Abstract:
:Interleukin-2 (IL-2) and T cell subpopulations were evaluated in children with rheumatic heart disease (RHD). Three groups were included: 13 patients with active RHD, 12 with non-active RHD, and 14 control children. Serum IL-2 and T cell subpopulations were measured by radioimmunoassay and monoclonal antibodies respectively. Patients with active RHD showed a significant increase in IL-2 concentrations and helper:suppressor (H:S) ratio compared with controls with a mean (SEM) IL-2 of 3.48 (0.62) v 1.26 (0.16) U/ml and H:S ratio 2.31 (0.14) v 1.66 (0.04). There was a significant decrease in T suppressor (CD8+) and pan T (CD3+) cells compared with controls with a mean (SEM) for CD8+ of 23.75 (1.19) v 32.23 (0.56)% and CD3+ of 79.55 (0.94) v 85.00 (0.11)%. Patients with non-active RHD showed a significant decrease only in the CD3+ cells (78.20 (0.20)%) when compared with controls. A deficiency of CD3+ cells is a constant finding in patients with RHD, whether the disease is active or not. There was a significant increase in IL-2 concentration with a significant decrease in CD8+ cells in patients with active RHD in comparison with the non-active group (mean (SEM) IL-2 of 3.48 (0.62) v 1.85 (0.24) U/ml and CD8+ of 23.75 (1.19) v 28.83 (1.91)%). Thus an increase in IL-2 and a decrease in CD8+ cells may be related to rheumatic activity. T helper (CD4+) cells did not differ significantly between groups.
journal_name
Arch Dis Childjournal_title
Archives of disease in childhoodauthors
Zedan MM,el-Shennawy FA,Abou-Bakr HM,al-Basousy AMdoi
10.1136/adc.67.11.1373subject
Has Abstractpub_date
1992-11-01 00:00:00pages
1373-5issue
11eissn
0003-9888issn
1468-2044journal_volume
67pub_type
杂志文章abstract::Renal candidal bezoar is uncommonly encountered in neonatal intensive care. An affected neonate who improved only after surgical removal of obstructive fungus from the renal pelvis and local irrigation with amphotericin B is described. The need for early consideration of surgical intervention is stressed. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.67.1_spec_no.63
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVE:To study the effect of body composition on average daily metabolic rate (ADMR) and basal metabolic rate (BMR) in adolescence, and to examine current BMR prediction equations. STUDY:Dutch adolescents were pooled with previously reported American and British subjects (n = 90 overall). BMR and ADMR were analyse...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.85.1.73
更新日期:2001-07-01 00:00:00
abstract::Growth velocity of head circumference was studied longitudinally in different gestational age groups of 222 appropriate-weight-for-dates (AFD) and 94 small-for-dates (SFD) healthy infants during the first 5 months of life. Term AFD and SFD infants showed a steady slowing of growth rate of head circumference from birth...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.52.2.105
更新日期:1977-02-01 00:00:00
abstract:AIMS:To compare physiological and autonomic responses to acute hypoglycaemia in diabetic children in pre-, mid-, and post-pubertal stages of development. METHODS:Twenty seven children (8 pre-pubertal, 7 mid-pubertal, 12 post-pubertal) with type 1 diabetes were studied. Hypoglycaemia was induced by insulin infusion unt...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2004.052035
更新日期:2005-02-01 00:00:00
abstract::Twenty-one babies of 34-41 weeks' gestational age with birth asphyxia (5 minute Apgar score less than or equal to 5 or umbilical artery pH less than or equal to 7.2) were studied during the first two days of life to find out whether the urinary excretion of tubular markers of renal function is of value in the early di...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.65.10_spec_no.1021
更新日期:1990-10-01 00:00:00
abstract::Fifty-one children with a bacteriologically proven urinary tract infection had both an intravenous urogram (IVU) and a micturating cystogram. The IVU was normal in 35. Only 6 of these children showed reflux in the cystogram, affecting 7 of the 70 ureters at risk. Since reflux on its own does not cause renal damage, wh...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.51.11.893
更新日期:1976-11-01 00:00:00
abstract:AIMS:To establish whether subjects with previous evidence of sleep apnoea prior to adenotonsillectomy continue to have evidence of narrower upper airways during sleep, 12 years later. METHODS:Twenty subjects (median age 16 years) underwent repeat sleep studies at home, 12 years after such studies had shown significant...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.86.1.34
更新日期:2002-01-01 00:00:00
