Abstract:
:The IgG subclass specific immune response against pneumococcal type 3 polysaccharide antigen before and after immunisation in healthy children and children with recurrent bronchitis was studied. Recurrent bronchitis was defined as three or more episodes a year, during at least two consecutive years, of bronchopulmonary infection, productive cough with or without fever, and/or diffuse rales by physical examination. Twenty five patients and 15 healthy children were selected. The patient group had lower concentrations of IgG1 and IgG2 specific pneumococcal antibodies compared with healthy children, regardless of whether or not the total IgG2 concentration was low. The children with recurrent bronchitis showed a greater increase in IgG1 and IgG2 antibodies after immunisation than the controls. It is concluded that children with recurrent bronchitis show a decreased humoral immune response to pneumococcal type 3 polysaccharide antigen. This finding suggests that a defect in the humoral immune response against polysaccharide antigens is an important cause of recurrent bronchitis in childhood.
journal_name
Arch Dis Childjournal_title
Archives of disease in childhoodauthors
de Baets F,Pauwels R,Schramme I,Leroy Jdoi
10.1136/adc.66.12.1378subject
Has Abstractpub_date
1991-12-01 00:00:00pages
1378-82issue
12eissn
0003-9888issn
1468-2044journal_volume
66pub_type
杂志文章abstract:AIMS:To determine whether current and postpartum maternal depression and low maternal intelligence are risk factors for malnutrition in children. METHODS:In rural South India 72 children with malnutrition were identified from a central register; 72 controls were matched for age, gender, and residence. RESULTS:Major d...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2002.009738
更新日期:2004-04-01 00:00:00
abstract::Twenty-one children who had been diagnosed as having laryngomalacia by direct laryngoscopy in infancy were reviewed 7 to 12 years later. The natural history of the disease is documented. A wide variation in the time of onset and duration of the stridor was found and there was a high incidence of feeding difficulties. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.52.3.215
更新日期:1977-03-01 00:00:00
abstract:PURPOSE:To estimate the minimum incidence of congenital Zika syndrome (CZS) and severe microcephaly in Canada and describe key clinical, epidemiological, aetiological and outcome features of these conditions. METHODS:Two separate national surveillance studies were conducted on CZS and severe microcephaly using the wel...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2020-320968
更新日期:2021-01-08 00:00:00
abstract::In a prospective follow up of 116 high risk infants, a 24 hour behavioural chart on seven consecutive days was analysed at seven and 12 weeks of age. Of children who manifested atopic disease at 2 years, 44/116 (38%), had shown significantly more fussing during the seventh, and colic type cry during the twelfth week t...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.84.4.349
更新日期:2001-04-01 00:00:00
abstract:AIMS:To test the hypothesis that oxygen free radicals are mediators of excessive protein permeability in steroid responsive nephrotic syndrome. DESIGN:Case control study. SUBJECTS: PATIENTS:20 children with steroid responsive nephrotic syndrome; controls: 20 children admitted for elective surgery. SETTING:The paedi...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.82.1.76
更新日期:2000-01-01 00:00:00
abstract::A picture archiving and communication system (PACS) is a computerised means of replacing the roles of conventional radiological film. This review describes the Hammersmith PACS, and discusses the advantages and disadvantages of PACS systems. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/adc.83.1.82
更新日期:2000-07-01 00:00:00
abstract::Rapid urbanisation in the 20th century has been accompanied by the development of slums. Nearly one-third of the world's population and more than 60% of urban populations in the least developed countries live in slums, including hundreds of millions of children. Slums are areas of broad social and health disadvantage ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2011-301621
更新日期:2013-10-01 00:00:00
abstract::We studied 91 offspring of ABO incompatible preganacies and 30 controls resulting from O--O pregnancies to test whether cord bilirubin levels could be used to predict the severity of hyperbilirubinaemia in ABO incompatibility. Blood group, direct Coombs's test, and serum bilirubin estimations were carried out on cord ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.52.3.219
更新日期:1977-03-01 00:00:00
