Long-term seroprotection after an adolescent booster meningococcal serogroup C vaccination.

Abstract:

OBJECTIVES:To determine long-term seroprotection after serogroup C meningococcal (MenC) vaccination at the age of 9-12 years, with or without booster vaccination at the age of 13-15 years. DESIGN:Observational cohort study; follow-on from randomised study. SETTING:Participants were recruited from English secondary schools (in Oxfordshire and Buckinghamshire). PARTICIPANTS AND INTERVENTIONS:Participants were primed with MenC CRM-glycoconjugate vaccine at the age of 9-12 years in the UK routine immunisation campaign. In previous studies they were randomised at 13 to 15 years of age to receive a booster dose of MenC-CRM glycoconjugate vaccine (CRM-group) or bivalent meningococcal serogroup A/C polysaccharide vaccine (PS-group), or they received no additional doses of MenC vaccine (control group). In this follow-on study, a blood sample was obtained 11 years after primary immunisation. Of 531 individuals eligible to participate, 134 were enrolled, and 124 were included in the analysis. MAIN OUTCOME MEASURES:MenC serum bactericidal antibody (SBA) geometric mean titre; proportion of participants with SBA titre ≥8 (putative protective threshold). RESULTS:Median ages at priming, boosting and blood sampling were 10.61, 14.42 and 22.11 years, respectively. Geometric mean titres for MenC SBA were: CRM group 1373 (95% CI 954 to 1977); PS group 1024 (687 to 1526); and controls 284 (167 to 483). SBA titres ≥8 were present in 50/54 (92.6%) controls and 70/70 (100%) boosted individuals. CONCLUSIONS:The planned introduction in the UK of an adolescent booster of MenC conjugate vaccine in 2013 is likely to provide sustained protection against MenC disease. TRIAL REGISTRATION:Registered on ClinicalTrials.gov (NCT01459432).

journal_name

Arch Dis Child

authors

de Whalley PC,Snape MD,Plested E,Thompson B,Nuthall E,Omar O,Borrow R,Pollard AJ

doi

10.1136/archdischild-2013-303893

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

686-91

issue

9

eissn

0003-9888

issn

1468-2044

pii

archdischild-2013-303893

journal_volume

98

pub_type

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