Abstract:
:The inflamed mucosa in ulcerative colitis produces high amount of prostaglandin (PG) and nitric oxide (NO) through inducible enzymes: cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), respectively, implicating them as potential anti-inflammatory drug targets. COX-2 or iNOS-related treatments in different models of colitis have yielded ambiguous results ranging from exacerbation of disease to abolition of inflammation. iNOS and COX-2 induction is blocked by potent anti-inflammatory glucocorticoids, however, serious side effects including relapses limit their usefulness in colitis for long time. Simultaneous inhibition of iNOS and COX-2 was investigated in the current study in 2, 4, 6 trinitrobenzene sulphonic acid (TNBS)-induced colitis in rats. Treatment group received rofecoxib, aminoguanidine hydrochloride or their combination at different doses at 48, 36, 24, 12 and 1 h prior to induction of colitis and 12 h later. Colonic myeloperoxidase (MPO), COX-2, nitrate and nitrite, tumor necrosis factor-alpha (TNF-alpha) and lipid peroxidation were maximally reduced by combination of 10 mg/kg rofecoxib and 30 mg/kg of aminoguanidine hydrochloride in TNBS-induced colitis in rats. However, maximum increase in SOD and catalase was noted by this combination. Rats treated with rofecoxib, aminoguanidine hydrochloride and their combinations reduced the inflammation, acute colonic damage produced by TNBS as verified by macroscopic changes in colon. Combination of rofecoxib (10 mg/kg) and aminoguanidine hydrochloride (30 mg/kg) has maximal protective effect on colonic injury induced by TNBS enema which is probably, via mechanism of local inhibition of iNOS and COX-2 activity in colonic mucosa and support the idea that simultaneous inhibition of iNOS and COX-2 inhibitors have a promising potential in the treatment of colitis.
journal_name
Inflammopharmacologyjournal_title
Inflammopharmacologyauthors
Dudhgaonkar SP,Tandan SK,Kumar D,Raviprakash V,Kataria Mdoi
10.1007/s10787-007-1603-3subject
Has Abstractpub_date
2007-10-01 00:00:00pages
188-95issue
5eissn
0925-4692issn
1568-5608journal_volume
15pub_type
杂志文章abstract::Colorectal cancer (CRC) remains the most cancer type related to chronic inflammation; however, the mechanisms that link inflammation to CRC development and progression are still poorly understood. Our study aimed to investigate one of the prominent inflammatory response in cancers, iNOS/NO system. In this regard, we e...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-019-00566-9
更新日期:2019-08-01 00:00:00
abstract::Since their development and licensing no class of drug has received as much attention both in the scientific and lay press as the cyclo-oxygenase 2 (COX-2) inhibitors. These compounds, also known as coxibs, were developed as a safer alternative to traditional non-steroidal anti-inflammatory drugs (NSAIDs) due to their...
journal_title:Inflammopharmacology
pub_type: 杂志文章,评审
doi:10.1163/156856005774415619
更新日期:2005-01-01 00:00:00
abstract::Silver and silver oxides are gaining interest in medical applications for their prominent antibacterial and antimicrobial potentials. Recent studies suggest that nanosilver oxide has remarkable anti-inflammatory effects and enhances wound healing. Nevertheless, its effect on gastric ulcer has not yet been illustrated....
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-017-0424-2
更新日期:2018-08-01 00:00:00
abstract::Pioglitazone, a specific ligand for peroxisome proliferator-activated receptor gamma (PPAR-gamma), was recently implicated in the control of inflammatory processes and in the modulation of the expression of various cytokines such as tumor necrosis factor alpha (TNF-alpha), but its role in the mechanism of gastric muco...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1163/156856005774423908
更新日期:2005-01-01 00:00:00
abstract::Mitochondria can interchange morphology due to their dynamic nature. It can exist in either fragmented disconnected arrangement or elongated interconnected mitochondrial networks due to fission and fusion, respectively. The recent studies have revealed the remarkable and unexpected insights into the physiological impa...
journal_title:Inflammopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s10787-017-0347-y
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:There is considerable interest in the possible importance of the gut microflora in the pathophysiology of the inflammatory bowel diseases (IBD) ulcerative colitis (UC) and Crohn's disease (CD). Probiotics offer a potential adjuvant treatment in these patients by modifying the intestinal milieu, but reports o...
