Trimethoprim-sulphamethoxazole in the treatment of persistent diarrhoea: a double blind placebo controlled clinical trial.

Abstract:

:The efficacy of an absorbable antimicrobial agent trimethoprim-sulphamethoxazole (TMP-SMX) in the management of children with persistent diarrhoea was evaluated in a double blind, randomised, and placebo controlled trial. Of the 55 patients studied, 28 received TMP-SMX, and 27 received placebo. A trend in stool weight reduction was observed from the third day after the drug was started, and the reduction was statistically significant on day 6 and day 7. However, the difference in total stool output (g/kg) up to day 7 was not significantly different between the two groups. The proportion of children whose diarrhoea resolved by day 7 (therapeutic success) was significantly more in the treatment group compared with the placebo group (23 v 15). Additionally, mean duration of diarrhoea in the group that received TMP-SMX was less compared with the placebo group (6.0 v 8.3 days); this difference, however, was not significant. Hospital infection (probably nosocomial infection) was significantly less in the TMP-SMX treated group (1 v 10). The results of our study indicate that TMP-SMX has a clinical benefit in respect of reducing the stool output, and higher recovery rate within seven days of treatment. In addition, it prevented possible hospital acquired infection.

journal_name

Arch Dis Child

authors

Alam NH,Bardhan PK,Haider R,Mahalanabis D

doi

10.1136/adc.72.6.483

subject

Has Abstract

pub_date

1995-06-01 00:00:00

pages

483-6

issue

6

eissn

0003-9888

issn

1468-2044

journal_volume

72

pub_type

临床试验,杂志文章,随机对照试验
  • Effect of taurine supplementation on fat and energy absorption in cystic fibrosis.

    abstract::In 10 children with cystic fibrosis and persisting steatorrhoea, supplementation with taurine (30-40 mg/kg/day) was given for two months as an adjunct to the usual pancreatic enzyme treatment. A three day fat and energy balance was performed in patients with cystic fibrosis, before and after the supplementation, and i...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.67.9.1082

    authors: De Curtis M,Santamaria F,Ercolini P,Vittoria L,De Ritis G,Garofalo V,Ciccimarra F

    更新日期:1992-09-01 00:00:00

  • Cutaneous manifestations in patients with Wiskott-Aldrich syndrome submitted to haematopoietic stem cell transplantation.

    abstract:INTRODUCTION:Wiskott-Aldrich syndrome (WAS) is an X-linked primary immunodeficiency caused by a mutation of the WAS protein gene. This protein actively participates in important cellular processes, and its presence is related to diverse clinical manifestations, including cutaneous alterations. The classical triad of WA...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2011-300812

    authors: Loyola Presa JG,de Carvalho VO,Morrisey LR,Bonfim CM,Abagge KT,Vasselai A,Marinoni LP

    更新日期:2013-04-01 00:00:00

  • Increased prescribing trends of paediatric psychotropic medications.

    abstract::Psychotropic medication use by children in the USA has increased. We used the IMS MIDAS Prescribing Insights to examine prescribing trends in nine countries between the years 2000 and 2002. Trends in seven countries rose significantly from year 2000 to 2002; the UK had the highest increase (68%). ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

    doi:10.1136/adc.2004.050468

    authors: Wong IC,Murray ML,Camilleri-Novak D,Stephens P

    更新日期:2004-12-01 00:00:00

  • Screening a state middle school for asthma using the free running asthma screening test.

    abstract::The free running asthma screening test (FRAST) was used to screen children in a state middle school during a normal physical education lesson. The test was conducted by the teachers with a general practitioner available via a radiopager. Of the 249 children attending the school, aged 8-12 years, 237 (95%) were tested....

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.69.6.667

    authors: Williams D,Bruton J,Wilson I

    更新日期:1993-12-01 00:00:00

  • 24 hour blood pressure monitoring in healthy and hypertensive children.

    abstract::24 Hour ambulatory blood pressure monitoring (ABPM) was performed to provide data on the normal daily blood pressure of healthy schoolchildren and on patients with hypertension. The subjects studied were 123 healthy schoolchildren with a mean (SD) age of 12.5 (1.6) years (range 9.5-14.5 years), 24 children with border...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.70.2.90

    authors: Reusz GS,Hóbor M,Tulassay T,Sallay P,Miltényi M

    更新日期:1994-02-01 00:00:00

  • Cockayne's syndrome and emphysema.

