Pulmonary intravascular lipid in neonatal necropsy specimens.


:The lungs of 482 liveborn infants were examined at necropsy for the presence of intravascular lipid. Forty one patients had received parenteral feeding (including lipid emulsion in 30), and 441 had died before starting feeds or had received enteral feeds alone. Tissue was processed into wax and then stained with Sudan black; intravascular lipid was found in 15 of 30 infants who had received intravenous fat (Intralipid), but in no others. Those patients with positive lipid staining had received significantly more fat during parenteral nutrition than those in whom intravascular lipid was not found but the two groups were otherwise clinically indistinguishable. Using this staining technique intravascular lipid can be shown relatively often, although only in patients who have received intravenous lipid emulsion. The location of fat, predominantly in small pulmonary capillaries, and the absence of lipid emboli in other organs, suggests that lipid coalescence takes place before death and is not a postmortem artefact. The clinical relevance remains uncertain.


Arch Dis Child


Puntis JW,Rushton DI




Has Abstract


1991-01-01 00:00:00




1 Spec No








  • Specific malabsorption of vitamin B12 in Down's syndrome.

    abstract::A 3 year old girl with Down's syndrome became lethargic and withdrawn, and investigations showed a specific malabsorption of vitamin B12 without proteinuria. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: Cartlidge PH,Curnock DA

    更新日期:1986-05-01 00:00:00

  • Imaging in suspected child abuse: necessity or radiation hazard?

    abstract::Imaging has many uses, but in cases of suspected child abuse, radiographs and CT scans are vital in identifying fractures and head injury that may not be clinically obvious. There are growing concerns about the small but potential adverse effects of radiation, including cancer, in the paediatric population as a result...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审


    authors: Bajaj M,Offiah AC

    更新日期:2015-12-01 00:00:00

  • Children's health in slum settings.

    abstract::Rapid urbanisation in the 20th century has been accompanied by the development of slums. Nearly one-third of the world's population and more than 60% of urban populations in the least developed countries live in slums, including hundreds of millions of children. Slums are areas of broad social and health disadvantage ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: Unger A

    更新日期:2013-10-01 00:00:00

  • Managing obesity in secondary care: a personal practice.

    abstract::Obesity is becoming a common clinical headache for child health professionals, as the increase in professional and media concern has not been matched by effective clinical solutions. Added to this is considerable confusion about both the definitions of obesity and about which groups of children and adolescents actuall...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审


    authors: Viner R,Nicholls D

    更新日期:2005-04-01 00:00:00

  • Effects of smoking on breast feeding.

    abstract::Infant feeding methods used by mothers who smoke and by mothers who do not, who delivered in one maternity hospital, were compared to determine if smoking affected breast feeding. Significantly more of the smoking group chose either to bottle feed from delivery or, having been discharged from the hospital breast feedi...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: Lyon AJ

    更新日期:1983-05-01 00:00:00

  • High volume milk feeds for preterm infants.

    abstract::Fifty nine preterm infants of between 1.0 and 2.0 kg birthweight who were fed 250 ml/kg/day of breast milk or standard formulas gained weight at the intrauterine rate without complications. It is suggested that high volume feeding is a satisfactory alternative to low birthweight formula milks and is more desirable in ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: Lewis MA,Smith BA

    更新日期:1984-08-01 00:00:00

  • Age specific xerophthalmia rates among displaced Ethiopians.

    abstract::The recent famine in Ethiopia has resulted in the dislocation of millions of people. Many of these individuals have moved to refugee camps in Sudan or to feeding centres within Ethiopia. A total of 1325 children up to the age of 15 years were examined by an ophthalmologist in January 1985 at several sites in these two...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: Pizzarello LD

    更新日期:1986-11-01 00:00:00

  • Sublingual immunotherapy in asthma and rhinoconjunctivitis; systematic review of paediatric literature.

    abstract:AIMS:To evaluate the clinical efficacy of sublingual immunotherapy (SLIT) in respiratory allergy in children. METHODS:A systematic literature review was conducted. The search was focused on all the double blind (and double dummy if necessary) studies. SEARCH STRATEGY:Medline, Embase, Cochrane Controlled Trial Registe...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审


    authors: Sopo SM,Macchiaiolo M,Zorzi G,Tripodi S

    更新日期:2004-07-01 00:00:00

  • Persistence of pneumococcal antibodies after primary immunisation with a polysaccharide-protein conjugate vaccine.

    abstract:INTRODUCTION:Despite immunisation, antibiotics and intensive care management, infection with Streptococcus pneumoniae remains a major cause of morbidity and mortality in children. The WHO currently recommends vaccinating infants with either a 3+0 schedule (6 weeks, 3-4 and 4-6 months of age) or 2+1 schedule (2 doses be...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,随机对照试验


    authors: Zimmermann P,Perrett KP,Berbers G,Curtis N

    更新日期:2019-07-01 00:00:00

  • Attentional ability among survivors of leukaemia treated without cranial irradiation.