abstract::Altogether 38 postpubertal children with coeliac disease were rebiopsied. Mucosal abnormality in nine (24%) of them indicated poor adherence to the diet. Gluten challenge with a diet containing a normal amount of gluten was performed in those 29 patients with a normal mucosa. During challenge, rebiopsy was done when r...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.64.11.1604
更新日期:1989-11-01 00:00:00
abstract::A 9 year old girl presented with clinical manifestations of Henoch-Schönlein syndrome and macroscopic haematuria. Laboratory investigations showed selective IgA deficiency and renal biopsy showed mesangial proliferative glomerulonephritis with diffuse granular deposits of C3 on immunofluorescence. IgA deposits were ab...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.60.2.160
更新日期:1985-02-01 00:00:00
abstract:BACKGROUND:Critical incidents are common during the inter-hospital transfer of sick patients, and infants are an especially vulnerable group. AIMS:To examine the effect of critical incident review on the number of adverse events during inter-hospital transfer of sick infants. METHODS:Critical incidents over an eight ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,多中心研究
doi:10.1136/adc.2004.066639
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVES:To assess bone and collagen turnover in asthmatic children treated with dry powder budesonide from the Turbuhaler and dry powder beclomethasone dipropionate from the Diskhaler in a dose of 800 micrograms/day. SUBJECTS:Thirteen prepubertal children with asthma. DESIGN:Open crossover study with two treatment...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/adc.73.6.524
更新日期:1995-12-01 00:00:00
abstract::Serial small intestinal biopsies related to withdrawal and challenge with cows' milk are described in 5 infants with cows' milk protein intolerenace. On the basis of these serial observations the existence of a cows' milk-sensitive enteropathy in infancy is clearly established. The cows' milk-sensitive mucosal lesion ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.53.5.375
更新日期:1978-05-01 00:00:00
abstract::Three children with cystic fibrosis developed steatorrhoea unresponsive to changes in pancreatic supplements. The final diagnoses were chronic giardiasis, stagnant loop syndrome, and Crohn's disease. Refractory intestinal symptoms in cystic fibrosis merit further investigation. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.63.12.1496
更新日期:1988-12-01 00:00:00
abstract::Analysis of both the content and process of examinations is central to planning the appropriate education and training of examiners in paediatric clinical examinations. This paper discusses the case for developing training, reviews the current literature, and suggests the desirable attributes of examiners and the comp...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/adc.2004.055103
更新日期:2005-01-01 00:00:00
abstract:AIM:To evaluate the quality of paediatric audits from 1966 to 1999. METHODS:A Medline search was performed using the MeSH terms audit, child, paediatric (and pediatric). Predefined core elements of audit were used as inclusion criteria for entry of an article into this study. These criteria were as follows: (1) an art...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/adc.2004.071381
更新日期:2007-04-01 00:00:00
abstract::The association of weight for height and triceps skinfold with seven respiratory symptoms has been examined using logistic regression analysis in 7800 5 to 11 year old children (6200 in England and 1600 in Scotland). The results support the view that overweight children have a greater liability to some respiratory sym...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.59.10.940
更新日期:1984-10-01 00:00:00
abstract:AIMS:To describe the epidemiology of children with traumatic brain injury (TBI) admitted to paediatric intensive care units (PICUs) in the UK. METHODS:Prospective collection of clinical and demographic information from paediatric and adult intensive care units in the UK and Eire between February 2001 and August 2003. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,多中心研究
doi:10.1136/adc.2005.072405
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVE:To review the clinical features, treatment, and outcome of children in the UK with Down's syndrome and acute myeloid leukaemia (AML). DESIGN:A retrospective study of 59 children with Down's syndrome and AML presenting between 1987 and 1995. Data were obtained from hospital case notes, trial records, and by q...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.81.1.32
更新日期:1999-07-01 00:00:00
abstract:OBJECTIVE:To examine the efficacy and safety of torasemide in children with chronic heart failure (HF). METHODS:102 children with chronic HF who had received oral torasemide were analysed. Of these, 62 (de novo group) were newly diagnosed as having HF and were given torasemide as a diuretic. The remaining 40 (replacem...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2007.129239
