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Development of intestinal, but not gastric damage caused by a low dose of indomethacin in the presence of rofecoxib.

Abstract：

:The ulcerogenic effect of rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, on the gastrointestinal mucosa was investigated in the presence of a low dose of indomethacin. Indomethacin at 3 mg/kg did not cause any damage in both the stomach and small intestine, despite inhibiting prostaglandin (PG) production. Rofecoxib had no effect on PG production and did not cause any damage in these tissues. In the presence of indomethacin, however, rofecoxib provoked damage in the small intestine but not the stomach. Indomethacin at 3 mg/kg induced hypermotility and COX-2 expression in the intestine but not in the stomach, both in an atropine-sensitive manner. These results suggest that a low dose of indomethacin produces damage in the small intestine but not in the stomach when administered together with rofecoxib. The PG deficiency caused by a low dose of indomethacin produces hypermotility and COX-2 expression in the small intestine, and results in damage when COX-2 is inhibited. It is assumed that the hypermotility response is a key event in the expression of COX-2 and thereby important in the development of mucosal damage in the gastrointestinal tract.

journal_name

Inflammopharmacology

journal_title

Inflammopharmacology

authors

Yokota A,Taniguchi M,Tanaka A,Takeuchi K

doi

10.1163/156856005774423755

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

209-16

issue

1-3

eissn

0925-4692

issn

1568-5608

journal_volume

13

pub_type

杂志文章

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