Abstract:
:To clarify roles of H2S in regulation of gastric circulation, we investigated effects of NaHS, a H2S donor, on tension of isolated rat gastric artery and gastric mucosal blood flow in rats. In the precontracted ring preparations, NaHS caused contraction and relaxation at low and high concentrations, respectively. The NaHS-induced vasorelaxation was only partially blocked by glibenclamide, a K+ (ATP) channel inhibitor. The contractile activity of NaHS disappeared by removal of the endothelium or by inhibition of nitric oxide synthase and the endothelium-derived hyperpolarizing factor (EDHF) pathways. Intravenous injection of NaHS caused transient increase followed by decrease in gastric mucosal blood flow in rats. Collectively, in the gastric artery, NaHS appears to cause relaxation through both K+ (ATP) channel-dependent and -independent pathways and contraction through inhibition of NO and EDHF pathways. Together with the in vivo results, our study implies that H2S plays multiple complex roles in regulation of gastric circulation.
journal_name
Inflammopharmacologyjournal_title
Inflammopharmacologyauthors
Kubo S,Kajiwara M,Kawabata Adoi
10.1007/s10787-007-1590-4subject
Has Abstractpub_date
2007-12-01 00:00:00pages
288-92issue
6eissn
0925-4692issn
1568-5608journal_volume
15pub_type
杂志文章abstract::Caffeic acid phenethyl ester (CAPE) is the active component of honey bee propolis extracts. The results of the current study demonstrate that CAPE attenuated immunoglobulin (Ig)E-mediated allergic response in mast cells. Oral administration of CAPE inhibited IgE-mediated passive cutaneous anaphylaxis. CAPE effectively...
journal_title:Inflammopharmacology
pub_type: 杂志文章
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journal_title:Inflammopharmacology
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journal_title:Inflammopharmacology
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doi:10.1007/s10787-015-0252-1
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journal_title:Inflammopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10787-019-00595-4
更新日期:2019-06-01 00:00:00
abstract::Inflammatory bowel diseases are associated with reduced colonic contractility and induction of cyclooxygenase-2. In this study a possible role of cyclooxygenase-2 in and the underlying mechanism of the reduced contractility were investigated in experimental colitis. The effects of meloxicam, a cyclooxygenase-2 selecti...
journal_title:Inflammopharmacology
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更新日期:2006-03-01 00:00:00
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journal_title:Inflammopharmacology
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doi:10.1007/s10787-999-0012-1
更新日期:1999-01-01 00:00:00
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journal_title:Inflammopharmacology
pub_type: 杂志文章
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journal_title:Inflammopharmacology
pub_type: 杂志文章,评审
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更新日期:2009-06-01 00:00:00
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journal_title:Inflammopharmacology
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更新日期:2020-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s10787-010-0032-x
更新日期:2010-04-01 00:00:00
abstract::In 1952 I re-joined the Pharmacological Division of the Research Department of the Boots Co. in Nottingham UK to work on rheumatoid arthritis (RA) but with the distinct disadvantage that the Division was housed in a group of rambling buildings attached to a Victorian house. The Division had moved there at the beginnin...
journal_title:Inflammopharmacology
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doi:10.1007/s10787-999-0002-3
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abstract::Nicotine mediates some of the injurious effects caused by consuming tobacco products. The aim of this work is to investigate the protective effects of Mentha spicata extract (ME) supplementation on the testis and brain of nicotine-induced oxidative damage rats. ME extract showed interesting hydrogen peroxide-scavengin...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-019-00650-0
更新日期:2020-08-01 00:00:00
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journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-013-0181-9
更新日期:2013-12-01 00:00:00
abstract::Prolonged stimulation of newborn mice by intraperitoneal injections with inactivated staphylococci induces a chronic neonatal inflammatory reaction and an associated oxidative-stress response. The chronically stimulated animals exhibit anorexy. show a reduction in their body weight and undergo a depression in both ant...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/BF02918381
更新日期:1999-01-01 00:00:00
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journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-998-0017-1
更新日期:1998-01-01 00:00:00
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journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-019-00681-7
更新日期:2020-04-01 00:00:00
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journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-018-0496-7
更新日期:2019-06-01 00:00:00
abstract::The safety of the cyclo-oxygenase-2 (COX-2) selective NSAID, nimesulide, has been evaluated from information (a) in clinical trials in osteoarthritis that have been performed in Europe as well as in earlier pilot studies that were performed in patients with rheumatoid arthritis in the USA, and (b) in post-marketing st...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-998-0020-6
更新日期:1998-01-01 00:00:00
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journal_title:Inflammopharmacology
pub_type: 杂志文章
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更新日期:1997-01-01 00:00:00
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journal_title:Inflammopharmacology
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更新日期:2012-02-01 00:00:00
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更新日期:2020-12-01 00:00:00
abstract::Propolis has been extensively used to improve health and prevent inflammatory diseases. Different types of Cuban propolis (red, brown and yellow) have been documented. The purpose of this research was to investigate the cytotoxic effects of Cuban red propolis (CP) on MDA MB-231 cell line, since breast cancer is consid...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-018-0492-y
更新日期:2019-10-01 00:00:00
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journal_title:Inflammopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s10787-008-8020-0
更新日期:2008-10-01 00:00:00
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journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-008-8045-4
更新日期:2009-04-01 00:00:00
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journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1163/156856005774423755
更新日期:2005-01-01 00:00:00
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journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-009-0027-7
更新日期:2010-04-01 00:00:00
abstract::A new compound derivative of glycoside 19-α-hydroxy-ursolic acid glucoside (19-α-hydroxyurs-12(13)-ene-28-oic acid-3-O-β-D-glucopyranoside (HEG) was isolated from whole plant of Wedelia calendulacea (Compositae). The structure was elucidated and established by standard spectroscopy approaches. Diethylnitrosamine (DEN)...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-017-0310-y
更新日期:2017-02-01 00:00:00
abstract::A methanol extract of the seeds of Adenanthera pavonina was evaluated for pharmacological effects in animal models. The extract (50-200 mg/kg) produced statistically significant (P < 0.05) inhibition of the carrageenan-induced paw oedema in the rat, as well as the acetic-acid-induced vascular permeability in mice. At ...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1163/1568560041352310
更新日期:2004-01-01 00:00:00
abstract::Mitochondria can interchange morphology due to their dynamic nature. It can exist in either fragmented disconnected arrangement or elongated interconnected mitochondrial networks due to fission and fusion, respectively. The recent studies have revealed the remarkable and unexpected insights into the physiological impa...
journal_title:Inflammopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s10787-017-0347-y
更新日期:2017-08-01 00:00:00