journal_title:Inflammopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10787-019-00595-4
更新日期:2019-06-01 00:00:00
abstract::Caffeic acid phenethyl ester (CAPE) is the active component of honey bee propolis extracts. The results of the current study demonstrate that CAPE attenuated immunoglobulin (Ig)E-mediated allergic response in mast cells. Oral administration of CAPE inhibited IgE-mediated passive cutaneous anaphylaxis. CAPE effectively...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-012-0138-4
更新日期:2013-04-01 00:00:00
abstract::The Maytenus genus is a member of the Celastraceae family. Numerous medicinal uses were assigned to species of this genus, with the use of roots, bark, and leaves for the treatment of gastric ulcers, as anti-inflammatory, analgesic, antiallergic, antitumor, among others. Several studies have demonstrated that natural ...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-018-0496-7
更新日期:2019-06-01 00:00:00
abstract::Pulmonary fibrosis is a result of an abnormal wound healing in lung tissue triggered by an excessive accumulation of extracellular matrix proteins, loss of tissue elasticity, and debit of ventilatory function. NKT cells are a major source of Th1 and Th2 cytokines and may be crucial in the polarization of M1/M2 macroph...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-017-0383-7
更新日期:2018-04-01 00:00:00
abstract::We clarified the roles of histamine H(1)-, H(2)-, H(3)-receptors and oxyradicals in the exacerbation of acid-induced gastric haemorrhage and stomach ulcer in endotoxaemic rats by measuring changes in gastric mucosal glutathione concentrations, lipid peroxide generation and histamine levels as well as in luminal electr...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-998-0017-1
更新日期:1998-01-01 00:00:00
abstract::The effect of lupeol, a natural pentacyclic triterpene on ethanol-induced gastric damage in mice was evaluated. The gastroprotection was assessed by determination of changes in mean gastric lesion area, quantification of mucosal non-protein sulfhydryls (NP-SH), and characterized using drugs that influence the endogeno...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-009-0009-9
更新日期:2009-08-01 00:00:00
abstract::In 1952 I re-joined the Pharmacological Division of the Research Department of the Boots Co. in Nottingham UK to work on rheumatoid arthritis (RA) but with the distinct disadvantage that the Division was housed in a group of rambling buildings attached to a Victorian house. The Division had moved there at the beginnin...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-999-0002-3
更新日期:1999-01-01 00:00:00
abstract::The central nervous system, one of the most delicate microenvironments of the body, is protected by the blood-brain barrier regulating its homeostasis. Blood-brain barrier is a highly complex structure that tightly regulates the movement of ions of a limited number of small molecules and of an even more restricted num...
journal_title:Inflammopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s10787-018-0468-y
更新日期:2018-06-01 00:00:00
abstract::Acute lung injury (ALI) and acute kidney injury (AKI) are major causes of sepsis-induced mortality. The objective of the study is to evaluate the effect of tocilizumab (TCZ), an IL-6 receptor inhibitor, in sepsis-induced ALI and AKI using the cecal ligation and puncture (CLP) rat model of sepsis. Clinical and experime...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-019-00628-y
更新日期:2020-02-01 00:00:00
abstract::The authors would like to inform you that Jie Yu and Haimei Lu contributed equally to this study and should be considered as co-first authors. ...
journal_title:Inflammopharmacology
pub_type: 杂志文章,已发布勘误
doi:10.1007/s10787-018-0518-5
更新日期:2019-02-01 00:00:00
abstract::TRP channels have been discovered as a specialized group of somatosensory neurons involved in the detection of noxious stimuli. Desensitization of TRPV1 located on dorsal root and trigeminal ganglia exhibits analgesic effect and makes it potential therapeutic target for treatment of neuropathic pain. With this backgro...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-016-0285-0
更新日期:2016-12-01 00:00:00
abstract::Kerabala (CB) is a novel ayurvedic formulation used for treating various inflammatory diseases. This formulation was made from virgin coconut oil and it comprises extracts of Sida cordifolia, coconut milk and sesame oil. The current study was performed to evaluate the anti-inflammatory action of CB on carrageenan-indu...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-016-0298-8
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVE:To evaluate the potential of Azadirachta indica leaf extracts against Salmonella typhimurium-induced inflammation in BALB/c mice. DESIGN:Qualitative tests of A. indica leaf extracts were conducted for screening of various phytochemicals. The antiinflammatory potential of A. indica leaf extracts on S. typhimu...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-008-8032-9
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND:Hydroxychloroquine (HCQ) is a widely prescribed medication to patients with systemic lupus erythematosus (SLE), with potential anti-inflammatory effects. This study was performed to investigate the efficacy of HCQ therapy by serial assessment of disease activity and serum levels of proinflammatory cytokines ...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-018-0512-y
更新日期:2018-10-01 00:00:00
abstract::Genistein is an isoflavone with oestrogenic activity that is present in a variety of soy products as a constituent of complex mixtures of bioactive compounds, whose matrix profiles play an important role in determining the overall oestrogenic bioactivity of genistein. We review data on how the profile of soy bioactive...
