Thyroid scintigraphy differentiates subtypes of congenital hypothyroidism.

Abstract:

INTRODUCTION:UK screening for congenital hypothyroidism (CH) is based on dried blood spot Thyroid Stimulating Hormone (TSH). Scintigraphy may identify CH subtypes classified as dysplasia, gland in situ (GIS) and ectopia, but is not performed in all centres. We retrospectively investigated the role of scintigraphy to identify CH subtypes in a single tertiary centre cohort. METHODS:Babies who screened positive for CH between 2007 and 2017 were studied (n=418 of 534 783). Scintigraphy outcomes were correlated with TSH and levothyroxine dose. GIS patients were analysed for 3-year outcomes. RESULTS:303 patients started levothyroxine. Scintigraphy demonstrated three subtypes: GIS (n=139, 46%) ectopia (n=84, 28%) and dysplasia (n=80, 26%). Three-year follow up demonstrated permanence in 54% of 37 GIS cases. DISCUSSION:Thyroid scintigraphy differentiates subtypes of CH and suggests a higher than expected proportion of patients with GIS and ectopia. CH is permanent in half of those with GIS.

journal_name

Arch Dis Child

authors

Worth C,Hird B,Tetlow L,Wright N,Patel L,Banerjee I

doi

10.1136/archdischild-2019-317665

subject

Has Abstract

pub_date

2021-01-01 00:00:00

pages

77-79

issue

1

eissn

0003-9888

issn

1468-2044

pii

archdischild-2019-317665

journal_volume

106

pub_type

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