Effect of adenoidectomy on respiratory function: a randomised prospective study.

Abstract:

OBJECTIVE:Risk of childhood asthma is increased in children with recurrent otitis media. This may be associated with recurrent respiratory tract infections in these children, but the role of adenoidectomy, a frequent operation during childhood, is unknown. Therefore, the role of adenoidectomy in the development of atopy and respiratory function changes characteristic of asthma was evaluated. DESIGN:Randomised controlled study. SETTING:Tertiary care centre. PATIENTS:166 children aged 12-48 months who had recurrent or persistent otitis media and who were followed-up for 3 years after randomisation. INTERVENTION:Randomisation to undergo insertion of tympanostomy tubes with or without adenoidectomy. MAIN OUTCOME MEASURES:The primary outcome measure was exercise-induced bronchoconstriction as evaluated by impulse oscillometry. The secondary outcome measures were bronchial inflammation as evaluated by exhaled nitric oxide and atopy as evaluated by skin prick tests. During the 3-year follow-up period otitis media episodes were documented in patient diaries. RESULTS:Adenoidectomy did not significantly influence baseline lung function, exercise-induced bronchoconstriction, exhaled nitric oxide concentration, the development of positive skin prick tests, or doctor-diagnosed asthma. Adenoidectomy did not significantly prevent otitis media. Recurrent otitis media (>or=4 episodes) during the first follow-up year was associated with an abnormal exercise-induced bronchoconstriction (OR 6.62, 95% CI 1.27 to 34) and an elevated exhaled nitric oxide concentration (OR 3.26, 95% CI 0.98 to 10.8) regardless of adenoidectomy. CONCLUSIONS:Adenoidectomy did not promote asthma or allergy. Recurrent respiratory tract infections during early childhood are associated with the risk of bronchial hyper-reactivity.

journal_name

Arch Dis Child

authors

Mattila PS,Hammarén-Malmi S,Pelkonen AS,Malmberg LP,Mäkelä MJ,Saxen H,Tarkkanen J

doi

10.1136/adc.2008.145664

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

366-70

issue

5

eissn

0003-9888

issn

1468-2044

pii

adc.2008.145664

journal_volume

94

pub_type

杂志文章,随机对照试验
  • Acute effects of instillation of surfactant in severe respiratory distress syndrome.

    abstract::Doppler ultrasound measurements of pulmonary blood flow in 20 babies with severe respiratory distress syndrome treated in a randomised controlled trial of surfactant replacement showed that the immediate improvement of oxygenation was not associated with a significant increase in pulmonary blood flow. Reduction in ven...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/adc.64.1_spec_no.13

    authors: Halliday HL,McCord FB,McClure BG,Reid MM

    更新日期:1989-01-01 00:00:00

  • Familial partial trisomy of the long arm of chromosome 3 (3q).

    abstract::A case of partial trisomy of the long arm of chromosome 3 (3q21 leads to qter) is described. The clinical findings are compared with those in 5 previously reported cases. There is hirsutism and characteristic facial dysmorphism, the common features of which are a square-shaped face, prominent nasal bridge, everted nos...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.54.2.135

    authors: Fear C,Briggs A

    更新日期:1979-02-01 00:00:00

  • Staff stress and job satisfaction at a children's hospice.

    abstract::A study of staff stress and job satisfaction was undertaken in a children's hospice. In addition factors were investigated which might be stressful or which helped staff to manage in difficult circumstances. Three quarters were under comparatively little stress and in general showed very few psychological symptoms but...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.64.1.114

    authors: Woolley H,Stein A,Forrest GC,Baum JD

    更新日期:1989-01-01 00:00:00

  • A retrospective observational study comparing rescue medication use in children on combined versus separate long-acting beta-agonists and corticosteroids.

    abstract:BACKGROUND:Data on the efficacy and safety of long-acting β2-agonists (LABA) in children are limited, and current guidelines recommend that LABA always be used with inhaled corticosteroids (ICS). OBJECTIVE:To compare asthma control, assessed by rescue medications use, in children prescribed LABA and ICS as a fixed-dos...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

    doi:10.1136/adc.2009.179069

    authors: Elkout H,McLay JS,Simpson CR,Helms PJ

    更新日期:2010-10-01 00:00:00

  • Changes in nocturnal oximetry after treatment of exacerbations in cystic fibrosis.