journal_title:Inflammopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s10787-008-8020-0
更新日期:2008-10-01 00:00:00
abstract::Most of the gastroprotective drugs which had been marketed in Japan were considered to have insufficient rationale for use as ulcer treatments. Such drugs may have a crucial role in maintaining mucosal integrity by the mechanisms other than inhibition of acid secretion. We re-evaluated the effect of gastroprotective d...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-006-0300-y
更新日期:2007-02-01 00:00:00
abstract:BACKGROUND:The role of angiotensin converting enzyme inhibitors on the inflammation process has been demonstrated previously. In the present study, the effects of captopril on lung injury induced by lipopolysaccharide (LPS) were investigated. METHODS:Control, LPS, 12.5, 25 and 50 mg/kg captopril-treated before LPS adm...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-018-0535-4
更新日期:2019-06-01 00:00:00
abstract::The therapeutic efficacy of the contemporary anti-inflammatory drugs are well established; however, prolonged use of such can often lead to serious and life-threatening side effects. Natural product-based anti-inflammatory compounds with superior efficacy and minimum toxicity can serve as possible therapeutic alternat...
journal_title:Inflammopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s10787-020-00734-2
更新日期:2020-10-01 00:00:00
abstract::Excess eicosanoid formation during inflammation has been attributed to the expression of the gene coding for the inducible isoform of prostaglandin G/H synthase (PGHS-2). Human and murine PGHS-2 proteins differ in 73 out of the 604 amino acids. When comparing the inhibitory effects of a panel of PGHS-inhibitors in a w...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-997-0020-y
更新日期:1997-01-01 00:00:00
abstract::Previous reports suggest flavonoids as potent analgesic compounds. Based on these observations, the present study investigated the antinociceptive action of flavonol, 3', 4'-dimethoxy flavonol, 6, 3'-dimethoxy flavonol, 7, 2'-dimethoxy flavonol, and 7, 3'-dimethoxy flavonol and the possible mechanisms involved in thes...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-019-00579-4
更新日期:2019-12-01 00:00:00
abstract::A new compound derivative of glycoside 19-α-hydroxy-ursolic acid glucoside (19-α-hydroxyurs-12(13)-ene-28-oic acid-3-O-β-D-glucopyranoside (HEG) was isolated from whole plant of Wedelia calendulacea (Compositae). The structure was elucidated and established by standard spectroscopy approaches. Diethylnitrosamine (DEN)...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-017-0310-y
更新日期:2017-02-01 00:00:00
abstract::Prompted by the findings that smokers have lowered brain and blood platelet monoamine oxidase-A and -B activities compared to non-smokers and that smokers have a lowered incidence of Parkinson's disease, we have examined the neuroprotective properties of an MAO inhibitor, 2,3,6-trimethyl-1,4-naphthoquinone (TMN), whic...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1163/156856003765764353
更新日期:2003-01-01 00:00:00
abstract::Methyl gallate is a gallotannin widely distributed in nature. Previous studies have demonstrated its antioxidant, anti-inflammatory, antimicrobial and anti-tumor activities. In the present study, the activity of methyl gallate on experimental models of inflammatory bowel disease has been investigated. Experimental col...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-017-0412-6
更新日期:2018-06-01 00:00:00
abstract::Nicotine mediates some of the injurious effects caused by consuming tobacco products. The aim of this work is to investigate the protective effects of Mentha spicata extract (ME) supplementation on the testis and brain of nicotine-induced oxidative damage rats. ME extract showed interesting hydrogen peroxide-scavengin...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-019-00650-0
更新日期:2020-08-01 00:00:00
abstract::A small GTPase, Rac1, is recognized as an important modulator of the inflammatory responses to bacterial lipopolysaccharide (LPS) by affecting the processes of phospholipase C activation. The activation of Rac1 involves the exchange of GDP for GTP and is catalyzed by the guanine nucleotide exchange factors (GEFs). Her...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-015-0235-2
更新日期:2015-06-01 00:00:00