Abstract:
AIMS:To compare the respiratory health and function at 8 to 9 years of age of a total population based cohort of 300 very low birthweight (VLBW) children with that of two classroom controls (n = 590) matched for age and sex. STUDY DESIGN:Cohort study with controls. SETTING:Schools throughout Scotland. RESULTS:The VLBW children were more likely than their peers to use an inhaler, to be absent from school, and to be admitted to hospital because of respiratory illness. They were significantly shorter than their classroom controls, but even after adjusting for differences in height, the VLBW children had reduced forced vital capacity (FVC); this was associated with a history of prolonged ventilation (> 28 days) and pneumothorax in the neonatal period. There were no significant differences between the groups in forced expiratory volume in one second (FEV1)/FVC but twice as many (7.9% v 3.7%) of the VLBW children had ratios < 70%, denoting obstructive airways disease. Poor expiratory function was associated with neonatal respiratory distress syndrome, prolonged ventilation, and the need for > 40% oxygen. Exercise induced airway narrowing was increased in VLBW children (odds ratio = 2.0; 95% confidence interval 1.2 to 3.4) and was very little changed by adjustment for inhaler use and exposure to cigarette smoke. CONCLUSIONS:As in other low birthweight cohorts, respiratory morbidity was increased. Unlike previous studies, FVC was more affected than expiratory function in this VLBW population. Our findings support the hypothesis that poorer lung function is associated with very low birth weight, but not with intrauterine growth retardation.
journal_name
Arch Dis Childjournal_title
Archives of disease in childhoodauthors
McLeod A,Ross P,Mitchell S,Tay D,Hunter L,Hall A,Paton J,Mutch Ldoi
10.1136/adc.74.3.188subject
Has Abstractpub_date
1996-03-01 00:00:00pages
188-94issue
3eissn
0003-9888issn
1468-2044journal_volume
74pub_type
杂志文章abstract:BACKGROUND:Human metapneumovirus (hMPV) causes lower respiratory tract infections, particularly in young children and the elderly. METHODS:A prospective study was conducted on the clinical characteristics of infants <2 years of age admitted to hospital for respiratory infection and the characteristics of hMPV infectio...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2005.082388
更新日期:2006-04-01 00:00:00
abstract::Three children with Reye's syndrome are described. One child died, the second had mild and transient illness, and the third had recurrent episodes. In all 3 children a muscle biopsy showed pronounced infiltration of the myofibres with fat microdroplets as shown by the oil red O stain and by electron microscopical exam...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.56.4.287
更新日期:1981-04-01 00:00:00
abstract:AIM:Childhood arthritis arises from several causes. The aim of this observational study is to compare the clinical and biological features and short-term outcome of different types of arthritis because they have different treatment and prognoses. METHODS:Children <16 years of age hospitalised in a French tertiary care...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,多中心研究
doi:10.1136/archdischild-2016-310594
更新日期:2017-04-01 00:00:00
abstract:AIMS:To explore the clinical course of children with "single kidney" (defined as either a solitary or single functioning kidney) with reference to renal function (glomerular filtration rate (GFR) and proteinuria), body height and particularly sonomorphological features. PATIENTS AND METHODS:This retrospective monocent...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2008.153601
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVE:Urolithiasis in renal transplant (RTx) recipients is a potential cause of allograft loss if obstruction is untreated. It is not clear if paediatric transplant recipients are following the global trend for increased prevalence of urolithiasis over time. DESIGN/SETTING/PATIENTS:A retrospective chart review was...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2019-317203
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:To examine information needs and preferences of parents regarding food allergy. DESIGN:Qualitative study including in-depth semi-structured interviews and focus group discussions. Data were audio-recorded, transcribed verbatim and analysed using the constant comparative method, aided by participant checking ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,多中心研究
doi:10.1136/adc.2006.114975
更新日期:2007-09-01 00:00:00
abstract::The fall in body temperature that occurs in babies soon after birth is influenced by the baby's weight and its environmental conditions. The rate of oxygen consumption 1 1/2 hours after birth was unrelated to body temperature and only slightly raised, indicating a limited thermogenic capacity. A radiant heater effecti...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.53.1.58
