Receiver operating characteristic curves for comparison of serial neutrophil band forms and C reactive protein in neonates at risk of infection.

Abstract:

:The performance of indirect indices of infection in the newborn vary because of differences in techniques, including diagnostic cut off levels. We have compared serial neutrophil band cell counts with C reactive protein measured by rate nephelometry. The 'gold standard' was a positive culture and the performance of the tests was compared by the technique of receiver operating characteristics (ROC) as well as sensitivity and specificity. A total of 172 septic screens were performed in 56 patients. The operational diagnostic cut off values were: C reactive protein greater than 8 mg/l, immature:total neutrophil ratio (I:T ratio) greater than 0.2, and band count greater than 5%. Compared with the sensitivity of C reactive protein (71%), I:T ratio (34%) was significantly different but band count (69%) was not. The specificity of C reactive protein (72%) was better than band count (39%) but no better than I:T ratio (73%). ROC curves were constructed for all possible diagnostic cut off values of the tests and superior performance was demonstrated for C reactive protein compared with band count and I:T ratio. We conclude that C reactive protein is a useful early indicator of infection in neonates and that ROC curves permit comprehensive and graphic comparison between tests and the calculation of optimal diagnostic cut off values.

journal_name

Arch Dis Child

authors

Russell GA,Smyth A,Cooke RW

doi

10.1136/adc.67.7_spec_no.808

subject

Has Abstract

pub_date

1992-07-01 00:00:00

pages

808-12

issue

7 Spec No

eissn

0003-9888

issn

1468-2044

journal_volume

67

pub_type

杂志文章
  • The sodium and potassium intake of 3 to 5 year olds.

    abstract::The sodium intake of preschool children in their home environment was investigated and the major sources of sodium other than added table salt identified. Thirty five children from a Southampton general practice were studied. Twenty four hour urinary sodium excretion was measured as a reliable indicator of daily total...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.61.2.159

    authors: Allison ME,Walker V

    更新日期:1986-02-01 00:00:00

  • Variation in paediatric hospital antibiotic guidelines in Europe.

    abstract:OBJECTIVE:To assess the availability and source of guidelines for common infections in European paediatric hospitals and determine their content and characteristics. DESIGN:Participating hospitals completed an online questionnaire on the availability and characteristics of antibiotic prescribing guidelines and on empi...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

    doi:10.1136/archdischild-2015-308255

    authors: Spyridis N,Syridou G,Goossens H,Versporten A,Kopsidas J,Kourlaba G,Bielicki J,Drapier N,Zaoutis T,Tsolia M,Sharland M,ARPEC Project Group Members.

    更新日期:2016-01-01 00:00:00

  • Prospective surveillance study of medium chain acyl-CoA dehydrogenase deficiency in the UK.

    abstract:BACKGROUND:Medium chain acyl-CoA dehydrogenase (MCAD) deficiency is a common disorder of fatty acid oxidation in north west Europe. It is very variable in its clinical consequences and is believed to be considerably underdiagnosed. OBJECTIVE:To investigate the diagnosis and outcome of MCAD deficiency in the UK. METHO...

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    doi:10.1136/adc.79.2.116

    authors: Pollitt RJ,Leonard JV

    更新日期:1998-08-01 00:00:00

  • Impact of HIV-1 infection in South Africa.

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    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.85.1.50

    authors: Pillay K,Colvin M,Williams R,Coovadia HM

    更新日期:2001-07-01 00:00:00

  • Utility of lung ultrasound scanning in neonatology.

    abstract::The utility of point-of-care lung ultrasound in neonatology is rapidly expanding. This review summarises current evidence of a diagnostic, procedural and observational tool valuable in the management of newborns requiring intensive care. Approaching a patient, probe in-hand with focused clinical question is essential,...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/archdischild-2017-314538

    authors: Woods PL

    更新日期:2019-09-01 00:00:00

  • Respiratory symptoms in children of low birth weight.

    abstract::We recorded the respiratory history by questionnaire in a 7 year old cohort of children whose birth weight was under 2000 g and an unselected reference group of local schoolchildren of the same age. Complete data were obtained in 121 low birthweight children (90% of those studied): 62 who had no neonatal respiratory i...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.64.9.1294

    authors: Chan KN,Elliman A,Bryan E,Silverman M

    更新日期:1989-09-01 00:00:00

  • Motor disorders of the oesophagus in gastro-oesophageal reflux.

    abstract::Mechanisms of gastro-oesophageal reflux were studied by oesophageal manometry and pH monitoring in 33 children: nine controls, 15 with gastro-oesophageal reflux alone, and nine with reflux oesophagitis. A total of 122 episodes of reflux were analysed in detail: 82 (67%) were synchronous with swallowing and 40 (33%) as...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.63.11.1333

    authors: Mahony MJ,Migliavacca M,Spitz L,Milla PJ

    更新日期:1988-11-01 00:00:00

  • Glycogenosis type IV: liver transplant at 12 years.

    abstract::Hepatomegaly, the presenting feature of type IV glycogen storage disease at 20 months of age, regressed during childhood. The patient remained asymptomatic until 12 years of age when, after an episode of shock, septicaemia, and spontaneous peritonitis, liver transplantation was successfully performed. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.71.5.450

    authors: Dhawan A,Tan KC,Portmann B,Mowat AP

    更新日期:1994-11-01 00:00:00

  • Cross-sectional epidemiology of hearing loss in Australian children aged 11-12 years old and 25-year secular trends.

    abstract:OBJECTIVE:In a national study of Australian children aged 11-12 years old, we examined the (1) prevalence and characteristics of hearing loss, (2) its demographic risk factors and (3) evidence for secular increases since 1990. METHODS:This is a cross-sectional CheckPoint wave within the Longitudinal Study of Australia...