abstract::A girl was born to a mother who had undergone treatment for epilepsy with carbamazepine during pregnancy. The infant had dysmorphic features and was physically and mentally retarded. We consider that the malformations were the result of the maternal treatment with carbamazepine. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.66.5.641
更新日期:1991-05-01 00:00:00
abstract:BACKGROUND:Children with severe malnutrition (SAM) present to hospital with an array of complications, resulting in high mortality despite adherence to WHO guidelines. Diagnostic resources in developing countries are limited and bedside tests could help identify high-risk children. Dipstick urinalysis is a bedside scre...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2009.168211
更新日期:2010-06-01 00:00:00
abstract:INTRODUCTION:Fetal anticonvulsant syndrome (FACS) describes the pattern of physical and developmental problems seen in those children exposed to certain antiepileptic drugs (AEDs) in utero. The diagnosis of FACS is a clinical one and so excluding alternative diagnoses such as genetic disorders is essential. METHODS:We...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2018-316547
更新日期:2020-04-01 00:00:00
abstract:AIMS:To compare the respiratory health and function at 8 to 9 years of age of a total population based cohort of 300 very low birthweight (VLBW) children with that of two classroom controls (n = 590) matched for age and sex. STUDY DESIGN:Cohort study with controls. SETTING:Schools throughout Scotland. RESULTS:The VL...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.74.3.188
更新日期:1996-03-01 00:00:00
abstract::Four child-protection scenarios were sent to 200 named/designated and non-named/non-designated doctors. The respondents judged each scenario as abuse or accident and indicated their degree of certainty. There was a 71% response rate. There were no significant differences in judgement or degrees of certainty of judgeme...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2006.105528
更新日期:2008-07-01 00:00:00
abstract::After their first episode of febrile convulsions, 195 previously healthy children, aged 6--30 months, were given either diazepam or phenobarbitone for a year. Each child was assigned at random to one of the two medications: children admitted on even days were given a suppository containing 5 mg diazepam every 8 hours ...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/adc.53.8.660
更新日期:1978-08-01 00:00:00
abstract:BACKGROUND:Data on the efficacy and safety of long-acting β2-agonists (LABA) in children are limited, and current guidelines recommend that LABA always be used with inhaled corticosteroids (ICS). OBJECTIVE:To compare asthma control, assessed by rescue medications use, in children prescribed LABA and ICS as a fixed-dos...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,多中心研究
doi:10.1136/adc.2009.179069
更新日期:2010-10-01 00:00:00
abstract::Blood pressure (BP) values and the phenomenon of tracking were evaluated in a group of 481 schoolchildren over a nine year period starting at age 6 years. BP values were obtained yearly by taking the mean of two measurements at one visit, measurements were taken by only two observers during the study. For both systoli...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.81.2.169
更新日期:1999-08-01 00:00:00
abstract::Two cross sectional surveys, 24 years apart, using the same respiratory questionnaire, were carried out to examine changes in prevalence rates of cough, phlegm, and wheeze and to relate changes in wheeze to objective peak expiratory flow rates (PEFRs). The surveys were done in towns in southern and northern England an...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.68.6.729
更新日期:1993-06-01 00:00:00
abstract::Three cases are reported in which thrombi were found in the aorta at postmortem. In each case the thrombus had originated within the ductus arteriosus. We believe that in recent years the attention paid to the presence of indwelling cannulae as a cause of embolic phenomena in the newborn period has led to a reduction ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.53.2.164
更新日期:1978-02-01 00:00:00
abstract::Somatomedin activity was assayed in the plasma of children suffering from protein calorie malnutrition by a bioassay using rat cartilage and expressed as sulphate uptake ratio. The sulphate uptake ratio was particularly reduced in kwashiorkor. In marasmus there was a slight reduction and the levels were still in the n...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.54.1.62
更新日期:1979-01-01 00:00:00
