Abstract：
OBJECTIVE:This pilot study aimed to determine the efficacy of acamprosate (N-acetyl homotaurine) in reducing the pathological features of experimental autoimmune encephalomyelitis (EAE) which is an animal model for multiple sclerosis (MS). BACKGROUND:The amino acid taurine has multiple biological activities including immunomodulation and neuromodulation. The synthetic acetylated taurine derivative, acamprosate, which crosses the blood-brain barrier more readily compared to taurine, is currently being used for the prevention of alcohol withdrawal symptoms associated with enhanced glutamatergic receptor function and GABA receptor hypofunction. METHODS:EAE was induced in C57BL/6 female mice with myelin oligodendrocyte glyocoprotein, amino acid 35-55. Mice were treated with 20, 100 and 500 mg/kg acamprosate for 21 days. RESULTS:Neurological scores at disease peak were reduced by 21, 64 and 9% in the 20, 100 and 500 mg/kg groups, respectively. Neurological improvement in the 100 mg/kg group correlated with a reduction in numbers of inflammatory lesions and the extent of CNS demyelination. Blood TNF-α levels were significantly reduced in the 500 mg/kg group. DISCUSSION:Acamprosate and other taurine analogs have a potential for future MS therapy.
journal_name
Inflammopharmacologyjournal_title
Inflammopharmacologyauthors
Sternberg Z,Cesario A,Rittenhouse-Olson K,Sobel RA,Leung YK,Pankewycz O,Zhu B,Whitcomb T,Sternberg DS,Munschauer FEdoi
10.1007/s10787-011-0097-1subject
Has Abstractpub_date
2012-02-01 00:00:00pages
39-48issue
1eissn
0925-4692issn
1568-5608journal_volume
20pub_type
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