HCG stimulation test in children with abnormal sexual development.

Abstract:

:Plasma testosterone was estimated by radioimmunoassay in 60 children with disorders of sexual development before and after stimulation with human chorionic gonadotrophin (HCG). In 21 children the testosterone levels after 3 and 5 daily injections of 1000 units HCG were compared and good correlation was found between the paired results (r =0-93), suggesting that the 5-day HCG test has no advantage over the 3-day test. In 7 boys with apparently normal genital development the increments in plasma testosterone ranged from 2-0 to 8-5 nmol/1 after 3 injections of HCG. 10 boys with anorchia showed little response to HCG stimulation, but in patients with other disorders, such as micropenis (10), cryptorchidism (8), hermaphroditism (3), male pseudohermaphroditism (13), hypospadias (3), and sex chromosome anomalies (6), there was considerable variation in the plasma testosterone level after HCG. In 2 boys with suspected anorchia the results suggested that testes were present and this was confirmed at operation.

journal_name

Arch Dis Child

authors

Grant DB,Laurance BM,Atherden SM,Ryness J

doi

10.1136/adc.51.8.596

subject

Has Abstract

pub_date

1976-08-01 00:00:00

pages

596-601

issue

8

eissn

0003-9888

issn

1468-2044

journal_volume

51

pub_type

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