abstract::Plasma testosterone was estimated by radioimmunoassay in 60 children with disorders of sexual development before and after stimulation with human chorionic gonadotrophin (HCG). In 21 children the testosterone levels after 3 and 5 daily injections of 1000 units HCG were compared and good correlation was found between t...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.51.8.596
更新日期:1976-08-01 00:00:00
abstract:OBJECTIVE:To investigate whether school readiness could be affected by placing electronic devices (EDs) in children's bedroom and whether the relationship was moderated by parental restriction and family socioeconomic status (SES). DESIGN:This is a cross-sectional study with bedroom ED placement and parental restricti...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2017-312639
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVE:To ascertain mortality from 1 to 18 years, and predictors of mortality. DESIGN:Long-term follow-up of population cohort born 1989-1992. SETTING:Births in South East Thames Region. PATIENTS:346 children with bilateral cerebral palsy (CP). INTERVENTIONS:Not applicable. MAIN OUTCOME MEASURES:Mortality; pred...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2009.172841
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:To examine the risk of disability from unintentional injury in teenagers and young adults. METHODS:Analyses of data from the National Child Development Study, a follow up study of 98% of all children born in England, Scotland, and Wales in one week in March, 1958. In 1981, 12,537 study participants, 76% of t...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.75.2.156
更新日期:1996-08-01 00:00:00
abstract::Immunohistochemical studies of pancreatic tissue from patients with cystic fibrosis associated with diabetes mellitus (CFDM) show increased numbers of somatostatin secreting delta cells. To look for a possible functional correlate to this finding basal and arginine stimulated plasma somatostatin and serum C peptide co...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.68.1.123
更新日期:1993-01-01 00:00:00
abstract::The revised BSPGHAN guidelines for the diagnosis and management of coeliac disease represent an important shift in diagnostic strategy, aimed at simplifying and shortening the diagnostic process in selected cases. Guidance is given concerning the indications for testing for coeliac disease, which is still significantl...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,实务指引
doi:10.1136/archdischild-2013-303996
更新日期:2013-10-01 00:00:00
abstract::Four preterm infants of very low birthweight (less than 1500 g) developed signs of copper deficiency between age 8 and 10 weeks. All had required prolonged ventilatory support, parenteral nutrition, and nasojejunal feeding. The clinical features, which included osteoporosis, oedema, anaemia, neutropenia, and late apno...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.60.7.644
更新日期:1985-07-01 00:00:00
abstract::Real time ultrasonography of the pelvic organs was performed on 114 normal premenarcheal girls aged between 2 years and 13 years 11 months. Values were obtained for total uterine length, anteroposterior diameters of the corpus and cervix, corpus/cervix ratio, and uterine and ovarian volumes and the resultant data were...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.60.2.120
更新日期:1985-02-01 00:00:00
abstract:AIMS:To determine whether the use of negative pressure ventilation (NPV) was associated with a lower rate of endotracheal intubation in infants with recurrent apnoea secondary to acute bronchiolitis. METHODS:Retrospective review of two paediatric intensive care units (PICU) databases and case notes; one PICU offered N...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,多中心研究
doi:10.1136/adc.2003.039404
更新日期:2005-03-01 00:00:00
abstract:AIM:To evaluate the quality of paediatric audits from 1966 to 1999. METHODS:A Medline search was performed using the MeSH terms audit, child, paediatric (and pediatric). Predefined core elements of audit were used as inclusion criteria for entry of an article into this study. These criteria were as follows: (1) an art...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/adc.2004.071381
更新日期:2007-04-01 00:00:00
abstract::The prevalence of thyroid disease in 134 children, adolescents, and young adults with diabetes mellitus beginning in childhood is described. Clustering of a family history of thyroid disease and the presence of thyrogastric antibodies in some patients supports the concept of familial autoimmunity. In 4 children a diag...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.57.8.622
更新日期:1982-08-01 00:00:00