Angiotensin AT1 receptor blockers suppress ischemia/reperfusion-induced gastric injury in rats.

abstract：:The aim of this study was to determine whether ethanol extracts of Etlingera pavieana rhizomes (EPE) can inhibit the expression of ICAM-1 and VCAM-1 in TNF-α-stimulated human vascular endothelial cells. EPE significantly reduced ICAM-1 and VCAM-1 expression in a concentration-dependent manner. EPE also suppressed phos...

journal_title：Inflammopharmacology

authors： Srisook K,Potiprasart K,Sarapusit S,Park CS,Srisook E

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVE:To evaluate the potential of Azadirachta indica leaf extracts against Salmonella typhimurium-induced inflammation in BALB/c mice. DESIGN:Qualitative tests of A. indica leaf extracts were conducted for screening of various phytochemicals. The antiinflammatory potential of A. indica leaf extracts on S. typhimu...

journal_title：Inflammopharmacology

authors： Koul A,Bharrhan S,Singh B,Rishi P

更新日期：2009-02-01 00:00:00

abstract：:Chronic inflammation is a world health problem. There is a need to develop new anti-inflammatory and analgesic drugs with improved activity and reduced side effects. In this context, the aim of this study was to evaluate the antinociceptive and anti-inflammatory effects of the pyrazole compound LQFM-021 after acute an...

journal_title：Inflammopharmacology

authors： Florentino IF,da Silva DP,Martins JL,da Silva TS,Santos FC,Tonussi CR,Vasconcelos GA,Vaz BG,Lião LM,Menegatti R,Costa EA

更新日期：2016-10-01 00:00:00

abstract：:The side effects of NSAIDs are equally evident in the stomach and the small bowel. The latter is increasingly seen as being clinically significant, contributing substantially to the iron-deficiency anaemia that is so common in patients with rheumatoid arthritis. Furthermore, NSAID-enteropathy may be associated with li...

journal_title：Inflammopharmacology

authors： Hotz-Behofsits CM,Walley MJ,Simpson R,Bjarnason IT

更新日期：2003-01-01 00:00:00

abstract：:P38 mitogen-activated protein kinase (p38 MAPK), a tissue inflammatory factor can be activated under oxidative stress and in conditions associated with hyperglycemia. Gingerol containing various natural herbs has been extensively studied for its pharmacological actions both in reducing the inflammation and as immunity...

journal_title：Inflammopharmacology

authors： Song S,Dang M,Kumar M

更新日期：2019-12-01 00:00:00

abstract：:In 1952 I re-joined the Pharmacological Division of the Research Department of the Boots Co. in Nottingham UK to work on rheumatoid arthritis (RA) but with the distinct disadvantage that the Division was housed in a group of rambling buildings attached to a Victorian house. The Division had moved there at the beginnin...

journal_title：Inflammopharmacology

authors： Adams SS

更新日期：1999-01-01 00:00:00

abstract：:Pulmonary fibrosis is a result of an abnormal wound healing in lung tissue triggered by an excessive accumulation of extracellular matrix proteins, loss of tissue elasticity, and debit of ventilatory function. NKT cells are a major source of Th1 and Th2 cytokines and may be crucial in the polarization of M1/M2 macroph...

journal_title：Inflammopharmacology

authors： Grabarz F,Aguiar CF,Correa-Costa M,Braga TT,Hyane MI,Andrade-Oliveira V,Landgraf MA,Câmara NOS

更新日期：2018-04-01 00:00:00

abstract：:The initial precipitating injury such as SE progresses to chronic epilepsy through multiple epileptogenic processes. Early epileptogenic events are generally characterized by neuroinflammation, neurodegeneration and abnormal neurogenesis in the hippocampus. Metformin has exhibited anti-inflammatory and neuroprotective...

journal_title：Inflammopharmacology

authors： Bojja SL,Medhi B,Anand S,Bhatia A,Joshi R,Minz RW

更新日期：2021-01-01 00:00:00

abstract：:Stress is a reflex response, both psychological and physiological, of the body to a difficult situation that requires adaptation. Stress is at the intersection of the objective event and the subjective event. The physiological mechanisms involved in chronic stress are numerous and can contribute to a wide variety of d...

journal_title：Inflammopharmacology

authors： Nessaibia I,Fouache A,Lobaccaro JA,Tahraoui A,Trousson A,Souidi M

更新日期：2019-02-01 00:00:00

abstract：:Methyl gallate is a gallotannin widely distributed in nature. Previous studies have demonstrated its antioxidant, anti-inflammatory, antimicrobial and anti-tumor activities. In the present study, the activity of methyl gallate on experimental models of inflammatory bowel disease has been investigated. Experimental col...

journal_title：Inflammopharmacology

authors： Anzoise ML,Basso AR,Del Mauro JS,Carranza A,Ordieres GL,Gorzalczany S

更新日期：2018-06-01 00:00:00

abstract：:Propolis is a resinous substance collected by honeybees from leaf buds and cracks in the bark of various plants. Propolis has been reported to have immunomodulatory activity. We hypothesized that propolis would be able to reduce the disease severity of rheumatoid arthritis. We evaluated the effect of Brazilian propoli...

