当前位置： SCI文献检索 > INFLAMMOPHARMACOLOGY期刊下所有文献 > Niflumic acid, a TRPV1 channel modulator, ameliorates stavudine-induced neuropathic pain.

Niflumic acid, a TRPV1 channel modulator, ameliorates stavudine-induced neuropathic pain.

Abstract：

:TRP channels have been discovered as a specialized group of somatosensory neurons involved in the detection of noxious stimuli. Desensitization of TRPV1 located on dorsal root and trigeminal ganglia exhibits analgesic effect and makes it potential therapeutic target for treatment of neuropathic pain. With this background, the present study was aimed to investigate the protective effect of niflumic acid, a TRPV1 modulator, on stavudine (STV)-induced neuropathic pain in rats. Stavudine (50 mg/kg) was administered intravenously via tail vein in rats to induce neuropathic pain. Various behavioral tests were performed to access neuropathic pain (hyperalgesia and allodynia) on 7th, 14th, 21st, and 28th days. Electrophysiology (motor nerve conduction velocity; MNCV) and biochemical estimations were conducted after 28th day. Niflumic acid (10, 15, and 20 mg/kg) was administered intraperitoneally and evaluated against behavioral, electrophysiological (MNCV), and biochemical alterations in stavudine-treated rats. Pregabalin (30 mg/kg) was taken as reference standard and administered intraperitoneally. Four weeks after stavudine injection, rats developed behavioral, electrophysiological (MNCV), and biochemical (oxidative, nitrosative stress, and inflammatory cytokines, TRPV1) alterations. Niflumic acid restored core and associated symptoms of peripheral neuropathy by suppressing oxidative-nitrosative stress, inflammatory cytokines (TNF-α, IL-1β) and TRPV1 level in stavudine-induced neuropathic pain in rats. Pharmacological efficacy of niflumic acid (20 mg/kg) was equivalent to pregabalin (30 mg/kg). In conclusion, niflumic acid attenuates STV-induced behavioral, electrophysiological and biochemical alterations by manipulating TRP channel activity in two manners: (1) direct antagonistic action against TRPV1 channels and (2) indirect inhibition of TRP channels by blocking oxidative and inflammatory surge. Therefore, NA can be developed as a potential pharmacotherapeutic adjunct for antiretroviral drug-induced neuropathy.

journal_name

Inflammopharmacology

journal_title

Inflammopharmacology

authors

Marwaha L,Bansal Y,Singh R,Saroj P,Sodhi RK,Kuhad A

doi

10.1007/s10787-016-0285-0

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

319-334

issue

6

eissn

0925-4692

issn

1568-5608

pii

10.1007/s10787-016-0285-0

journal_volume

24

pub_type

杂志文章

相关文献

INFLAMMOPHARMACOLOGY文献大全
  • Analgesic and anti-inflammatory effect of aqueous extract of the stem bark of Allanblackia gabonensis (Guttiferae).

    abstract：:Allanblackia gabonensis (Guttiferae) is a plant used in the African traditional medicine as remedies against pain, rheumatism, inflammations. In the present work, the analgesic effect of aqueous extract has been evaluated using acetic acid, formalin, hot-plate test, tail immersion and paw-pressure test. The anti-infla...

    journal_title：Inflammopharmacology

    pub_type： 杂志文章

    doi：10.1007/s10787-011-0096-2

    authors： Ymele EV,Dongmo AB,Dimo T

    更新日期：2013-02-01 00:00:00

  • Potential usefulness of methyl gallate in the treatment of experimental colitis.

    abstract：:Methyl gallate is a gallotannin widely distributed in nature. Previous studies have demonstrated its antioxidant, anti-inflammatory, antimicrobial and anti-tumor activities. In the present study, the activity of methyl gallate on experimental models of inflammatory bowel disease has been investigated. Experimental col...

