanian V

更新日期：2019-12-01 00:00:00

abstract：:Central nervous system (CNS) has a completely separate immune system that communicates with the neurons by small molecules called cytokines. Cytokines are involved in many crucial processes in neuron including cell metabolism and neurotransmitter synthesis. It has been reported that cytokine imbalance is involved in t...

journal_title：Inflammopharmacology

authors： Al-Amin MM,Uddin MM,Rahman MM,Reza HM,Rana MS

更新日期：2013-12-01 00:00:00

abstract：:A methanol extract of the seeds of Adenanthera pavonina was evaluated for pharmacological effects in animal models. The extract (50-200 mg/kg) produced statistically significant (P < 0.05) inhibition of the carrageenan-induced paw oedema in the rat, as well as the acetic-acid-induced vascular permeability in mice. At ...

journal_title：Inflammopharmacology

authors： Olajide OA,Echianu CA,Adedapo AD,Makinde JM

更新日期：2004-01-01 00:00:00

abstract：:Kerabala (CB) is a novel ayurvedic formulation used for treating various inflammatory diseases. This formulation was made from virgin coconut oil and it comprises extracts of Sida cordifolia, coconut milk and sesame oil. The current study was performed to evaluate the anti-inflammatory action of CB on carrageenan-indu...

journal_title：Inflammopharmacology

authors： Ratheesh M,Sandya S,Pramod C,Asha S,Svenia JP,Premlal S,GrishKumar B

更新日期：2017-02-01 00:00:00

abstract：:Pain is recognized as a multifactorial sensory experience that is wholly unpleasant. It can vary in intensity from mild to severe and its duration can be anything from transient to persistent. Today we know so much more about the peripheral nociceptor as the primary detection apparatus for painful stimuli. We also und...

journal_title：Inflammopharmacology

authors： Rodger IW

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVE:To evaluate the potential of Azadirachta indica leaf extracts against Salmonella typhimurium-induced inflammation in BALB/c mice. DESIGN:Qualitative tests of A. indica leaf extracts were conducted for screening of various phytochemicals. The antiinflammatory potential of A. indica leaf extracts on S. typhimu...

journal_title：Inflammopharmacology

authors： Koul A,Bharrhan S,Singh B,Rishi P

更新日期：2009-02-01 00:00:00

abstract：:The idea that microbes induce disease has steered medical research toward the discovery of antibacterial products for the prevention and treatment of microbial infections. The twentieth century saw increasing dependency on antimicrobials as mainline therapy accentuating the notion that bacterial interactions with huma...

journal_title：Inflammopharmacology

authors： Vitetta L,Briskey D,Hayes E,Shing C,Peake J

更新日期：2012-10-01 00:00:00

abstract：AIM:Activation of sphingosine kinase (SK) is a key response to many inflammatory processes. The present studies test the hypothesis that an orally available SK inhibitor, ABC294640, would be effective in rodent models of Crohn's disease. METHODS:Trinitrobenzene sulfonic acid (TNBS) was administered rectally to mice an...

journal_title：Inflammopharmacology

authors： Maines LW,Fitzpatrick LR,Green CL,Zhuang Y,Smith CD

更新日期：2010-04-01 00:00:00

abstract：:A new compound derivative of glycoside 19-α-hydroxy-ursolic acid glucoside (19-α-hydroxyurs-12(13)-ene-28-oic acid-3-O-β-D-glucopyranoside (HEG) was isolated from whole plant of Wedelia calendulacea (Compositae). The structure was elucidated and established by standard spectroscopy approaches. Diethylnitrosamine (DEN)...

journal_title：Inflammopharmacology

authors： Verma A,Ahmed B,Anwar F,Rahman M,Patel DK,Kaithwas G,Rani R,Bhatt PC,Kumar V

更新日期：2017-02-01 00:00:00

abstract：:Rhynchosia minima root, a folk herbal medicine in southern China, is used to relieve itch and swelling. In this study, we examined the anti-inflammatory property of an ethanol fraction (EEF6) from R. minima root on lipopolysaccharide (LPS)-induced RAW 264.7 cells, as well as its underlying mechanism. The compound comp...

journal_title：Inflammopharmacology

authors： Jia X,Zhang C,Bao J,Wang K,Tu Y,Wan JB,He C

更新日期：2020-02-01 00:00:00

abstract：:Paracetamol-induced toxicity is mainly due to the accumulation of its CYP450-mediated N-hydroxylation product - N-acetylimidoquinone. We examined cell viability, proliferation rates and intracellular calcium in PC12 cells and in a PC12 cell line transfected with cytochrome P4502E1 exposed to paracetamol. This drug had...

journal_title：Inflammopharmacology

authors： Holownia A,Menez JF,Braszko JJ

更新日期：1998-01-01 00:00:00

abstract：AIMS:To compare methodological aspects of the impact of different classification procedures used in three phases of a twin study examining genetic factors in the aetiopathogenesis of rheumatoid arthritis (RA). METHODS:We have previously reported the results of a study of the aetiopathogenesis of RA based on the Austra...

