Abstract：
:The intestinal mucosa is subject to a variety of physical forces in a complex manner during normal gut function and in disease. Intestinal mucosal atrophy during some disease states is a troubling phenomenon that is only partially explained by nutritional parameters. Increasing evidence suggests the possibility that repetitive deformation engendered by peristalsis, villous motility, and interaction with luminal chyme may be trophic for the gut mucosa in normal function, but that the intestinal epithelial response to repetitive deformation may be altered by inflammatory or other states in which plasma or tissue fibronectin levels are increased.
journal_name
Inflammopharmacologyjournal_title
Inflammopharmacologyauthors
Basson MDdoi
10.1007/s10787-007-1562-8subject
Has Abstractpub_date
2007-06-01 00:00:00pages
109-14issue
3eissn
0925-4692issn
1568-5608journal_volume
15pub_type
杂志文章,评审abstract：:Nicotine mediates some of the injurious effects caused by consuming tobacco products. The aim of this work is to investigate the protective effects of Mentha spicata extract (ME) supplementation on the testis and brain of nicotine-induced oxidative damage rats. ME extract showed interesting hydrogen peroxide-scavengin...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00650-0
更新日期：2020-08-01 00:00:00
abstract：:Gout, the most prevalent inflammatory arthritis worldwide, released interleukin-1β (IL-1β) and Cathepsin B inflammatory mediators that constitute the hallmark of the disease. Herein we aimed to investigate whether procyanidin B2 (PCB2), a natural dietary compound, can suppress MSU crystals-stimulated gouty inflammatio...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-020-00758-8
更新日期：2020-12-01 00:00:00
abstract：:Acute lung injury (ALI) and acute kidney injury (AKI) are major causes of sepsis-induced mortality. The objective of the study is to evaluate the effect of tocilizumab (TCZ), an IL-6 receptor inhibitor, in sepsis-induced ALI and AKI using the cecal ligation and puncture (CLP) rat model of sepsis. Clinical and experime...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00628-y
更新日期：2020-02-01 00:00:00
abstract：:Silver and silver oxides are gaining interest in medical applications for their prominent antibacterial and antimicrobial potentials. Recent studies suggest that nanosilver oxide has remarkable anti-inflammatory effects and enhances wound healing. Nevertheless, its effect on gastric ulcer has not yet been illustrated....
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-017-0424-2
更新日期：2018-08-01 00:00:00
abstract：:Pioglitazone, a specific ligand for peroxisome proliferator-activated receptor gamma (PPAR-gamma), was recently implicated in the control of inflammatory processes and in the modulation of the expression of various cytokines such as tumor necrosis factor alpha (TNF-alpha), but its role in the mechanism of gastric muco...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1163/156856005774423908
更新日期：2005-01-01 00:00:00
abstract：:The ozonised sunflower oil, Bioperoxoil, was tested for its antimicrobial activity against some pathological strains in vitro together with its healing potential against Staphylococcus aureus in vivo. Bioperoxoil was tested against S. aureus, Pseudomonas aeroginosa, Candida albicans, S. typhimurium and Escherichia col...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1163/1568560042342275
更新日期：2004-01-01 00:00:00
abstract：:The inflamed mucosa in ulcerative colitis produces high amount of prostaglandin (PG) and nitric oxide (NO) through inducible enzymes: cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), respectively, implicating them as potential anti-inflammatory drug targets. COX-2 or iNOS-related treatments in diff...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-007-1603-3
更新日期：2007-10-01 00:00:00
abstract：:The effect of lupeol, a natural pentacyclic triterpene on ethanol-induced gastric damage in mice was evaluated. The gastroprotection was assessed by determination of changes in mean gastric lesion area, quantification of mucosal non-protein sulfhydryls (NP-SH), and characterized using drugs that influence the endogeno...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-009-0009-9
更新日期：2009-08-01 00:00:00
