Abstract：
:There is a growing body of evidence that plant polyphenols such as resveratrol, anthocyanins, catechins, and terpenes like taxol are effectively used in the treatment of chronic conditions including cancer, Alzheimer, Parkinsonism, diabetes, aging, etc. The link between oxidative stress and inflammation is well accepted. Thus, the mechanism of action of these natural products is partly believed to be through their significant antioxidant properties. The main constituent of green tea, with clinical significance, is epigallocatechin gallate (EGCG). It has been associated with antitumor, anti-Alzheimer, and anti-aging properties, improve redox status at the tissue level possibly preventing system level structural damage. This review focuses on EGCG and its potential therapeutic role in health and disease.
journal_name
Inflammopharmacologyjournal_title
Inflammopharmacologyauthors
Afzal M,Safer AM,Menon Mdoi
10.1007/s10787-015-0236-1subject
Has Abstractpub_date
2015-08-01 00:00:00pages
151-61issue
4eissn
0925-4692issn
1568-5608journal_volume
23pub_type
杂志文章,评审abstract：OBJECTIVE AND DESIGN:The objective of this study was to investigate the leucocyte-related antiinflammatory properties of rose hip. MATERIALS AND METHODS:The effect of rose hip on a number of inflammatory parameters was evaluated using the following models: (1) The effect of rose hip extract on chemotaxis and chemilumi...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-999-0031-y
更新日期：1999-01-01 00:00:00
abstract：:In 1952 I re-joined the Pharmacological Division of the Research Department of the Boots Co. in Nottingham UK to work on rheumatoid arthritis (RA) but with the distinct disadvantage that the Division was housed in a group of rambling buildings attached to a Victorian house. The Division had moved there at the beginnin...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-999-0002-3
更新日期：1999-01-01 00:00:00
abstract：OBJECTIVE:This pilot study aimed to determine the efficacy of acamprosate (N-acetyl homotaurine) in reducing the pathological features of experimental autoimmune encephalomyelitis (EAE) which is an animal model for multiple sclerosis (MS). BACKGROUND:The amino acid taurine has multiple biological activities including ...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-011-0097-1
更新日期：2012-02-01 00:00:00
abstract：:Nicotine mediates some of the injurious effects caused by consuming tobacco products. The aim of this work is to investigate the protective effects of Mentha spicata extract (ME) supplementation on the testis and brain of nicotine-induced oxidative damage rats. ME extract showed interesting hydrogen peroxide-scavengin...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00650-0
更新日期：2020-08-01 00:00:00
abstract：:A methanol extract of the seeds of Adenanthera pavonina was evaluated for pharmacological effects in animal models. The extract (50-200 mg/kg) produced statistically significant (P < 0.05) inhibition of the carrageenan-induced paw oedema in the rat, as well as the acetic-acid-induced vascular permeability in mice. At ...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1163/1568560041352310
更新日期：2004-01-01 00:00:00
abstract：:The ozonised sunflower oil, Bioperoxoil, was tested for its antimicrobial activity against some pathological strains in vitro together with its healing potential against Staphylococcus aureus in vivo. Bioperoxoil was tested against S. aureus, Pseudomonas aeroginosa, Candida albicans, S. typhimurium and Escherichia col...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1163/1568560042342275
更新日期：2004-01-01 00:00:00
abstract：AIM:The aim of the present study was to evaluate the anti-inflammatory effect of thymol in acetic acid-induced rat colitis through inhibiting the NF-κB signaling pathway. METHODS:Colitis was induced by intra-rectal administration of 2 mL of diluted acetic acid (4%) solution using a flexible plastic rubber catheter in ...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00583-8
更新日期：2019-12-01 00:00:00
abstract：:Bioactivity-guided investigation of the methanol extract of Crepis sancta aerial parts, collected off Al-Tafilah, South Jordan, was applied, and in this study, the extract was explored for its phytochemical components and in vivo antiulcer activity. In addition, a docking study involving the purified compounds with th...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00637-x
更新日期：2020-02-01 00:00:00