journal_title：Inflammopharmacology

authors： Tanaka M,Okamoto Y,Fukui T,Masuzawa T

更新日期：2012-02-01 00:00:00

abstract：:Neuropathic pain triggers a cascade of events in the sensory neurons. It is the main complication of diabetes after cardiovascular disease. Nitric oxide (NO) produced from nitric oxide synthases (NOS) is an important signaling molecule which is crucial for many physiological processes such as synaptic plasticity, neur...

journal_title：Inflammopharmacology

authors： Ahlawat A,Rana A,Goyal N,Sharma S

更新日期：2014-10-01 00:00:00

abstract：:Mitochondria can interchange morphology due to their dynamic nature. It can exist in either fragmented disconnected arrangement or elongated interconnected mitochondrial networks due to fission and fusion, respectively. The recent studies have revealed the remarkable and unexpected insights into the physiological impa...

journal_title：Inflammopharmacology

authors： Singh S,Sharma S

更新日期：2017-08-01 00:00:00

abstract：:The ulcerogenic effect of rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, on the gastrointestinal mucosa was investigated in the presence of a low dose of indomethacin. Indomethacin at 3 mg/kg did not cause any damage in both the stomach and small intestine, despite inhibiting prostaglandin (PG) production....

journal_title：Inflammopharmacology

authors： Yokota A,Taniguchi M,Tanaka A,Takeuchi K

更新日期：2005-01-01 00:00:00

abstract：:Prompted by the findings that smokers have lowered brain and blood platelet monoamine oxidase-A and -B activities compared to non-smokers and that smokers have a lowered incidence of Parkinson's disease, we have examined the neuroprotective properties of an MAO inhibitor, 2,3,6-trimethyl-1,4-naphthoquinone (TMN), whic...

journal_title：Inflammopharmacology

authors： Castagnoli K,Petzer JB,Steyn SJ,van der Schyf CJ,Castagnoli N Jr

更新日期：2003-01-01 00:00:00

abstract：:The inflamed mucosa in ulcerative colitis produces high amount of prostaglandin (PG) and nitric oxide (NO) through inducible enzymes: cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), respectively, implicating them as potential anti-inflammatory drug targets. COX-2 or iNOS-related treatments in diff...

journal_title：Inflammopharmacology

authors： Dudhgaonkar SP,Tandan SK,Kumar D,Raviprakash V,Kataria M

更新日期：2007-10-01 00:00:00

abstract：:R-phenylpiracetam (R-PhP, (4R)-2-(4-phenyl-2-oxopyrrolidin-1-yl)acetamide) is an optical isomer of phenotropil, a clinically-used nootropic drug that improves physical condition and cognition. Recently, R-PhP was shown to bind to the dopamine transporter (DAT). Since growing evidence suggests that dysfunction of the d...

journal_title：Inflammopharmacology

authors： Zvejniece L,Zvejniece B,Videja M,Stelfa G,Vavers E,Grinberga S,Svalbe B,Dambrova M

更新日期：2020-10-01 00:00:00

abstract：AIM:Activation of sphingosine kinase (SK) is a key response to many inflammatory processes. The present studies test the hypothesis that an orally available SK inhibitor, ABC294640, would be effective in rodent models of Crohn's disease. METHODS:Trinitrobenzene sulfonic acid (TNBS) was administered rectally to mice an...

journal_title：Inflammopharmacology

authors： Maines LW,Fitzpatrick LR,Green CL,Zhuang Y,Smith CD

更新日期：2010-04-01 00:00:00

abstract：:2-(4-phenylquinoline-2-yl)phenol derivatives (4a-l) with COX-2 enzyme inhibition, analgesic, anti-inflammatory and antipyretic potentials were executed and reported. From the in vitro COX-2 enzyme inhibition assay, compounds 4 h (IC50 0.026 µM) and 4j (IC50 0.102 µM) were found as most potent COX-2 inhibitors. Consequ...

journal_title：Inflammopharmacology

authors： Manikandan A,Ravichandran S,Sathiyanarayanan KI,Sivakumar A

更新日期：2017-12-01 00:00:00

abstract：:Excess eicosanoid formation during inflammation has been attributed to the expression of the gene coding for the inducible isoform of prostaglandin G/H synthase (PGHS-2). Human and murine PGHS-2 proteins differ in 73 out of the 604 amino acids. When comparing the inhibitory effects of a panel of PGHS-inhibitors in a w...

journal_title：Inflammopharmacology

authors： Berg J,Fellier H,Bodenteich A,Christoph T,Towart R

更新日期：1997-01-01 00:00:00

abstract：INTRODUCTION:Retinoic Acid Related Orphan Nuclear Receptor gamma T (RORγT) is a lineage specifying transcription factor for IL-17 expressing cells, which may contribute to the pathogenesis of Inflammatory Bowel Disease (IBD). VPR-254 is a selective in vitro inhibitor of RORγT. AIMS:The main goals of our study were two...