    journal_title：Inflammopharmacology

    pub_type： 杂志文章

    doi：10.1007/s10787-017-0412-6

    authors： Anzoise ML,Basso AR,Del Mauro JS,Carranza A,Ordieres GL,Gorzalczany S

    更新日期：2018-06-01 00:00:00

  • Management of Gout-associated MSU crystals-induced NLRP3 inflammasome activation by procyanidin B2: targeting IL-1β and Cathepsin B in macrophages.

    abstract：:Gout, the most prevalent inflammatory arthritis worldwide, released interleukin-1β (IL-1β) and Cathepsin B inflammatory mediators that constitute the hallmark of the disease. Herein we aimed to investigate whether procyanidin B2 (PCB2), a natural dietary compound, can suppress MSU crystals-stimulated gouty inflammatio...

    journal_title：Inflammopharmacology

    pub_type： 杂志文章

    doi：10.1007/s10787-020-00758-8

    authors： Qiao CY,Li Y,Shang Y,Jiang M,Liu J,Zhan ZY,Ye H,Lin YC,Jiao JY,Sun RH,Zhang ZH,Piao MH,Wu YL,Nan JX,Lian LH

    更新日期：2020-12-01 00:00:00

  • A review of the pharmacobiotic regulation of gastrointestinal inflammation by probiotics, commensal bacteria and prebiotics.

    abstract：:The idea that microbes induce disease has steered medical research toward the discovery of antibacterial products for the prevention and treatment of microbial infections. The twentieth century saw increasing dependency on antimicrobials as mainline therapy accentuating the notion that bacterial interactions with huma...

    journal_title：Inflammopharmacology

    pub_type： 杂志文章,评审

    doi：10.1007/s10787-012-0126-8

    authors： Vitetta L,Briskey D,Hayes E,Shing C,Peake J

    更新日期：2012-10-01 00:00:00

  • Oral administration of Centella asiatica (L.) Urb leave aqueous extract ameliorates cerebral oxidative stress, inflammation, and apoptosis in male rats with type-2 diabetes.

    abstract：:Centella asiatica is claimed to have a neuroprotective effect; however, its ability to protect the cerebrum against damage in diabetes has never been identified. The aims were to identify the possibility that C. asiatica ameliorates inflammation, oxidative stress, and apoptosis in the cerebrum in diabetes. C. asiatica...

    journal_title：Inflammopharmacology

    pub_type： 杂志文章

    doi：10.1007/s10787-020-00733-3

    authors： Giribabu N,Karim K,Kilari EK,Nelli SR,Salleh N

    更新日期：2020-12-01 00:00:00

  • Simvastatin ameliorates experimental autoimmune encephalomyelitis by inhibiting Th1/Th17 response and cellular infiltration.

    abstract：AIM:Experimental autoimmune encephalomyelitis (EAE) is a CD4(+)-mediated autoimmune pathology of the central nervous system (CNS) that is used as a model for the study of the human neuroinflammatory disease, multiple sclerosis. During the development of EAE, auto-reactive Th1 and Th17 CD4(+) T cells infiltrate the CNS ...

    journal_title：Inflammopharmacology

    pub_type： 杂志文章

    doi：10.1007/s10787-015-0252-1

    authors： de Oliveira DM,de Oliveira EM,Ferrari Mde F,Semedo P,Hiyane MI,Cenedeze MA,Pacheco-Silva A,Câmara NO,Peron JP

    更新日期：2015-12-01 00:00:00

  • Effects of repetitive deformation on intestinal epithelial cells.

    abstract：:The intestinal mucosa is subject to a variety of physical forces in a complex manner during normal gut function and in disease. Intestinal mucosal atrophy during some disease states is a troubling phenomenon that is only partially explained by nutritional parameters. Increasing evidence suggests the possibility that r...

    journal_title：Inflammopharmacology

    pub_type： 杂志文章,评审

    doi：10.1007/s10787-007-1562-8

    authors： Basson MD

    更新日期：2007-06-01 00:00:00

  • Dual modulation of the tension of isolated gastric artery and gastric mucosal circulation by hydrogen sulfide in rats.

