Abstract:
:To test whether early treatment could postpone the chronic colonisation of the respiratory tract with mucoid strains of Pseudomonas aeruginosa in patients with cystic fibrosis, we performed a pilot study in 28 patients aged 2 to 18 years. A two week course of azlocillin (150 mg/kg/day) and tobramycin (10 to 15 mg/kg/day) was given after a mean duration of P aeruginosa colonisation of five months (range one to 11 months). Weight for height increased significantly by 3.5% (SEM 0.7%) of the predicted normal after chemotherapy. The eradication of P aeruginosa that was achieved in 18 children directly after hospital treatment was only temporary. Samples from only 10 and five patients remained negative three and six months after treatment, respectively. Five children remained free from P aeruginosa for a prolonged period of 14 to 32 months. We conclude that, apart from the clinical improvement in all patients, some children might benefit from early antipseudomonas treatment with respect to the bacteriological outcome. Most children, however, experience only a temporary reduction in colonisation. Further investigations in form of controlled clinical trials seem justified.
journal_name
Arch Dis Childjournal_title
Archives of disease in childhoodauthors
Steinkamp G,Tümmler B,Malottke R,von der Hardt Hdoi
10.1136/adc.64.7.1022subject
Has Abstractpub_date
1989-07-01 00:00:00pages
1022-8issue
7eissn
0003-9888issn
1468-2044journal_volume
64pub_type
杂志文章abstract:INTRODUCTION:Langerhans cell histiocytosis (LCH) is a rare disease with diverse clinical courses. Despite improvement in survival outcomes in the recent decades, sequelae of the disease remain a concern. This study aimed to provide information on the long-term outcomes in patients with LCH, particularly on the sequelae...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2016-312185
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVES:To develop waist circumference (WC) centile curves for UK South Asian children, to make comparisons with published centiles for British, indigenous Indian and Pakistani children, as well as to make anthropometric comparisons with their UK white peers. DESIGN:Cross-sectional study. SETTING:School-aged child...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2018-315722
更新日期:2020-01-01 00:00:00
abstract::Pyogenic meningitis occurred in 6 infants in the course of chronic gastroenteritis, in 5 of whom a normal CSF had been recorded earlier in the illness. Clinical signs of meningitis were often absent. The problems of diagnosis and management and of possible predisposition to pneumococcal meningitis in children sufferin...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.52.2.159
更新日期:1977-02-01 00:00:00
abstract::We describe a child with primary defect of polymorph bacterial killing associated with systemic lungs erythematosus. We suggest that her autoimmune disease results from chronic bacterial antigen stimulation and propose a hypothetical model linking immunodeficiency with autoimmunity. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.56.5.382
更新日期:1981-05-01 00:00:00
abstract::This study aimed to examine the overnight temperature pattern of babies during the prodromal phase of minor illnesses. The overnight rectal temperature pattern of 123 babies was recorded weekly from about 6 to at least 16 weeks old, while parents maintained detailed records of signs of illness. By analysis of patterns...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.71.1.80
更新日期:1994-07-01 00:00:00
abstract::Multiple double blind placebo controlled challenges with tartrazine 50 mg (three challenges) and glucose placebo (three challenges) were performed in 12 children with atopic eczema aged 1 to 6 years. The children were selected on the basis of severity (regular clinic attenders) and a parental history that tartrazine p...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/adc.67.6.709
更新日期:1992-06-01 00:00:00
abstract::The effect of phototherapy on plasma cyclic-AMP in newborn infants has been studied. Our results suggest that phototherapy does not produce appreciable changes in plasma cyclic-AMP levels. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.52.5.416
更新日期:1977-05-01 00:00:00
abstract:BACKGROUND:Recent research in febrile neutropaenia (FN) has focused on reducing the intensity of treatment for those thought to be at low risk of significant morbidity or mortality. This has not led to a reduced burden of treatment for either families or healthcare systems. An alternative approach is to discharge all p...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2019-317908
更新日期:2020-09-01 00:00:00
abstract::The clinical response to sodium cromoglycate treatment was compared with its concentration in serum. Twenty five children with asthma entered a 10 week trial of two baseline weeks followed by eight weeks of treatment by the inhalation of 20 mg of sodium cromoglycate spincaps four times a day. Individual clinical respo...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.63.6.592
更新日期:1988-06-01 00:00:00
abstract:AIM:To determine the incidence of hypocalcaemia in critically ill children with meningococcal disease. METHODS:In a prospective cohort study, 70 of 80 patients admitted consecutively with a clinical diagnosis of meningococcal disease to intensive care had measurements of total and ionised calcium on admission. Paratho...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.83.6.510
更新日期:2000-12-01 00:00:00
abstract:OBJECTIVE:This study aimed to determine the glycaemic profile of patients with cystic fibrosis using a continuous glucose monitoring system (CGMS), and to evaluate the associations of glycaemic abnormalities with sex, age, pubertal stage, CFTR gene mutations, nutritional status, lung function, oral glucose tolerance te...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2017-314250
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVE:To describe the prevalence of depression in children with chronic fatigue syndrome (CFS)/myalgic encephalomyelitis (ME) and investigate the relationship between depression in CFS/ME and clinical symptoms such as fatigue, disability, pain and school attendance. DESIGN:Cross-sectional survey data using the Hos...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2012-303396
更新日期:2013-06-01 00:00:00
abstract:RATIONALE:Studies suggest that increased breastfeeding rates can provide substantial financial savings, but the scale of such savings in the UK is not known. OBJECTIVE:To calculate potential cost savings attributable to increases in breastfeeding rates from the National Health Service perspective. DESIGN AND SETTINGS...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2014-306701
更新日期:2015-04-01 00:00:00
