Abstract:
:The idea that microbes induce disease has steered medical research toward the discovery of antibacterial products for the prevention and treatment of microbial infections. The twentieth century saw increasing dependency on antimicrobials as mainline therapy accentuating the notion that bacterial interactions with humans were to be avoided or desirably controlled. The last two decades, though, have seen a refocusing of thinking and research effort directed towards elucidating the critical inter-relationships between the gut microbiome and its host that control health/wellness or disease. This research has redefined the interactions between gut microbes and vertebrates, now recognizing that the microbial active cohort and its mammalian host have shared co-evolutionary metabolic interactions that span millennia. Microbial interactions in the gastrointestinal tract provide the necessary cues for the development of regulated pro- and anti-inflammatory signals that promotes immunological tolerance, metabolic regulation and other factors which may then control local and extra-intestinal inflammation. Pharmacobiotics, using nutritional and functional food additives to regulate the gut microbiome, will be an exciting growth area of therapeutics, developing alongside an increased scientific understanding of gut-microbiome symbiosis in health and disease.
journal_name
Inflammopharmacologyjournal_title
Inflammopharmacologyauthors
Vitetta L,Briskey D,Hayes E,Shing C,Peake Jdoi
10.1007/s10787-012-0126-8subject
Has Abstractpub_date
2012-10-01 00:00:00pages
251-66issue
5eissn
0925-4692issn
1568-5608journal_volume
20pub_type
杂志文章,评审abstract::The initial precipitating injury such as SE progresses to chronic epilepsy through multiple epileptogenic processes. Early epileptogenic events are generally characterized by neuroinflammation, neurodegeneration and abnormal neurogenesis in the hippocampus. Metformin has exhibited anti-inflammatory and neuroprotective...
journal_title:Inflammopharmacology
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journal_title:Inflammopharmacology
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journal_title:Inflammopharmacology
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journal_title:Inflammopharmacology
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abstract::Prolonged stimulation of newborn mice by intraperitoneal injections with inactivated staphylococci induces a chronic neonatal inflammatory reaction and an associated oxidative-stress response. The chronically stimulated animals exhibit anorexy. show a reduction in their body weight and undergo a depression in both ant...
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journal_title:Inflammopharmacology
pub_type: 杂志文章
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更新日期:2018-06-01 00:00:00
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journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-007-1603-3
更新日期:2007-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2004-01-01 00:00:00
abstract::Bioactivity-guided investigation of the methanol extract of Crepis sancta aerial parts, collected off Al-Tafilah, South Jordan, was applied, and in this study, the extract was explored for its phytochemical components and in vivo antiulcer activity. In addition, a docking study involving the purified compounds with th...
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更新日期:2020-02-01 00:00:00
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