    abstract：:To clarify roles of H2S in regulation of gastric circulation, we investigated effects of NaHS, a H2S donor, on tension of isolated rat gastric artery and gastric mucosal blood flow in rats. In the precontracted ring preparations, NaHS caused contraction and relaxation at low and high concentrations, respectively. The ...

    journal_title：Inflammopharmacology

    pub_type： 杂志文章

    doi：10.1007/s10787-007-1590-4

    authors： Kubo S,Kajiwara M,Kawabata A

    更新日期：2007-12-01 00:00:00

  • Dynamin-related protein-1 as potential therapeutic target in various diseases.

    abstract：:Mitochondria can interchange morphology due to their dynamic nature. It can exist in either fragmented disconnected arrangement or elongated interconnected mitochondrial networks due to fission and fusion, respectively. The recent studies have revealed the remarkable and unexpected insights into the physiological impa...

    journal_title：Inflammopharmacology

    pub_type： 杂志文章,评审

    doi：10.1007/s10787-017-0347-y

    authors： Singh S,Sharma S

    更新日期：2017-08-01 00:00:00

  • Pharmacological and toxicological evaluations of the new pyrazole compound (LQFM-021) as potential analgesic and anti-inflammatory agents.

    abstract：:Chronic inflammation is a world health problem. There is a need to develop new anti-inflammatory and analgesic drugs with improved activity and reduced side effects. In this context, the aim of this study was to evaluate the antinociceptive and anti-inflammatory effects of the pyrazole compound LQFM-021 after acute an...

    journal_title：Inflammopharmacology

    pub_type： 杂志文章

    doi：10.1007/s10787-016-0282-3

    authors： Florentino IF,da Silva DP,Martins JL,da Silva TS,Santos FC,Tonussi CR,Vasconcelos GA,Vaz BG,Lião LM,Menegatti R,Costa EA

    更新日期：2016-10-01 00:00:00

  • Phytoestrogens and breast cancer: a complex story.

    abstract：:Genistein is an isoflavone with oestrogenic activity that is present in a variety of soy products as a constituent of complex mixtures of bioactive compounds, whose matrix profiles play an important role in determining the overall oestrogenic bioactivity of genistein. We review data on how the profile of soy bioactive...

    journal_title：Inflammopharmacology

    pub_type： 杂志文章,评审

    doi：10.1007/s10787-008-8020-0

    authors： Helferich WG,Andrade JE,Hoagland MS

    更新日期：2008-10-01 00:00:00

  • A randomised, double-blind, placebo-controlled trial of a multi-strain probiotic in patients with asymptomatic ulcerative colitis and Crohn's disease.

    abstract：BACKGROUND:There is considerable interest in the possible importance of the gut microflora in the pathophysiology of the inflammatory bowel diseases (IBD) ulcerative colitis (UC) and Crohn's disease (CD). Probiotics offer a potential adjuvant treatment in these patients by modifying the intestinal milieu, but reports o...

    journal_title：Inflammopharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s10787-019-00595-4

    authors： Bjarnason I,Sission G,Hayee B

    更新日期：2019-06-01 00:00:00

  • Diclofenac increases the accumulation of kynurenate following tryptophan pretreatment in the rat: a possible factor contributing to its antihyperalgesic effect.

    abstract：:Kynurenate, a metabolite of tryptophan formed serially from kynurenine, inhibits N-methyl-D-aspartate (NMDA) receptor responses. Non-steroidal anti-inflammatory drugs (NSAIDs) may produce anti-hyperalgesic effects by altering tryptophan metabolism to increase kynurenate concentrations. We examined whether the NSAID di...

    journal_title：Inflammopharmacology

    pub_type： 杂志文章

    doi：10.1163/156856003322315622

    authors： Edwards SR,Mather LE

    更新日期：2003-01-01 00:00:00

  • Triptolide prevents osteoarthritis via inhibiting hsa-miR-20b.

