Abstract：
:Propolis is a resinous substance collected by honeybees from leaf buds and cracks in the bark of various plants. Propolis has been reported to have immunomodulatory activity. We hypothesized that propolis would be able to reduce the disease severity of rheumatoid arthritis. We evaluated the effect of Brazilian propolis ethanolic extract on the pathogenesis of collagen-induced arthritis (CIA) in mice. Mice fed propolis exhibited significant lower clinical arthritis scores than those fed the control diet. To investigate the mechanism of the effect of propolis on CIA mice, we examined interleukin-17 (IL-17) production in CIA mice fed propolis using an enzyme-linked immunospot assay and flow cytometric analysis. The numbers of IL-17-producing cells in the CIA mice fed propolis were significantly decreased. To determine direct influence of propolis on cytokine production, splenocytes were stimulated with phorbol myristate acetate in the presence of propolis extract in vitro. Concentration-dependent declines in IL-17 expression were observed by ELISA and real-time PCR methods. We further found that propolis significantly inhibited the differentiation of Th17 cells from murine splenocytes in a concentration-dependent manner. Taken together, our results may provide a new light on the potential mechanism of the immunosuppressive and anti-inflammatory effects of propolis.
journal_name
Inflammopharmacologyjournal_title
Inflammopharmacologyauthors
Tanaka M,Okamoto Y,Fukui T,Masuzawa Tdoi
10.1007/s10787-011-0088-2subject
Has Abstractpub_date
2012-02-01 00:00:00pages
19-26issue
1eissn
0925-4692issn
1568-5608journal_volume
20pub_type
杂志文章abstract：BACKGROUND:There is considerable interest in the possible importance of the gut microflora in the pathophysiology of the inflammatory bowel diseases (IBD) ulcerative colitis (UC) and Crohn's disease (CD). Probiotics offer a potential adjuvant treatment in these patients by modifying the intestinal milieu, but reports o...
journal_title：Inflammopharmacology
pub_type： 杂志文章,随机对照试验
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更新日期：2019-06-01 00:00:00
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pub_type： 杂志文章,评审
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abstract：:Since their development and licensing no class of drug has received as much attention both in the scientific and lay press as the cyclo-oxygenase 2 (COX-2) inhibitors. These compounds, also known as coxibs, were developed as a safer alternative to traditional non-steroidal anti-inflammatory drugs (NSAIDs) due to their...
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pub_type： 杂志文章,评审
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doi：10.1007/s10787-008-8032-9
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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更新日期：2011-02-01 00:00:00
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更新日期：2009-08-01 00:00:00
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更新日期：2019-12-01 00:00:00
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更新日期：2020-12-01 00:00:00
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更新日期：2020-12-01 00:00:00
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更新日期：2017-02-01 00:00:00
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更新日期：2007-12-01 00:00:00
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journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1163/1568560041352310
更新日期：2004-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s10787-018-0504-y
更新日期：2019-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-10-01 00:00:00
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pub_type： 杂志文章
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