abstract::Linkage of bacterial capsular polysaccharides to proteins to create conjugate vaccines has had a dramatic impact on the health of children. Although unconjugated polysaccharides are poorly immunogenic in infants and some older children and adults, their covalent coupling with proteins stimulates T cell dependent antig...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/adc.88.5.375
更新日期:2003-05-01 00:00:00
abstract::Life was sorted. With membership of the college under my belt, and my paediatric training completed, I needed a new challenge. I decided to launch into the deep waters of qualitative research. Stepping out with some trepidation into semistructured interviews and grounded theory, I soon found that the water was neither...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.88.1.44
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVES:To assess the potential effect of two guideline discharge oxygen saturation (SpO(2)) recommendations (≥90% and ≥94%) in recovering bronchiolitis. METHODS AND PATIENTS:Infants aged up to 18 months requiring therapeutic oxygen for SpO(2) (≤93%) had SpO(2) assessed in air every 2 h. Time from admission to re-e...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2010.205211
更新日期:2012-04-01 00:00:00
abstract::Travel for the purposes of obtaining medical treatment is increasing, but very little is known about the extent or nature of child medical travel. This paper discusses the outcome of a systematic search for academic literature on paediatric medical travel, outlines the potential significance of 'return health migratio...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/archdischild-2012-303189
更新日期:2013-06-01 00:00:00
abstract::Children with cystic fibrosis have variable degrees of exocrine pancreatic insufficiency which, if untreated, is the main cause of fat malabsorption. The impact of pancreatic enzyme supplementation on fat digestion was measured in 41 children with cystic fibrosis, 11 healthy controls, and five children with mucosal di...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.76.4.349
更新日期:1997-04-01 00:00:00
abstract:OBJECTIVE:To assess height and body mass index standard deviation scores up to 20 years after treatment for acute lymphoblastic leukaemia (ALL). SUBJECTS AND METHODS:Height and body mass index standard deviation scores were measured in 33 patients (14 boys and 19 girls) with childhood ALL at diagnosis, after the end o...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.79.2.161
更新日期:1998-08-01 00:00:00
abstract:AIM:To investigate the rate and nature of anxiety symptoms and disorders in children, and their relation to social adversities in a cultural sample not previously researched. METHODS:237 children aged 9 to 13 years living in the Gaza Strip were selected randomly from 112 schools. Children completed the revised manifes...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.78.5.439
更新日期:1998-05-01 00:00:00
abstract::Imaging has many uses, but in cases of suspected child abuse, radiographs and CT scans are vital in identifying fractures and head injury that may not be clinically obvious. There are growing concerns about the small but potential adverse effects of radiation, including cancer, in the paediatric population as a result...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/archdischild-2015-308418
更新日期:2015-12-01 00:00:00
abstract::A 3 year old girl with Down's syndrome became lethargic and withdrawn, and investigations showed a specific malabsorption of vitamin B12 without proteinuria. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.61.5.514
更新日期:1986-05-01 00:00:00
abstract::Of the 265 children aged between 6 and 18 months admitted to hospital in a 26-month period each with his first febrile convulsion, there were 64 who satisfied our criteria for a simple febrile convulsion. Of these, 43 (random) were entered into a double-blind trial of continuous sodium valproate versus phenobarbitone,...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章
doi:10.1136/adc.55.3.171
更新日期:1980-03-01 00:00:00
abstract:OBJECTIVE:Cochlear implantation in one ear (unilateral implantation) has been the standard treatment for severe-profound childhood deafness. We assessed whether cochlear implantation in both ears (bilateral implantation) is associated with better listening skills, higher health-related quality of life (health utility) ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2009.160325
更新日期:2010-02-01 00:00:00
abstract:AIMS:The Royal College of Paediatrics and Child Health (RCPCH) Science and Research Department was commissioned by the Department of Health to develop national care pathways for children with allergies: the asthma/rhinitis care pathway is the third such pathway. Asthma and rhinitis have been considered together. These ...
journal_title:Archives of disease in childhood
pub_type: 共识发展会议,杂志文章
doi:10.1136/adc.2011.213462
更新日期:2011-11-01 00:00:00
abstract::Published reports on the treatment of large strawberry naevi have been reviewed. It is suggested that they should normally be left untreated, and that corticosteroids, given for a short period only, should be reserved for massive naevi close to the eye, or interfering with respiration or suckling, or associated with t...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/adc.51.2.138
更新日期:1976-02-01 00:00:00
abstract::Safe and effective paediatric pharmacotherapy requires careful evaluation of the type of drug substance, the necessary dose and the age-appropriateness of the formulation. Generally, the younger the child, the more the attention that is required. For decades, there has been a general lack of (authorised) formulations ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/archdischild-2015-308227
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVE:There are no objective ambulatory studies on the temporal relationship between reflux and cough in children. Commercial pHmetry loggers have slow capture rates (0.25 Hz) that limit objective quantification of reflux and cough. The authors aimed to evaluate if there is a temporal association between cough and ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2009.177733
更新日期:2011-05-01 00:00:00
abstract::A percutaneous lung biopsy sample was used to diagnose interstitial lung disease in nine children aged less than 42 months. Fibrosing alveolitis was diagnosed in eight children and Pneumocystis carinii pneumonia in one child. Complications associated with the procedure were minimal and the results of the biopsy sample...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.70.2.143
更新日期:1994-02-01 00:00:00
abstract::The concept of neural plasticity and the early natural abilities of hearing children to acquire speech and language without instruction have led many authorities to advocate cochlear implantation before the age of 5 years in congenital deafness. Older children therefore become lower priority for scarce public funds be...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.88.8.708
更新日期:2003-08-01 00:00:00