    abstract:BACKGROUND:Previous research has indicated that children who have received treatment for leukaemia which includes cranial irradiation exhibit deficits in their ability to focus attention. It has been suggested that the use of cranial irradiation may have a role to play in long term sequelae. AIMS:To investigate neurop...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: Rodgers J,Marckus R,Kearns P,Windebank K

    更新日期:2003-02-01 00:00:00

  • When should oxygen be given to children at high altitude? A systematic review to define altitude-specific hypoxaemia.

    abstract:BACKGROUND:Acute respiratory infections (ARI) cause 3 million deaths in children worldwide each year. Most of these deaths occur from pneumonia in developing countries, and hypoxaemia is the most common fatal complication. Simple and adaptable indications for oxygen therapy are important in the management of ARI. The c...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审


    authors: Subhi R,Smith K,Duke T

    更新日期:2009-01-01 00:00:00

  • The importance of reverse triiodothyronine in hypothyroid children on replacement treatment.

    abstract::Reverse triiodothyronine (rT3), triiodothyronine (T3), thyroxine (T4), and thyroid stimulating hormone (TSH) values were measured by radioimmunoassay in 40 children with congenital hypothyroidism who were being given levothyroxine (0.05-0.35 mg/day) and in 14 normal controls. In 15 of the children with hypothyroidism ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: Desai M,Irani AJ,Patil K,Pandya CS

    更新日期:1984-01-01 00:00:00

  • Late outcomes in children with Langerhans cell histiocytosis.

    abstract:INTRODUCTION:Langerhans cell histiocytosis (LCH) is a rare disease with diverse clinical courses. Despite improvement in survival outcomes in the recent decades, sequelae of the disease remain a concern. This study aimed to provide information on the long-term outcomes in patients with LCH, particularly on the sequelae...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: Chow TW,Leung WK,Cheng FWT,Kumta SM,Chu WCW,Lee V,Shing MMK,Li CK

    更新日期:2017-09-01 00:00:00

  • Long term behavioural outcome after neonatal arterial switch operation for transposition of the great arteries.

    abstract:AIMS:To evaluate behavioural outcome and quality of life in children aged 8-14 years after neonatal arterial switch operation for transposition of the great arteries. METHODS:Sixty children operated as neonates with combined deep hypothermic circulatory arrest and low flow cardiopulmonary bypass were evaluated at age ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: Hövels-Gürich HH,Konrad K,Wiesner M,Minkenberg R,Herpertz-Dahlmann B,Messmer BJ,Von Bernuth G

    更新日期:2002-12-01 00:00:00

  • Early excessive growth with distinct seasonality in preschool obesity.

    abstract:OBJECTIVES:Healthy-weight children tend to gain weight during winter but lose weight during summer. However, overweight elementary school children have shown accelerated summertime weight gain. Whether this seasonal growth variation occurs during preschool period is of substantial interest. METHODS:Data were derived f...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: Isojima T,Kato N,Yokoya S,Ono A,Tanaka T,Yokomichi H,Yamagata Z,Tanaka S,Matsubara H,Ishikuro M,Kikuya M,Chida S,Hosoya M,Kuriyama S,Kure S

    更新日期:2019-01-01 00:00:00

  • Familial congenital heart block and hydrops fetalis.

    abstract::Two siblings were born with congenital heart block, and one suffered from severe hydrops fetalis, although maintaining a higher heart rate than the other. The association of hydrops fetalis with disorders of cardiac rhythm is unlikely to be simply a manifestation of congestive cardiac failure in the fetus. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: Cooke RW,Mettau JW,Van Cappelle AW,de Villeneuve VH

    更新日期:1980-06-01 00:00:00

  • Hypothyroidism and growth failure in diabetes mellitus.

    abstract::The prevalence of thyroid disease in 134 children, adolescents, and young adults with diabetes mellitus beginning in childhood is described. Clustering of a family history of thyroid disease and the presence of thyrogastric antibodies in some patients supports the concept of familial autoimmunity. In 4 children a diag...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: Court S,Parkin JM

    更新日期:1982-08-01 00:00:00

  • Nebulised therapy in acute severe bronchiolitis in infancy.

    abstract::We have measured total work of breathing before and after the inhalation of water, salbutamol, and ipratropium bromide, given as nebulised solutions, in 39 studies on 25 infants with acute, severe bronchiolitis. Twenty minutes after nebulised water, mean work of breathing per minute was increased by 4% and work per li...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章


    authors: Stokes GM,Milner AD,Hodges IG,Henry RL,Elphick MC

    更新日期:1983-04-01 00:00:00

  • Production of the hydroxylated metabolites of vitamin D in a neonate with a single hypoplastic-dysplastic kidney.

    abstract::The ability to produce dihydroxylated metabolites of vitamin D was studied in a term neonate suffering from severe renal insufficiency. The infant died at age 26 days owing to end-stage renal failure and the necropsy examination showed a single dysplastic kidney weighing 1.5 g. At age 2 weeks the serum levels of the d...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: Alkalay A,Mogilner BM,Nissim F,Edelstein S

    更新日期:1983-01-01 00:00:00

  • Precocious pubarche is associated with SGA, prematurity, weight gain, and obesity.

