An objective study of acid reflux and cough in children using an ambulatory pHmetry-cough logger.

Abstract:

OBJECTIVE:There are no objective ambulatory studies on the temporal relationship between reflux and cough in children. Commercial pHmetry loggers have slow capture rates (0.25 Hz) that limit objective quantification of reflux and cough. The authors aimed to evaluate if there is a temporal association between cough and acid pH in ambulatory children with chronic cough. DESIGN, SETTING AND PATIENTS:The authors studied children (aged <14 years) with chronic cough, suspected of acid reflux and considered for pHmetry using a specifically built ambulatory pHmetry-cough logger that enabled the simultaneous ambulatory recording of cough and pH with a fast (10 Hz) capture rate. MAIN OUTCOME MEASURES:Coughs within (before and after) 10, 30, 60 and 120 s of a reflux episode (pH<4 for >0.5 s). RESULTS:Analysis of 5628 coughs in 20 children. Most coughs (83.9%) were independent of a reflux event. Cough-reflux (median 19, IQR 3-45) and reflux-cough (24.5, 13-51) sequences were equally likely to occur within 120 s. Within the 10 and 30 s time frame, reflux-cough (10 s=median 2.5, IQR 0-7.25; 30 s=6.5, 1.25-22.25) sequences were significantly less frequent than reflux-no cough (10 s=27, IQR 15-65; 30 s=24.5, 14.5-55.5) sequences, (p=0.0001 and p=0.001, respectively). No differences were found for 60 and 120 s time frame. Cough-reflux sequence (median 1.0, IQR 0-8) within 10 s was significantly less (p=0.0001) than no cough-reflux sequences (median 29.5, 15-67), within 30 s (p=0.006) and 60 s (p=0.048) but not within 120 s (p=0.47). CONCLUSIONS:In children with chronic cough and suspected of having gastro-oesophageal reflux disease, the temporal relationship between acid reflux and cough is unlikely causal.

journal_name

Arch Dis Child

authors

Chang AB,Connor FL,Petsky HL,Eastburn MM,Lewindon PJ,Hall C,Wilson SJ,Katelaris PH

doi

10.1136/adc.2009.177733

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

468-72

issue

5

eissn

0003-9888

issn

1468-2044

pii

adc.2009.177733

journal_volume

96

pub_type

杂志文章
  • Named/designated doctor status and judgement in child-protection scenarios.

    abstract::Four child-protection scenarios were sent to 200 named/designated and non-named/non-designated doctors. The respondents judged each scenario as abuse or accident and indicated their degree of certainty. There was a 71% response rate. There were no significant differences in judgement or degrees of certainty of judgeme...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2006.105528

    authors: Power S

    更新日期:2008-07-01 00:00:00

  • Psychological outcome and quality of life in children born with congenital diaphragmatic hernia.

    abstract:OBJECTIVE:To assess psychological and social functioning and health related quality of life and its early determinants in children born with congenital diaphragmatic hernia (CDH). DESIGN:Cross-sectional follow-up study. SETTING:Outpatient clinic of a tertiary care hospital. PARTICIPANTS:33 CDH survivors aged 6-16 ye...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2008.156158

    authors: Peetsold MG,Huisman J,Hofman VE,Heij HA,Raat H,Gemke RJ

    更新日期:2009-11-01 00:00:00

  • Effect of adenoidectomy on respiratory function: a randomised prospective study.

    abstract:OBJECTIVE:Risk of childhood asthma is increased in children with recurrent otitis media. This may be associated with recurrent respiratory tract infections in these children, but the role of adenoidectomy, a frequent operation during childhood, is unknown. Therefore, the role of adenoidectomy in the development of atop...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/adc.2008.145664

    authors: Mattila PS,Hammarén-Malmi S,Pelkonen AS,Malmberg LP,Mäkelä MJ,Saxen H,Tarkkanen J

    更新日期:2009-05-01 00:00:00

  • Delayed visual maturation.

    abstract::Sixteen blind babies who were considered to be showing the characteristics of delayed visual maturation were studied prospectively. The diagnosis was made on clinical grounds, and the criteria for this are discussed. All of these infants developed visual responses between 4 and 6 months of age and had normal or near n...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.59.2.107

    authors: Cole GF,Hungerford J,Jones RB

    更新日期:1984-02-01 00:00:00

  • Coping and health service utilisation in a UK study of paediatric sickle cell pain.