journal_title：Inflammopharmacology

authors： Bellamy N,Duffy DL,Sambrook P,Buchanan RR,Brooks PM,Dunckley H,Healey SC,Mason S,Martin NG

更新日期：1998-01-01 00:00:00

abstract：:The up-regulation of angiotensin II AT1 receptors has been implicated as a major mediator in the development of hypertension and progressive nephropathy in experimental diabetes. In spite of the documented potential of garlic treatments in ameliorating diabetic complications, the possible involvement of the angiotensi...

journal_title：Inflammopharmacology

authors： Mansour MH,Al-Qattan K,Thomson M,Ali M

更新日期：2013-04-01 00:00:00

abstract：:The aim of the study was to evaluate the effect of Pterocarpus marsupium (PM) on acetic acid (AA)-induced ulcerative colitis (UC) in rats. The rats were divided into five groups, each having six rats. PM extract 100 mg and 200 mg/kg was given orally to groups four and five, respectively, and standard drug sulfasalazin...

journal_title：Inflammopharmacology

authors： Mathew MM,Han NV,Murugesan A,Raj EA,Prasanth KG

更新日期：2015-08-01 00:00:00

abstract：:Most of the gastroprotective drugs which had been marketed in Japan were considered to have insufficient rationale for use as ulcer treatments. Such drugs may have a crucial role in maintaining mucosal integrity by the mechanisms other than inhibition of acid secretion. We re-evaluated the effect of gastroprotective d...

journal_title：Inflammopharmacology

authors： Higuchi K,Watanabe T,Tanigawa T,Shiba M,Tominaga K,Fujiwara Y,Oshitani N,Arakawa T

更新日期：2007-02-01 00:00:00

abstract：:Helicobacter pylori infection, as well as NSAIDs induce oxidative stress on gastric mucosa, thereby causing mucosal damage and retarding mucosal repair. Cells can survive against chronic oxidative stress by enhancing activities of anti-oxidant enzymes, thereby protecting cells from DNA damage. Recent studies have clea...

journal_title：Inflammopharmacology

authors： Yanaka A,Zhang S,Tauchi M,Suzuki H,Shibahara T,Matsui H,Nakahara A,Tanaka N,Yamamoto M

更新日期：2005-01-01 00:00:00

abstract：:Since their development and licensing no class of drug has received as much attention both in the scientific and lay press as the cyclo-oxygenase 2 (COX-2) inhibitors. These compounds, also known as coxibs, were developed as a safer alternative to traditional non-steroidal anti-inflammatory drugs (NSAIDs) due to their...

journal_title：Inflammopharmacology

authors： Ostor AJ,Hazleman BL

更新日期：2005-01-01 00:00:00

abstract：:Pulmonary fibrosis is a result of an abnormal wound healing in lung tissue triggered by an excessive accumulation of extracellular matrix proteins, loss of tissue elasticity, and debit of ventilatory function. NKT cells are a major source of Th1 and Th2 cytokines and may be crucial in the polarization of M1/M2 macroph...

journal_title：Inflammopharmacology

authors： Grabarz F,Aguiar CF,Correa-Costa M,Braga TT,Hyane MI,Andrade-Oliveira V,Landgraf MA,Câmara NOS

更新日期：2018-04-01 00:00:00

abstract：:In 1952 I re-joined the Pharmacological Division of the Research Department of the Boots Co. in Nottingham UK to work on rheumatoid arthritis (RA) but with the distinct disadvantage that the Division was housed in a group of rambling buildings attached to a Victorian house. The Division had moved there at the beginnin...

journal_title：Inflammopharmacology

authors： Adams SS

更新日期：1999-01-01 00:00:00

abstract：:Prompted by the findings that smokers have lowered brain and blood platelet monoamine oxidase-A and -B activities compared to non-smokers and that smokers have a lowered incidence of Parkinson's disease, we have examined the neuroprotective properties of an MAO inhibitor, 2,3,6-trimethyl-1,4-naphthoquinone (TMN), whic...

journal_title：Inflammopharmacology

authors： Castagnoli K,Petzer JB,Steyn SJ,van der Schyf CJ,Castagnoli N Jr

更新日期：2003-01-01 00:00:00

abstract：:The Maytenus genus is a member of the Celastraceae family. Numerous medicinal uses were assigned to species of this genus, with the use of roots, bark, and leaves for the treatment of gastric ulcers, as anti-inflammatory, analgesic, antiallergic, antitumor, among others. Several studies have demonstrated that natural ...

journal_title：Inflammopharmacology

authors： Veloso CC,Oliveira MC,Rodrigues VG,Oliveira CC,Duarte LP,Teixeira MM,Ferreira AVM,Perez AC

更新日期：2019-06-01 00:00:00