    abstract::Sleep related arterial oxygen desaturation has been described in clinically stable young adults with cystic fibrosis. The incidence and severity of nocturnal oxygen desaturation in children during infective exacerbations and the changes that occur with treatment were examined. Forty five children with proved cystic fi...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.69.2.197

    authors: Allen MB,Mellon AF,Simmonds EJ,Page RL,Littlewood JM

    更新日期:1993-08-01 00:00:00

  • Pupil size in diabetes.

    abstract::Sympathetic function was studied in 101 diabetic children and 102 age and sex matched control children, as part of a longitudinal study of the evolution of microvascular disease in the population of diabetic children and adolescents in Avon County. The median (range) age of the diabetic population was 13.5 (6.0-17.2) ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.71.6.511

    authors: Karavanaki K,Davies AG,Hunt LP,Morgan MH,Baum JD

    更新日期:1994-12-01 00:00:00

  • An observational study to evaluate micronutrient status during enteral feeding.

    abstract:BACKGROUND:There are few data on the optimal micronutrient composition of paediatric enteral feeds. The recent European Directive on Foods for Special Medical Purposes (1999/21/EC) did not distinguish between the composition of adult and paediatric feeds. AIMS:To evaluate, in an open, observational study, the long ter...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.86.6.411

    authors: Johnson TE,Janes SJ,MacDonald A,Elia M,Booth IW

    更新日期:2002-06-01 00:00:00

  • Non-cardiac benefits of human recombinant erythropoietin in end stage renal failure and anaemia.

    abstract::Recombinant human erythropoietin (r-HuEpo) is now available to correct the anaemia of end stage renal failure. The clinical consequences of increasing the haemoglobin concentration in children on dialysis are incompletely documented; a placebo controlled study is essential when assessing subjective changes, for exampl...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/adc.69.5.580

    authors: Morris KP,Sharp J,Watson S,Coulthard MG

    更新日期:1993-11-01 00:00:00

  • Intravenous atropine treatment in infantile hypertrophic pyloric stenosis.

    abstract:AIMS:To assess the efficacy of a new regimen of intravenous atropine treatment for infantile hypertrophic pyloric stenosis (IHPS) with special reference to regression of pyloric hypertrophy. METHODS:Atropine was given intravenously at a dose of 0.01 mg/kg six times a day before feeding in 19 patients with IHPS diagnos...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.87.1.71

    authors: Kawahara H,Imura K,Nishikawa M,Yagi M,Kubota A

    更新日期:2002-07-01 00:00:00

  • Effects of overweight on lung function.

    abstract::Spirometric data from 1586 healthy children, who did not smoke, were analysed to examine the effects of overweight as measured by the body mass index (weight/height2) on lung function. Overweight (72 boys, 88 girls) was defined as on or above the 90th percentile weight for height. After having controlled for the confo...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.65.5.512

    authors: Fung KP,Lau SP,Chow OK,Lee J,Wong TW

    更新日期:1990-05-01 00:00:00

  • Maternal mental health and childhood injury: evidence from the UK Millennium Cohort Study.

    abstract:OBJECTIVE:We assessed whether maternal mental health problems increased rates for child injury during the preschool years and mid-childhood, and the extent to which associations could be accounted for by a range of potential explanatory factors. DESIGN:We analysed the UK Millennium Cohort Study, a nationally represent...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2017-313809

    authors: Hope S,Deighton J,Micali N,Law C

    更新日期:2019-03-01 00:00:00

  • Ultrastructural abnormalities of bronchial cilia in children with recurrent airway infections and bronchiectasis.

    abstract::Anomalies of the bronchial cilia were studied in 5 children with recurrent pulmonary infections. Case 1 had Kartagener's syndrome and an absence of the inner and outer dynein arms in most cilia, although a few shortened and even some normal arms could be seen. Cases 2 and 3 had unilateral bronchiectasis without family...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.56.12.929

    authors: Corbeel L,Cornillie F,Lauweryns J,Boel M,van den Berghe G

    更新日期:1981-12-01 00:00:00

  • Tuberous sclerosis complex and Wolff-Parkinson-White syndrome.