    abstract:AIMS:To assess sickle cell pain and coping in children and to examine the relation between these factors and the utilisation of health services. METHODS:Cross sectional study involving 67 children with sickle cell disease attending three London hospitals. Interviews and questionnaires involved measures of pain, health...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

    doi:10.1136/adc.86.5.325

    authors: Anie KA,Steptoe A,Ball S,Dick M,Smalling BM

    更新日期:2002-05-01 00:00:00

  • Capillary refill: prognostic value in Kenyan children.

    abstract:AIMS:To determine whether delayed capillary refill time (>3 seconds) is a useful prognostic indicator in Kenyan children admitted to hospital. METHODS:A total of 4160 children admitted to Kilifi District Hospital with malaria, malarial anaemia, acute respiratory tract infection (ARI), severe anaemia (haemoglobin <50 g...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2003.032516

    authors: Pamba A,Maitland K

    更新日期:2004-10-01 00:00:00

  • Cortical bone geometry in asthmatic children.

    abstract::At the mid-radius, pre-pubertal asthmatic children had smaller periosteal and endosteal circumferences and thicker cortical shells compared to controls, when assessed by peripheral quantitative computed tomography. Asthmatics had diminished periosteal expansion for muscle size, suggesting that asthma, its treatment, o...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2005.084996

    authors: Quick JL,Ward KA,Adams JE,Mughal MZ

    更新日期:2006-04-01 00:00:00

  • How to avoid paediatric medication errors: a user's guide to the literature.

    abstract::The National Health Service, in its report An organisation with memory, has called for a fundamental rethinking of the way the healthcare system learns from error. The NHS further details its goal to reduce serious medication errors by 40% in a second report entitled Building a safer NHS: improving medication safety. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/adc.2003.048827

    authors: Walsh KE,Kaushal R,Chessare JB

    更新日期:2005-07-01 00:00:00

  • Assuring validity of multisource feedback in a national programme.

    abstract:OBJECTIVE:To report the evidence for and challenges to the validity of Sheffield Peer Review Assessment Tool (SPRAT) with paediatric Specialist Registrars (SpRs) across the UK as part of Royal College of Paediatrics and Child Health workplace based assessment programme. DESIGN:Quality assurance analysis, including gen...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

    doi:10.1136/adc.2008.146209

    authors: Archer J,McGraw M,Davies H

    更新日期:2010-05-01 00:00:00

  • Managing bone and joint infection in children.

    abstract::There is little high quality evidence on which to base the management of bone and joint infections in children. This pragmatic practice note aims to provide a consensus framework of best current practice prior to the availability of data from large national randomised controlled trials. For straightforward infection i...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/archdischild-2011-301089

    authors: Faust SN,Clark J,Pallett A,Clarke NM

    更新日期:2012-06-01 00:00:00

  • The abnormal nucleus as a cause of congenital facial palsy.

    abstract:BACKGROUND:Congenital facial palsy (CFP) is clinically defined as facial palsy present at birth. It is associated with considerable disfigurement and causes functional and emotional problems for the affected child. The aetiology of the majority of cases however, remains elusive. AIMS:To investigate the role of a neuro...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.83.3.256

    authors: Jemec B,Grobbelaar AO,Harrison DH

    更新日期:2000-09-01 00:00:00

  • Necrotising enterocolitis after cardiac catheterisation in infants.

    abstract::Necrotising enterocolitis occurred in 3 infants after angiography at cardiac catheterisation. It is suggested that hypertonic contrast medium might have been responsible and that this complication could be avoided by the use of nonionic contrast media. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.55.1.66

    authors: Cooke RW,Meradji M,de Villeneuve VH

    更新日期:1980-01-01 00:00:00

  • Stop, think SCORTCH: rethinking the traditional 'TORCH' screen in an era of re-emerging syphilis.

    abstract:BACKGROUND:The epidemiology of congenital infections is ever changing, with a recent resurgence in syphilis infection rates seen in the UK. Identification of congenital infection is often delayed; early recognition and management of congenital infections is important. Testing modalities and investigations are often lim...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/archdischild-2020-318841

    authors: Penner J,Hernstadt H,Burns JE,Randell P,Lyall H

    更新日期:2021-02-01 00:00:00

  • Renal scarring and vesicoureteric reflux.

