Abstract:
AIM:Childhood arthritis arises from several causes. The aim of this observational study is to compare the clinical and biological features and short-term outcome of different types of arthritis because they have different treatment and prognoses. METHODS:Children <16 years of age hospitalised in a French tertiary care centre for a first episode of arthritis lasting for less than 6 weeks who underwent joint aspiration were retrospectively included. We performed non-parametrical tests to compare groups (septic arthritis (SA), juvenile idiopathic arthritis (JIA) and arthritis with no definitive diagnosis). The time before apyrexia or C reactive protein (CRP) <10 mg/L was analysed using the Kaplan-Meier method. RESULTS:We studied 125 children with a sex ratio (M/F) of 1.1 and a median age of 2.2 years (range 0.3 to 14.6). SA was associated with a lower age at onset (1.5 years, IQR 1.2-3.0 vs 3.6 years, IQR 2.2-5.6), shorter duration of symptoms before diagnosis (2 days, IQR 1-4 vs 7 days, IQR 1-19) and higher synovial white blood cell count (147 cells ×103/mm3, IQR 71-227, vs 51 cells ×103/mm3, IQR 12-113), than JIA. Apyrexia occurred later in children with JIA (40% after 2 days, 95% CI 17% to 75%) than children with SA (82%, 95% CI 68% to 92%), as did CRP<10 mg/L (18% at 7 days, 95% CI 6.3% to 29.6% vs 82.1%, 95% CI 76.1% to 89.7%, p=0.01). CONCLUSIONS:There were no sufficiently reliable predictors for differentiating between SA and JIA at onset. The outcomes were different; JIA should be considered in cases of poor disease evolution after antibiotic treatment and joint aspiration.
journal_name
Arch Dis Childjournal_title
Archives of disease in childhoodauthors
Aupiais C,Basmaci R,Ilharreborde B,Blachier A,Desmarest M,Job-Deslandre C,Faye A,Bonacorsi S,Alberti C,Lorrot Mdoi
10.1136/archdischild-2016-310594subject
Has Abstractpub_date
2017-04-01 00:00:00pages
316-322issue
4eissn
0003-9888issn
1468-2044pii
archdischild-2016-310594journal_volume
102pub_type
杂志文章,多中心研究abstract::Over a period of 30 months, umbilical artery catheters were inserted in 229 infants. The main complications were haemorrhage, infection, and obstruction of a blood vessel. The incidence of infection was not affected by the use of prophylactic antibiotics. Vascular obstruction was more common in small infants, and in t...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.48.4.296
更新日期:1973-04-01 00:00:00
abstract:AIM:To investigate the epidemiology, clinical profile and risk factors of pseudotumor cerebri syndrome (PTCS) in children aged 1-16 years. METHODS:A national prospective population-based cohort study over 25 months. Newly diagnosed PTCS cases notified via British Paediatric Surveillance Unit were ascertained using cla...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2016-312238
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:The evidence base to guide the pharmacological management of tone and abnormal movements in cerebral palsy (CP) is limited, as is an understanding of routine clinical practice in the UK. We aimed to establish details of motor phenotype and current pharmacological management of a representative cohort across ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2018-316309
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND/AIM:The British Committee for Standards in Haematology currently recommends concomitant splenectomy in children with mild hereditary spherocytosis (HS) undergoing cholecystectomy for symptomatic gallstones. However, splenectomy is associated with a risk of life-threatening infection, particularly in young ch...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2009.178228
更新日期:2010-08-01 00:00:00
abstract:OBJECTIVES:Healthy-weight children tend to gain weight during winter but lose weight during summer. However, overweight elementary school children have shown accelerated summertime weight gain. Whether this seasonal growth variation occurs during preschool period is of substantial interest. METHODS:Data were derived f...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2018-314862
更新日期:2019-01-01 00:00:00
abstract::An usually high rate of both tuberculosis infection and active disease is reported in 11 of 38 nursery children in contact with a case of smear positive pulmonary tuberculosis, emphasising the susceptibility of young children to this disease. This report also underlines some important principles in case finding and di...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.82.5.386
更新日期:2000-05-01 00:00:00
abstract::The partial androgen insensitivity syndrome occurs in 46,XY subjects with phenotypes ranging from perineoscrotal hypospadias with cryptorchidism and micropenis (mild undervirilisation) to clitoromegaly and partial labial fusion (marked undervirilisation). Within an affected family, wide variation in the degree of geni...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.68.4.453