    abstract：:Triptolide has been widely reported to exhibit potential therapeutic value in multiple inflammatory diseases, such as rheumatoid arthritis, systemic lupus erythematosus, and psoriasis. Although its safety and efficacy as an anti-inflammatory agent have been verified by many studies, the effect of triptolide on osteoar...

    journal_title：Inflammopharmacology

    pub_type： 杂志文章

    doi：10.1007/s10787-018-0509-6

    authors： Qian K,Zhang L,Shi K

    更新日期：2019-02-01 00:00:00

  • Prunus cerasoides fruit extract ameliorates inflammatory stress by modulation of iNOS pathway and Th1/Th2 immune homeostasis in activated murine macrophages and lymphocytes.

    abstract：:The present investigation assessed the potential of Prunus cerasoides fruit extract (PCFE) in alleviation of inflammatory stress in response to lipopolysaccharide (LPS) and interferon-γ (IFN-γ)-stimulated murine peritoneal macrophages as well as in concanavalin A (Con A)-activated splenic lymphocytes. We observed a st...

    journal_title：Inflammopharmacology

    pub_type： 杂志文章

    doi：10.1007/s10787-018-0448-2

    authors： Sharma A,Joshi R,Kumar S,Sharma R,Rajneesh,Padwad Y,Gupta M

    更新日期：2018-12-01 00:00:00

  • Cicatrizing and antimicrobial properties of an ozonised oil from sunflower seeds.

    abstract：:The ozonised sunflower oil, Bioperoxoil, was tested for its antimicrobial activity against some pathological strains in vitro together with its healing potential against Staphylococcus aureus in vivo. Bioperoxoil was tested against S. aureus, Pseudomonas aeroginosa, Candida albicans, S. typhimurium and Escherichia col...

    journal_title：Inflammopharmacology

    pub_type： 杂志文章

    doi：10.1163/1568560042342275

    authors： Rodrigues KL,Cardoso CC,Caputo LR,Carvalho JC,Fiorini JE,Schneedorf JM

    更新日期：2004-01-01 00:00:00

  • Anti-inflammatory glucocorticoid drugs: reflections after 60 years.

    abstract：:This review considers the problem of the serious concomitant side effects of powerful anti-inflammatory drugs modelled upon the principal human glucocorticoid hormone, cortisol. The very nature of the original bio-assays to validate their cortisol-like hormonal and anti-inflammatory activities ensured that pleiotropic...

    journal_title：Inflammopharmacology

    pub_type： 杂志文章,评审

    doi：10.1007/s10787-010-0056-2

    authors： Whitehouse MW

    更新日期：2011-02-01 00:00:00

  • Flavonoids from Rhynchosia minima root exerts anti-inflammatory activity in lipopolysaccharide-stimulated RAW 264.7 cells via MAPK/NF-κB signaling pathway.

    abstract：:Rhynchosia minima root, a folk herbal medicine in southern China, is used to relieve itch and swelling. In this study, we examined the anti-inflammatory property of an ethanol fraction (EEF6) from R. minima root on lipopolysaccharide (LPS)-induced RAW 264.7 cells, as well as its underlying mechanism. The compound comp...

    journal_title：Inflammopharmacology

    pub_type： 杂志文章

    doi：10.1007/s10787-019-00632-2

    authors： Jia X,Zhang C,Bao J,Wang K,Tu Y,Wan JB,He C

    更新日期：2020-02-01 00:00:00

  • Effect of diclofenac and antidepressants on the inflammatory response in astrocyte cell culture.

    abstract：:Central nervous system (CNS) has a completely separate immune system that communicates with the neurons by small molecules called cytokines. Cytokines are involved in many crucial processes in neuron including cell metabolism and neurotransmitter synthesis. It has been reported that cytokine imbalance is involved in t...

    journal_title：Inflammopharmacology

    pub_type： 杂志文章

    doi：10.1007/s10787-013-0181-9

    authors： Al-Amin MM,Uddin MM,Rahman MM,Reza HM,Rana MS

    更新日期：2013-12-01 00:00:00

  • Metformin ameliorates the status epilepticus- induced hippocampal pathology through possible mTOR modulation.