    abstract::A review of 105 children with urinary tract infection showed an increasing prevalence of grades II-III vesicoureteric reflux with diminishing age. During infancy reflux was almost always severe, and affected boys as often as girls. Radiologically scarred kidneys were drained by refluxing ureters in 98% of cases. The p...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.53.3.210

    authors: Shah KJ,Robins DG,White RH

    更新日期:1978-03-01 00:00:00

  • Pulmonary intravascular lipid in neonatal necropsy specimens.

    abstract::The lungs of 482 liveborn infants were examined at necropsy for the presence of intravascular lipid. Forty one patients had received parenteral feeding (including lipid emulsion in 30), and 441 had died before starting feeds or had received enteral feeds alone. Tissue was processed into wax and then stained with Sudan...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.66.1_spec_no.26

    authors: Puntis JW,Rushton DI

    更新日期:1991-01-01 00:00:00

  • Diagnostic value of a psychological test in cases of suspected child abuse.

    abstract::The use of the Bene-Anthony Family Relations Test is described and illustrated by three examples of child abuse. This test should be considered in the investigation of definite or suspected cases of abuse and as part of the preparation of court evidence. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.52.9.708

    authors: Geddis DC,Turner IF,Eardley J

    更新日期:1977-09-01 00:00:00

  • Prevalence of nasopharyngeal carriage of pneumococcus in preschool children attending day care in London.

    abstract:OBJECTIVE:To estimate the prevalence of nasopharyngeal (NP) carriage of pneumococcus (Streptococcus pneumoniae) and describe the antibiotic resistance patterns and serotypes in young children attending group day care in London. DESIGN AND SUBJECTS:Cross-sectional survey of attendees at a sample of registered child day...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2007.126359

    authors: Roche A,Heath PT,Sharland M,Strachan D,Breathnach A,Haigh J,Young Y

    更新日期:2007-12-01 00:00:00

  • Familial congenital heart block and hydrops fetalis.

    abstract::Two siblings were born with congenital heart block, and one suffered from severe hydrops fetalis, although maintaining a higher heart rate than the other. The association of hydrops fetalis with disorders of cardiac rhythm is unlikely to be simply a manifestation of congestive cardiac failure in the fetus. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.55.6.479

    authors: Cooke RW,Mettau JW,Van Cappelle AW,de Villeneuve VH

    更新日期:1980-06-01 00:00:00

  • Intrapulmonary shunting in the biliary atresia/polysplenia syndrome: reversal after liver transplantation.

    abstract:UNLABELLED:One hundred and seventy three children, including 93 with biliary atresia, received liver grafts at Addenbrooke's Hospital between 1983 and 1993. Of these, only seven developed cyanosis due to intrapulmonary shunting as a complication of their liver disease, and all seven of these had the biliary atresia/pol...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.70.6.501

    authors: Fewtrell MS,Noble-Jamieson G,Revell S,Valente J,Friend P,Johnston P,Rasmussen A,Jamieson N,Calne RY,Barnes ND

    更新日期:1994-06-01 00:00:00

  • Group B streptococcal conjugate vaccines.

    abstract::Linkage of bacterial capsular polysaccharides to proteins to create conjugate vaccines has had a dramatic impact on the health of children. Although unconjugated polysaccharides are poorly immunogenic in infants and some older children and adults, their covalent coupling with proteins stimulates T cell dependent antig...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/adc.88.5.375

    authors: Baker CJ,Edwards MS

    更新日期:2003-05-01 00:00:00

  • Thyroid scintigraphy differentiates subtypes of congenital hypothyroidism.

    abstract:INTRODUCTION:UK screening for congenital hypothyroidism (CH) is based on dried blood spot Thyroid Stimulating Hormone (TSH). Scintigraphy may identify CH subtypes classified as dysplasia, gland in situ (GIS) and ectopia, but is not performed in all centres. We retrospectively investigated the role of scintigraphy to id...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2019-317665

    authors: Worth C,Hird B,Tetlow L,Wright N,Patel L,Banerjee I

    更新日期:2021-01-01 00:00:00

  • Socioeconomic disadvantage and onset of childhood chronic disabling conditions: a cohort study.

    abstract:OBJECTIVE:To study the temporal relationship between socioeconomic disadvantage and onset of chronic disabling conditions in childhood. METHOD:Using parent reported data from the Longitudinal Study of Australian Children, we compared children who developed a chronic disabling condition between the ages of 6/7 and 10/1...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2013-305634

    authors: Spencer N,Strazdins L

    更新日期:2015-04-01 00:00:00

  • Problems of differentiation between epilepsy and non-epileptic paroxysmal events in the first year of life.