    abstract::A 5-year-old boy with Cockayne's syndrome is described. In addition to the recognised clinical features, he presented with severe fixed airways obstruction, and investigations confirmed clinical and physiological emphysema. In a disorder associated with many of the features of aging, it is probably that the presence o...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.53.9.722

    authors: Cunningham M,Godfrey S,Moffat WM

    更新日期:1978-09-01 00:00:00

  • Gaviscon and Carobel compared with cisapride in gastro-oesophageal reflux.

    abstract::We compared the efficacy of the prokinetic agent cisapride with that of Gaviscon (an alginate/alkaline compound) plus Carobel (carob seed flour) in the treatment of gastrooesophageal reflux (GOR). Fifty infants with confirmed GOR received either oral cisapride (0.8 mg/kg/day) or Gaviscon plus Carobel for one month in ...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/adc.67.5.618

    authors: Greally P,Hampton FJ,MacFadyen UM,Simpson H

    更新日期:1992-05-01 00:00:00

  • Time trends in respiratory symptoms in childhood over a 24 year period.

    abstract::Two cross sectional surveys, 24 years apart, using the same respiratory questionnaire, were carried out to examine changes in prevalence rates of cough, phlegm, and wheeze and to relate changes in wheeze to objective peak expiratory flow rates (PEFRs). The surveys were done in towns in southern and northern England an...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.68.6.729

    authors: Whincup PH,Cook DG,Strachan DP,Papacosta O

    更新日期:1993-06-01 00:00:00

  • Arthritis in children: comparison of clinical and biological characteristics of septic arthritis and juvenile idiopathic arthritis.

    abstract:AIM:Childhood arthritis arises from several causes. The aim of this observational study is to compare the clinical and biological features and short-term outcome of different types of arthritis because they have different treatment and prognoses. METHODS:Children <16 years of age hospitalised in a French tertiary care...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

    doi:10.1136/archdischild-2016-310594

    authors: Aupiais C,Basmaci R,Ilharreborde B,Blachier A,Desmarest M,Job-Deslandre C,Faye A,Bonacorsi S,Alberti C,Lorrot M

    更新日期:2017-04-01 00:00:00

  • A decade of growth hormone treatment in girls with Turner syndrome in the UK. UK KIGS Executive Group.

    abstract::Fifteen per cent of children treated with growth hormone (GH) are receiving treatment for Turner syndrome, but few results are available on final height in the UK. In this study, data were obtained from the UK KIGS database for 485 girls with Turner syndrome who were treated from 1986, allowing an audit of practice an...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.80.3.221

    authors: Betts PR,Butler GE,Donaldson MD,Dunger DB,Johnston DI,Kelnar CJ,Kirk J,Price DA,Wilton P

    更新日期:1999-03-01 00:00:00

  • Prevalence of microcephaly in eight south-eastern and midwestern Brazilian neonatal intensive care units: 2011-2015.

    abstract:OBJECTIVE:To describe the prevalence of microcephaly in infants admitted to the neonatal intensive care units (NICUs) in eight private hospitals in south-eastern and midwestern Brazil, from 2011 to 2015. DESIGN:Observational, cross-sectional study in a cohort of neonates. SETTING:Eight private NICUs situated in the c...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

    doi:10.1136/archdischild-2016-311541

    authors: de Magalhães-Barbosa MC,Prata-Barbosa A,Robaina JR,Raymundo CE,Lima-Setta F,Antonio José Ledo Alves da Cunha

    更新日期:2017-08-01 00:00:00

  • A drug utilisation study of antidepressants in children and adolescents using the General Practice Research Database.

    abstract:AIMS:To characterise prescribing patterns of antidepressants (ATDs) to children and adolescents aged < or =18 years in the UK. METHODS:Subjects issued at least one ATD prescription between 1 January 1992 and 31 December 2001 were identified from the UK General Practice Research Database. Prescribing patterns, annual p...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2004.064956

    authors: Murray ML,de Vries CS,Wong IC

    更新日期:2004-12-01 00:00:00

  • Radiological abnormalities in infants with urinary tract infections.

    abstract::An intravenous urogram and micturating cystourethrogram were carried out in 100 infants presenting with documented urinary tract infections. Ninety three cases were identified by suprapubic aspiration and 7 by culture of two voided urine samples containing greater than 100 X 10(6) organisms per litre. The urinary trac...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.59.7.620

    authors: Bourchier D,Abbott GD,Maling TM

    更新日期:1984-07-01 00:00:00

  • Congenital laryngomalacia is related to exercise-induced laryngeal obstruction in adolescence.

