Abstract：
:The aim of the study was to evaluate the effect of Pterocarpus marsupium (PM) on acetic acid (AA)-induced ulcerative colitis (UC) in rats. The rats were divided into five groups, each having six rats. PM extract 100 mg and 200 mg/kg was given orally to groups four and five, respectively, and standard drug sulfasalazine (100 mg/kg, p.o) to group three. Group two served as UC control animals, and group one control animals received vehicle for 7 days. UC was induced by administering AA (3 % v/v of 2 ml) to all the animals except group one. After 72 h, the animals were killed and the colon was dissected out for microscopic, clinical evaluation, histopathological study and biochemical estimation. PM (100 and 200 mg/kg)-treated group had significantly reduced colon inflammation and mucosal damage. The treatment also normalized the altered antioxidant enzyme levels (LPO, SOD and GSH). Histopathological studies support the effect. The protective effect of PM may be due to antiinflammatory and antioxidant properties.
journal_name
Inflammopharmacologyjournal_title
Inflammopharmacologyauthors
Mathew MM,Han NV,Murugesan A,Raj EA,Prasanth KGdoi
10.1007/s10787-015-0234-3subject
Has Abstractpub_date
2015-08-01 00:00:00pages
195-201issue
4eissn
0925-4692issn
1568-5608journal_volume
23pub_type
杂志文章abstract：:The side effects of NSAIDs are equally evident in the stomach and the small bowel. The latter is increasingly seen as being clinically significant, contributing substantially to the iron-deficiency anaemia that is so common in patients with rheumatoid arthritis. Furthermore, NSAID-enteropathy may be associated with li...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1163/156856003322699546
更新日期：2003-01-01 00:00:00
abstract：:The ulcerogenic effect of rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, on the gastrointestinal mucosa was investigated in the presence of a low dose of indomethacin. Indomethacin at 3 mg/kg did not cause any damage in both the stomach and small intestine, despite inhibiting prostaglandin (PG) production....
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1163/156856005774423755
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND:Hydroxychloroquine (HCQ) is a widely prescribed medication to patients with systemic lupus erythematosus (SLE), with potential anti-inflammatory effects. This study was performed to investigate the efficacy of HCQ therapy by serial assessment of disease activity and serum levels of proinflammatory cytokines ...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-018-0512-y
更新日期：2018-10-01 00:00:00
abstract：:This review considers the problem of the serious concomitant side effects of powerful anti-inflammatory drugs modelled upon the principal human glucocorticoid hormone, cortisol. The very nature of the original bio-assays to validate their cortisol-like hormonal and anti-inflammatory activities ensured that pleiotropic...
journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s10787-010-0056-2
更新日期：2011-02-01 00:00:00
abstract：:The ozonised sunflower oil, Bioperoxoil, was tested for its antimicrobial activity against some pathological strains in vitro together with its healing potential against Staphylococcus aureus in vivo. Bioperoxoil was tested against S. aureus, Pseudomonas aeroginosa, Candida albicans, S. typhimurium and Escherichia col...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1163/1568560042342275
更新日期：2004-01-01 00:00:00
abstract：:Silver and silver oxides are gaining interest in medical applications for their prominent antibacterial and antimicrobial potentials. Recent studies suggest that nanosilver oxide has remarkable anti-inflammatory effects and enhances wound healing. Nevertheless, its effect on gastric ulcer has not yet been illustrated....