abstract：OBJECTIVE:To study the effect of hyaluronan on cell adhesion and recruitment both in vitro and in vivo, since hyaluronan both inhibits restenosis and is anti-inflammatory. When administered to animals undergoing angioplasty the recruitment of cells into the restenotic plaque is inhibited, as well as into inflammatory l...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1163/156856005774382733
更新日期：2005-01-01 00:00:00
abstract：:The anti-inflammatory activity of the aqueous extract of Chromolaena odorata was investigated in rats using the carrageenan-induced oedema, cotton pellet granuloma and formalin-induced oedema methods. The extract was administered orally at doses of 25, 50, 100 and 200 mg/kg. In the carrageenan method the paw oedema wa...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1163/156856005774649386
更新日期：2005-01-01 00:00:00
abstract：:Caffeic acid phenethyl ester (CAPE) is the active component of honey bee propolis extracts. The results of the current study demonstrate that CAPE attenuated immunoglobulin (Ig)E-mediated allergic response in mast cells. Oral administration of CAPE inhibited IgE-mediated passive cutaneous anaphylaxis. CAPE effectively...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-012-0138-4
更新日期：2013-04-01 00:00:00
abstract：:Biologic disease modifying anti-rheumatic drugs have transformed the management of rheumatoid arthritis (RA) since their introduction into clinical practice over a decade ago. Following large-scale clinical trials, a number of biologics, with different mechanisms of action, have been licensed for the condition. In thi...
journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s10787-012-0123-y
更新日期：2012-04-01 00:00:00
abstract：:Prolonged stimulation of newborn mice by intraperitoneal injections with inactivated staphylococci induces a chronic neonatal inflammatory reaction and an associated oxidative-stress response. The chronically stimulated animals exhibit anorexy. show a reduction in their body weight and undergo a depression in both ant...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/BF02918381
更新日期：1999-01-01 00:00:00
abstract：:Tovophyllin A (TA) is a xanthone isolated from Garcinia mangostana L. (GM, Guttiferae) pericarps that possesses various beneficial bioactivities. However, its protective effects on acute lung injury (ALI) and lung carcinoma have not yet been explored. The current work was designed to investigate the protective potenti...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00609-1
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:Resveratrol exerts an anti-inflammatory effect on collagen-induced arthritis and osteoarthritis in rats via activation of sirtuin 1 (SIRT1). Autophagy can be induced by resveratrol and leads to amelioration of interleukin-1 beta (IL-1β) release in vitro. We aimed to determine the anti-inflammatory mechanisms...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-018-00555-4
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND:Indomethacin (IND) is a widely used non-steroidal anti-inflammatory agent in the treatment of various inflammatory disorders, which causes gastrointestinal injury in humans and animal experiments. Vitamin A and beta-carotene prevent the IND-induced gastric mucosal injury. These compounds modify the membrane-...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-999-0012-1
更新日期：1999-01-01 00:00:00
abstract：:Centella asiatica is claimed to have a neuroprotective effect; however, its ability to protect the cerebrum against damage in diabetes has never been identified. The aims were to identify the possibility that C. asiatica ameliorates inflammation, oxidative stress, and apoptosis in the cerebrum in diabetes. C. asiatica...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-020-00733-3
更新日期：2020-12-01 00:00:00
abstract：:R-phenylpiracetam (R-PhP, (4R)-2-(4-phenyl-2-oxopyrrolidin-1-yl)acetamide) is an optical isomer of phenotropil, a clinically-used nootropic drug that improves physical condition and cognition. Recently, R-PhP was shown to bind to the dopamine transporter (DAT). Since growing evidence suggests that dysfunction of the d...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-020-00705-7
更新日期：2020-10-01 00:00:00
abstract：:The intestinal mucosa is subject to a variety of physical forces in a complex manner during normal gut function and in disease. Intestinal mucosal atrophy during some disease states is a troubling phenomenon that is only partially explained by nutritional parameters. Increasing evidence suggests the possibility that r...
journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s10787-007-1562-8
更新日期：2007-06-01 00:00:00
abstract：:Rheumatoid arthritis (RA) is a systemic autoimmune disease, which is characterized by a chronic fluctuating course and immune dysfunction, resulting in affecting the health and life quality of RA patients. Methotrexate (MTX), as the standard gold treatment of RA, has received more and more clinical applications and ba...
journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s10787-020-00741-3
更新日期：2020-10-01 00:00:00
abstract：:Excess eicosanoid formation during inflammation has been attributed to the expression of the gene coding for the inducible isoform of prostaglandin G/H synthase (PGHS-2). Human and murine PGHS-2 proteins differ in 73 out of the 604 amino acids. When comparing the inhibitory effects of a panel of PGHS-inhibitors in a w...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-997-0020-y
更新日期：1997-01-01 00:00:00
abstract：:Tumour necrosis factor (TNF) and kinins have been associated with neuropathic pain-like behaviour in numerous animal models. However, the way that they interact to cause neuron sensitisation remains unclear. This study assessed the interaction of kinin receptors and TNF receptor TNFR1/p55 in mechanical hypersensitivit...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00578-5
更新日期：2019-06-01 00:00:00
abstract：:A series of quinazoline clubbed 1,3,5-triazine derivatives (QCT) were synthesized and evaluated for their in vitro anticancer activity against HeLa (human cervical cancer), MCF-7 (human breast cancer cell), HL-60 (human promyelocytic leukemia cell), HepG2 (human Hepatocellular carcinoma cell), and one normal cell line...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-018-0471-3
更新日期：2018-12-01 00:00:00
abstract：:P38 mitogen-activated protein kinase (p38 MAPK), a tissue inflammatory factor can be activated under oxidative stress and in conditions associated with hyperglycemia. Gingerol containing various natural herbs has been extensively studied for its pharmacological actions both in reducing the inflammation and as immunity...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00569-6
更新日期：2019-12-01 00:00:00
abstract：:Kerabala (CB) is a novel ayurvedic formulation used for treating various inflammatory diseases. This formulation was made from virgin coconut oil and it comprises extracts of Sida cordifolia, coconut milk and sesame oil. The current study was performed to evaluate the anti-inflammatory action of CB on carrageenan-indu...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-016-0298-8
更新日期：2017-02-01 00:00:00
abstract：:A small GTPase, Rac1, is recognized as an important modulator of the inflammatory responses to bacterial lipopolysaccharide (LPS) by affecting the processes of phospholipase C activation. The activation of Rac1 involves the exchange of GDP for GTP and is catalyzed by the guanine nucleotide exchange factors (GEFs). Her...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-015-0235-2
更新日期：2015-06-01 00:00:00
abstract：:The inflamed mucosa in ulcerative colitis produces high amount of prostaglandin (PG) and nitric oxide (NO) through inducible enzymes: cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), respectively, implicating them as potential anti-inflammatory drug targets. COX-2 or iNOS-related treatments in diff...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-007-1603-3
更新日期：2007-10-01 00:00:00
abstract：:Chronic inflammation is a world health problem. There is a need to develop new anti-inflammatory and analgesic drugs with improved activity and reduced side effects. In this context, the aim of this study was to evaluate the antinociceptive and anti-inflammatory effects of the pyrazole compound LQFM-021 after acute an...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-016-0282-3
更新日期：2016-10-01 00:00:00
abstract：:The initial precipitating injury such as SE progresses to chronic epilepsy through multiple epileptogenic processes. Early epileptogenic events are generally characterized by neuroinflammation, neurodegeneration and abnormal neurogenesis in the hippocampus. Metformin has exhibited anti-inflammatory and neuroprotective...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-020-00782-8
更新日期：2021-01-01 00:00:00
abstract：:- The use of the non-steroidal anti-inflammatory drug, diclofenac, is associated with occasional serious side effects in the gastrointestinal (GI) tract. We examined the effect of altering the site of release of diclofenac sodium on GI tract side effects. Dissolution and pharmacokinetic studies were carried out to sub...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1163/156856004773121383
更新日期：2004-01-01 00:00:00