    abstract::This report highlights the association between tuberous sclerosis and Wolff-Parkinson-White syndrome. Ten patients with concurrent diagnoses of Wolff-Parkinson-White syndrome and tuberous sclerosis were identified. Wolff-Parkinson-White syndrome presented early in life, nine cases being diagnosed in the first year. Ei...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/adc.78.2.159

    authors: O'Callaghan FJ,Clarke AC,Joffe H,Keeton B,Martin R,Salmon A,Thomas RD,Osborne JP

    更新日期:1998-02-01 00:00:00

  • Anthropometry of patients with osteogenesis imperfecta.

    abstract::Standing height, sitting height, armspan, subischial leg length, head circumference, and growth hormone-insulin-like growth factor I (IGF-I) axis were determined in 86 patients with osteogenesis imperfecta. The aim of this study was to determine standing height and body proportions and their variability among osteogen...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.80.6.524

    authors: Lund AM,Müller J,Skovby F

    更新日期:1999-06-01 00:00:00

  • Neuropathy in a petrol sniffer.

    abstract::A 4 year old boy developed a profound motor neuropathy after repeated deliberate inhalation of petroleum vapour. The condition was characterised by extreme slowing of the nerve conduction velocity. He made a gradual recovery over six months. The neuropathy was attributed to the N-hexane component of petroleum. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.61.9.900

    authors: Hall DM,Ramsey J,Schwartz MS,Dookun D

    更新日期:1986-09-01 00:00:00

  • Fibrosing colonopathy in cystic fibrosis.

    abstract::The introduction of enteric coated pancreatic enzyme supplements in the early 1980s was undoubtedly one of the major advances in the care of children with cystic fibrosis. Further refinements in the presentation of these preparations inevitably followed, to improve patient acceptability and compliance. The emergence o...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/adc.74.5.464

    authors: Smyth RL

    更新日期:1996-05-01 00:00:00

  • Socioeconomic disadvantage and onset of childhood chronic disabling conditions: a cohort study.

    abstract:OBJECTIVE:To study the temporal relationship between socioeconomic disadvantage and onset of chronic disabling conditions in childhood. METHOD:Using parent reported data from the Longitudinal Study of Australian Children, we compared children who developed a chronic disabling condition between the ages of 6/7 and 10/1...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2013-305634

    authors: Spencer N,Strazdins L

    更新日期:2015-04-01 00:00:00

  • The role of inflammation in childhood asthma.

    abstract::The role of inflammation in adult asthma is well known, involving a cascade of immunological stimulation in which mast cells and eosinophils play pivotal roles. However, the assessment of airway inflammation in children is more difficult as the invasive methods used in adults cannot ethically be used for this purpose ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/adc.82.suppl_2.ii6

    authors: Chedevergne F,Le Bourgeois M,de Blic J,Scheinmann P

    更新日期:2000-06-01 00:00:00

  • Acquired aplastic anaemia: still a serious disease.

    abstract::Over 15 years, 42 children aged 2-14 years were diagnosed as having acquired aplastic anaemia. Adequate clinical details were available for 38 children who were categorised as very severe (n = 13), severe (n = 16), or nonsevere (n = 9) by the modified Camitta criteria. Treatment varied over the study period. Seven chi...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.66.7.858

    authors: Webb DK,Hann IM,Chessells JM

    更新日期:1991-07-01 00:00:00

  • Cord blood IgE and month of birth.

    abstract::If cord blood IgE is used to detect those predisposed to become allergic it is important to define appropriately the normal values for this measurement. A commonly cited cut off point is 1.0 IU/ml. We analysed 5353 cord blood samples for IgE by means of an enzyme linked immunosorbent assay. Descriptive statistics of t...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.62.5.478

    authors: Kimpen J,Callaert H,Embrechts P,Bosmans E

    更新日期:1987-05-01 00:00:00

  • Health consequences of obesity.

    abstract::The recent epidemic of childhood obesity(1) has raised concern because of the possible clinical and public health consequences.(2,)(3) However, there remains a widespread perception among health professionals that childhood obesity is a largely cosmetic problem, with minor clinical effects. No systematic review has ye...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,meta分析,评审

    doi:10.1136/adc.88.9.748

    authors: Reilly JJ,Methven E,McDowell ZC,Hacking B,Alexander D,Stewart L,Kelnar CJ

    更新日期:2003-09-01 00:00:00

  • Predicting treatment outcome in nocturnal enuresis.