更新日期:2008-09-01 00:00:00
abstract:AIMS:To examine the disease burden and epidemiology of community acquired rotavirus gastroenteritis in Austrian children treated in a paediatric practice. METHODS:A prospective, population based, multicentre study in four paediatric practices and two children's hospitals (Innsbruck and Leoben). Children = 48 months ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,多中心研究
doi:10.1136/adc.84.5.393
更新日期:2001-05-01 00:00:00
abstract::The performance of indirect indices of infection in the newborn vary because of differences in techniques, including diagnostic cut off levels. We have compared serial neutrophil band cell counts with C reactive protein measured by rate nephelometry. The 'gold standard' was a positive culture and the performance of th...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.67.7_spec_no.808
更新日期:1992-07-01 00:00:00
abstract:BACKGROUND:Faecal impaction is frequently observed in children with chronic constipation. The term megarectum is often used to describe this finding. AIM:To evaluate rectal functioning and rectal measures in constipated children with a filled rectum, in order to define the terms faecal impaction, enlarged rectum, and ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.83.1.52
更新日期:2000-07-01 00:00:00
abstract::The measurement of albumin/creatinine ratios and simple albumin concentrations in early morning urine specimens were evaluated to establish which was the best screening test for those likely to have microalbuminuria by the reference standard analysis of timed overnight urine specimens. The measurement of an albumin/cr...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.72.6.524
更新日期:1995-06-01 00:00:00
abstract::Seven children with precocious puberty were treated with cyproterone acetate and their adrenal function studied. In each child the drug caused significant adrenal hypofunction which was secondary to adrenocorticotrophic hormone suppression. None of these children had clinical evidence of adrenal hypofunction and it is...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.56.3.218
更新日期:1981-03-01 00:00:00
abstract::Diseases causing high mortality in children under 5 years of age in resource limited settings (RLS) could be treated if children in these countries had access to existing medicines. It took 30 years before the WHO Essential Medicines List (EML) considered the issue of medicines for children, with the first EML for chi...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/adc.2009.180000
更新日期:2011-08-01 00:00:00
abstract::We studied the effects on the family of childhood chronic renal failure by contrasting children with varying degrees of severity of illness with healthy controls. Disruption of family life was most common in families with the more severely ill children (on hospital haemodialysis) and there was a tendency for more ment...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.63.7.821
更新日期:1988-07-01 00:00:00
abstract::Children with end stage renal failure and anaemia have an increased cardiac index and often gross ventricular hypertrophy. Correction of anaemia with recombinant human erythropoietin (r-HuEpo) for less than six months results in a reduction in the cardiac index without a significant reduction in left ventricular hyper...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.71.2.119
更新日期:1994-08-01 00:00:00
abstract:OBJECTIVE:To explore the effect of research ethics, governance and consent requirements and recent reforms on UK-wide follow-up of children with congenital heart defects (CHD). DESIGN:Prospective cohort study. SETTING:UK National Health Service. PATIENTS:3897 children with CHD requiring intervention, or resulting in...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,多中心研究
doi:10.1136/adc.2008.152975
更新日期:2011-01-01 00:00:00
abstract::This paper describes 48 children, aged 14 years or less, who met diagnostic criteria for anorexia nervosa modified from Morgan and Russell. The characteristics of the sample (13 boys and 35 girls) are described along with features of the illness, associated family characteristics, treatment in hospital, and a brief de...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/adc.62.2.114
更新日期:1987-02-01 00:00:00
abstract::The clinical profile, malignant potential, and management of 17 children with juvenile polyposis (more than five juvenile polyps) were evaluated clinically and endoscopically. Colonoscopy and polypectomy were done three weekly until colonic clearance was achieved, and thereafter two yearly. All polyps were subjected t...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.78.3.264
更新日期:1998-03-01 00:00:00