    abstract：:The initial precipitating injury such as SE progresses to chronic epilepsy through multiple epileptogenic processes. Early epileptogenic events are generally characterized by neuroinflammation, neurodegeneration and abnormal neurogenesis in the hippocampus. Metformin has exhibited anti-inflammatory and neuroprotective...

    journal_title：Inflammopharmacology

    pub_type： 杂志文章

    doi：10.1007/s10787-020-00782-8

    authors： Bojja SL,Medhi B,Anand S,Bhatia A,Joshi R,Minz RW

    更新日期：2021-01-01 00:00:00

  • An analysis from clinico-epidemiological data of the principal adverse events from the COX-2 selective NSAID, nimesulide, with particular reference to hepatic injury.

    abstract：:The safety of the cyclo-oxygenase-2 (COX-2) selective NSAID, nimesulide, has been evaluated from information (a) in clinical trials in osteoarthritis that have been performed in Europe as well as in earlier pilot studies that were performed in patients with rheumatoid arthritis in the USA, and (b) in post-marketing st...

    journal_title：Inflammopharmacology

    pub_type： 杂志文章

    doi：10.1007/s10787-998-0020-6

    authors： Rainsford KD

    更新日期：1998-01-01 00:00:00

  • Immunomodulatory properties of captopril, an ACE inhibitor, on LPS-induced lung inflammation and fibrosis as well as oxidative stress.

    abstract：BACKGROUND:The role of angiotensin converting enzyme inhibitors on the inflammation process has been demonstrated previously. In the present study, the effects of captopril on lung injury induced by lipopolysaccharide (LPS) were investigated. METHODS:Control, LPS, 12.5, 25 and 50 mg/kg captopril-treated before LPS adm...

    journal_title：Inflammopharmacology

    pub_type： 杂志文章

    doi：10.1007/s10787-018-0535-4

    authors： Boskabadi J,Askari VR,Hosseini M,Boskabady MH

    更新日期：2019-06-01 00:00:00

  • The advances of methotrexate resistance in rheumatoid arthritis.

    abstract：:Rheumatoid arthritis (RA) is a systemic autoimmune disease, which is characterized by a chronic fluctuating course and immune dysfunction, resulting in affecting the health and life quality of RA patients. Methotrexate (MTX), as the standard gold treatment of RA, has received more and more clinical applications and ba...

    journal_title：Inflammopharmacology

    pub_type： 杂志文章,评审

    doi：10.1007/s10787-020-00741-3

    authors： Yu J,Zhou P

    更新日期：2020-10-01 00:00:00

  • Correction to: Oral prednisolone versus non-steroidal anti-inflammatory drugs in the treatment of acute gout: a meta-analysis of randomized controlled trials.

    abstract：:The authors would like to inform you that Jie Yu and Haimei Lu contributed equally to this study and should be considered as co-first authors. ...

    journal_title：Inflammopharmacology

    pub_type： 杂志文章,已发布勘误

    doi：10.1007/s10787-018-0518-5

    authors： Yu J,Lu H,Zhou J,Xie Z,Wen C,Xu Z

    更新日期：2019-02-01 00:00:00

  • Potential of Azadirachta indica against Salmonella typhimurium-induced inflammation in BALB/c mice.

    abstract：OBJECTIVE:To evaluate the potential of Azadirachta indica leaf extracts against Salmonella typhimurium-induced inflammation in BALB/c mice. DESIGN:Qualitative tests of A. indica leaf extracts were conducted for screening of various phytochemicals. The antiinflammatory potential of A. indica leaf extracts on S. typhimu...

    journal_title：Inflammopharmacology

    pub_type： 杂志文章

    doi：10.1007/s10787-008-8032-9

    authors： Koul A,Bharrhan S,Singh B,Rishi P

    更新日期：2009-02-01 00:00:00

  • VPR-254: an inhibitor of ROR-gamma T with potential utility for the treatment of inflammatory bowel disease.