    abstract:OBJECTIVES:Congenital laryngomalacia (CLM) is the major cause of stridor in infants. Most cases are expected to resolve before 2 years of age, but long-term respiratory prospects are poorly described. We aimed to investigate if CLM was associated with altered laryngeal structure or function in later life. METHODS:Twen...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2015-308450

    authors: Hilland M,Røksund OD,Sandvik L,Haaland Ø,Aarstad HJ,Halvorsen T,Heimdal JH

    更新日期:2016-05-01 00:00:00

  • Pelvic ultrasonography in premenarcheal girls: relation to puberty and sex hormone concentrations.

    abstract::Real time ultrasonography of the pelvic organs was performed on 114 normal premenarcheal girls aged between 2 years and 13 years 11 months. Values were obtained for total uterine length, anteroposterior diameters of the corpus and cervix, corpus/cervix ratio, and uterine and ovarian volumes and the resultant data were...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.60.2.120

    authors: Salardi S,Orsini LF,Cacciari E,Bovicelli L,Tassoni P,Reggiani A

    更新日期:1985-02-01 00:00:00

  • Costs and outcomes in a regional neonatal intensive care unit.

    abstract::At the Birmingham Maternity Hospital the mean cost of caring for surviving infants who require neonatal intensive care ranges from approximately pounds 2500 (for infants above 1500 g birthweight), to pounds 5500 (for infants 1000 to 1499 g birthweight), to pounds 10 000 (for infants less than 1000 g birthweight). The ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.59.11.1064

    authors: Newns B,Drummond MF,Durbin GM,Culley P

    更新日期:1984-11-01 00:00:00

  • Renal scarring and vesicoureteric reflux.

    abstract::A review of 105 children with urinary tract infection showed an increasing prevalence of grades II-III vesicoureteric reflux with diminishing age. During infancy reflux was almost always severe, and affected boys as often as girls. Radiologically scarred kidneys were drained by refluxing ureters in 98% of cases. The p...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.53.3.210

    authors: Shah KJ,Robins DG,White RH

    更新日期:1978-03-01 00:00:00

  • Behaviour and development in 24-month-old moderately preterm toddlers.

    abstract:OBJECTIVE:Moderately preterm children (gestational age 32-36+6 weeks) are at risk of cognitive and behaviour problems at school age. The aim of this study was to investigate if these problems are already present at the age of 2 years. STUDY DESIGN:Developmental outcome was assessed at 24-months (corrected age) with th...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2014-307016

    authors: de Jong M,Verhoeven M,Lasham CA,Meijssen CB,van Baar AL

    更新日期:2015-06-01 00:00:00

  • Cows' milk-sensitive enteropathy.

    abstract::Serial small intestinal biopsies related to withdrawal and challenge with cows' milk are described in 5 infants with cows' milk protein intolerenace. On the basis of these serial observations the existence of a cows' milk-sensitive enteropathy in infancy is clearly established. The cows' milk-sensitive mucosal lesion ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.53.5.375

    authors: Walker-Smith J,Harrison M,Kilby A,Phillips A,France N

    更新日期:1978-05-01 00:00:00

  • Varicella paediatric hospitalisations in Belgium: a 1-year national survey.

    abstract:BACKGROUND:Varicella universal vaccination (UV) has been implemented in many countries for several years. Nevertheless, varicella UV remains debated in Europe and few data are available on the real burden of infection. We assessed the burden of varicella in Belgium through analysis of hospitalised cases during a 1-year...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

    doi:10.1136/archdischild-2015-308283

    authors: Blumental S,Sabbe M,Lepage P,Belgian Group for Varicella.

    更新日期:2016-01-01 00:00:00

  • Inferior vena cava thrombosis as a complication of femoral vein catheterisation.

    abstract::Indwelling femoral venous catheters were prospectively studied by ultrasonography to define the frequency and evolution of inferior vena cava (IVC) thrombosis. IVC thrombosis was identified in six of 56 catheters (54 children). Only one patient with a positive ultrasound scan had clinical signs of thrombosis. All chil...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.72.4.343

    authors: Shefler A,Gillis J,Lam A,O'Connell AJ,Schell D,Lammi A

    更新日期:1995-04-01 00:00:00

  • The role of inflammation in childhood asthma.