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    pub_type: 杂志文章

    doi:10.1136/archdischild-2017-313505

    authors: Wang J,le Clercq CMP,Sung V,Carew P,Liu RS,Mensah FK,Burt RA,Gold L,Wake M

    更新日期:2018-06-01 00:00:00

  • Intelligence and development in Aarskog syndrome.

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    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.79.4.359

    authors: Logie LJ,Porteous ME

    更新日期:1998-10-01 00:00:00

  • Short stay facilities: the future of efficient paediatric emergency services.

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    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.74.4.309

    authors: Browne GJ,Penna A

    更新日期:1996-04-01 00:00:00

  • Human chorionic gonadotrophin secreting pineal germinoma and precocious puberty.

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    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.58.9.743

    authors: Ahmed SR,Shalet SM,Price DA,Pearson D

    更新日期:1983-09-01 00:00:00

  • Plasma somatomedin activity in protein calorie malnutrition.

    abstract::Somatomedin activity was assayed in the plasma of children suffering from protein calorie malnutrition by a bioassay using rat cartilage and expressed as sulphate uptake ratio. The sulphate uptake ratio was particularly reduced in kwashiorkor. In marasmus there was a slight reduction and the levels were still in the n...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.54.1.62

    authors: Mohan PS,Jaya Rao KS

    更新日期:1979-01-01 00:00:00

  • The nutritional cost of measles in Africa.

    abstract::A 24 hour energy balance study was carried out on 20 black Kenyan children with acute measles and repeated after recovery. The energy content of a weighed 24 hour food intake and of a simultaneous collection of faeces and urine was determined by bomb calorimetry. Energy expenditure was measured by indirect calorimetry...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.61.1.61

    authors: Duggan MB,Alwar J,Milner RD

    更新日期:1986-01-01 00:00:00

  • Asthma drug adherence in a long term clinical trial.

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    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/adc.83.4.330

    authors: Jónasson G,Carlsen KH,Mowinckel P

    更新日期:2000-10-01 00:00:00

  • Promoting research for children.

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    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2009.178160

    authors: Modi N

    更新日期:2010-11-01 00:00:00

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    journal_title:Archives of disease in childhood

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    doi:10.1136/archdischild-2017-313032

    authors: Wray J,Hobden S,Knibbs S,Oldham G

    更新日期:2018-03-01 00:00:00

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    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/adc.2008.146027

    authors: Schwartz J,Dube K,Sichert-Hellert W,Kannenberg F,Kunz C,Kalhoff H,Kersting M

    更新日期:2009-11-01 00:00:00

  • Continuing need for mineralocorticoid therapy in salt-losing congenital adrenal hyperplasia.

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    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.54.5.350

    authors: Hughes IA,Wilton A,Lole CA,Gray OP

    更新日期:1979-05-01 00:00:00

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    abstract:OBJECTIVE:To describe the significance of pericardial effusion (PE), mitral regurgitation (MR) and impaired systolic function in predicting coronary artery lesions (CAL) at diagnosis and follow-up in Kawasaki disease (KD). DESIGN:Echocardiographic records on admission, at 1-3 weeks of illness, and at 6-8 weeks of illn...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2011-301256

    authors: Lega JC,Bozio A,Cimaz R,Veyrier M,Floret D,Ducreux C,Reix P,Di Filippo S

    更新日期:2013-02-01 00:00:00

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    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.51.3.227

    authors: Horst R,Dyer D,Hallett A

    更新日期:1976-03-01 00:00:00

  • Antenatal and early infant predictors of postnatal growth in rural Vietnam: a prospective cohort study.

    abstract:OBJECTIVE:To determine which antenatal and early-life factors were associated with infant postnatal growth in a resource-poor setting in Vietnam. STUDY DESIGN:Prospective longitudinal study following infants (n=1046) born to women who had previously participated in a cluster randomised trial of micronutrient supplemen...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2014-306328

    authors: Hanieh S,Ha TT,De Livera AM,Simpson JA,Thuy TT,Khuong NC,Thoang DD,Tran TD,Tuan T,Fisher J,Biggs BA

    更新日期:2015-02-01 00:00:00

  • Thyroid scintigraphy differentiates subtypes of congenital hypothyroidism.

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    更新日期:2021-01-01 00:00:00

  • Anthropometric measures are simple and accurate paediatric weight-prediction proxies in resource-poor settings with a high HIV prevalence.

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    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2015-309645

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    更新日期:2017-01-01 00:00:00

  • Randomised double blind placebo controlled trial of the effect of botulinum toxin on walking in cerebral palsy.

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    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/adc.83.6.481

    authors: Ubhi T,Bhakta BB,Ives HL,Allgar V,Roussounis SH

    更新日期:2000-12-01 00:00:00

  • Pathogenesis of liver damage during parenteral nutrition: is lipofuscin a clue?

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    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.60.8.774

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    更新日期:1985-08-01 00:00:00

  • Cat scratch disease in Greece.

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    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.78.1.64

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    更新日期:1998-01-01 00:00:00

  • Lack of effect of phototherapy on plasma cyclic-AMP in newborn infants.

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    doi:10.1136/adc.52.5.416

    authors: Constantopoulos A,Karaboula K,Matsaniotis N

    更新日期:1977-05-01 00:00:00

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    doi:10.1136/adc.53.7.545

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