Abstract:
AIM AND OBJECTIVE:6-hydroxy dopamine (6-OHDA) is a neurotoxin which on intranigral administration produces severe nigrostriatal damage with motor and cognitive deficit in animals. Curcumin (CMN) in combination with bioenhancer piperine (PP) in 6-hydroxydopamine-induced Parkinsonian rats was used to investigate the antioxidant, neuromodulatory and neuroprotective mechanisms. MATERIALS AND METHODS:Hemi-Parkinson's rat model was developed with intranigral infusion of 6-OHDA (8 μg/2 μl, once, unilaterally), treatment with CMN (25 and 50 mg/kg) and combination of PP (2.5 mg/kg) with CMN (25 mg/kg) was given daily for 21 days starting from the 7th day after 6-OHDA infusion. The behavioral (locomotor, grip strength, and narrow beam walk) parameters were studied on weekly basis. On 22nd day, isolated brain preparations were subjected to biochemical (lipid peroxidation, glutathione, and nitrite), neuroinflammatory (IL-1β, IL-6, and TNF- α), and neurochemical (DA, NE, 5- HT, GABA, Glutamate, DOPAC, HVA, and 5-HIAA) analysis. RESULTS:Oral administration of CMN had significantly prevented behavioral, neuroinflammatory, and neurochemical changes and preserved the antioxidant potential of the nigrostriatum in rats treated with 6-OHDA. CONCLUSION:In the present study, PP and CMN had afforded a better neuroprotective effect compared to alone treatment on behavior, biochemical, neuroinflammatory, and neurochemical parameters in rats.
journal_name
Inflammopharmacologyjournal_title
Inflammopharmacologyauthors
Singh S,Kumar Pdoi
10.1007/s10787-016-0297-9subject
Has Abstractpub_date
2017-02-01 00:00:00pages
69-79issue
1eissn
0925-4692issn
1568-5608pii
10.1007/s10787-016-0297-9journal_volume
25pub_type
杂志文章abstract::The ulcerogenic effect of rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, on the gastrointestinal mucosa was investigated in the presence of a low dose of indomethacin. Indomethacin at 3 mg/kg did not cause any damage in both the stomach and small intestine, despite inhibiting prostaglandin (PG) production....
journal_title:Inflammopharmacology
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pub_type: 杂志文章,已发布勘误
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journal_title:Inflammopharmacology
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journal_title:Inflammopharmacology
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journal_title:Inflammopharmacology
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journal_title:Inflammopharmacology
pub_type: 杂志文章,评审
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journal_title:Inflammopharmacology
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doi:10.1007/s10787-007-1587-z
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journal_title:Inflammopharmacology
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更新日期:2009-08-01 00:00:00
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journal_title:Inflammopharmacology
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journal_title:Inflammopharmacology
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journal_title:Inflammopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s10787-010-0056-2
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