abstract：:Triptolide has been widely reported to exhibit potential therapeutic value in multiple inflammatory diseases, such as rheumatoid arthritis, systemic lupus erythematosus, and psoriasis. Although its safety and efficacy as an anti-inflammatory agent have been verified by many studies, the effect of triptolide on osteoar...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-018-0509-6
更新日期：2019-02-01 00:00:00
abstract：AIM:Experimental autoimmune encephalomyelitis (EAE) is a CD4(+)-mediated autoimmune pathology of the central nervous system (CNS) that is used as a model for the study of the human neuroinflammatory disease, multiple sclerosis. During the development of EAE, auto-reactive Th1 and Th17 CD4(+) T cells infiltrate the CNS ...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-015-0252-1
更新日期：2015-12-01 00:00:00
abstract：OBJECTIVE:The present study aimed to evaluate the anti-inflammatory and analgesic activities of the ginsenoside metabolite compound K (CK) and its mechanisms. METHODS:Mice model of xylene-induced ear swelling and rat model of carrageenan-induced paw swelling were used to evaluate the effect of CK on acute inflammation...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-018-0504-y
更新日期：2019-02-01 00:00:00
abstract：:The ulcerogenic effect of rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, on the gastrointestinal mucosa was investigated in the presence of a low dose of indomethacin. Indomethacin at 3 mg/kg did not cause any damage in both the stomach and small intestine, despite inhibiting prostaglandin (PG) production....
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1163/156856005774423755
更新日期：2005-01-01 00:00:00
abstract：:A new compound derivative of glycoside 19-α-hydroxy-ursolic acid glucoside (19-α-hydroxyurs-12(13)-ene-28-oic acid-3-O-β-D-glucopyranoside (HEG) was isolated from whole plant of Wedelia calendulacea (Compositae). The structure was elucidated and established by standard spectroscopy approaches. Diethylnitrosamine (DEN)...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-017-0310-y
更新日期：2017-02-01 00:00:00
abstract：BACKGROUND:Hydroxychloroquine (HCQ) is a widely prescribed medication to patients with systemic lupus erythematosus (SLE), with potential anti-inflammatory effects. This study was performed to investigate the efficacy of HCQ therapy by serial assessment of disease activity and serum levels of proinflammatory cytokines ...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-018-0512-y
更新日期：2018-10-01 00:00:00
abstract：:Rhynchosia minima root, a folk herbal medicine in southern China, is used to relieve itch and swelling. In this study, we examined the anti-inflammatory property of an ethanol fraction (EEF6) from R. minima root on lipopolysaccharide (LPS)-induced RAW 264.7 cells, as well as its underlying mechanism. The compound comp...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00632-2
更新日期：2020-02-01 00:00:00
abstract：:Allanblackia gabonensis (Guttiferae) is a plant used in the African traditional medicine as remedies against pain, rheumatism, inflammations. In the present work, the analgesic effect of aqueous extract has been evaluated using acetic acid, formalin, hot-plate test, tail immersion and paw-pressure test. The anti-infla...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-011-0096-2
更新日期：2013-02-01 00:00:00
abstract：:TRP channels have been discovered as a specialized group of somatosensory neurons involved in the detection of noxious stimuli. Desensitization of TRPV1 located on dorsal root and trigeminal ganglia exhibits analgesic effect and makes it potential therapeutic target for treatment of neuropathic pain. With this backgro...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-016-0285-0
更新日期：2016-12-01 00:00:00
abstract：:Ischemia/reperfusion (I/R) damages gastric mucosa via reactive oxygen species (ROS) activity. ROS was reportedly produced through angiotensin II stimulation in tissues such as kidney, heart and brain. To determine whether AT1 receptor plays a role in gastric mucosal damage, we examined the effect of AT1 receptor block...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-006-1551-3
更新日期：2007-08-01 00:00:00
abstract：:The idea that microbes induce disease has steered medical research toward the discovery of antibacterial products for the prevention and treatment of microbial infections. The twentieth century saw increasing dependency on antimicrobials as mainline therapy accentuating the notion that bacterial interactions with huma...
journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s10787-012-0126-8
更新日期：2012-10-01 00:00:00
abstract：:The aim of this study was to determine whether ethanol extracts of Etlingera pavieana rhizomes (EPE) can inhibit the expression of ICAM-1 and VCAM-1 in TNF-α-stimulated human vascular endothelial cells. EPE significantly reduced ICAM-1 and VCAM-1 expression in a concentration-dependent manner. EPE also suppressed phos...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00676-4
更新日期：2020-12-01 00:00:00
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journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s10787-010-0056-2
更新日期：2011-02-01 00:00:00
abstract：:Prolonged stimulation of newborn mice by intraperitoneal injections with inactivated staphylococci induces a chronic neonatal inflammatory reaction and an associated oxidative-stress response. The chronically stimulated animals exhibit anorexy. show a reduction in their body weight and undergo a depression in both ant...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/BF02918381
更新日期：1999-01-01 00:00:00
abstract：BACKGROUND:Resveratrol exerts an anti-inflammatory effect on collagen-induced arthritis and osteoarthritis in rats via activation of sirtuin 1 (SIRT1). Autophagy can be induced by resveratrol and leads to amelioration of interleukin-1 beta (IL-1β) release in vitro. We aimed to determine the anti-inflammatory mechanisms...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-018-00555-4
更新日期：2019-02-01 00:00:00
abstract：:A series of quinazoline clubbed 1,3,5-triazine derivatives (QCT) were synthesized and evaluated for their in vitro anticancer activity against HeLa (human cervical cancer), MCF-7 (human breast cancer cell), HL-60 (human promyelocytic leukemia cell), HepG2 (human Hepatocellular carcinoma cell), and one normal cell line...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-018-0471-3
更新日期：2018-12-01 00:00:00
abstract：:Euphorbia hirta L. (Euphorbiaceae) (E. hirta) is a tree locally used as a traditional medicine in Africa and Australia to treat numerous diseases such as hypertension, respiratory ailments, tumors, wounds, antipyretic, anti-inflammatory activities, etc. Therefore, we undertook to investigate their immunomodulatory eff...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-012-0144-6
更新日期：2013-04-01 00:00:00
abstract：:A methanol extract of the seeds of Adenanthera pavonina was evaluated for pharmacological effects in animal models. The extract (50-200 mg/kg) produced statistically significant (P < 0.05) inhibition of the carrageenan-induced paw oedema in the rat, as well as the acetic-acid-induced vascular permeability in mice. At ...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1163/1568560041352310
更新日期：2004-01-01 00:00:00
abstract：:The central nervous system, one of the most delicate microenvironments of the body, is protected by the blood-brain barrier regulating its homeostasis. Blood-brain barrier is a highly complex structure that tightly regulates the movement of ions of a limited number of small molecules and of an even more restricted num...
journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s10787-018-0468-y
更新日期：2018-06-01 00:00:00
abstract：BACKGROUND:There is considerable interest in the possible importance of the gut microflora in the pathophysiology of the inflammatory bowel diseases (IBD) ulcerative colitis (UC) and Crohn's disease (CD). Probiotics offer a potential adjuvant treatment in these patients by modifying the intestinal milieu, but reports o...
journal_title：Inflammopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10787-019-00595-4
更新日期：2019-06-01 00:00:00
abstract：:The authors would like to inform you that Jie Yu and Haimei Lu contributed equally to this study and should be considered as co-first authors. ...
journal_title：Inflammopharmacology
pub_type： 杂志文章,已发布勘误
doi：10.1007/s10787-018-0518-5
更新日期：2019-02-01 00:00:00
abstract：:The safety of the cyclo-oxygenase-2 (COX-2) selective NSAID, nimesulide, has been evaluated from information (a) in clinical trials in osteoarthritis that have been performed in Europe as well as in earlier pilot studies that were performed in patients with rheumatoid arthritis in the USA, and (b) in post-marketing st...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-998-0020-6
更新日期：1998-01-01 00:00:00
