Abstract:
BACKGROUND:Cerebral palsy is the commonest cause of severe physical disability in childhood. For many years treatment has centred on the use of physiotherapy and orthotics to overcome the problems of leg spasticity, which interferes with walking and can lead to limb deformity. Intramuscular botulinum toxin (BT-A) offers a targeted form of therapy to reduce spasticity in specific muscle groups. AIMS:To determine whether intramuscular BT-A can improve walking in children with cerebral palsy. DESIGN:Randomised, double blind, placebo controlled trial. METHODS:Forty patients with spastic diplegia or hemiplegia were enrolled. Twenty two received botulinum toxin and 18 received placebo. The primary outcome measure was video gait analysis and secondary outcome measures were gross motor function measure (GMFM), physiological cost index (PCI), and passive ankle dorsiflexion. RESULTS:Video gait analysis showed clinically and statistically significant improvement in initial foot contact following BT-A at six weeks and 12 weeks compared to placebo. Forty eight per cent of BT-A treated children showed clinical improvement in VGA compared to 17% of placebo treated children. The GMFM (walking dimension) showed a statistically significant improvement in favour of the botulinum toxin treated group. Changes in PCI and passive ankle dorsiflexion were not statistically significant. CONCLUSION:The study gives further support to the use of intramuscular botulinum toxin type A as an adjunct to conventional physiotherapy and orthoses to reduce spasticity and improve functional mobility in children with spastic diplegic or hemiplegic cerebral palsy.
journal_name
Arch Dis Childjournal_title
Archives of disease in childhoodauthors
Ubhi T,Bhakta BB,Ives HL,Allgar V,Roussounis SHdoi
10.1136/adc.83.6.481subject
Has Abstractpub_date
2000-12-01 00:00:00pages
481-7issue
6eissn
0003-9888issn
1468-2044journal_volume
83pub_type
临床试验,杂志文章,随机对照试验abstract::The provision of positive end expiratory pressure, via a unique portable system, in the long term management of a child with thoracic dystrophy is reported. The system uses low gas flow enabling a reduction in equipment and simplification of the circuit as compared with a standard continuous positive airways pressure ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.67.1.136
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abstract:AIM:To examine evolution of the physical characteristics of Marfan's syndrome throughout childhood. METHODS:40 children were ascertained during the development of a regional register for Marfan's syndrome. Evolution of the clinical characteristics was determined by repeat evaluation of 10 patients with sporadic Marfan...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.76.1.41
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abstract::The effect of phototherapy on plasma cyclic-AMP in newborn infants has been studied. Our results suggest that phototherapy does not produce appreciable changes in plasma cyclic-AMP levels. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.52.5.416
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abstract::Atypical, non-diarrhoea associated haemolytic uraemic syndrome (D-HUS) is a heterogeneous disorder with a generally poor outcome, although this view has now been questioned. The clinical and laboratory features of 23 children with D-HUS, representing a third of all patients with HUS seen during the last 26 years, were...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/adc.76.6.518
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journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.77.6.524
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journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章
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abstract:OBJECTIVE:To assess the accuracy of parental recall of birth weight in a British population and to investigate whether social class and age of the child significantly influence the accuracy of recalled birth weight. METHODS:A questionnaire was given to parents whose children were participating in a blood pressure stud...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.82.3.202
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journal_title:Archives of disease in childhood
pub_type: 杂志文章
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journal_title:Archives of disease in childhood
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journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.53.1.58
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journal_title:Archives of disease in childhood
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journal_title:Archives of disease in childhood
pub_type: 杂志文章
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journal_title:Archives of disease in childhood
pub_type: 杂志文章
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journal_title:Archives of disease in childhood
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journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2016-311535.21
更新日期:2016-09-01 00:00:00
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journal_title:Archives of disease in childhood
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journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1993-03-01 00:00:00
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journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
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journal_title:Archives of disease in childhood
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journal_title:Archives of disease in childhood
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journal_title:Archives of disease in childhood
pub_type: 杂志文章
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journal_title:Archives of disease in childhood
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journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.61.12.1178
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journal_title:Archives of disease in childhood
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journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Archives of disease in childhood
pub_type: 杂志文章,实务指引
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journal_title:Archives of disease in childhood
pub_type: 杂志文章,多中心研究
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更新日期:1998-03-01 00:00:00
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journal_title:Archives of disease in childhood
pub_type: 杂志文章
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