Abstract：
:Caffeic acid phenethyl ester (CAPE) is the active component of honey bee propolis extracts. The results of the current study demonstrate that CAPE attenuated immunoglobulin (Ig)E-mediated allergic response in mast cells. Oral administration of CAPE inhibited IgE-mediated passive cutaneous anaphylaxis. CAPE effectively reduced both histamine and serotonin (5-HT)-induced vascular permeability in rats. CAPE also reduced histamine and leukotrienes (LTs) release from isolated rat peritoneal mast cells. Moreover, CAPE suppressed contraction induced by histamine (3 × 10(-8)-3 × 10(-5) M), 5-HT (3 × 10(-9)-10(-6) M) and adenosine (3 × 10(-8)-10(-5) M) in guinea pig tracheal zigzag. These findings provide evidence that CAPE may serve as an effective therapeutic agent for allergic diseases.
journal_name
Inflammopharmacologyjournal_title
Inflammopharmacologyauthors
Nader MAdoi
10.1007/s10787-012-0138-4subject
Has Abstractpub_date
2013-04-01 00:00:00pages
169-76issue
2eissn
0925-4692issn
1568-5608journal_volume
21pub_type
杂志文章abstract：:Silver and silver oxides are gaining interest in medical applications for their prominent antibacterial and antimicrobial potentials. Recent studies suggest that nanosilver oxide has remarkable anti-inflammatory effects and enhances wound healing. Nevertheless, its effect on gastric ulcer has not yet been illustrated....
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-017-0424-2
更新日期：2018-08-01 00:00:00
abstract：:Propolis is a resinous substance collected by honeybees from leaf buds and cracks in the bark of various plants. Propolis has been reported to have immunomodulatory activity. We hypothesized that propolis would be able to reduce the disease severity of rheumatoid arthritis. We evaluated the effect of Brazilian propoli...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-011-0088-2
更新日期：2012-02-01 00:00:00
abstract：:Allanblackia gabonensis (Guttiferae) is a plant used in the African traditional medicine as remedies against pain, rheumatism, inflammations. In the present work, the analgesic effect of aqueous extract has been evaluated using acetic acid, formalin, hot-plate test, tail immersion and paw-pressure test. The anti-infla...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-011-0096-2
更新日期：2013-02-01 00:00:00
abstract：:- The use of the non-steroidal anti-inflammatory drug, diclofenac, is associated with occasional serious side effects in the gastrointestinal (GI) tract. We examined the effect of altering the site of release of diclofenac sodium on GI tract side effects. Dissolution and pharmacokinetic studies were carried out to sub...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1163/156856004773121383
更新日期：2004-01-01 00:00:00
abstract：OBJECTIVE:This pilot study aimed to determine the efficacy of acamprosate (N-acetyl homotaurine) in reducing the pathological features of experimental autoimmune encephalomyelitis (EAE) which is an animal model for multiple sclerosis (MS). BACKGROUND:The amino acid taurine has multiple biological activities including ...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-011-0097-1
更新日期：2012-02-01 00:00:00
abstract：:Triptolide has been widely reported to exhibit potential therapeutic value in multiple inflammatory diseases, such as rheumatoid arthritis, systemic lupus erythematosus, and psoriasis. Although its safety and efficacy as an anti-inflammatory agent have been verified by many studies, the effect of triptolide on osteoar...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-018-0509-6
更新日期：2019-02-01 00:00:00
abstract：:The safety of the cyclo-oxygenase-2 (COX-2) selective NSAID, nimesulide, has been evaluated from information (a) in clinical trials in osteoarthritis that have been performed in Europe as well as in earlier pilot studies that were performed in patients with rheumatoid arthritis in the USA, and (b) in post-marketing st...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-998-0020-6
更新日期：1998-01-01 00:00:00
abstract：:Nicotine mediates some of the injurious effects caused by consuming tobacco products. The aim of this work is to investigate the protective effects of Mentha spicata extract (ME) supplementation on the testis and brain of nicotine-induced oxidative damage rats. ME extract showed interesting hydrogen peroxide-scavengin...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00650-0
更新日期：2020-08-01 00:00:00
abstract：:A methanol extract of the seeds of Adenanthera pavonina was evaluated for pharmacological effects in animal models. The extract (50-200 mg/kg) produced statistically significant (P < 0.05) inhibition of the carrageenan-induced paw oedema in the rat, as well as the acetic-acid-induced vascular permeability in mice. At ...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1163/1568560041352310
更新日期：2004-01-01 00:00:00
abstract：:Biologic disease modifying anti-rheumatic drugs have transformed the management of rheumatoid arthritis (RA) since their introduction into clinical practice over a decade ago. Following large-scale clinical trials, a number of biologics, with different mechanisms of action, have been licensed for the condition. In thi...
journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s10787-012-0123-y
更新日期：2012-04-01 00:00:00
abstract：:Rhynchosia minima root, a folk herbal medicine in southern China, is used to relieve itch and swelling. In this study, we examined the anti-inflammatory property of an ethanol fraction (EEF6) from R. minima root on lipopolysaccharide (LPS)-induced RAW 264.7 cells, as well as its underlying mechanism. The compound comp...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00632-2
更新日期：2020-02-01 00:00:00
abstract：:TRP channels have been discovered as a specialized group of somatosensory neurons involved in the detection of noxious stimuli. Desensitization of TRPV1 located on dorsal root and trigeminal ganglia exhibits analgesic effect and makes it potential therapeutic target for treatment of neuropathic pain. With this backgro...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-016-0285-0
更新日期：2016-12-01 00:00:00
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journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-999-0002-3
更新日期：1999-01-01 00:00:00
abstract：:Centella asiatica is claimed to have a neuroprotective effect; however, its ability to protect the cerebrum against damage in diabetes has never been identified. The aims were to identify the possibility that C. asiatica ameliorates inflammation, oxidative stress, and apoptosis in the cerebrum in diabetes. C. asiatica...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-020-00733-3
更新日期：2020-12-01 00:00:00
abstract：:2-(4-phenylquinoline-2-yl)phenol derivatives (4a-l) with COX-2 enzyme inhibition, analgesic, anti-inflammatory and antipyretic potentials were executed and reported. From the in vitro COX-2 enzyme inhibition assay, compounds 4 h (IC50 0.026 µM) and 4j (IC50 0.102 µM) were found as most potent COX-2 inhibitors. Consequ...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-017-0342-3
更新日期：2017-12-01 00:00:00
abstract：:Kerabala (CB) is a novel ayurvedic formulation used for treating various inflammatory diseases. This formulation was made from virgin coconut oil and it comprises extracts of Sida cordifolia, coconut milk and sesame oil. The current study was performed to evaluate the anti-inflammatory action of CB on carrageenan-indu...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-016-0298-8
更新日期：2017-02-01 00:00:00
abstract：:Methyl gallate is a gallotannin widely distributed in nature. Previous studies have demonstrated its antioxidant, anti-inflammatory, antimicrobial and anti-tumor activities. In the present study, the activity of methyl gallate on experimental models of inflammatory bowel disease has been investigated. Experimental col...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-017-0412-6
更新日期：2018-06-01 00:00:00
abstract：:Prolonged stimulation of newborn mice by intraperitoneal injections with inactivated staphylococci induces a chronic neonatal inflammatory reaction and an associated oxidative-stress response. The chronically stimulated animals exhibit anorexy. show a reduction in their body weight and undergo a depression in both ant...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/BF02918381
更新日期：1999-01-01 00:00:00
abstract：BACKGROUND:Resveratrol exerts an anti-inflammatory effect on collagen-induced arthritis and osteoarthritis in rats via activation of sirtuin 1 (SIRT1). Autophagy can be induced by resveratrol and leads to amelioration of interleukin-1 beta (IL-1β) release in vitro. We aimed to determine the anti-inflammatory mechanisms...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-018-00555-4
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND:Osthole is a bioactive component reported in medicinal plants such as Angelica pubescens and Cnidium monnieri, known for analgesic activity. However, the toxicity, median effective dose (ED50), and dual modulation of nitric oxide and cyclooxygenase pathways along with inflammatory cytokines of osthole are ye...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-018-0486-9
更新日期：2019-10-01 00:00:00