journal_title：Inflammopharmacology

authors： Fitzpatrick LR,Small J,O'Connell R,Talbott G,Alton G,Zapf J

更新日期：2020-04-01 00:00:00

abstract：:Helicobacter pylori infection, as well as NSAIDs induce oxidative stress on gastric mucosa, thereby causing mucosal damage and retarding mucosal repair. Cells can survive against chronic oxidative stress by enhancing activities of anti-oxidant enzymes, thereby protecting cells from DNA damage. Recent studies have clea...

journal_title：Inflammopharmacology

authors： Yanaka A,Zhang S,Tauchi M,Suzuki H,Shibahara T,Matsui H,Nakahara A,Tanaka N,Yamamoto M

更新日期：2005-01-01 00:00:00

abstract：:Pioglitazone, a specific ligand for peroxisome proliferator-activated receptor gamma (PPAR-gamma), was recently implicated in the control of inflammatory processes and in the modulation of the expression of various cytokines such as tumor necrosis factor alpha (TNF-alpha), but its role in the mechanism of gastric muco...

journal_title：Inflammopharmacology

authors： Brzozowski T,Konturek PC,Pajdo R,Kwiecień SN,Konturek S,Targosz A,Burnat G,Cieszkowski J,Pawlik WW,Hahn EG

更新日期：2005-01-01 00:00:00

abstract：:- The use of the non-steroidal anti-inflammatory drug, diclofenac, is associated with occasional serious side effects in the gastrointestinal (GI) tract. We examined the effect of altering the site of release of diclofenac sodium on GI tract side effects. Dissolution and pharmacokinetic studies were carried out to sub...

journal_title：Inflammopharmacology

authors： Khazaeinia T,Jamali F

更新日期：2004-01-01 00:00:00

abstract：:A series of quinazoline clubbed 1,3,5-triazine derivatives (QCT) were synthesized and evaluated for their in vitro anticancer activity against HeLa (human cervical cancer), MCF-7 (human breast cancer cell), HL-60 (human promyelocytic leukemia cell), HepG2 (human Hepatocellular carcinoma cell), and one normal cell line...

journal_title：Inflammopharmacology

authors： Pathak P,Shukla PK,Kumar V,Kumar A,Verma A

更新日期：2018-12-01 00:00:00

abstract：:A new compound derivative of glycoside 19-α-hydroxy-ursolic acid glucoside (19-α-hydroxyurs-12(13)-ene-28-oic acid-3-O-β-D-glucopyranoside (HEG) was isolated from whole plant of Wedelia calendulacea (Compositae). The structure was elucidated and established by standard spectroscopy approaches. Diethylnitrosamine (DEN)...

journal_title：Inflammopharmacology

authors： Verma A,Ahmed B,Anwar F,Rahman M,Patel DK,Kaithwas G,Rani R,Bhatt PC,Kumar V

更新日期：2017-02-01 00:00:00

abstract：:Acute lung injury (ALI) and acute kidney injury (AKI) are major causes of sepsis-induced mortality. The objective of the study is to evaluate the effect of tocilizumab (TCZ), an IL-6 receptor inhibitor, in sepsis-induced ALI and AKI using the cecal ligation and puncture (CLP) rat model of sepsis. Clinical and experime...

journal_title：Inflammopharmacology

authors： Ibrahim YF,Moussa RA,Bayoumi AMA,Ahmed AF

更新日期：2020-02-01 00:00:00

abstract：:Most of the gastroprotective drugs which had been marketed in Japan were considered to have insufficient rationale for use as ulcer treatments. Such drugs may have a crucial role in maintaining mucosal integrity by the mechanisms other than inhibition of acid secretion. We re-evaluated the effect of gastroprotective d...

journal_title：Inflammopharmacology

authors： Higuchi K,Watanabe T,Tanigawa T,Shiba M,Tominaga K,Fujiwara Y,Oshitani N,Arakawa T

更新日期：2007-02-01 00:00:00

abstract：OBJECTIVE:To study the effect of hyaluronan on cell adhesion and recruitment both in vitro and in vivo, since hyaluronan both inhibits restenosis and is anti-inflammatory. When administered to animals undergoing angioplasty the recruitment of cells into the restenotic plaque is inhibited, as well as into inflammatory l...

journal_title：Inflammopharmacology

authors： Alam CA,Seed MP,Freemantle C,Brown J,Perretti M,Carrier M,Divwedi A,West DC,Gustafson S,Colville-Nash PR,Willoughby DA

更新日期：2005-01-01 00:00:00

abstract：:Pain is recognized as a multifactorial sensory experience that is wholly unpleasant. It can vary in intensity from mild to severe and its duration can be anything from transient to persistent. Today we know so much more about the peripheral nociceptor as the primary detection apparatus for painful stimuli. We also und...

journal_title：Inflammopharmacology

authors： Rodger IW

更新日期：2009-06-01 00:00:00