Production of the hydroxylated metabolites of vitamin D in a neonate with a single hypoplastic-dysplastic kidney.

Abstract:

:The ability to produce dihydroxylated metabolites of vitamin D was studied in a term neonate suffering from severe renal insufficiency. The infant died at age 26 days owing to end-stage renal failure and the necropsy examination showed a single dysplastic kidney weighing 1.5 g. At age 2 weeks the serum levels of the dihydroxylated metabolites of vitamin D were found to be normal and a pronounced increase was noted 24 hours after injection of 100 000 IU vitamin D2. The study suggests that during the neonatal period a small renal mass is sufficient to maintain optimal circulating levels of the dihydroxylated metabolites of vitamin D.

journal_name

Arch Dis Child

authors

Alkalay A,Mogilner BM,Nissim F,Edelstein S

doi

10.1136/adc.58.1.66

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

66-8

issue

1

eissn

0003-9888

issn

1468-2044

journal_volume

58

pub_type

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