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-017-0424-2
更新日期：2018-08-01 00:00:00
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journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s10787-007-1562-8
更新日期：2007-06-01 00:00:00
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journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-999-0002-3
更新日期：1999-01-01 00:00:00
abstract：:Euphorbia hirta L. (Euphorbiaceae) (E. hirta) is a tree locally used as a traditional medicine in Africa and Australia to treat numerous diseases such as hypertension, respiratory ailments, tumors, antipyretic, anti-inflammatory activities. In the present study, we investigated the anti-arthritic activity of fresh lea...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-012-0161-5
更新日期：2013-10-01 00:00:00
abstract：:The anti-inflammatory activity of the aqueous extract of Chromolaena odorata was investigated in rats using the carrageenan-induced oedema, cotton pellet granuloma and formalin-induced oedema methods. The extract was administered orally at doses of 25, 50, 100 and 200 mg/kg. In the carrageenan method the paw oedema wa...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1163/156856005774649386
更新日期：2005-01-01 00:00:00
abstract：:Chronic inflammation is a world health problem. There is a need to develop new anti-inflammatory and analgesic drugs with improved activity and reduced side effects. In this context, the aim of this study was to evaluate the antinociceptive and anti-inflammatory effects of the pyrazole compound LQFM-021 after acute an...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-016-0282-3
更新日期：2016-10-01 00:00:00
abstract：:A new compound derivative of glycoside 19-α-hydroxy-ursolic acid glucoside (19-α-hydroxyurs-12(13)-ene-28-oic acid-3-O-β-D-glucopyranoside (HEG) was isolated from whole plant of Wedelia calendulacea (Compositae). The structure was elucidated and established by standard spectroscopy approaches. Diethylnitrosamine (DEN)...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-017-0310-y
更新日期：2017-02-01 00:00:00
abstract：AIMS:To compare methodological aspects of the impact of different classification procedures used in three phases of a twin study examining genetic factors in the aetiopathogenesis of rheumatoid arthritis (RA). METHODS:We have previously reported the results of a study of the aetiopathogenesis of RA based on the Austra...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-998-0009-1
更新日期：1998-01-01 00:00:00
abstract：:There is a growing body of evidence that plant polyphenols such as resveratrol, anthocyanins, catechins, and terpenes like taxol are effectively used in the treatment of chronic conditions including cancer, Alzheimer, Parkinsonism, diabetes, aging, etc. The link between oxidative stress and inflammation is well accept...
journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s10787-015-0236-1
更新日期：2015-08-01 00:00:00
abstract：:Genistein is an isoflavone with oestrogenic activity that is present in a variety of soy products as a constituent of complex mixtures of bioactive compounds, whose matrix profiles play an important role in determining the overall oestrogenic bioactivity of genistein. We review data on how the profile of soy bioactive...
journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s10787-008-8020-0
更新日期：2008-10-01 00:00:00
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journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00566-9
更新日期：2019-08-01 00:00:00
abstract：:2-(4-phenylquinoline-2-yl)phenol derivatives (4a-l) with COX-2 enzyme inhibition, analgesic, anti-inflammatory and antipyretic potentials were executed and reported. From the in vitro COX-2 enzyme inhibition assay, compounds 4 h (IC50 0.026 µM) and 4j (IC50 0.102 µM) were found as most potent COX-2 inhibitors. Consequ...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-017-0342-3
更新日期：2017-12-01 00:00:00
abstract：:The present investigation assessed the potential of Prunus cerasoides fruit extract (PCFE) in alleviation of inflammatory stress in response to lipopolysaccharide (LPS) and interferon-γ (IFN-γ)-stimulated murine peritoneal macrophages as well as in concanavalin A (Con A)-activated splenic lymphocytes. We observed a st...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-018-0448-2
更新日期：2018-12-01 00:00:00
abstract：:Triptolide has been widely reported to exhibit potential therapeutic value in multiple inflammatory diseases, such as rheumatoid arthritis, systemic lupus erythematosus, and psoriasis. Although its safety and efficacy as an anti-inflammatory agent have been verified by many studies, the effect of triptolide on osteoar...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-018-0509-6
更新日期：2019-02-01 00:00:00
abstract：:Rheumatoid arthritis (RA) is a systemic autoimmune disease, which is characterized by a chronic fluctuating course and immune dysfunction, resulting in affecting the health and life quality of RA patients. Methotrexate (MTX), as the standard gold treatment of RA, has received more and more clinical applications and ba...
journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s10787-020-00741-3
更新日期：2020-10-01 00:00:00
abstract：:Inflammatory bowel diseases are associated with reduced colonic contractility and induction of cyclooxygenase-2. In this study a possible role of cyclooxygenase-2 in and the underlying mechanism of the reduced contractility were investigated in experimental colitis. The effects of meloxicam, a cyclooxygenase-2 selecti...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-006-1507-7
更新日期：2006-03-01 00:00:00
abstract：:Pioglitazone, a specific ligand for peroxisome proliferator-activated receptor gamma (PPAR-gamma), was recently implicated in the control of inflammatory processes and in the modulation of the expression of various cytokines such as tumor necrosis factor alpha (TNF-alpha), but its role in the mechanism of gastric muco...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1163/156856005774423908
更新日期：2005-01-01 00:00:00
abstract：:In the process of the oxygen reduction, NADPH oxidase is the enzyme that produces superoxide anion, which subsequently produces reactive oxygen species (ROS) and causes damage in various tissues and microorganisms. NADPH oxidase is demonstrated to exist in several types of cells such as endothelial cells and vascular ...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-007-1587-z
更新日期：2007-12-01 00:00:00
abstract：OBJECTIVE AND DESIGN:The objective of this study was to investigate the leucocyte-related antiinflammatory properties of rose hip. MATERIALS AND METHODS:The effect of rose hip on a number of inflammatory parameters was evaluated using the following models: (1) The effect of rose hip extract on chemotaxis and chemilumi...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-999-0031-y
更新日期：1999-01-01 00:00:00
abstract：:Helicobacter pylori infection, as well as NSAIDs induce oxidative stress on gastric mucosa, thereby causing mucosal damage and retarding mucosal repair. Cells can survive against chronic oxidative stress by enhancing activities of anti-oxidant enzymes, thereby protecting cells from DNA damage. Recent studies have clea...
journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1163/156856005774423863
更新日期：2005-01-01 00:00:00
abstract：:Euphorbia hirta L. (Euphorbiaceae) (E. hirta) is a tree locally used as a traditional medicine in Africa and Australia to treat numerous diseases such as hypertension, respiratory ailments, tumors, wounds, antipyretic, anti-inflammatory activities, etc. Therefore, we undertook to investigate their immunomodulatory eff...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-012-0144-6
更新日期：2013-04-01 00:00:00
abstract：:A methanol extract of the seeds of Adenanthera pavonina was evaluated for pharmacological effects in animal models. The extract (50-200 mg/kg) produced statistically significant (P < 0.05) inhibition of the carrageenan-induced paw oedema in the rat, as well as the acetic-acid-induced vascular permeability in mice. At ...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1163/1568560041352310
更新日期：2004-01-01 00:00:00
abstract：:Most of the gastroprotective drugs which had been marketed in Japan were considered to have insufficient rationale for use as ulcer treatments. Such drugs may have a crucial role in maintaining mucosal integrity by the mechanisms other than inhibition of acid secretion. We re-evaluated the effect of gastroprotective d...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-006-0300-y
更新日期：2007-02-01 00:00:00
abstract：BACKGROUND:Osthole is a bioactive component reported in medicinal plants such as Angelica pubescens and Cnidium monnieri, known for analgesic activity. However, the toxicity, median effective dose (ED50), and dual modulation of nitric oxide and cyclooxygenase pathways along with inflammatory cytokines of osthole are ye...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-018-0486-9
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:Resveratrol exerts an anti-inflammatory effect on collagen-induced arthritis and osteoarthritis in rats via activation of sirtuin 1 (SIRT1). Autophagy can be induced by resveratrol and leads to amelioration of interleukin-1 beta (IL-1β) release in vitro. We aimed to determine the anti-inflammatory mechanisms...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-018-00555-4
更新日期：2019-02-01 00:00:00