    abstract::Twenty two babies under 1 year old were referred for evaluation of suspected epileptic seizures. Nine were found to have epilepsy. In the other 13--all developing normally, aged up to 10 months--the spells were non-epileptic paroxysmal events (NEPE). They consisted of five patterns of movement: (1) eye blinking; (2) '...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.73.4.342

    authors: Shuper A,Mimouni M

    更新日期:1995-10-01 00:00:00

  • Changes in nocturnal oximetry after treatment of exacerbations in cystic fibrosis.

    abstract::Sleep related arterial oxygen desaturation has been described in clinically stable young adults with cystic fibrosis. The incidence and severity of nocturnal oxygen desaturation in children during infective exacerbations and the changes that occur with treatment were examined. Forty five children with proved cystic fi...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.69.2.197

    authors: Allen MB,Mellon AF,Simmonds EJ,Page RL,Littlewood JM

    更新日期:1993-08-01 00:00:00

  • Necrotising pneumonia due to influenza A (H1N1) and community-acquired methicillin-resistant Staphylococcus aureus clone USA300: successful management of the first documented paediatric case.

    abstract::Necrotising pneumonia in young, previously healthy patients due to Panton-Valentine leucocidin (PVL) producing Staphylococcus aureus has been increasingly recognised. PVL pneumonia is often associated with influenza co-infection and high mortality. This case report describes the successful management of the first docu...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2009.175281

    authors: Obando I,Valderrabanos ES,Millan JA,Neth OW

    更新日期:2010-04-01 00:00:00

  • Treatment of pseudomonas aeruginosa colonisation in cystic fibrosis.

    abstract::To test whether early treatment could postpone the chronic colonisation of the respiratory tract with mucoid strains of Pseudomonas aeruginosa in patients with cystic fibrosis, we performed a pilot study in 28 patients aged 2 to 18 years. A two week course of azlocillin (150 mg/kg/day) and tobramycin (10 to 15 mg/kg/d...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.64.7.1022

    authors: Steinkamp G,Tümmler B,Malottke R,von der Hardt H

    更新日期:1989-07-01 00:00:00

  • Primary antiphospholipid syndrome presenting as complicated Henoch-Schönlein purpura.

    abstract::A child showing signs of Henoch-Schönlein purpura developed a right tibiofibular vascular thrombosis. Antiphospholipid antibody tests were positive for both lupus anticoagulant and anticardiolipin antibodies. This suggests that an antiphospholipid syndrome should be considered in cases of Henoch-Schönlein purpura and ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/adc.86.2.132

    authors: Monastiri K,Selmi H,Tabarki B,Yacoub M,Mahjoub T,Essoussi AS

    更新日期:2002-02-01 00:00:00

  • Chronic fatigue syndrome in children: a cross sectional survey.

    abstract:BACKGROUND:Chronic fatigue syndrome (CFS) in children is a controversial diagnosis with unclear aetiology, ill defined but likely increasing incidence, and debatable clinical management options. However these children experience real and considerable suffering. Appropriate research in this clinical population is sparse...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.88.10.894

    authors: Patel MX,Smith DG,Chalder T,Wessely S

    更新日期:2003-10-01 00:00:00

  • Systematic review and meta-analyses of risk factors for childhood overweight identifiable during infancy.

    abstract:OBJECTIVE:To determine risk factors for childhood overweight that can be identified during the first year of life to facilitate early identification and targeted intervention. DESIGN:Systematic review and meta-analysis. SEARCH STRATEGY:Electronic database search of MEDLINE, EMBASE, PubMed and CAB Abstracts. ELIGIBIL...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,meta分析,评审

    doi:10.1136/archdischild-2012-302263

    authors: Weng SF,Redsell SA,Swift JA,Yang M,Glazebrook CP

    更新日期:2012-12-01 00:00:00

  • Withdrawal of ventilatory support outside the intensive care unit: guidance for practice.

    abstract:OBJECTIVE:To review the work of one tertiary paediatric palliative care service in facilitating planned withdrawal of ventilatory support outside the intensive care setting, with the purpose of developing local guidance for practice. METHODS:Retrospective 10-year (2003-2012) case note review of intensive care patients...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2013-305492

    authors: Laddie J,Craig F,Brierley J,Kelly P,Bluebond-Langner M

    更新日期:2014-09-01 00:00:00