Abstract：
AIM:Activation of sphingosine kinase (SK) is a key response to many inflammatory processes. The present studies test the hypothesis that an orally available SK inhibitor, ABC294640, would be effective in rodent models of Crohn's disease. METHODS:Trinitrobenzene sulfonic acid (TNBS) was administered rectally to mice and rats. Rats were treated with ABC294640 orally alone or in combination with olsalazine and disease progression was monitored. RESULTS:For both rodent species, treatment with ABC294640 attenuated disease progression. Colon samples from the ABC294640-treated animals had improved histology and cytokine parameters when compared with vehicle-treated animals. The expression of SK was similarly increased in TNBS-treated animals and in human colon tissue specimens from inflammatory bowel disease patients relative to normal, control patients. CONCLUSIONS:Sphingosine kinase may be a critical mediator of colonic damage during intestinal inflammation, and pharmacologic inhibitors of this enzyme may prove useful in the treatment of Crohn's disease.
journal_name
Inflammopharmacologyjournal_title
Inflammopharmacologyauthors
Maines LW,Fitzpatrick LR,Green CL,Zhuang Y,Smith CDdoi
10.1007/s10787-010-0032-xsubject
Has Abstractpub_date
2010-04-01 00:00:00pages
73-85issue
2eissn
0925-4692issn
1568-5608journal_volume
18pub_type
杂志文章abstract：:Caffeic acid phenethyl ester (CAPE) is the active component of honey bee propolis extracts. The results of the current study demonstrate that CAPE attenuated immunoglobulin (Ig)E-mediated allergic response in mast cells. Oral administration of CAPE inhibited IgE-mediated passive cutaneous anaphylaxis. CAPE effectively...
journal_title：Inflammopharmacology
pub_type： 杂志文章
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journal_title：Inflammopharmacology
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journal_title：Inflammopharmacology
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journal_title：Inflammopharmacology
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abstract：:Tovophyllin A (TA) is a xanthone isolated from Garcinia mangostana L. (GM, Guttiferae) pericarps that possesses various beneficial bioactivities. However, its protective effects on acute lung injury (ALI) and lung carcinoma have not yet been explored. The current work was designed to investigate the protective potenti...
journal_title：Inflammopharmacology
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journal_title：Inflammopharmacology
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doi：10.1007/s10787-018-0496-7
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journal_title：Inflammopharmacology
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journal_title：Inflammopharmacology
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doi：10.1007/s10787-020-00705-7
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journal_title：Inflammopharmacology
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journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1163/1568560042342275
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journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
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更新日期：2008-10-01 00:00:00
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journal_title：Inflammopharmacology
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journal_title：Inflammopharmacology
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journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
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journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
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journal_title：Inflammopharmacology
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doi：10.1007/s10787-019-00676-4
更新日期：2020-12-01 00:00:00
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journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00632-2
更新日期：2020-02-01 00:00:00
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更新日期：2015-06-01 00:00:00
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journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
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更新日期：2020-10-01 00:00:00
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journal_title：Inflammopharmacology
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更新日期：2018-12-01 00:00:00
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journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
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更新日期：2017-08-01 00:00:00
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journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/BF02918381
更新日期：1999-01-01 00:00:00
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journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-998-0009-1
更新日期：1998-01-01 00:00:00
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journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00583-8
更新日期：2019-12-01 00:00:00