abstract：:Some B vitamins exhibit activities in models of nociceptive pain, inflammatory pain, and neuropathic pain induced by nerve lesions and also in certain painful conditions in humans. In the present study, we investigated the effects of thiamine, riboflavin, and nicotinamide in a neuropathic pain model induced by the che...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00625-1
更新日期：2020-02-01 00:00:00
abstract：:Tovophyllin A (TA) is a xanthone isolated from Garcinia mangostana L. (GM, Guttiferae) pericarps that possesses various beneficial bioactivities. However, its protective effects on acute lung injury (ALI) and lung carcinoma have not yet been explored. The current work was designed to investigate the protective potenti...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00609-1
更新日期：2020-02-01 00:00:00
abstract：:The Maytenus genus is a member of the Celastraceae family. Numerous medicinal uses were assigned to species of this genus, with the use of roots, bark, and leaves for the treatment of gastric ulcers, as anti-inflammatory, analgesic, antiallergic, antitumor, among others. Several studies have demonstrated that natural ...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-018-0496-7
更新日期：2019-06-01 00:00:00
abstract：:There is a growing body of evidence that plant polyphenols such as resveratrol, anthocyanins, catechins, and terpenes like taxol are effectively used in the treatment of chronic conditions including cancer, Alzheimer, Parkinsonism, diabetes, aging, etc. The link between oxidative stress and inflammation is well accept...
journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s10787-015-0236-1
更新日期：2015-08-01 00:00:00
abstract：:Chronic inflammation is a world health problem. There is a need to develop new anti-inflammatory and analgesic drugs with improved activity and reduced side effects. In this context, the aim of this study was to evaluate the antinociceptive and anti-inflammatory effects of the pyrazole compound LQFM-021 after acute an...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-016-0282-3
更新日期：2016-10-01 00:00:00
abstract：BACKGROUND:Hydroxychloroquine (HCQ) is a widely prescribed medication to patients with systemic lupus erythematosus (SLE), with potential anti-inflammatory effects. This study was performed to investigate the efficacy of HCQ therapy by serial assessment of disease activity and serum levels of proinflammatory cytokines ...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-018-0512-y
更新日期：2018-10-01 00:00:00
abstract：:The effect of lupeol, a natural pentacyclic triterpene on ethanol-induced gastric damage in mice was evaluated. The gastroprotection was assessed by determination of changes in mean gastric lesion area, quantification of mucosal non-protein sulfhydryls (NP-SH), and characterized using drugs that influence the endogeno...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-009-0009-9
更新日期：2009-08-01 00:00:00
abstract：:The authors would like to inform you that Jie Yu and Haimei Lu contributed equally to this study and should be considered as co-first authors. ...
journal_title：Inflammopharmacology
pub_type： 杂志文章,已发布勘误
doi：10.1007/s10787-018-0518-5
更新日期：2019-02-01 00:00:00
abstract：:The inflamed mucosa in ulcerative colitis produces high amount of prostaglandin (PG) and nitric oxide (NO) through inducible enzymes: cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), respectively, implicating them as potential anti-inflammatory drug targets. COX-2 or iNOS-related treatments in diff...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-007-1603-3
更新日期：2007-10-01 00:00:00
abstract：AIM:The aim of the present study was to evaluate the anti-inflammatory effect of thymol in acetic acid-induced rat colitis through inhibiting the NF-κB signaling pathway. METHODS:Colitis was induced by intra-rectal administration of 2 mL of diluted acetic acid (4%) solution using a flexible plastic rubber catheter in ...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00583-8
更新日期：2019-12-01 00:00:00