更新日期:1993-04-01 00:00:00
abstract::Three cases are reported in which thrombi were found in the aorta at postmortem. In each case the thrombus had originated within the ductus arteriosus. We believe that in recent years the attention paid to the presence of indwelling cannulae as a cause of embolic phenomena in the newborn period has led to a reduction ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.53.2.164
更新日期:1978-02-01 00:00:00
abstract::The range of thermal control and the thermoneutral range of preterm infants under 30 weeks' gestation was calculated by extrapolation of data from studies on more mature infants. Even assuming some thermoregulatory capacity, the range of control is less than 3 degrees C, the thermoneutral range is less than 0.5 degree...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.58.7.504
更新日期:1983-07-01 00:00:00
abstract:OBJECTIVE:To undertake a systematic review and meta-analysis to establish the effectiveness of handwashing in reducing absence and/or the spread of respiratory tract (RT) and/or gastrointestinal (GI) infection among school-aged children and/or staff in educational settings. DESIGN:Randomised-controlled trials (RCTs). ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,meta分析,评审
doi:10.1136/archdischild-2015-308875
更新日期:2016-01-01 00:00:00
abstract::Lymphocytes bearing the T cell receptor gamma delta (TCR-gamma delta) were searched for in human early milk lymphocyte suspensions by two colour cytofluorimetric analysis. It was found that the proportion of TCR-gamma delta+ cells was twofold greater in colostrum than in either autologous or heterologous blood samples...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.65.11.1274-a
更新日期:1990-11-01 00:00:00
abstract:AIMS:To test the hypothesis that oxygen free radicals are mediators of excessive protein permeability in steroid responsive nephrotic syndrome. DESIGN:Case control study. SUBJECTS: PATIENTS:20 children with steroid responsive nephrotic syndrome; controls: 20 children admitted for elective surgery. SETTING:The paedi...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.82.1.76
更新日期:2000-01-01 00:00:00
abstract::We report a child who presented with a progressive neurological disorder associated with hypertension and paroxysms of irritability and sweating in whom an abnormality of catecholamine metabolism or excretion was demonstrated. An elder sister died at the age of 2 1/2 years with similar clinical symptoms but without bl...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.53.8.682
更新日期:1978-08-01 00:00:00
abstract:OBJECTIVE:To assess height and body mass index standard deviation scores up to 20 years after treatment for acute lymphoblastic leukaemia (ALL). SUBJECTS AND METHODS:Height and body mass index standard deviation scores were measured in 33 patients (14 boys and 19 girls) with childhood ALL at diagnosis, after the end o...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.79.2.161
更新日期:1998-08-01 00:00:00
abstract::The efficacy of an absorbable antimicrobial agent trimethoprim-sulphamethoxazole (TMP-SMX) in the management of children with persistent diarrhoea was evaluated in a double blind, randomised, and placebo controlled trial. Of the 55 patients studied, 28 received TMP-SMX, and 27 received placebo. A trend in stool weight...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/adc.72.6.483
更新日期:1995-06-01 00:00:00
abstract:AIMS:(1) To determine the pattern of respiratory impairment in children with thalassaemia major (TM); (2) to assess the relation between the degree of respiratory impairment and total body iron content. METHODS:Twenty nine TM patients were recruited. All underwent physical examination, standardised pulmonary function ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.87.4.328
更新日期:2002-10-01 00:00:00
abstract:BACKGROUND:In 1999, invasive meningococcal disease was hyperendemic in Ireland at 14.75/100 000 population, with 60% group B and 30% group C diseases. National sepsis guidelines and meningococcal C vaccines were introduced in 2000. Despite a spontaneous decline in group B infection, invasive meningococcal disease remai...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,多中心研究
doi:10.1136/archdischild-2015-310215
更新日期:2016-12-01 00:00:00
abstract::A trial was conducted using sequential analysis by pairs to compare the efficacy of corticosteroids and salicylates in the treatment of acute rheumatic carditis. The results show a significantly favourable effect of steroid treatment both in clinical response and in reduction of the erythrocyte sedimentation rate. In ...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章
doi:10.1136/adc.59.5.410
更新日期:1984-05-01 00:00:00
