Abstract：
:The side effects of NSAIDs are equally evident in the stomach and the small bowel. The latter is increasingly seen as being clinically significant, contributing substantially to the iron-deficiency anaemia that is so common in patients with rheumatoid arthritis. Furthermore, NSAID-enteropathy may be associated with life-threatening events. The pathogenesis of NSAID-enteropathy is uncertain but inhibition of COX-1 is believed to be of pivotal importance. However there is increasing evidence that COX-2 inhibition and the topical effect may have a synergistic detrimental action. We examined the role of COX-1, COX-2 and the so called topical effect of acidic NSAIDs. We found that COX-1 or COX-2 inhibition and the topical effect alone do not damage the GI tract. Dual inhibition of COX-1 and COX-2 results in intestinal inflammation similar to that caused by Indomethacin. The topical effect may act synergistically in this damage. The conventional view that the mechanism of gastrointestinal damage is principally caused by COX-1 inhibition needs to be revised in view of recent studies using selective inhibitors of the COX enzymes and COX knockout animals.
journal_name
Inflammopharmacologyjournal_title
Inflammopharmacologyauthors
Hotz-Behofsits CM,Walley MJ,Simpson R,Bjarnason ITdoi
10.1163/156856003322699546subject
Has Abstractpub_date
2003-01-01 00:00:00pages
363-70issue
4eissn
0925-4692issn
1568-5608journal_volume
11pub_type
杂志文章abstract：:Euphorbia hirta L. (Euphorbiaceae) (E. hirta) is a tree locally used as a traditional medicine in Africa and Australia to treat numerous diseases such as hypertension, respiratory ailments, tumors, antipyretic, anti-inflammatory activities. In the present study, we investigated the anti-arthritic activity of fresh lea...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-012-0161-5
更新日期：2013-10-01 00:00:00
abstract：BACKGROUND:Osthole is a bioactive component reported in medicinal plants such as Angelica pubescens and Cnidium monnieri, known for analgesic activity. However, the toxicity, median effective dose (ED50), and dual modulation of nitric oxide and cyclooxygenase pathways along with inflammatory cytokines of osthole are ye...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-018-0486-9
更新日期：2019-10-01 00:00:00
abstract：:The up-regulation of angiotensin II AT1 receptors has been implicated as a major mediator in the development of hypertension and progressive nephropathy in experimental diabetes. In spite of the documented potential of garlic treatments in ameliorating diabetic complications, the possible involvement of the angiotensi...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-012-0139-3
更新日期：2013-04-01 00:00:00
abstract：:Previous reports suggest flavonoids as potent analgesic compounds. Based on these observations, the present study investigated the antinociceptive action of flavonol, 3', 4'-dimethoxy flavonol, 6, 3'-dimethoxy flavonol, 7, 2'-dimethoxy flavonol, and 7, 3'-dimethoxy flavonol and the possible mechanisms involved in thes...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00579-4
更新日期：2019-12-01 00:00:00
abstract：:Centella asiatica is claimed to have a neuroprotective effect; however, its ability to protect the cerebrum against damage in diabetes has never been identified. The aims were to identify the possibility that C. asiatica ameliorates inflammation, oxidative stress, and apoptosis in the cerebrum in diabetes. C. asiatica...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-020-00733-3
更新日期：2020-12-01 00:00:00
abstract：:Bioactivity-guided investigation of the methanol extract of Crepis sancta aerial parts, collected off Al-Tafilah, South Jordan, was applied, and in this study, the extract was explored for its phytochemical components and in vivo antiulcer activity. In addition, a docking study involving the purified compounds with th...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00637-x
更新日期：2020-02-01 00:00:00
abstract：:Alzheimer's disease (AD) is prevalent in old age people and is one of the most common brain diseases. Brain insulin resistance, neuroinflammation, oxidative stress, and mitochondrial and cholinergic dysfunction are key features of the disease. In our study, streptozotocin (STZ) in a dose of 3 mg/kg was injected in mal...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00681-7
更新日期：2020-04-01 00:00:00
abstract：:Stress is a reflex response, both psychological and physiological, of the body to a difficult situation that requires adaptation. Stress is at the intersection of the objective event and the subjective event. The physiological mechanisms involved in chronic stress are numerous and can contribute to a wide variety of d...
journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s10787-018-0546-1
更新日期：2019-02-01 00:00:00
abstract：:Triptolide has been widely reported to exhibit potential therapeutic value in multiple inflammatory diseases, such as rheumatoid arthritis, systemic lupus erythematosus, and psoriasis. Although its safety and efficacy as an anti-inflammatory agent have been verified by many studies, the effect of triptolide on osteoar...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-018-0509-6
更新日期：2019-02-01 00:00:00
abstract：AIM:Activation of sphingosine kinase (SK) is a key response to many inflammatory processes. The present studies test the hypothesis that an orally available SK inhibitor, ABC294640, would be effective in rodent models of Crohn's disease. METHODS:Trinitrobenzene sulfonic acid (TNBS) was administered rectally to mice an...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-010-0032-x
更新日期：2010-04-01 00:00:00
abstract：:TRP channels have been discovered as a specialized group of somatosensory neurons involved in the detection of noxious stimuli. Desensitization of TRPV1 located on dorsal root and trigeminal ganglia exhibits analgesic effect and makes it potential therapeutic target for treatment of neuropathic pain. With this backgro...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-016-0285-0
更新日期：2016-12-01 00:00:00
abstract：:Chronic inflammation is a world health problem. There is a need to develop new anti-inflammatory and analgesic drugs with improved activity and reduced side effects. In this context, the aim of this study was to evaluate the antinociceptive and anti-inflammatory effects of the pyrazole compound LQFM-021 after acute an...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-016-0282-3
更新日期：2016-10-01 00:00:00
abstract：:Genistein is an isoflavone with oestrogenic activity that is present in a variety of soy products as a constituent of complex mixtures of bioactive compounds, whose matrix profiles play an important role in determining the overall oestrogenic bioactivity of genistein. We review data on how the profile of soy bioactive...
journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s10787-008-8020-0
更新日期：2008-10-01 00:00:00
abstract：:The central nervous system, one of the most delicate microenvironments of the body, is protected by the blood-brain barrier regulating its homeostasis. Blood-brain barrier is a highly complex structure that tightly regulates the movement of ions of a limited number of small molecules and of an even more restricted num...
journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s10787-018-0468-y
更新日期：2018-06-01 00:00:00
abstract：BACKGROUND:There is considerable interest in the possible importance of the gut microflora in the pathophysiology of the inflammatory bowel diseases (IBD) ulcerative colitis (UC) and Crohn's disease (CD). Probiotics offer a potential adjuvant treatment in these patients by modifying the intestinal milieu, but reports o...
journal_title：Inflammopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10787-019-00595-4
更新日期：2019-06-01 00:00:00
abstract：:P38 mitogen-activated protein kinase (p38 MAPK), a tissue inflammatory factor can be activated under oxidative stress and in conditions associated with hyperglycemia. Gingerol containing various natural herbs has been extensively studied for its pharmacological actions both in reducing the inflammation and as immunity...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00569-6
更新日期：2019-12-01 00:00:00
abstract：:The aim of this study was to determine whether ethanol extracts of Etlingera pavieana rhizomes (EPE) can inhibit the expression of ICAM-1 and VCAM-1 in TNF-α-stimulated human vascular endothelial cells. EPE significantly reduced ICAM-1 and VCAM-1 expression in a concentration-dependent manner. EPE also suppressed phos...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00676-4
更新日期：2020-12-01 00:00:00
abstract：:The safety of the cyclo-oxygenase-2 (COX-2) selective NSAID, nimesulide, has been evaluated from information (a) in clinical trials in osteoarthritis that have been performed in Europe as well as in earlier pilot studies that were performed in patients with rheumatoid arthritis in the USA, and (b) in post-marketing st...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-998-0020-6
更新日期：1998-01-01 00:00:00
abstract：:Since their development and licensing no class of drug has received as much attention both in the scientific and lay press as the cyclo-oxygenase 2 (COX-2) inhibitors. These compounds, also known as coxibs, were developed as a safer alternative to traditional non-steroidal anti-inflammatory drugs (NSAIDs) due to their...
journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1163/156856005774415619
更新日期：2005-01-01 00:00:00
abstract：INTRODUCTION:Retinoic Acid Related Orphan Nuclear Receptor gamma T (RORγT) is a lineage specifying transcription factor for IL-17 expressing cells, which may contribute to the pathogenesis of Inflammatory Bowel Disease (IBD). VPR-254 is a selective in vitro inhibitor of RORγT. AIMS:The main goals of our study were two...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00643-z
更新日期：2020-04-01 00:00:00
abstract：AIM AND OBJECTIVE:6-hydroxy dopamine (6-OHDA) is a neurotoxin which on intranigral administration produces severe nigrostriatal damage with motor and cognitive deficit in animals. Curcumin (CMN) in combination with bioenhancer piperine (PP) in 6-hydroxydopamine-induced Parkinsonian rats was used to investigate the anti...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-016-0297-9
更新日期：2017-02-01 00:00:00
abstract：:A methanol extract of the seeds of Adenanthera pavonina was evaluated for pharmacological effects in animal models. The extract (50-200 mg/kg) produced statistically significant (P < 0.05) inhibition of the carrageenan-induced paw oedema in the rat, as well as the acetic-acid-induced vascular permeability in mice. At ...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1163/1568560041352310
更新日期：2004-01-01 00:00:00
abstract：:Prompted by the findings that smokers have lowered brain and blood platelet monoamine oxidase-A and -B activities compared to non-smokers and that smokers have a lowered incidence of Parkinson's disease, we have examined the neuroprotective properties of an MAO inhibitor, 2,3,6-trimethyl-1,4-naphthoquinone (TMN), whic...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1163/156856003765764353
更新日期：2003-01-01 00:00:00
abstract：:Some B vitamins exhibit activities in models of nociceptive pain, inflammatory pain, and neuropathic pain induced by nerve lesions and also in certain painful conditions in humans. In the present study, we investigated the effects of thiamine, riboflavin, and nicotinamide in a neuropathic pain model induced by the che...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00625-1
更新日期：2020-02-01 00:00:00
abstract：:Mitochondria can interchange morphology due to their dynamic nature. It can exist in either fragmented disconnected arrangement or elongated interconnected mitochondrial networks due to fission and fusion, respectively. The recent studies have revealed the remarkable and unexpected insights into the physiological impa...
journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s10787-017-0347-y
更新日期：2017-08-01 00:00:00
abstract：AIM:The capture, analysis and utilisation of health status information are attended by logistic considerations and interpretation challenges. We report a preliminary evaluation of cellular technology in capturing WOMAC NRS 3.1 Index data. METHODS:A Java midlet for delivering the WOMAC NRS3.1 Index on Nokia-6300, Motor...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-008-8045-4
更新日期：2009-04-01 00:00:00
abstract：OBJECTIVE:The present study aimed to evaluate the anti-inflammatory and analgesic activities of the ginsenoside metabolite compound K (CK) and its mechanisms. METHODS:Mice model of xylene-induced ear swelling and rat model of carrageenan-induced paw swelling were used to evaluate the effect of CK on acute inflammation...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-018-0504-y
更新日期：2019-02-01 00:00:00
abstract：:Pioglitazone, a specific ligand for peroxisome proliferator-activated receptor gamma (PPAR-gamma), was recently implicated in the control of inflammatory processes and in the modulation of the expression of various cytokines such as tumor necrosis factor alpha (TNF-alpha), but its role in the mechanism of gastric muco...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1163/156856005774423908
更新日期：2005-01-01 00:00:00
abstract：:Pulmonary fibrosis is a result of an abnormal wound healing in lung tissue triggered by an excessive accumulation of extracellular matrix proteins, loss of tissue elasticity, and debit of ventilatory function. NKT cells are a major source of Th1 and Th2 cytokines and may be crucial in the polarization of M1/M2 macroph...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-017-0383-7
更新日期：2018-04-01 00:00:00
abstract：:Pain is recognized as a multifactorial sensory experience that is wholly unpleasant. It can vary in intensity from mild to severe and its duration can be anything from transient to persistent. Today we know so much more about the peripheral nociceptor as the primary detection apparatus for painful stimuli. We also und...
journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s10787-009-0006-z
更新日期：2009-06-01 00:00:00