更新日期:1978-01-01 00:00:00
abstract:OBJECTIVES:(1) To determine the prevalence of cough, wheeze, and breathlessness, both as single symptoms and in combination, in primary schoolchildren and their relation to doctor diagnosed asthma. (2) To identify in areas with different levels of dust pollution whether questionnaire reported 'cough alone' (without whe...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.75.6.489
更新日期:1996-12-01 00:00:00
abstract::Twenty-one babies of 34-41 weeks' gestational age with birth asphyxia (5 minute Apgar score less than or equal to 5 or umbilical artery pH less than or equal to 7.2) were studied during the first two days of life to find out whether the urinary excretion of tubular markers of renal function is of value in the early di...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.65.10_spec_no.1021
更新日期:1990-10-01 00:00:00
abstract:OBJECTIVE:Assays based on interferon gamma (IFNgamma) are an exciting new development for screening for latent tuberculosis infection (LTBI) in adults, but there are limited data on their effectiveness in children. Nevertheless new National Institute for Health and Clinical Excellence (NICE) guidelines recommend their ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2006.106617
更新日期:2008-03-01 00:00:00
abstract::The frequency of negative hydrogen breath tests due to colonic bacterial flora which are unable to produce hydrogen was determined after oral lactulose challenge in 98 healthy Dutch schoolchildren. There was a negative result in 9.2%. The probability of a false normal lactose breath test (1:77) was calculated from the...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.60.4.333
更新日期:1985-04-01 00:00:00
abstract::A study was conducted to see if the discharge weight of preterm infants born at less than or equal to 2000 g could safely be reduced. A study group (21 infants) was discharged 'early' at a mean weight of 2010 g (1890-2190) provided there were no medical problems, weight gain was adequate, temperature control in room a...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.57.7.511
更新日期:1982-07-01 00:00:00
abstract::Plasma concentrations of motilin, gastrin, and enteroglucagon were measured in cord blood and during the first 24 days of life before feeding in 45 term and 63 preterm, healthy infants. Levels of these hormones rose steeply after birth, reaching concentrations that were much higher than those in fasting adults. These ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.55.9.673
更新日期:1980-09-01 00:00:00
abstract::Plasma amino acids were measured in 35 preterm infants, of whom 11 weighed less than 1000 g and 24 weighed between 1000 g and 1500 g at the time of sampling. Repeat samples were obtained in 18 at least seven days later. Seventeen infants were fed with preterm formula milk and 18 with expressed maternal breast milk at ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.62.12.1257
更新日期:1987-12-01 00:00:00
abstract::The benefits of achieving a long term event free survival of 60-70% by using increasingly intense treatment regimens must be weighed against the increased risk of treatment toxicity. From 1985 to 1990, 1612 children with childhood acute lymphoblastic leukaemia (ALL) in the UK were treated on MRC UKALL X with intensive...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1136/adc.74.2.101
更新日期:1996-02-01 00:00:00
abstract::Aortic arch anomalies in infancy often cause intrathoracic airway obstruction. Airway function was assessed as part of the diagnostic evaluation in six symptomatic infants both by plethysmography and using a chest compression technique to obtain partial flow-volume loops. Two infants had normal intrathoracic airway fu...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.65.2.171
更新日期:1990-02-01 00:00:00
abstract::During a five and a half year period, exchange transfusions were performed through the peripheral vessels in 201 of the 214 infants (94%) who required either double volume or partial plasma exchange transfusions. Peripheral vessel exchange transfusion is simple, practicable, and safe with few complications. Technical ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.65.7_spec_no.676
更新日期:1990-07-01 00:00:00
abstract::Two very preterm infants (born at 29 and 25 weeks, respectively) were found to have abnormal ribs. Though this was thought unimportant at the time, it was subsequently shown to indicate that some members of their families had a dominantly inherited risk of developing skin cancer and other serious problems. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.66.10_spec_no.1162
更新日期:1991-10-01 00:00:00