    abstract：INTRODUCTION:Retinoic Acid Related Orphan Nuclear Receptor gamma T (RORγT) is a lineage specifying transcription factor for IL-17 expressing cells, which may contribute to the pathogenesis of Inflammatory Bowel Disease (IBD). VPR-254 is a selective in vitro inhibitor of RORγT. AIMS:The main goals of our study were two...

    journal_title：Inflammopharmacology

    pub_type： 杂志文章

    doi：10.1007/s10787-019-00643-z

    authors： Fitzpatrick LR,Small J,O'Connell R,Talbott G,Alton G,Zapf J

    更新日期：2020-04-01 00:00:00

  • Resveratrol ameliorates gouty inflammation via upregulation of sirtuin 1 to promote autophagy in gout patients.

    abstract：BACKGROUND:Resveratrol exerts an anti-inflammatory effect on collagen-induced arthritis and osteoarthritis in rats via activation of sirtuin 1 (SIRT1). Autophagy can be induced by resveratrol and leads to amelioration of interleukin-1 beta (IL-1β) release in vitro. We aimed to determine the anti-inflammatory mechanisms...

    journal_title：Inflammopharmacology

    pub_type： 杂志文章

    doi：10.1007/s10787-018-00555-4

    authors： Yang QB,He YL,Zhong XW,Xie WG,Zhou JG

    更新日期：2019-02-01 00:00:00

  • Tocilizumab attenuates acute lung and kidney injuries and improves survival in a rat model of sepsis via down-regulation of NF-κB/JNK: a possible role of P-glycoprotein.

    abstract：:Acute lung injury (ALI) and acute kidney injury (AKI) are major causes of sepsis-induced mortality. The objective of the study is to evaluate the effect of tocilizumab (TCZ), an IL-6 receptor inhibitor, in sepsis-induced ALI and AKI using the cecal ligation and puncture (CLP) rat model of sepsis. Clinical and experime...

    journal_title：Inflammopharmacology

    pub_type： 杂志文章

    doi：10.1007/s10787-019-00628-y

    authors： Ibrahim YF,Moussa RA,Bayoumi AMA,Ahmed AF

    更新日期：2020-02-01 00:00:00

  • Effects of indomethacin, with vitamin A or beta-carotene, on the rat gastric mucosa: extra-and intracellular membrane-bound ATP mechanisms.

    abstract：BACKGROUND:Indomethacin (IND) is a widely used non-steroidal anti-inflammatory agent in the treatment of various inflammatory disorders, which causes gastrointestinal injury in humans and animal experiments. Vitamin A and beta-carotene prevent the IND-induced gastric mucosal injury. These compounds modify the membrane-...

    journal_title：Inflammopharmacology

    pub_type： 杂志文章

    doi：10.1007/s10787-999-0012-1

    authors： Mózsik G,Rumi G,Bódis B,Figler M,Király A,Sütõ G,Vincze A

    更新日期：1999-01-01 00:00:00

  • Aberrant up-regulation of iNOS/NO system is correlated with an increased abundance of Foxp3+ cells and reduced effector/memory cell markers expression during colorectal cancer: immunomodulatory effects of cetuximab combined with chemotherapy.

    abstract：:Colorectal cancer (CRC) remains the most cancer type related to chronic inflammation; however, the mechanisms that link inflammation to CRC development and progression are still poorly understood. Our study aimed to investigate one of the prominent inflammatory response in cancers, iNOS/NO system. In this regard, we e...

    journal_title：Inflammopharmacology

    pub_type： 杂志文章

    doi：10.1007/s10787-019-00566-9

    authors： Benkhelifa S,Rafa H,Belhadef S,Ait-Kaci H,Medjeber O,Belkhelfa M,Hetit S,Ait-Younes S,De Launoit Y,Moralès O,Mahfouf H,Delhem N,Touil-Boukoffa C

    更新日期：2019-08-01 00:00:00