    abstract::The role of inflammation in adult asthma is well known, involving a cascade of immunological stimulation in which mast cells and eosinophils play pivotal roles. However, the assessment of airway inflammation in children is more difficult as the invasive methods used in adults cannot ethically be used for this purpose ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/adc.82.suppl_2.ii6

    authors: Chedevergne F,Le Bourgeois M,de Blic J,Scheinmann P

    更新日期:2000-06-01 00:00:00

  • Randomised trial of early tapping in neonatal posthaemorrhagic ventricular dilatation. Ventriculomegaly Trial Group.

    abstract::Treatment of posthaemorrhagic ventricular dilatation by early repeated cerebrospinal fluid taps was compared with conservative management in a randomised controlled trial of 157 infants in 15 centres. Thirty infants died and six moved abroad before follow up. During the first 14 days after randomisation, the early tre...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1136/adc.65.1_spec_no.3

    authors:

    更新日期:1990-01-01 00:00:00

  • USE OF PILL GLIDE TO ENCOURAGE TRANSITION FROM LIQUID TO SOLID DOSAGE FORMULATIONS.

    abstract:SITUATION:Patient I is a 15 year old female with ornithine transcarbamylase deficiency prescribed L-arginine 1.5 g three times daily and sodium benzoate 4.2 g three times daily. By taking her medication and controlling her diet she is able to lead a normal life and does well at school. However she struggles with the pa...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2016-311535.8

    authors: Gaskell C

    更新日期:2016-09-01 00:00:00

  • Production of the hydroxylated metabolites of vitamin D in a neonate with a single hypoplastic-dysplastic kidney.

    abstract::The ability to produce dihydroxylated metabolites of vitamin D was studied in a term neonate suffering from severe renal insufficiency. The infant died at age 26 days owing to end-stage renal failure and the necropsy examination showed a single dysplastic kidney weighing 1.5 g. At age 2 weeks the serum levels of the d...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.58.1.66

    authors: Alkalay A,Mogilner BM,Nissim F,Edelstein S

    更新日期:1983-01-01 00:00:00

  • Managing bone and joint infection in children.

    abstract::There is little high quality evidence on which to base the management of bone and joint infections in children. This pragmatic practice note aims to provide a consensus framework of best current practice prior to the availability of data from large national randomised controlled trials. For straightforward infection i...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/archdischild-2011-301089

    authors: Faust SN,Clark J,Pallett A,Clarke NM

    更新日期:2012-06-01 00:00:00

  • Natural history of trisomy 13.

    abstract::The poor prognosis of patients with trisomy 13 has long been accepted and has been ascribed to brain and heart malformations. It has been suggested, however, that the long term survival is better than was previously thought and that cardiac surgery may be justified. This population based study reviews the incidence, a...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.71.4.343

    authors: Wyllie JP,Wright MJ,Burn J,Hunter S

    更新日期:1994-10-01 00:00:00

  • Are treatment targets for hypercholesterolemia evidence based? Systematic review and meta-analysis of randomised controlled trials.

    abstract:OBJECTIVE:Search for evidence supporting target age, level of intervention and target values for low-density lipoprotein (LDL) cholesterol levels in children with familial hypercholesterolemia. DESIGN:Systematic review and meta-analysis. PubMed, Medline, CINAHL and Cochrane Reviews databases from 1966 to 2007 were sea...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,meta分析,评审

    doi:10.1136/adc.2008.157024

    authors: Lebenthal Y,Horvath A,Dziechciarz P,Szajewska H,Shamir R

    更新日期:2010-09-01 00:00:00

  • Alteration of lung diffusion capacity in IgA nephropathy.

    abstract:OBJECTIVE:To establish whether changes of lung transfer for carbon monoxide (TLCO) are related to the phase of IgA nephropathy. METHODS:Respiratory function was tested in 12 children with IgA nephropathy assessed by percutaneous renal biopsy. This was done during acute exacerbations or haematuria-free phases of the di...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章

    doi:10.1136/adc.74.3.236

    authors: Ravilly S,Chaussain M,Iniguez JL,Lenhert A,Kalifa G,Brun P,Niaudet P,Gendrel D

    更新日期:1996-03-01 00:00:00

  • Assuring validity of multisource feedback in a national programme.

    abstract:OBJECTIVE:To report the evidence for and challenges to the validity of Sheffield Peer Review Assessment Tool (SPRAT) with paediatric Specialist Registrars (SpRs) across the UK as part of Royal College of Paediatrics and Child Health workplace based assessment programme. DESIGN:Quality assurance analysis, including gen...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

    doi:10.1136/adc.2008.146209

    authors: Archer J,McGraw M,Davies H

    更新日期:2010-05-01 00:00:00