    abstract:BACKGROUND:Perinatal stress is thought to underlie the Barker sequelae of low birth weight, of which precocious pubarche may be a manifestation. AIMS:To explore whether prematurity as well as smallness for gestational age (SGA) predisposes to precocious pubarche, and the potential role of excess weight gain during chi...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: Neville KA,Walker JL

    更新日期:2005-03-01 00:00:00

  • Effect of bacterial filters on spirometry measurements.

    abstract::Lung function measurements with and without a disposable bacterial filter were compared in 60 children. Although statistically significant, the reduction of lung function measurements caused by using bacterial filters was small and clinically irrelevant (2-4% of predicted for forced expiratory volume in one second and...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: Kamps AW,Vermeer K,Roorda RJ,Brand PL

    更新日期:2001-10-01 00:00:00

  • Evidence for persistence of upper airway narrowing during sleep, 12 years after adenotonsillectomy.

    abstract:AIMS:To establish whether subjects with previous evidence of sleep apnoea prior to adenotonsillectomy continue to have evidence of narrower upper airways during sleep, 12 years later. METHODS:Twenty subjects (median age 16 years) underwent repeat sleep studies at home, 12 years after such studies had shown significant...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: Tasker C,Crosby JH,Stradling JR

    更新日期:2002-01-01 00:00:00

  • Neonatal hypocalcaemia associated with maternal hyperparathyroidism. New pathogenetic observations.

    abstract::A 32-day-old male infant had hypocalcaemic convulsions associated with asymptomatic maternal hyperparathyroidism. Very low total and ionised serum calcium, increased serum phosphate, and normal serum parathyroid hormone (PTH) and 25-hydroxycholecalciferol (25-OHD3) concentrations were found at admission. After treatme...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: Jacobsen BB,Terslev E,Lund B,Sørensen OH

    更新日期:1978-04-01 00:00:00

  • Is late walking a marker of morbidity? Steering Committee, Oxford Region Child Development Project.

    abstract::We identified 410 infants who were not walking independently by the age of 18 months from among a geographically defined population of 4275 infants who either were born weighing less than 2000 g or had needed admission to the special care nursery in the neonatal period. The outcome of the late walkers was ascertained ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: Johnson A,Goddard O,Ashurst H

    更新日期:1990-05-01 00:00:00

  • Cardiovascular abnormalities in end stage renal failure: the effect of anaemia or uraemia?

    abstract::Children with end stage renal failure and anaemia have an increased cardiac index and often gross ventricular hypertrophy. Correction of anaemia with recombinant human erythropoietin (r-HuEpo) for less than six months results in a reduction in the cardiac index without a significant reduction in left ventricular hyper...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: Morris KP,Skinner JR,Hunter S,Coulthard MG

    更新日期:1994-08-01 00:00:00

  • Pathogenesis of liver damage during parenteral nutrition: is lipofuscin a clue?

    abstract::Lipofuscin develops in cells when peroxidation damage occurs. Its development in the liver of patients receiving prolonged parenteral nutrition suggests that peroxidation damage by free radicals has occurred. Deficiencies in antioxidants such as vitamin E may be an important contributing factor. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: Berger HM,Den Ouden AL,Calame JJ

    更新日期:1985-08-01 00:00:00

  • Nebulised water as a bronchoconstricting challenge in infancy.

    abstract::The pulmonary response to inhalation challenge with nebulised distilled water was measured in 100 sedated infants with a history of wheeze. Lung function was measured by total body plethysmography. Satisfactory results were obtained in 88 infants. Fifty one were considered to have responded by developing a greater tha...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: O'Callaghan C,Milner AD,Webb MS,Swarbrick A

    更新日期:1991-08-01 00:00:00

  • Auditory integration training and other sound therapies for autism spectrum disorders: a systematic review.

    abstract:OBJECTIVES:To determine the effectiveness of auditory integration training (AIT) or other methods of sound therapy in people with autism spectrum disorders (ASD). STUDY DESIGN:A systematic review was carried out of randomised controlled trials (RCTs) of adults or children with ASD. Meta-analysis was attempted. RESULT...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,meta分析,评审


    authors: Sinha Y,Silove N,Wheeler D,Williams K

    更新日期:2006-12-01 00:00:00

  • Named/designated doctor status and judgement in child-protection scenarios.

    abstract::Four child-protection scenarios were sent to 200 named/designated and non-named/non-designated doctors. The respondents judged each scenario as abuse or accident and indicated their degree of certainty. There was a 71% response rate. There were no significant differences in judgement or degrees of certainty of judgeme...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: Power S

    更新日期:2008-07-01 00:00:00

  • Change in blood pressure after treatment of patent ductus arteriosus with indomethacin.

    abstract::The effect of indomethacin treatment of patent ductus arteriosus (PDA) on blood pressure was studied in 24 preterm infants. PDA was diagnosed clinically and confirmed by echocardiography; the effect of treatment was monitored echocardiographically. Hourly intra-arterial recordings of systolic, diastolic, and mean bloo...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: Evans N,Iyer P

    更新日期:1993-05-01 00:00:00