    abstract::A presenting sample of 127 consecutive referrals to a community based enuresis clinic were evaluated after treatment with baseline behavioural recording and the enuresis alarm. Almost one in five became dry after baseline recording only while 81 of 96 (84%) enuretics who used the alarm achieved the initial dryness cri...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章

    doi:10.1136/adc.65.10.1158

    authors: Devlin JB,O'Cathain C

    更新日期:1990-10-01 00:00:00

  • The clinical and health economic burden of respiratory syncytial virus disease among children under 2 years of age in a defined geographical area.

    abstract:AIMS:To describe the clinical and health economic impact of respiratory syncytial virus (RSV) disease in children under 2 years of age. METHODS:Hospitalised children less than 2 years of age with a respiratory illness were studied over three consecutive RSV seasons (1996-99). RESULTS:The rates (per 1000 infants under...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.88.12.1065

    authors: Deshpande SA,Northern V

    更新日期:2003-12-01 00:00:00

  • Growth and nutrition in children with ataxia telangiectasia.

    abstract:BACKGROUND:Ataxia telangiectasia (A-T) is a rare multisystem disease with high early mortality from lung disease and cancer. Nutritional failure adversely impacts outcomes in many respiratory diseases. Several factors influence nutrition in children with A-T. We hypothesised that children with A-T have progressive grow...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2015-310373

    authors: Stewart E,Prayle AP,Tooke A,Pasalodos S,Suri M,Bush A,Bhatt JM

    更新日期:2016-12-01 00:00:00

  • Generalised lymphangiomatosis with chylothorax.

    abstract::A 9 month old boy presented with acute respiratory distress and was found to have a left pleural effusion. The chylous nature of the effusion, multiple bony lytic lesions, and splenic cysts lead to the diagnosis of congenital lymphangiomatosis with chylothorax. Surgical intervention including pleurectomy was required ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.64.7.1058

    authors: Dunkelman H,Sharief N,Berman L,Ninan T

    更新日期:1989-07-01 00:00:00

  • Raised intracranial pressure not detected by ultrasound.

    abstract::Two patients with raised intracranial pressure responding to ventriculoperitoneal shunting are described in whom ultrasound failed to show dilated ventricles. The importance of not equating absence of ventricular dilatation with normal pressure and ventricular dilatation with high pressure is emphasised. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.60.6.581

    authors: Pilling DW,Cudmore RE

    更新日期:1985-06-01 00:00:00

  • Thermoregulation in babies immediately after birth.

    abstract::The fall in body temperature that occurs in babies soon after birth is influenced by the baby's weight and its environmental conditions. The rate of oxygen consumption 1 1/2 hours after birth was unrelated to body temperature and only slightly raised, indicating a limited thermogenic capacity. A radiant heater effecti...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.53.1.58

    authors: Smales OR,Kime R

    更新日期:1978-01-01 00:00:00

  • Constipation and reversible urinary tract abnormalities.

    abstract::Urinary tract anomalies were prospectively investigated with ultrasound in 29 children with functional constipation. These children were compared before and after treatment with 451 age matched healthy controls without constipation. The bladder residue and upper renal tract dilatation after micturition were significan...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.70.1.56

    authors: Dohil R,Roberts E,Jones KV,Jenkins HR

    更新日期:1994-01-01 00:00:00

  • Growth of primary school children: a validation of the 1990 references and their use in growth monitoring.

    abstract:AIMS:To determine whether the British 1990 growth charts are valid for cross sectional and longitudinal use in primary school children. METHODS:A total of 694 children aged 7-10 years from 10 Leeds primary schools were weighed and measured annually over three years by an expert auxologist. SD scores were calculated us...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.83.4.298

    authors: Rudolf MC,Cole TJ,Krom AJ,Sahota P,Walker J

    更新日期:2000-10-01 00:00:00

  • Chronic lymphoglandular enlargement and toxoplasmosis in children.

    abstract::Serum antitoxoplasma titres were determined simultaneously by the direct agglutination and the indirect immunofluorescent tests in 52 children aged 2 to 16 years having chronic lymph node enlargement, mainly cervical. Direct agglutination titres were raised (64 to 4096) in 22 children (42%), but rarely in the control ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.52.5.403

    authors: Thomaidis T,Anastassea-Vlachou K,Mandalenaki-Lambrou C,Theodoridis C,Vrahnou E

    更新日期:1977-05-01 00:00:00