abstract:BACKGROUND:Respiratory viral infections precipitate exacerbations of chronic respiratory diseases such as asthma and chronic obstructive pulmonary disease though similar data in non-cystic fibrosis (CF) bronchiectasis are missing. Our study aimed to determine the point prevalence of viruses associated with exacerbation...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2013-305147
更新日期:2014-08-01 00:00:00
abstract::During the 6-year period from 1 October 1971 to 30 September 1977, 13 (about 1%) of 1225 admissions to hospital with asthma developed severe ventilatory failure (peak arterial PCO 2 greater than 8 kPa). Mean age was 4.1 years (2.3--7.9), and on average each patient had been admitted to hospital on 5 occasions during t...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.53.9.714
更新日期:1978-09-01 00:00:00
abstract:AIMS:To determine the accuracy of a low cost, spring calibrated, hand held scale in classifying newborns into three weight categories (> or =2500 g, 2000-2499 g, <2000 g). METHODS:The test device was compared to a gold standard digital baby scale with precision to 2 g. In Sarlahi district, Nepal, 1890 newborns were el...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2005.088781
更新日期:2006-05-01 00:00:00
abstract::Six families with at least one infant each with confirmed ornithine transcarbamylase deficiency were investigated by DNA analysis. All the affected sons had died, and no DNA had been stored. Using the restriction endonucleases MspI and Bam HI three restriction fragment length polymorphisms were detected which led to e...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.63.3.297
更新日期:1988-03-01 00:00:00
abstract::Fifty nine children of short stature exercised for 10 minutes on a non-motorised treadmill. In 49 a growth hormone concentration of greater than 15 mU/l was reached, effectively excluding growth hormone deficiency. In 10 children the growth hormone concentration failed to reach 15 mU/l; growth hormone deficiency was c...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.59.12.1179
更新日期:1984-12-01 00:00:00
abstract:OBJECTIVES:To determine long-term seroprotection after serogroup C meningococcal (MenC) vaccination at the age of 9-12 years, with or without booster vaccination at the age of 13-15 years. DESIGN:Observational cohort study; follow-on from randomised study. SETTING:Participants were recruited from English secondary sc...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,随机对照试验
doi:10.1136/archdischild-2013-303893
更新日期:2013-09-01 00:00:00
abstract::Interstitial nephritis was diagnosed at renal biopsy in 10 previously healthy children. All had identical clinical symptoms: anaemia, raised sedimentation rate, low glomerular filtration rate, protein and leucocytes in the urine, but no bacteria; nine also had glycosuria. Six of the children had a history of recent in...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.60.8.752
更新日期:1985-08-01 00:00:00
abstract::Two siblings were born with congenital heart block, and one suffered from severe hydrops fetalis, although maintaining a higher heart rate than the other. The association of hydrops fetalis with disorders of cardiac rhythm is unlikely to be simply a manifestation of congestive cardiac failure in the fetus. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.55.6.479
更新日期:1980-06-01 00:00:00
abstract:OBJECTIVE:To study the clinical characteristics and predictors of mortality from snake bite envenomation in children. DESIGN:Prospective observational study with a one-group cohort design. SETTING:Paediatric intensive care unit of a tertiary care hospital in South India. SUBJECTS:The study cohort consisted of 145 ch...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2016-311142
更新日期:2017-05-01 00:00:00
abstract::A child with chronic diarrhoea since birth responded to the prostaglandin synthetase inhibitors aspirin and indomethacin. During a period without treatment, raised levels of prostaglandins F2alpha and E2 were observed. No source for these raised prostaglandins was shown, and it is suggested that she may have an inborn...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.52.10.800
更新日期:1977-10-01 00:00:00
abstract:OBJECTIVE:To assess height and body mass index standard deviation scores up to 20 years after treatment for acute lymphoblastic leukaemia (ALL). SUBJECTS AND METHODS:Height and body mass index standard deviation scores were measured in 33 patients (14 boys and 19 girls) with childhood ALL at diagnosis, after the end o...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.79.2.161
更新日期:1998-08-01 00:00:00
abstract::The ability to produce dihydroxylated metabolites of vitamin D was studied in a term neonate suffering from severe renal insufficiency. The infant died at age 26 days owing to end-stage renal failure and the necropsy examination showed a single dysplastic kidney weighing 1.5 g. At age 2 weeks the serum levels of the d...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.58.1.66
更新日期:1983-01-01 00:00:00