Abstract:
BACKGROUND:Data on the efficacy and safety of long-acting β2-agonists (LABA) in children are limited, and current guidelines recommend that LABA always be used with inhaled corticosteroids (ICS). OBJECTIVE:To compare asthma control, assessed by rescue medications use, in children prescribed LABA and ICS as a fixed-dose combination (LABA/ICS) or concurrently via separate inhalers (LABA+ICS). METHODS:Retrospective observational study of asthma medication prescribed to children aged 0-18 years registered with 40 primary care practices for the years 2002-6. Asthma control, reflected by requirement for oral corticosteroids (OCS) and/or six or more short-acting β2-agonist (SABA) canisters per year, was assessed for children prescribed LABA/ICS or LABA+ICS. RESULTS:10,454 (8%) of all registered children received at least one prescription for asthma medication over the study period. Prescribing of LABA/ICS increased significantly, with a concomitant decrease in prescribing of LABA+ICS. Use of OCS increased by 60%, with the lowest use in children prescribed only SABA and highest use in those prescribed LABA. Children prescribed LABA/ICS were significantly less likely than those prescribed LABA+ICS to require OCS rescue therapy and or >6 SABA inhalers a year (OR 1.6; 95% CI 1.1 to 2.2; p=0.04 and OR 1.7; 95% CI 1.1 to 2.5; p=0.005, respectively, for the years 2005-6). CONCLUSIONS:The results of this retrospective observational study suggest that children prescribed fixed-dose LABA-and-ICS combination devices achieve better asthma control, as reflected in reduced requirements for SABA and reduced courses of OCS than equivalent doses in separate devices.
journal_name
Arch Dis Childjournal_title
Archives of disease in childhoodauthors
Elkout H,McLay JS,Simpson CR,Helms PJdoi
10.1136/adc.2009.179069subject
Has Abstractpub_date
2010-10-01 00:00:00pages
817-21issue
10eissn
0003-9888issn
1468-2044pii
adc.2009.179069journal_volume
95pub_type
杂志文章,多中心研究abstract::Multiple double blind placebo controlled challenges with tartrazine 50 mg (three challenges) and glucose placebo (three challenges) were performed in 12 children with atopic eczema aged 1 to 6 years. The children were selected on the basis of severity (regular clinic attenders) and a parental history that tartrazine p...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/adc.67.6.709
更新日期:1992-06-01 00:00:00
abstract::Persistent daytime incontinence is a fairly uncommon but important problem. Videourodynamic studies were carried out in 215 children presenting with this problem in whom there were no neurological signs and who had not responded to simple measures. Over 90% of symptomatic children were shown to have an abnormality, of...
journal_title:Archives of disease in childhood
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journal_title:Archives of disease in childhood
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abstract::A retrospective study was made of 30 children with Leber's amaurosis (congenital retinal blindness). 24 presented with severe visual impairment, typical ophalmological findings, and absent electroretinograms. 6 other children, though presenting with marked visual loss and absent electroetinograms were later shown to b...
journal_title:Archives of disease in childhood
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doi:10.1136/adc.52.5.399
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journal_title:Archives of disease in childhood
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doi:10.1136/adc.65.10_spec_no.1033
更新日期:1990-10-01 00:00:00
abstract:INTRODUCTION:UK screening for congenital hypothyroidism (CH) is based on dried blood spot Thyroid Stimulating Hormone (TSH). Scintigraphy may identify CH subtypes classified as dysplasia, gland in situ (GIS) and ectopia, but is not performed in all centres. We retrospectively investigated the role of scintigraphy to id...
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journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:
更新日期:1982-01-01 00:00:00
abstract::Sympathetic function was studied in 101 diabetic children and 102 age and sex matched control children, as part of a longitudinal study of the evolution of microvascular disease in the population of diabetic children and adolescents in Avon County. The median (range) age of the diabetic population was 13.5 (6.0-17.2) ...
journal_title:Archives of disease in childhood
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更新日期:1994-12-01 00:00:00
abstract::Clostridium difficile cytopathic toxin was found in the faeces or gut content of five of 39 neonates with necrotising enterocolitis (NEC). Toxin concentrations were uniformly low and did not differ from those found in healthy neonates. C difficile is unlikely to be involved in the pathogenesis of NEC. Stools from 33 b...
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journal_title:Archives of disease in childhood
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doi:10.1136/adc.88.12.1101
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更新日期:1989-01-01 00:00:00
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journal_title:Archives of disease in childhood
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journal_title:Archives of disease in childhood
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更新日期:2002-03-01 00:00:00
abstract::Seventy three preterm infants weighing less than 1500 g or less than 32 weeks' gestation, or both, were allocated randomly to treatment (fresh frozen plasma 10 ml/kg on admission and at 24 hours of age) or control groups. Fifteen (41%) out of 37 control patients sustained intraventricular haemorrhage compared with fiv...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1985-08-01 00:00:00
abstract::The family histories relating to asthma and wheezy bronchitis were examined in 77 asthmatic, 78 wheezy bronchitic, and 87 control children, aged between 1 and 12 years. The percentage of children with at least one asthmatic relative was significantly greater in the asthmatic and wheezy bronchitic probands than in the ...
journal_title:Archives of disease in childhood
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doi:10.1136/adc.55.5.354
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journal_title:Archives of disease in childhood
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journal_title:Archives of disease in childhood
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journal_title:Archives of disease in childhood
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更新日期:2016-09-01 00:00:00
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journal_title:Archives of disease in childhood
pub_type: 杂志文章
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更新日期:1988-08-01 00:00:00
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journal_title:Archives of disease in childhood
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更新日期:2019-09-01 00:00:00
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journal_title:Archives of disease in childhood
pub_type: 杂志文章
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更新日期:2016-09-01 00:00:00
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journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.52.3.219
更新日期:1977-03-01 00:00:00
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journal_title:Archives of disease in childhood
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2007-11-01 00:00:00
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journal_title:Archives of disease in childhood
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doi:10.1136/adc.87.4.354
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journal_title:Archives of disease in childhood
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2000-01-01 00:00:00