abstract:OBJECTIVE:Outcome of children with intestinal failure (IF) has improved on treatment with parenteral nutrition (PN). The effects of PN and IF on body composition (BC) are unknown. The aim was to review BC in PN-treated children and those weaned off and to compare with reference data. DESIGN:Children on long-term/home ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2012-303516
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:It has been suggested that increasing obesity levels in young women lead to intrauterine environments that, in turn, stimulate increased obesity among their offspring, generating an intergenerational acceleration of obesity levels. If this mechanism is important, the association of maternal body mass index (...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2006.104869
更新日期:2007-10-01 00:00:00
abstract::Levels of calcium, magnesium, and glucose were measured in the blood and cerebrospinal fluid (CSF) of children with febrile convulsions. Calcium and magnesium levels were within the normal range and the blood: CSF ratios were similar to those of normal subjects. Hyperglycaemia was a frequent finding and was reflected ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.51.2.141
更新日期:1976-02-01 00:00:00
abstract::At the mid-radius, pre-pubertal asthmatic children had smaller periosteal and endosteal circumferences and thicker cortical shells compared to controls, when assessed by peripheral quantitative computed tomography. Asthmatics had diminished periosteal expansion for muscle size, suggesting that asthma, its treatment, o...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2005.084996
更新日期:2006-04-01 00:00:00
abstract::We report a child with Down's syndrome in whom metrorrhagia and precocious puberty revealed primary autoimmune hypothyroidism. The patient had a decreased growth velocity, exaggerated weight gain, bone age delay, and bilaterally enlarged multicystic ovaries. Delays in the diagnosis and treatment of hypothyroidism can ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.88.4.330
更新日期:2003-04-01 00:00:00
abstract:BACKGROUND:Recent research in febrile neutropaenia (FN) has focused on reducing the intensity of treatment for those thought to be at low risk of significant morbidity or mortality. This has not led to a reduced burden of treatment for either families or healthcare systems. An alternative approach is to discharge all p...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2019-317908
更新日期:2020-09-01 00:00:00
abstract::We report three cases of Hurler's disease in which glaucoma developed in early childhood. We draw attention to the fact that glaucoma may be a commonly unrecognised early complication of this condition. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.63.9.1091
更新日期:1988-09-01 00:00:00
abstract::Moderate and severe malnutrition are endemic in much of the developing world and in association with pockets of deprivation in the developed world. The cost in terms of individual and social development is high. The principles of effective management are clearly documented. A low cost, community based treatment progra...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.71.4.297
更新日期:1994-10-01 00:00:00
abstract::Parent reported pulse rates could provide important information on a child's clinical condition. The agreement between the parent's measurement of their child's pulse and a pulse oximeter was assessed following a brief educational intervention. Parents can be taught to measure the pulse of school age children, but hav...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2002.025643
更新日期:2004-03-01 00:00:00
abstract::Seventy infants with suspected bacterial infection in the first 48 hours of life were treated either with piperacillin and flucloxacillin or with penicillin and gentamicin. Infection was confirmed and successfully eradicated in 6 of the 35 infants receiving piperacillin and flucloxacillin. Four infants treated with pe...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.58.12.1006
更新日期:1983-12-01 00:00:00
abstract::In a multicentre study on perinatal HIV-I infection including 1493 children born from 1471 pregnancies to 1415 infected mothers, 22 twin pairs and 56 sibships (115 children) were recorded. The frequency of twin pregnancies was 1.5 (22/1471) and 3.9% (56/1415) seropositive women had more than one at risk pregnancy. In ...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1136/adc.66.10.1235
更新日期:1991-10-01 00:00:00
abstract:AIMS:To assess the impact of two paediatric intensive care unit retrieval teams on the performance of three mortality risk scoring systems: pre-ICU PRISM, PIM, and PRISM II. METHODS:A total of 928 critically ill children retrieved for intensive care from district general hospitals in the south east of England (crude m...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.87.5.421
更新日期:2002-11-01 00:00:00